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Combined Modality Therapy of Central Nervous System Tumors pp 37–51Cite as

Molecular Biology

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The initial event in the generation of all central nervous system (CNS) tumors is the transformation of a normal cell into a cancer cell. The biological processes associated with this development eventually lead to the survival of cancer cells and to the formation of a solid tumor. Steps involved in this tumorigenic process include the cell¡¯s escape from the immune system surveillance (i.e., antitumor response), aberrant proliferation and multiplication, tumor cell invasion, and angiogenesis. Over the past decade, much has been learned about the basic genetic events and the molecular biology underlying the development of CNS cancers.This review attempts to describe the molecular biology of CNS tumors, highlighting potential targets for therapeutic interventions.

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  1. Reiner Class
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Editors and Affiliations

  1. Department of Radiation Oncology, University of Southern California, Keck School of Medicine 1441 Eastlake Avenue, Room G356, Los Angeles, CA, 90033-0804, USA

    Zbigniew Petrovich MD, FACR (Professor and Chairman) (Professor and Chairman)

  2. Department of Radiation Oncology, Hahnemann University Hospital, Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102, USA

    Luther W. Brady MD (Hylda Cohn/ American Cancer Society Professor of Clinical Oncology and Professor) (Hylda Cohn/ American Cancer Society Professor of Clinical Oncology and Professor)

  3. Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA

    Michael L. J. Apuzzo MD (Edwin M. Todd/Trent H. Wells, Jr. Professor of Neurological Surgery and Professor of Radiation Oncology) (Edwin M. Todd/Trent H. Wells, Jr. Professor of Neurological Surgery and Professor of Radiation Oncology)

  4. Department of Radiotherapy, Eberhard-Karls-Universität, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany

    Michael Bamberg MD

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Class, R. (2003). Molecular Biology. In: Petrovich, Z., Brady, L.W., Apuzzo, M.L.J., Bamberg, M. (eds) Combined Modality Therapy of Central Nervous System Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56411-6_3

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