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Craniopharyngiomas: Surgical Management

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Book cover Combined Modality Therapy of Central Nervous System Tumors

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Craniopharyngiomas are an unusual group of epithelial tumors thought to be derived from the embryonic remnants of an incompletely involuted hypophyseal-pharyngeal duct (Erdheim 1904). The name of the tumor was first introduced by Cushing in 1932, and has been considered by many to be a misnomer as Rathke’s pouch is actually an evagination of the primitive stomodeum and not the pharynx proper. They are encountered primarily in the sellar and parasellar regions but can be found anywhere along the developmental path of Rathke’s pouch (Podoshin et al. 1970). They occur with a peak incidence between 5 to 15 years of age but can present at any age (Sung et al. 1981). Visual loss and impairment, headache, apathy, depression, incontinence,hypersomnia, cognitive deficits, memory loss,sexual dysfunction, and growth failure are typical symptoms. Hydrocephalus and endocrine disorders are often present at the time of diagnosis (Carmel 1982). Due to the slow growth rate of these tumors,they are often quite large before becoming symptomatic.

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Authors
  1. Larry T. Khoo
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  2. Jeremy Flagel
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  3. Mark Liker
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  4. Michael L. Levy
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Editors and Affiliations

  1. Department of Radiation Oncology, University of Southern California, Keck School of Medicine 1441 Eastlake Avenue, Room G356, Los Angeles, CA, 90033-0804, USA

    Zbigniew Petrovich MD, FACR (Professor and Chairman) (Professor and Chairman)

  2. Department of Radiation Oncology, Hahnemann University Hospital, Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102, USA

    Luther W. Brady MD (Hylda Cohn/ American Cancer Society Professor of Clinical Oncology and Professor) (Hylda Cohn/ American Cancer Society Professor of Clinical Oncology and Professor)

  3. Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA

    Michael L. J. Apuzzo MD (Edwin M. Todd/Trent H. Wells, Jr. Professor of Neurological Surgery and Professor of Radiation Oncology) (Edwin M. Todd/Trent H. Wells, Jr. Professor of Neurological Surgery and Professor of Radiation Oncology)

  4. Department of Radiotherapy, Eberhard-Karls-Universität, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany

    Michael Bamberg MD

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Khoo, L.T., Flagel, J., Liker, M., Levy, M.L. (2003). Craniopharyngiomas: Surgical Management. In: Petrovich, Z., Brady, L.W., Apuzzo, M.L.J., Bamberg, M. (eds) Combined Modality Therapy of Central Nervous System Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56411-6_10

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