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Valproinsäure in der Kopfschmerzbehandlung

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Valproinsäure

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Zusammenfassung

In den letzten Jahren konnten mehrere zum Teil umfangreiche Multicenter-Studien den therapeutischen Nutzen von Valproinsäure in der Behandlung von Kopfschmerzen belegen. Ein besonderer Anwendungsbereich entstand für die Valproinsäure in der prophylaktischen Behandlung der Migräne. Klinischer Haupteffekt ist dabei eine signifikante Reduktion der Attackenfrequenz, die etwa den Effekten der Betablocker entspricht. Im folgenden Beitrag werden die Ergebnisse der bisher durchgeführten klinischen Studien besprochen sowie die möglichen Wirkmechanismen in der Kopfschmerztherapie diskutiert.

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Literatur

  • Balfour JA, Bryson HM (1994) Valproic acid - a review of its pharmacology and therapeutic potential in indications other than epilepsy. CNS Drugs 2: 144–173

    Article  Google Scholar 

  • Bryant AE, Dreifuss FE (1995) Hepatotoxicity associated with antiepileptic drug therapy. Avoidance, identification and management. CNS Drugs 4: 99–113

    Article  CAS  Google Scholar 

  • Coria F, Sempere AP, Duarte J, Claveria LE, Cabezas C, Bayon C (1994) Low-dose sodium valproate in the prophylaxis of migraine. Clin Neuropharmacol 17: 569–573

    Article  Google Scholar 

  • Crowder JM, Bradfort HF (1987) Common anticonvulsants inhibit Ca+ uptake and amino acid neurotransmitter release in vitro. Epilepsia 28: 378–382

    Article  PubMed  CAS  Google Scholar 

  • Cutrer FM, Limmroth V, Ayata G, Moskowitz MA(1995)Attenuation by valproate of c-fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin. Br J Pharmaco 1116: 3199–3204

    Article  Google Scholar 

  • Cutrer FM, Limmroth V, Moskowitz MA (1997) The mechanism of valproate in the treatment of migraine. Cephalalgia 17: 93–100

    Article  PubMed  CAS  Google Scholar 

  • Diener HC, Brune K, Gerber WD, Göbel H, Pfaffenrath V (1997) Behandlung der Migräneattacke and Migräneprophylaxe. Dtsch Ärztebl 94: A-3092-A3102

    Google Scholar 

  • Dreifuss FE, Langer DH (1988) Side effects of valproate. Am J Med 84 (Supl A): 34–41

    Article  PubMed  CAS  Google Scholar 

  • Godin Y, Heiner L, Mark J, Mandel P (1969) Effects of di-n-propylacetate, an anticonvulsive compound on GABA metabolism. J Neurochem 16: 869–873

    Article  PubMed  CAS  Google Scholar 

  • Headache Classification Committee of the International Headache Society (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 8: 1–93

    Article  Google Scholar 

  • Hering R, Kuritzky A (1989) Sodium valproate in the treatment of cluster headache: an open clinical trial. Cephalalgia 9: 195–198

    PubMed  CAS  Google Scholar 

  • Hering R, Kuritzky A (1992) Sodium valproate in the prophylactic treatment of migraine: a double-blind study versus placebo. Cephalalgia 12: 81–84

    Article  PubMed  CAS  Google Scholar 

  • Jensen R, Brinck T, Olesen J (1994) Sodim valproate has a prophylactic effect in migraine with-out aura: a triple-blind, placebo-controlled crossover study. Neurology 44: 647–651

    Article  PubMed  CAS  Google Scholar 

  • Kaniecki RG (1997) A comparison of divalproex with propranolol and placebo for the prophyla-xis of migraine without aura. Arch Neurol 54: 1141–1145

    Article  PubMed  CAS  Google Scholar 

  • Kaube H, Goadsby PJ (1994) Anti-migraine compounds fail to modulate the propagation of cortical spreading depression in the cat. Eur Neurol 34: 30–35

    Article  PubMed  CAS  Google Scholar 

  • Klapper J, on behalf of the Divalproex Sodium in Migraine Prophylaxis Study Group (1997) Divalproex sodium in migraine prophylaxis: A dose-controlled study. Cephalalgia 17: 103–108

    Article  PubMed  CAS  Google Scholar 

  • Kondo E, Kiyama H, Araki T, Shida T, Ueda Y, Tohojama M (1994) Coexpression of GABA(A) receptor gamma 1 and gamma 2 subunits in the rat trigeminal ganglion. Mol Brain Res 21: 363–367

    Article  PubMed  CAS  Google Scholar 

  • Kozubski W, Sokolowski P (1994) Sodium valproate vs ergot derivatives in acute treatment of migraine attacks. Abstracts of the loth Migraine Trust International Symposium. London, September 5–8

    Google Scholar 

  • Lee WS, Limmroth V, Ayata C, Cutrer FM, Waeber C, Yu X, Moskowitz MA (1995) Peripheral GABAA, receptors mediated effects of sodium valproate on durai plasma protein extravasation to substance P and trigeminal stimulation. Br J Pharmaco 1116:1661–1667

    Article  Google Scholar 

  • Lenaerts M, Bastings E, Sianard J, Schoenen J (1996) Sodium valproate in severe migraine and tension-type headache: An open study of long-term efficacy and correlation with blood levels. Acta Neurol Belg 96: 126–129

    PubMed  CAS  Google Scholar 

  • Limmroth V, Cutrer FM, Moskowitz MA (1996a) The role of neurotransmitters and neuropeptides in headache. Curr Opin Neurol 9: 206–210

    Article  PubMed  CAS  Google Scholar 

  • Limmroth V, Lee WS, Moskowitz MA (1996b) GABAA-receptor mediated effects of progesterone, its ringA-reduced metabolites and synthetic neuroactive steroids on neurogenic edema in the rat meninges. Br J Pharmacol 117: 99–104

    Article  PubMed  CAS  Google Scholar 

  • Lindhout D, Omtzigt JGC (1994) Teratogenic effects on antiepileptic drugs: Implications for the management of epilepsy in women of childbearing age. Epilepsia 35, Suppl 4: S19–S28

    Article  PubMed  Google Scholar 

  • Löscher W (1981) Valproate induced changes in GABA metabolism at the subcellular level. Bio-chem Pharmacol 30:1364–1366

    Article  Google Scholar 

  • Markowitz S, Saito K, Moskowitz MA (1987) Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. J Neuroscience 7: 4129–4136

    CAS  Google Scholar 

  • Mathew NT, Ali S (1991) Valproate in the treatment of persistent chronic daily headache. An open label study. Headache 31: 71–74

    Article  PubMed  CAS  Google Scholar 

  • Mathew NT, Saper JR, Silberstein SD et al. (1995) Migraine prophylaxis with divalproex. Arch Neurol 52: 281–286

    Article  PubMed  CAS  Google Scholar 

  • MacDonald LR, Olsen RW (1994) GABAA receptor channels. Annu Rev Neurosci 17: 569–602

    Article  PubMed  CAS  Google Scholar 

  • Rothrock JF, Kelly NM, Brody ML, Golbeck A (1994) A differential response to treatment with divalproex sodium in patients with intractable headache. Cephalalgia 14: 241–244

    Article  PubMed  CAS  Google Scholar 

  • Sorensen KV (1988) Valproate: A new drug in migraine prophylaxis. Acta Neurol Scand 78: 346-348

    Article  PubMed  CAS  Google Scholar 

  • Vijayan N, Spillane T (1995) Valproic acid treatment of chronic daily headache. Headache 35: 540–543

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Volker Limmroth
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  2. H.-C. Diener
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Editor information

Editors and Affiliations

  1. Schweizerisches Epilepsie-Zentrum, Bleulerstr. 60, Zürich, 8008, Schweiz

    Günter Krämer

  2. Abt. Psychiatrie und Psychotherapie, Klinikum der Albert-Ludwig-Universität, Hauptstr. 5, Freiburg, 79104, Destschland

    Jörg Walden

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© 2002 Springer-Verlag Berlin Heidelberg

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Limmroth, V., Diener, HC. (2002). Valproinsäure in der Kopfschmerzbehandlung. In: Krämer, G., Walden, J. (eds) Valproinsäure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56329-4_20

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  • DOI: https://doi.org/10.1007/978-3-642-56329-4_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63068-2

  • Online ISBN: 978-3-642-56329-4

  • eBook Packages: Springer Book Archive

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