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Pharmaka mit Wirkung auf den Verdauungstrakt

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Pharmakologie und Toxikologie

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Zusammenfassung

Bei einer Hypo- oder Achlorhydrie kann u.U. die Zufuhr von Säure notwendig werden, weil der optimale pH-Wert von etwa 2 für die Aktivierung von Pepsin nicht mehr erreicht wird. Bei der Substitution mit Säuren ergibt sich jedoch die Schwierigkeit, daß die üblicherweise verwendeten Mengen bei weitem nicht ausreichen, weil durch den Mageninhalt eine starke Pufferung stattfindet. Der Wert einer „üblichen“ Säuresubstitution bleibt daher zweifelhaft.

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Literatur

  • Ardizzone S, Porro GB (1998) A practical guide to the management of distal ulcerative colitis. Drugs 55:519–542

    Article  PubMed  CAS  Google Scholar 

  • Avery GS, Davies EF, Brogden RN (1972) Lactulose: A review of its therapeutic and pharmacological properties with particular reference to ammonia metabolism and its mode of action in portal systemic encephalopathy. Drugs 4:7–48

    Article  PubMed  CAS  Google Scholar 

  • Awouters F, Niemeggers CJE, Janssen PAJ (1983) Pharmacology of antidiarrheal drugs. Annu Rev Pharmacol Toxicol 23:279–301

    Article  PubMed  CAS  Google Scholar 

  • Bertaccini G (ed) (1982) Mediators and drugs in gastrointestinal motility I and II. Handbook of experimental pharmacology, vol 59/I, 59/II. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Bianchi-Porro G, Parente F (1991) „Difficult“ duodenal ulcer patients: Clinical and therapeutic problems. Dig Dis 9:219–228

    Article  PubMed  CAS  Google Scholar 

  • Bornkessel B (1997) Medikamentöse Behandlung von Ulkuserkrankungen: Consensusstatement des American College of Gastroenterology. Arzneimitteltherapie 4:124–127

    Google Scholar 

  • Brogden RN, Carmine AA, Heel RC, Speight TM, Avery GS (1982) Ranitidine: A review of its pharmacological and therapeutic use in peptic ulcer disease and other allied diseases. Drugs 24:267–303

    Article  PubMed  CAS  Google Scholar 

  • Clemett D, Markham A (2000) Prolonged-release mesalazine: A review of its therapeutic potential in ulcerative colitis and Crohn’s disease. Drugs 59:929–956

    Article  PubMed  CAS  Google Scholar 

  • Collen MJ, Benjamin SB (eds) (1991) Pharmacology of peptic ulcer disease, In: Handbook of experimental pharmacology, vol 99. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Cover TL, Blaser MJ (1992) Helicobacter pylori and gastroduodenal disease. Annu Rev Med 43:135–145

    Article  PubMed  CAS  Google Scholar 

  • Czaky TZ (ed) (1984) Pharmacology of intestinal permeation I and II. Handbook of experimental pharmacology, vol 70/I, 70/II. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Guerrant RL, Bobak DA (1991) Bacterial and protozoal gastroenteritis. N Engl J Med 325:327–340

    Article  PubMed  CAS  Google Scholar 

  • Harrington RA, Hamilton CW, Brogden RN, Linkewich JA, Romanhiewicz JA, Heel RC (1983) Metoclopramide: An updated review of its pharmacological properties and clinical use. Drugs 25:451–494

    Article  PubMed  CAS  Google Scholar 

  • Hersey SJ, Sachs G (1995) Gastric acid secretion. Physiol Rev 75:155–189

    PubMed  CAS  Google Scholar 

  • Kruis W, Pohl C (1998) Rezidiv-verhütende (remissionserhaltende) Therapie bei chronisch-entzündlichen Darmerkrankungen. Dtsch Med Wochenschr 123:85–87

    Article  PubMed  CAS  Google Scholar 

  • Langtry H, Wilde MI (1998) Omeprazole. Drugs 56:447–486

    Article  PubMed  CAS  Google Scholar 

  • Lanzini A, Northfield TC (1994) Pharmacological treatment of gallstones: Practical guidelines. Drugs 47:458–470

    Article  PubMed  CAS  Google Scholar 

  • Lauritsen K, Laursen LS, Rask-Madsen J (1990) Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part I and II). Clin Pharmacokinet 19:11–31, 94–125

    Article  PubMed  CAS  Google Scholar 

  • Leopolder-Ochsendorf A, Holtermüller K-H (1985) Nebenwirkungen der Antazida. Dtsch Med Wochenschr 110:1216–1219

    Article  PubMed  CAS  Google Scholar 

  • Logan RP (1996) The chemotherapeutic effects of H+/K+ inhibitors on Helicobacter pylori infection. Pharmacol Ther 69:79–83

    Article  PubMed  CAS  Google Scholar 

  • Malagelada JR, Distrutti E (1996) Management of gastrointestinal motility disorders: A practical guide to drug selection and appropriate ancillary measures. Drugs 52:94–506

    Article  Google Scholar 

  • Maton PN, Burton ME (1998) Antacids revisited. Drugs 57:855–870

    Article  Google Scholar 

  • McCarthy DM (1991) Sucralfate. N Engl J Med 325:1017–1025

    Article  PubMed  CAS  Google Scholar 

  • Murer H, Burckhardt G (1983) Membrane transport of anions across epithelia of mammalian small intestine and kidney proximal tubule. Rev Physiol Biochem Pharmacol 96:1–51

    Article  PubMed  CAS  Google Scholar 

  • Nash J, Lambert L, Deakin M (1994) Histamine H2-receptor antagonists in peptic ulcer disease: Evidence for a prophylactic use. Drugs 47:862–871

    Article  PubMed  CAS  Google Scholar 

  • NN (1980) Laxanzien - pharmakologische Wirkungen, Nebenwirkungen und kritischer Gebrauch. Arzneimittelbrief 14:85–89

    Google Scholar 

  • Okhuysen PC, Ericsson CD (1992) Travellers’ diarrhea, prevention and treatment. Med Clin North Am 76:1357–1373

    PubMed  CAS  Google Scholar 

  • Pope AJ, Parsons ME (1993) Reversible inhibitors of the gastric H+/K+-transporting ATPase: A new class of anti-secretory agents. Trends Pharmacol Sci 14:323–325

    Article  PubMed  CAS  Google Scholar 

  • Prakash A, Wagstaff AJ (1998) Domperidone. Drugs 56:429–445

    Article  PubMed  CAS  Google Scholar 

  • Raufman J-P (1992) Gastric chief cells: Receptors and signaltransduction mechanisms. Gastroenterology 102:699–710

    PubMed  CAS  Google Scholar 

  • Richardson P, Hawkey CJ, Stack WA (1998) Proton pump inhibitors. Drugs 56:307–335

    Article  PubMed  CAS  Google Scholar 

  • Rösch W (1993) Diagnose und Therapie der funktionellen Dyspepsie. Dtsch Med Wochenschr 118:1729–1732

    Article  PubMed  Google Scholar 

  • Ruoff H-J, Fladung B, Demol P, Weihrauch TR (1991) Gastrointestinal receptors and drugs in motility disorders. Digestion 48:1–17

    Article  PubMed  CAS  Google Scholar 

  • Sachs G, Shin JM, Briving C, Wallmark B, Gersey S (1995) The pharmacology of the gastric acid pump: The H+/K+ ATPase. Annu Rev Pharmacol 35:277–305

    Article  CAS  Google Scholar 

  • Sack DA (1982) Treatment of acute diarrhoea with oral rehydratation solution. Drugs 23:150–157

    Article  PubMed  CAS  Google Scholar 

  • Simon B, Müller P (1991) Ondansetron. Arzneimitteltherapie 9:97–99

    Google Scholar 

  • Slomiany BL, Piotrowsi J, Tamura S, Slomiany A (1991) Enhancement of the protective qualities of gastric mucus by sucralfate: Role of phosphoinositides. Am J Med 91 [Suppl 2A]:30S–36S

    Article  PubMed  CAS  Google Scholar 

  • Stange EF, Schreiber S (1997) Morbus Crohn und Colitis ulcerosa. Von der Immunpathogenese zur Therapie. Dtsch Ärztebl 94:A1493–1498

    Google Scholar 

  • Walsh JH, Peterson WL (1995) The treatment of Helicobacter pylori in the management of peptic ulcer disease. N Engl J Med 333:984–991

    Article  PubMed  CAS  Google Scholar 

  • Walt RP (1992) Misoprostol for the treatment of peptic ulcer and antiinflammatory-drug-induced gastroduodenal ulceration. N Engl J Med 327:1575–1580

    Article  PubMed  CAS  Google Scholar 

  • Wanitschke R (1985) Leitsymptom Diarrhö. Dtsch Ärztebl 82:563–573

    Google Scholar 

  • Wöhrle M (1998) Antiemetika. Dtsch Apoth Ztg 19:43–46

    Google Scholar 

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Authors
  1. E. Oberdisse
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Editors and Affiliations

  1. Fachbereich Humanmedizin — Institut für Pharmakologie, Freie Universität Berlin, Thielallee 67-73, 14195, Berlin, Germany

    Eckard Oberdisse

  2. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany

    Eberhard Hackenthal

  3. Institut für Pharmakologie und Toxikologie, Universität Marburg/Lahn, Ketzerbach 63, 35032, Marburg, Germany

    Klaus Kuschinsky

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© 2002 Springer-Verlag Berlin Heidelberg

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Oberdisse, E. (2002). Pharmaka mit Wirkung auf den Verdauungstrakt. In: Oberdisse, E., Hackenthal, E., Kuschinsky, K. (eds) Pharmakologie und Toxikologie. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56314-0_30

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  • DOI: https://doi.org/10.1007/978-3-642-56314-0_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62634-0

  • Online ISBN: 978-3-642-56314-0

  • eBook Packages: Springer Book Archive

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