Skip to main content
SpringerLink
Log in
Book cover

Pharmakologie und Toxikologie pp 461–472Cite as

Pharmaka zur Behandlung von Anämien, zum Blutersatz und zur Verbesserung der Rheologie

  • Chapter

  • 842 Accesses

Part of the book series: Springer-Lehrbuch ((SLB))

Zusammenfassung

Eine Anämie ist gekennzeichnet durch eine Verringerung der Erythrozytenzahl, Hämoglobinmenge und Hämatokritwert (Normwerte s. Tabelle 26.1). Eine Einteilung der verschiedenen Anämieformen und deren Ursachen ist nachfolgend zusammengefaßt. Die Therapie einer Anämie ist bei Eisen-, Folsäure- oder Vitamin-B12-Mangel im Sinne einer Substitution möglich, alle anderen Anämieformen können nur symptomatisch behandelt werden.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   149.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Adamson JW, Spivak JL (1994) Physiologic basis for the pharmacologic use of recombinant human erythropoietin in surgery and cancer treatment. Surgery 115:7–15

    PubMed  CAS  Google Scholar 

  • Aisen P, Brown EB (1977) The iron-binding function of transferrin in iron metabolism. Semin Hematol 1431–53

    Google Scholar 

  • Bartzsch O, Riepl M, Busch M, Michael G, Allgauer M, Voss AC, Sauer R, Duhmke E, Gademann G, Molls M (1998) Use of G-CSF (Neupogen) in multimodal treatment in radiotherapy. Strahlenther Onkol 174:551–555

    Article  PubMed  CAS  Google Scholar 

  • Beck WS (1991) Diagnosis of megaloblastic anemia. Annu Rev Med 42:311–322

    Article  PubMed  CAS  Google Scholar 

  • Begemann H, Rastetter J (1986) Klinische Hämatologie. 3. Aufl. Thieme, Stuttgart New York

    Google Scholar 

  • Bothwell TH, Charlton RW, Cool JD, Finch CA (1979) Iron metabolism in man. Blackwell Scientific Publications, Oxford

    Google Scholar 

  • Brizzi MF, Avanzi GC, Pegoraro (1991) Hematopoietic growth factor receptors. Intern J Cell Cloning 9:274–300

    Article  CAS  Google Scholar 

  • Burns DL, Mascioli EA, Bistrian B (1995) Parenteral iron dextran: A review. Nutrition 11:163–168

    PubMed  CAS  Google Scholar 

  • Burns DL, Pomposelli 1J (1999) Toxicity of parenteral iron dextran therapy. Kidney Int 55: Suppl 69:S-119–124

    Google Scholar 

  • Collins AJ, Keane WF (1998) Higher haematocrit levels: do they improve patient outcomes, and are they cost effective? Nephrol Dial Transplant 13:1627–1629

    Article  PubMed  CAS  Google Scholar 

  • Cook ID (1977) Absorption of food iron. Fed Proc 36:2028–2932

    PubMed  CAS  Google Scholar 

  • Cook JD, Skikne BS, Baynes RD (1993) Serum transferrin receptor. Annu Rev Med 44:63–74

    Article  PubMed  CAS  Google Scholar 

  • Crosier PS, Clark SC (1992) Basic biology of the hematopoietic growth factors. Semin Oncol 19:349–361

    PubMed  CAS  Google Scholar 

  • D’Andrea AA (1994) Cytokine receptors in congenital hematopoietic disease. N Engl J Med 330:839–846

    Article  PubMed  Google Scholar 

  • Demetri GD, Antman KHS (1992) Granulocyte-macrophage colony-stimulating factor (GM-CSF): Preclinical and clinical investigations. Semin Oncol 19:362–385

    PubMed  CAS  Google Scholar 

  • Eckardt KU, Bauer C (1989) Erythropoietin in health and disease. Eur J Clin Invest 19:117–127

    Article  PubMed  CAS  Google Scholar 

  • Eckardt KU (1998) Erythropoietin: Karriere eines Hormons. Dt Ärztebl 95: A285–290

    Google Scholar 

  • Eder M, Geissler G, Ganser A (1997) IL-3 in the clinic. Stem Cells 15:327–333

    Article  PubMed  CAS  Google Scholar 

  • Foote M, Welch W (1999) Biopharmaceutical drug development: Filgrastim (r-metHuG-CSF) use in patients with HIV infection. J Hematother Stem Cell Res 8 (Suppl l):S3–8

    Article  PubMed  CAS  Google Scholar 

  • Forth W, Rummel W (1973) Iron absorption. Physiol Rev 53: 724–792

    PubMed  CAS  Google Scholar 

  • Garcia JF, Ebbe SN, Hollander L, Cutting HO, Miller ME, Cronkite EP (1982) Radioimmunoassay of erythropoietin: Circulatory levels in normal and polycythemic human beings. J Lab Clin Med 99:624–635

    PubMed  CAS  Google Scholar 

  • Goodnough LT, Monk TG, Andriole GL (1997) Erythropoietin therapy. N Engl J Med 336: 993–938

    Article  Google Scholar 

  • Groopman JE, Molina J-M, Scadden DT (1989) Hematopoietic growth factors: Biology and clinical applications. N Engl J Med 321: 1449–1459

    Article  PubMed  CAS  Google Scholar 

  • Hallberg L (1982) Iron absorption and iron deficiency. Hum Nutr Clin Nutr 36C:259–278

    CAS  Google Scholar 

  • Haller H, Cristel C, Dannenberg L, Thiele P, Luft FC (1996) Signal transduction of erythropoietin in endothelial cells. Kidney Int 50:481–488

    Article  PubMed  CAS  Google Scholar 

  • Hartung T, Pitrak D, Foote MA (1998) Filgrastim restores interleukin-2 production in blood from patients with advanced human immunodeficiency virus infection. J Infect Dis 178:686

    Article  PubMed  CAS  Google Scholar 

  • Hood SA, O’ Brien M, Higgins R (2000) The safety of intravenous iron dextran (Dexferrum) during hemodialysis in patients with end stage renal disease. Nephrol Nurs J 27:41–42

    PubMed  CAS  Google Scholar 

  • Heinrich HC (1978) Ätiologie, Diagnostik und Dimensionierung der Therapie des Eisenmangels. Löhr GW et al. (Hrsg.): Probleme der Erythropoese, Granulozytopoese und des malignen Lymphoms. Hämatologie und Bluttransfusion. Nd. 21, Springer, Berlin Heidelberg New York

    Google Scholar 

  • Hoyer LW (1994) Hemophilia A. N Engl J Med 330:38–47

    Article  PubMed  CAS  Google Scholar 

  • Huebers H, Huebers E, Csiba E, Rummel W (1983) The significance of transferrin for intestinal iron absorption. Blood 61:283–290

    PubMed  CAS  Google Scholar 

  • Jacobs A (1977) Serum ferritin and iron stores. Fed Proc 36:2024–2027

    PubMed  CAS  Google Scholar 

  • Jelkmann W (1992) Erythropoietin: Structure, control of production, and function. Physiol Rev 72:449–489

    PubMed  CAS  Google Scholar 

  • Lieschke GJ, Burgess AW (1992) Granulozyte colony-stimulation factor and granulocyte-macrophage colony-stimulation factor, part I and II. N Engl J Med 327:28–35, 99-106

    Article  PubMed  CAS  Google Scholar 

  • Luft FC (2000) Erythropoietin and arterial hypertension. Clin Nephrol 53 (Suppl 1):S61–64

    Google Scholar 

  • Munn DH, Cheung NK (1992) Preclinical and clinical studies of macrophage colony-stimulating factor. Semin Oncol 19:395–407

    PubMed  CAS  Google Scholar 

  • Nicola NA (1989) Hematopoietic cell growth factors and their receptors. Ann Rev Biochem 58:45–78

    Article  PubMed  CAS  Google Scholar 

  • Oski FA (1993) Iron deficiency in infancy and childhood. N Engl J Med 329:190–193

    Article  PubMed  CAS  Google Scholar 

  • Ostendorf PC (Hrsg.) (1991) Hämatologie. Urban & Schwarzenberg, München Wien Baltimore

    Google Scholar 

  • Pruthi RK, Tefferi A (1994) Pernicious anemia revisited. Mayo Clin Proc 69:144–150

    Article  PubMed  CAS  Google Scholar 

  • Sears D (1991) Iron deficiency. In: Rakel RE (ed): Conn’s current therapy. S 299–301. Saunders, Philadelphia

    Google Scholar 

  • Sowade B, Sowade O, Mocks J, Franke W, Warnke H (1998) The safety of treatment with recombinant human erythropoietin in clinical use: a review of controlled studies. Int J Mol Med 1(2):303–314

    PubMed  CAS  Google Scholar 

  • Spangrude GJ (1994) Biological and clinical aspects of hematopoietic stem cells. Annu Rev Med 45:93–104

    Article  PubMed  CAS  Google Scholar 

  • Spivak JL (1993) Recombinant erythropoietin. Annu Rev Med 44: 243–253

    Article  PubMed  CAS  Google Scholar 

  • Treib J, Haaß A, Pindur G, Wenzel E, Schimrigk K (1997) Blu- tungskomplikationen durch Hydroxyethylstärke sind vermeidbar. Dt Ärztebl 94: A 2326–2330

    Google Scholar 

  • Vadhan-Raj S, Keating M, LeMaistre A, Hiltelman WW, McCudie K, Tryillo JM, Broxmeyer HE, Herney C, Gulterman JU (1987) Effects of recombinant human granulocyte macrophage colony-stimulating factor in patients with myelodysplastic syndromes. N Engl J Med 317:1545–1552

    Article  PubMed  CAS  Google Scholar 

  • Williams WJ, Beutler E, Erslen AJ, Lichtman MA (1990) Hematology. McGraw-Hill, New York

    Google Scholar 

Download references

Authors
  1. C. Taube
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Fachbereich Humanmedizin — Institut für Pharmakologie, Freie Universität Berlin, Thielallee 67-73, 14195, Berlin, Germany

    Eckard Oberdisse

  2. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany

    Eberhard Hackenthal

  3. Institut für Pharmakologie und Toxikologie, Universität Marburg/Lahn, Ketzerbach 63, 35032, Marburg, Germany

    Klaus Kuschinsky

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Taube, C. (2002). Pharmaka zur Behandlung von Anämien, zum Blutersatz und zur Verbesserung der Rheologie. In: Oberdisse, E., Hackenthal, E., Kuschinsky, K. (eds) Pharmakologie und Toxikologie. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56314-0_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-56314-0_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62634-0

  • Online ISBN: 978-3-642-56314-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation