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Pharmakologie und Toxikologie pp 361–391Cite as

Antihypertensiva

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Zusammenfassung

Anatomisch und funktionell wird der Kreislauf unterteilt in das Kapazitätssystem (venöse Gefäße) und das Widerstandssystem (arterielle Gefäße). Im venösen Kapazitätssystem findet die Volumenregulation des Blutkreislaufes statt. Der Druck ist gering und abhängig von den hydrostatischen Gegeben-heiten (zentraler Venendruck ca. 3–6 mm Hg). Im Widerstandssystem wird der arterielle Blutdruck durch die Pumparbeit des Herzens aufgebaut. Ein erheblicher Teil dieser Pumparbeit wird in die elastische Dehnung der großen Arterien überführt, die einen stetigen Blutfluß in die Peripherie auch während der Diastole ermöglicht (Windkesselfunktion). Die Höhe des Blutdruckes hängt ab

  1. 1)

    von der Arbeit des Herzens (Druck · Volumen),

  2. 2)

    dem Tonus der Widerstandsgefäße und

  3. 3)

    dem Füllungszustand des Systems.

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Authors
  1. E. Hackenthal
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Editors and Affiliations

  1. Fachbereich Humanmedizin — Institut für Pharmakologie, Freie Universität Berlin, Thielallee 67-73, 14195, Berlin, Germany

    Eckard Oberdisse

  2. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany

    Eberhard Hackenthal

  3. Institut für Pharmakologie und Toxikologie, Universität Marburg/Lahn, Ketzerbach 63, 35032, Marburg, Germany

    Klaus Kuschinsky

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© 2002 Springer-Verlag Berlin Heidelberg

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Hackenthal, E. (2002). Antihypertensiva. In: Oberdisse, E., Hackenthal, E., Kuschinsky, K. (eds) Pharmakologie und Toxikologie. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56314-0_21

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  • DOI: https://doi.org/10.1007/978-3-642-56314-0_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62634-0

  • Online ISBN: 978-3-642-56314-0

  • eBook Packages: Springer Book Archive

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