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Hepatozelluläres Karzinom

  • Chapter
Molekularmedizinische Grundlagen von nicht-hereditären Tumorerkrankungen

Part of the book series: Molekulare Medizin ((MOLMED))

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Zusammenfassung

Tumoren der Leber können benigne oder maligne Läsionen sein. Maligne Neoplasien der Leber sind primär hepatisch oder sekundär metastatisch. In westlichen Ländern überwiegen metastatische Läsionen, während in Asien und Teilen Afrikas primäre Lebermalignome häufiger sind. Die primären Lebertumoren sind entweder epithelialen Ursprungs und gehen von Hepatozyten bzw. Gallengangsepithelzellen aus oder sie sind mesenchymaler, seltener auch gemischtzelliger Herkunft. Das hepatozelluläre Karzinom (HCC) ist klinisch ein hoch maligner Tumor mit rascher Progredienz und limitierten therapeutischen Möglichkeiten (Wands u. Blum 1991, Blum 1995, Okuda 2000). Im Folgenden werden epidemiologische, klinische, pathogenetische, diagnostische und therapeutische Aspekte des HCC besprochen.

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Literatur

  • Aghi M, Chou TC, Suling K, Breakefield XO, Chiocca EA(1999) Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganeiclovir/herpes simplex virus thymidine kinase gene Therapics. Cancer Res 59:3861–3865

    PubMed  CAS  Google Scholar 

  • Aguilar F, Hussain SP, Cerutti P (1993) Aflatoxin B1 induces the transversion of G → T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci USA 90:8586–8590

    PubMed Central  PubMed  CAS  Google Scholar 

  • Allgaier HP, Deibert P, Olschewski M et al. (1998a) Survival benefit of patients with inoperable hepatocellular careinoma treated by a combination of transarterial chemoembolization and percutaneous ethanol injection-a single-center analysis including 132 patients. Int J Cancer 79:601–605

    PubMed  CAS  Google Scholar 

  • Allgaier HP, Deibert P, Zuber I, Blum HE (1998b) Perkutane Behandlung von Lebertumoren durch interstitielle Radiofrequenzthermoablation. Dtsch Med Wochensehr 123:907–911

    CAS  Google Scholar 

  • Allgaier HP, Deibert P, Zuber I, Olschewski M, Blum HE (1999) Percutaneous radiofrequency interstitial thermal ablation of small hepatocellular carcinoma. Lancet 353:1676–1677

    PubMed  CAS  Google Scholar 

  • Alter MJ (1997) Epidemiology of hepatitis C. Hepatology [Suppl 1] 26:62S–65S

    PubMed  CAS  Google Scholar 

  • Beasley RP, Hwang L-Y, Lin C-C, Chien C-S (1981) Hepatocellular carcinoma and hepatitis B virus-a prospective study of 22707 men in Taiwan. Lancet II:1129–1133

    Google Scholar 

  • Becker SA, Lee T-H, Butel JS, Slagle BL (1998) Hepatitis B virus X protein interferes with cellular DNA repair. J Vir-ol 72:266–272

    CAS  Google Scholar 

  • Benn J, Schneider RJ (1994) Hepatitis B virus X protein activates Ras-GTP complex formation and establishes aRas, Raf, MAP kinase signaling cascade. Proc Natl Acad Sci USA 91:10350–10354

    PubMed Central  PubMed  CAS  Google Scholar 

  • Bischoff JR, Kirn DH, Williams A et al. (1996) An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 274:373–376

    PubMed  CAS  Google Scholar 

  • Blum HE (1994) Does hepatitis C virus cause hepatocellular carcinoma? Hepatology 19:251–255

    PubMed  CAS  Google Scholar 

  • Blum HE (1995) Tumoren der Leber und des biliären Systems. In: Gerok W, Blum HE (Hrsg) Hepatologie. Urban & Schwarzenberg, München Wien Baltimore, S 635–650

    Google Scholar 

  • Blum HE, Liang TJ, Galun E, Wands JR (1991) Persistence of hepatitis B viral DNA after serological recovery from hepatitis B virus infection. Hepatology 14:56–62

    PubMed  CAS  Google Scholar 

  • Bosch FX, Ribes J, Borras J (1999) Epidemiology of primary liver cancer. Semin Liver Dis 19:271–285

    PubMed  CAS  Google Scholar 

  • Brand N, Petkovich M, Krust A et al. (1988) Identification of a second human retinoic acid receptor. Nature 332:850–853

    PubMed  CAS  Google Scholar 

  • Bréchot C, Degos F, Lugassy C et al. (1985) Hepatitis B virus DNA in patients with chronic liver disease and negativetests for hepatitis B surface antigen. N Engl J Med 312:270–276

    PubMed  Google Scholar 

  • Bressac B, Kew M, Wands J, Ozturk M (1991) Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 350:429–431

    PubMed  CAS  Google Scholar 

  • Buendia MA (1994) Animal models for hepatitis B virus and liver cancer. In: Brechot C (ed) Primary liver cancer: etiological and progression factors. CRC Press, Boca Raton, FL

    Google Scholar 

  • Bui LA, Butterfield LH, Kim JY et al. (1997) In vivo therapy of hepatocelluIar carcinoma with a tumor-specific adeno-viral vector expressing interleukin-2. Hum Gene Ther 8:2173–2182

    PubMed  CAS  Google Scholar 

  • Cao G, Kuriyama S, Du P et al. (1997) Complete regression of established murine hepatocellular carcinoma by in vivo tumor necrosis factor alpha gene transfer. Gastroenterology 112:501–510

    PubMed  CAS  Google Scholar 

  • Cariani E, Lasserre C, Kemeny F, Franeo D, Bréchot C (1991) Expression of insulin-like growth factor 11, a-fetoprotein, and hepatitis B virus transcripts in human primary liver cancer. Hepatology 13:644–649

    PubMed  CAS  Google Scholar 

  • Caselmann WH, Koshy R (1998) Transactivators of HBV, signal transduction and tumorigenesis. In: Caselmann WH, Koshy R (eds) Hepatitis B virus. Imperial College Press, London

    Google Scholar 

  • Caselmann WH, Meyer M, Kekulé AS, Lauer U, Hofschneider PH, Koshy R (1990) A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA. Proc Natl Acad Sci USA 87:2970–2974

    PubMed Central  PubMed  CAS  Google Scholar 

  • Castells A, Bruix J, Bru C et al. (1993) Treatment of small hepatocellular carcinoma in cirrhotic patients: a cohort study comparing surgical resection and percutaneous ethanol injection. Hepatology 18:1121–1126

    PubMed  CAS  Google Scholar 

  • Chang M-H, Chen C-J, Lai M-S et al. (1997) Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. N Engl J Med 336:1855–1859

    PubMed  CAS  Google Scholar 

  • Chang J, Yang S-H, Cho Y-G, Hwang SB, Hahn YS, Sung YC (1998) Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in co operation with the H-ras oncogene. J Virol 72:3060–3065

    PubMed Central  PubMed  CAS  Google Scholar 

  • Chen QR, Kumar D, Stass SA, Mixson AJ (1999) Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice. Cancer Res 59:3308–3312

    PubMed  CAS  Google Scholar 

  • Chisari FV (1995) Hepatitis B virus transgenie mice: insights into the virus and the disease. Hepatology 22:1316–1325

    PubMed  CAS  Google Scholar 

  • Chisari FV, Filippi P, McLachlan A et al. (1986) Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol 60:880–887

    PubMed Central  PubMed  CAS  Google Scholar 

  • Chisari FV, Filippi P, Buras J et al. (1987) Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice. Proc Natl Acad Sci USA 84:6909–6913

    PubMed Central  PubMed  CAS  Google Scholar 

  • Choo Q-L, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M (1989) Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359–362

    PubMed  CAS  Google Scholar 

  • CLIP Group (Cancer of the Liver Italian Programme) (1998) Tamoxifen in treatment of hepatocellular carcinoma: a randomised controlled trial. Lancet 352:17–20

    Google Scholar 

  • Coffin CS, Michalak TI (1999) Persistence of infectious hepadnavirus in the offspring of woodchuck mothers recovered from viral hepatitis. J Clin Invest 104:203–212

    PubMed Central  PubMed  CAS  Google Scholar 

  • Colombo M, Cambieri R, Rumi MG, Ronchi G, Ninno E del, Franchis R de (1983) Long-term delta superinfection in hepatitis B surface antigen carriers and its relationship to the course of chronic hepatitis. Gastroenterology 85:235–239

    PubMed  CAS  Google Scholar 

  • Compagnon B, Moradpour D, Alford DR et al. (1997) Enhanced gene delivery and expression in human hepatocellular carcinoma cells by cationic immunoliposomes. J Liposome Res 7:127–141

    CAS  Google Scholar 

  • Cross M, Dexter TM (1991) Growth factors in development, transformation, and tumorigenesis. Cell 64:271–280

    PubMed  CAS  Google Scholar 

  • Dejean A, de Thé H (1990) Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma. Mol Biol Med 7:213–222

    PubMed  CAS  Google Scholar 

  • Dejean A, Sonigo P, Wain-Hobson S, Tiollais P (1984) Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat. Proc Natl Acad Sci USA 81:5350–5354

    PubMed Central  PubMed  CAS  Google Scholar 

  • Dejean A, Bougueleret L, Grzeschik K-H, Tiollais P (1986) Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature 322:70–72

    PubMed  CAS  Google Scholar 

  • De la Coste A, Romagnolo B, Billuart P et al. (1998) Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 95:8847–8851

    PubMed Central  Google Scholar 

  • Derynck R, Zhang Y, Feng XH (1998) Smads: transcriptional activators of TGF-beta responses. Cell 95:737–740

    PubMed  CAS  Google Scholar 

  • De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL (1995) M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat Genet11:447–449

    PubMed  Google Scholar 

  • De Thé H, Marchio A, Tiollais P, Dejean A (1987) A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature 330:667–670

    PubMed  Google Scholar 

  • Deuffic S, Poynard T, Buffat L, Valleron AJ (1998) Trends in primary liver cancer. Lancet 351:214–215

    PubMed  CAS  Google Scholar 

  • Di Bisceglie AM (1997) Hepatitis C and hepatocellular carcinoma.Hepatology [Suppl 1] 26:34S–38S

    PubMed  Google Scholar 

  • Dienstag JL (1997) Sexual and perinatal transmission of hepatitis C. Hepatology 26:66S–70S

    PubMed  CAS  Google Scholar 

  • Donnelly JJ, Ulmer JB, Shiver JW, Liu MA (1997) DNA vaccines. Annu Rev Immunol 15:617–648

    PubMed  CAS  Google Scholar 

  • Douglas JT, Rogers BE, Rosenfeld ME, Michael SI, Feng M, Curiel DT (1996) Targeted gene delivery by tropism-modified adenoviral vectors. Nat Biotechnol 14:1574–1578

    PubMed  CAS  Google Scholar 

  • Dunsford HA, Sell S, Chisari FV (1990) Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice. Cancer Res 50:3400–3407

    PubMed  CAS  Google Scholar 

  • El-Serag HB, Mason AC (1999) Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 340:745–750

    PubMed  CAS  Google Scholar 

  • Encell LP, Landis DM, Loeb LA (1999) Improving enzymes for cancer gene therapy. Nat Biotechnol 17:143–147

    PubMed  CAS  Google Scholar 

  • Fausto N (1999) Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease. Semin Liver Dis 19:243–252

    PubMed  CAS  Google Scholar 

  • Fausto N, Webber EM (1993) Mechanisms of growth regulation in liver regeneration and hepatic carcinogenesis. In: Boyer JL, Ockner RK (eds) Progress in liver diseases. Saunders, Philadelphia, pp 115–137

    Google Scholar 

  • Feitelson MA, Zhu M, Duan L-X, London WT (1993) Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma. Oncogene 8:1109–1117

    PubMed  CAS  Google Scholar 

  • Ferry N, Heard JM (1998) Liver-directed gene transfer vectors. Hum Gene Ther 9:1975–1981

    PubMed  CAS  Google Scholar 

  • Fourel G, Trepo C, Bougueleret L et al. (1990) Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumors. Nature 347:294–298

    PubMed  CAS  Google Scholar 

  • Fourel G, Couturier J, Wei Y, Apiou F, Tiollais P, Buendia MA (1994) Evidence for long-range oncogene activation by hepadnavirus insertion. EMBO J 13:2526–2534

    PubMed Central  PubMed  CAS  Google Scholar 

  • Fujimoto Y, Hampton LL, Wirth PJ, Wang NJ, Xie JP, Thorgeirsson SS (1994) Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China. Cancer Res 54:281–285

    PubMed  CAS  Google Scholar 

  • Gale M Jr, Korth MJ, Tang NM et al. (1997) Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5 A protein. Virology 230:217–227

    PubMed  CAS  Google Scholar 

  • Gale M Jr, Blakely CM, Kwieciszewski B et al. (1998) Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol Cell Biol 18:5208–5218

    PubMed Central  PubMed  CAS  Google Scholar 

  • Gale M Jr, Kwieciszewski B, Dossett M, Nakao H, Katze MG (1999) Antiapoptotic and oncogenic potentials of hepatitis virus are linked to interferon resistance by viral repression of the PKR protein kinase. J Virol 73:6506–6516

    PubMed Central  PubMed  CAS  Google Scholar 

  • Graef E, Caselmann WH, Wells J, Koshy R (1994) Insertional activation of mevalonate kin ase by hepatitis B virus DNA in a human hepatoma cell line. Oncogene 9:81–87

    PubMed  CAS  Google Scholar 

  • Graef E, Caselmann WH, Hofschneider PH, Koshy R (1995) Enzymatic properties of overexpressed HBV-mevalonate kinase fusion proteins and mevalonate kinase proteins in the human hepatoma cell line PLC/PRF/5. Virology 208:696–703

    PubMed  CAS  Google Scholar 

  • Haber DA (1995) Telomeres, cancer, and immortality. N Engl J Med 332:955–956

    PubMed  CAS  Google Scholar 

  • Habib NA, Hodgson HJ, Lemoine N, Pignatelli M (1999) A phase IIII study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumours. Hum Gene Ther 10:2019–2034

    PubMed  CAS  Google Scholar 

  • Hallenbeck PL, Chang YN, Hay C et al. (1999) A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma. Hum Gene Ther 10:1721–1733

    PubMed  CAS  Google Scholar 

  • Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.Cell 86:353–364

    PubMed  CAS  Google Scholar 

  • Hanahan D, Weinberg RA (2000) The hallmarks of cancer.Cell 100:57–70

    PubMed  CAS  Google Scholar 

  • Hansen LJ, Tennant BC, Seeger C, Ganem D (1993) Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses. Mol Cell Biol 13:659–667

    PubMed Central  PubMed  CAS  Google Scholar 

  • Harvey CJ, Blomley MJK, Eckersley RJ, Heckemann RA, Butler-Barnes J, Cosgrove DO (2000) Pulse-inversion mode imaging of liver specific microbubbles: improved detection of subcentimetre metastases. Lancet 355:807–808

    PubMed  CAS  Google Scholar 

  • He TC, Zhou S, Costa da LT, Yu J, Kinzier KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509–2514

    PubMed Central  PubMed  CAS  Google Scholar 

  • Heintges T, Wands JR (1997) Hepatitis C virus: epidemiology and transmission. Hepatology 26:521–526

    PubMed  CAS  Google Scholar 

  • Heise CC, Williams AM, Xue S, Propst M, Kirn DH (1999) Intravenous administration of ONYX-DIS, a selectively replicating adenovirus, induces antitumoral efficacy. Cancer Res 59:2623–2628

    PubMed  CAS  Google Scholar 

  • Henry SH, Bosch FX, Troxell TC, Bolger PM (1999) Reducing liver cancer-global control of aflatoxin. Science 286:2453–2454

    PubMed  CAS  Google Scholar 

  • Higashitsuji H, Itoh K, Nagao T et al. (2000) Reduced stability of retinoblastoma pro tein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. Nat Med 6:96–99

    PubMed  CAS  Google Scholar 

  • Hock H, Dorsch M, Kunzendorf U et al. (1993) Vaceinations with tumor cells genetically engineered to produce different cytokines: effectivity not superior to a classical adjuvant. Cancer Res 53:714–716

    PubMed  CAS  Google Scholar 

  • Höhne M, Schaefer S, Seifer M, Feitelson MA, Paul D, Gerlich WH (1990) Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA. EMBO J 9:1137–1145

    PubMed Central  PubMed  Google Scholar 

  • Hoofnagle JH (1997) Hepatitis C: the clinical spectrum of disease. Hepatology [Suppl 1] 26:15S–20S

    PubMed  CAS  Google Scholar 

  • Hsu T-Y, Möröy T, Etiemble T et al. (1988) Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma. Cell 55:627–635

    PubMed  CAS  Google Scholar 

  • Hsu IC, Metcalf RA, Sun T, Welsh JA, Wang NJ, Harris CC (1991) Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 350:427–428

    PubMed  CAS  Google Scholar 

  • Huang H, Chen SH, Kosai K, Finegold MJ, Woo SL (1996) Gene therapy for hepatocellular carcinoma: long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo. Gene Ther 3:980–987

    PubMed  CAS  Google Scholar 

  • Im SA, Gomez-Manzano C, Fueyo J et al. (1999) Antiangiogenesis treatment for gliomas: transfer of antisense-vascular endothelial growth factor inhibits tumor growth in vivo. Cancer Res 59:895–900

    PubMed  CAS  Google Scholar 

  • Ishikawa H, Nakata K, Mawatari F et al. (1999) Utilization of variant-type of human alpha-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma. Gene Ther 6:465–470

    PubMed  CAS  Google Scholar 

  • Isokawa O, Suda T, Aoyagi Y et al. (1999) Reduction of telomeric repeats as a possible predictor for development of hepatocellular carcinoma: convenient evaluation by slot-blot analysis. Hepatology 30:408–412

    PubMed  CAS  Google Scholar 

  • Ito T, Sasaki Y, Wands JR (1996) Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases. Mol Cell Biol 16:943–951

    PubMed Central  PubMed  CAS  Google Scholar 

  • Kafri T, Blomer U, Peterson DA, Gage FH, Verma IM (1997) Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet 17:314–317

    PubMed  CAS  Google Scholar 

  • Kanai F, Lan KH, Shiratori Y et al. (1997) In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene. Cancer Res 57:461–465

    PubMed  CAS  Google Scholar 

  • Kekulé AS, Lauer U, Meyer M, Caselmann WH, Hofschneider PH, Koshy R (1990) The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature 343:457–461

    PubMed  Google Scholar 

  • Kekulé AS, Lauer U, Weiss L, Luber B, Hofschneider PH (1993) Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 361:742–745

    PubMed  Google Scholar 

  • Kim C-M, Koike R, Saito I, Miyamura T, Jay G (1991) HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351:317–320

    PubMed  CAS  Google Scholar 

  • Kim NW, Piatyszek MA, Prowse KR et al. (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011–2015

    PubMed  CAS  Google Scholar 

  • Kinzier KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87:159–170

    Google Scholar 

  • Kita R, Nishida N, Fukuda Y et al. (1996) Infrequent alterations of the p16INK4A gene in liver cancer. Int J Cancer 67:176–180

    PubMed  CAS  Google Scholar 

  • Kiyosawa K, Sodeyama T, Tanaka E et al. (1990) Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 12:671–675

    PubMed  CAS  Google Scholar 

  • Kojima H, Yokosuka O, Imazeki F, Saisho H, Omata M (1997) Telomerase activity and telomere length in hepatocellular carcinoma and chronic liver disease. Gastroenterology 112:493–500

    PubMed  CAS  Google Scholar 

  • Kojima H, Yokosuka O, Kato N et al. (1999) Quantitative evaluation of telomerase activity in small liver tumors: analysis of ultrasonography-guided liver biopsy specimens. J Hepatol 31:514–520

    PubMed  CAS  Google Scholar 

  • Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, Hirohashi S (1999) Microsatellite instability associated with hepatocarcinogenesis. J Hepatol 31:529–536

    PubMed  CAS  Google Scholar 

  • Korba BE, Wells FV, Baldwin B et al. (1989) Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infection. Hepatology 9:461–470

    PubMed  CAS  Google Scholar 

  • Kouroumalis E, Skordilis P, Thermos K, Vasilaki A, Moschandrea J, Manousos ON (1998) Treatment of hepatocellular carcinoma with octreotide: a randomised controlled study. Gut 42:442–447

    PubMed Central  PubMed  CAS  Google Scholar 

  • Kuo G, Choo Q-L, Alter HJ et al. (1989) An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244:362–364

    PubMed  CAS  Google Scholar 

  • Kuriyama S, Masui K, Kikukawa M et al. (1999) Complete cure of established murine hepatocellular carcinoma is achievable by repeated injections of retroviruses carrying the herpes simplex virus thymidine kinase gene. Gene Ther 6:525–533

    PubMed  CAS  Google Scholar 

  • Livraghi T, Bolondi L, Lazzaroni S et al. (1992) Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients. Cancer 69:925–929

    PubMed  CAS  Google Scholar 

  • Livraghi T, Giorgio A, Marin G et al. (1995) Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection. Radiology 197:101–108

    PubMed  CAS  Google Scholar 

  • Lukacs KV, Porter CD, Pardo OE et al. (1999) In vivo transfer of bacterial marker genes results in differing levels of gene expression and tumor progression in immunocompetent and immunodeficient mice. Hum Gene Ther 10: 2373–2379

    PubMed  CAS  Google Scholar 

  • Macdonald GA, Greenson JK, Saito K, Cherian SP, Appelman H.D., Boland CR (1998) Microsatellite instability and loss of heterozygosity at DNA mismatch repair gene loci occurs during hepatic carcinogenesis. Hepatology 28:90–97

    PubMed  CAS  Google Scholar 

  • Martin LA, Vile R, Lemoine NR, Sikora K, Pandha HS (1997) Genetic prodrug activation therapy. Lancet 350:1793–1794

    PubMed  CAS  Google Scholar 

  • Matsubara K, Tokino T (1990) Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis. Mol Biol Med 7:243–260

    PubMed  CAS  Google Scholar 

  • Mazzaferro V, Regalia E, Doci R et al. (1996) Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 334:693–699

    PubMed  CAS  Google Scholar 

  • Michalak TI, Pasquinelli C, Guilhot S, Chisari FV (1994) Hepatitis B virus persistence after recovery from acute viral hepatitis. J Clin Invest 93:230–239

    PubMed Central  PubMed  CAS  Google Scholar 

  • Michalak TI, Pardoe I.U., Coffin CS et al. (1999) Occult life-long persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis. Hepatology 29:928–938

    PubMed  CAS  Google Scholar 

  • Miller JF, Morahan G (1992) Peripheral T cell tolerance. Annu Rev Immunol 10:51–69

    PubMed  CAS  Google Scholar 

  • Mise M, Arii S, Higashituji H et al. (1996) Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology 23:455–464

    PubMed  CAS  Google Scholar 

  • Miyoshi Y, Iwao K, Nagasawa Y et al. (1998) Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res 58:2524–2527

    PubMed  CAS  Google Scholar 

  • Mohr L, Schauer JI, Boutin RH, Moradpour D, Wands JR (1999) Targeted gene transfer to hepatocellular carcinoma cells in vitro using a novel monodonal antibody-based gene delivery system. Hepatology 29:82–89

    PubMed  CAS  Google Scholar 

  • Moradpour D, Blum HE (1999) Current and evolving Therapics for hepatitis C. Eur J Gastroenterol Hepatol 11:1199–1202

    PubMed  CAS  Google Scholar 

  • Morel A, De la Coste A, Fernandez N et al. (1998) Does preventive vaccination with engineered tumor cells work in cancer-prone transgenic mice? Cancer Gene Ther 5:92–100

    PubMed  CAS  Google Scholar 

  • Moriya K, Fujie H, Shintani Y et al. (1998) The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 4:1065–1067

    PubMed  CAS  Google Scholar 

  • Möröy T, Marchio A, Etiemble J, Trépo C, Tiollais P, Buendia M-A (1986) Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks. Nature 324:276–279

    PubMed  Google Scholar 

  • Moscow JA, Huang H, Carter C et al. (1999) Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy. Blood 94:52–61

    PubMed  CAS  Google Scholar 

  • Murakami Y, Hayashi K, Hirohashi S, Sekiya T (1991) Aber-rations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas. Cancer Res 51:5520–5525

    PubMed  CAS  Google Scholar 

  • Nabel GJ (1999) Development of optimized vectors for gene therapy. Proc Natl Acad Sci USA 96:324–326

    PubMed Central  PubMed  CAS  Google Scholar 

  • Nagaya T, Nakamura T, Tokino T et al. (1987) The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma. Genes Dev 1:773–782

    PubMed  CAS  Google Scholar 

  • Nakamoto Y, Guidotti LC, Kuhlen CV, Fowler P, Chisari FV (1998) Immune pathogenesis of hepatocellular carcinoma. J Exp Med 188:341–350

    PubMed Central  PubMed  CAS  Google Scholar 

  • Nassal M (1996) Hepatitis B virus morphogenesis. Curr Top Microbiol Immunol 214:297–337

    PubMed  CAS  Google Scholar 

  • Nassal M (1999) Hepatitis B virus replication: novel roles for virus-host interactions. Intervirology 42:100–116

    PubMed  CAS  Google Scholar 

  • Nishida N, Fukuda Y, Komeda T et al. (1994) Amplification and overexpression of the cydin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res 54:3107–3110

    PubMed  CAS  Google Scholar 

  • Nishiyama M, Wands JR (1992) Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma. Biochem Biophys Res Commun 183:280–285

    PubMed  CAS  Google Scholar 

  • Nurse P (2000) A long twentieth century of the cell cycle and beyond. Cell 100:71–78

    PubMed  CAS  Google Scholar 

  • Oda H, Imai Y, Nakatsuru Y, Hata J, Ishikawa T (1996) Somatic mutations of the APC gene in sporadic hepatoblastomas. Cancer Res 56:3320–3323

    PubMed  CAS  Google Scholar 

  • Ogata N, Kamimura T, Asakura H (1991) Point mutation, allelic loss and increased methylation of c-Ha-Ras gene in human hepatocellular carcinoma. Hepatology 13:31–37

    PubMed  CAS  Google Scholar 

  • Ohguchi S, Nakatsukasa H, Higashi T et al. (1998) Expression of alpha-fetoprotein and albumin genes in human hepatocellular carcinomas: limitations in the application of the genes for targeting human hepatocellular carcinoma in gene therapy. Hepatology 27:599–607

    PubMed  CAS  Google Scholar 

  • Ohto H, Terazawa S, Sasaki N et al. (1994) Transmission of hepatitis C virus from mothers to infants. N Engl J Med 330:744–750

    PubMed  CAS  Google Scholar 

  • Ohwada A, Hirschowitz EA, Crystal RG (1996) Regional delivery of an adenovirus vector containing the Escherichia cali cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver. Hum Gene Ther 7:1567–1576

    PubMed  CAS  Google Scholar 

  • Okada S, Shimada K, Yamamoto J et al. (1994) Predictive factors for postoperative recurrence of hepatocellular carcinoma. Gastroenterology 106:1618–1624

    PubMed  CAS  Google Scholar 

  • Okuda K (2000) Hepatocellular carcinoma. J Hepatol [Suppl1] 32:225–237

    PubMed  CAS  Google Scholar 

  • Ozturk M (1999) Genetic aspects of hepatocellular carcinogenesis.Semin Liver Dis 19:235–242

    PubMed  CAS  Google Scholar 

  • Park JS, Yang JM, Min MK (2000) Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene. Biochem Biophys Res Commun 267:581–587

    PubMed  CAS  Google Scholar 

  • Pasquinelli C, Bhavani K, Chisari FV (1992) Multiple oncogenes and tumor suppressor genes are structurally and functionally intact during hepatocarcinogenesis in hepatitis B virus transgenic mice. Cancer Res 52:2823–2829

    PubMed  CAS  Google Scholar 

  • Paterlini P, Gerken G, Nakajima E et al. (1990) Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen. N Engl J Med 323:80–85

    PubMed  CAS  Google Scholar 

  • Pileri P, Uematsu Y, Campagnoli S et al. (1998) Binding of hepatitis C virus to CD81. Science 282:938–941

    PubMed  CAS  Google Scholar 

  • Pineau P, Marchio A, Terris B et al. (1996) A t(3;8) chromosomal translocation associated with hepatitis B virus integration involves the carboxypeptidase N locus. J Virol 70:7280–7284

    PubMed Central  PubMed  CAS  Google Scholar 

  • Pitot HC (1990) Proto-oncogene activation in multistage murine hepatocarcinogenesis. Prog Clin Biol Res 331: 311–324

    PubMed  CAS  Google Scholar 

  • Puisieux A, Lim S, Groopman J, Ozturk M (1991) Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res 51:6185–6189

    PubMed  CAS  Google Scholar 

  • Puisieux A, Ji J, Guillot C et al. (1995) p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus. Proc Natl Acad Sci USA 92:1342–1346

    PubMed Central  PubMed  CAS  Google Scholar 

  • Qian C, Idoate M, Bilbao R et al. (1997) Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma. Hum Gene Ther 8:349–358

    PubMed  CAS  Google Scholar 

  • Qian C, Drozdzik M, Caselmann WH, Prieto J (2000) The potential of gene therapy in the treatment of hepatocellular carcinoma. J Hepatol 32:344–351

    PubMed  CAS  Google Scholar 

  • Ray RB, Lagging LM, Meyer K, Ray R (1996) Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J Virol 70:4438–4443

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ray RB, Steele R, Meyer K, Ray R (1997) Transcriptional repression of p53 promoter by hepatitis C virus core protein. J Biol Chem 272:10983–10986

    PubMed  CAS  Google Scholar 

  • Ray RB, Steele R, Meyer K, Ray R (1998) Hepatitis C virus core protein represses p21 WAF1/Cip1/Sid1 promoter activity. Gene 208:331–336

    PubMed  CAS  Google Scholar 

  • Reed KE, Rice CM (2000) Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties. Curr Top Microbiol Immunol 242:55–84

    PubMed  CAS  Google Scholar 

  • Rehermann B, Ferrari C, Pasquinelli C, Chisari FV (1996) The hepatitis B virus persists for decades after patients’ recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med 2:1104–1108

    PubMed  CAS  Google Scholar 

  • Rice CM (1996) Flaviviridae: the viruses and their replication. In: Fields B.N., Knipe DM, Howley PM (eds) Fields virology. Lippincott-Raven, Philadelphia, pp 931–959

    Google Scholar 

  • Ross RK, Yuan JM, Yu MC et al. (1992) Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 339:943–946

    PubMed  CAS  Google Scholar 

  • Rossi S, Buscarini E, Garbagnati F et al. (1998) Percutaneous treatment of small hepatic tumors by an expandable RF needle electrode. AJR Am J Roentgenol 170:1015–1022

    PubMed  CAS  Google Scholar 

  • Sakamuro D, Furukawa T, Takegami T (1995) Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J Virol 69:3893–3896

    PubMed Central  PubMed  CAS  Google Scholar 

  • Santoni-Rugiu E, Preisegger KH, Kiss A et al. (1996) Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model. Proc Natl Acad Sci USA 93:9577–9582

    PubMed Central  PubMed  CAS  Google Scholar 

  • Schreiber GB, Busch MP, Kleinman SH et al. (1996) The risk of transfusion-transmitted viral infections. N Engl J Med 334:1685–1690

    PubMed  CAS  Google Scholar 

  • Seeff LB (1997) Natural history of hepatitis C. Hepatology [Suppl 1] 26:21S–28S

    PubMed  CAS  Google Scholar 

  • Shih C, Burke K, Chou M-J et al. (1987) Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region. J Virol 61:3491–3498

    PubMed Central  PubMed  CAS  Google Scholar 

  • Shiota G, Rhoads DB, Wang TC, Nakamura T, Schmidt EV (1992) Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci USA 89:373–377

    PubMed Central  PubMed  CAS  Google Scholar 

  • Shiota G, Wang TC, Nakamura T, Schmidt EV (1994) Hepatic growth factor in transgenic mice: effect on hepatocyte growth, liver regeneration and gene expression. Hepatology 19:962–972

    PubMed  CAS  Google Scholar 

  • Slagle B, Zhou Y-Z, Birchmeier W, Scorsone KA (1993) Deletion of the E-cadherin gene in hepatitis B virus-positive Chinese hepatocellular carcinomas. Hepatology 18:757–762

    PubMed  CAS  Google Scholar 

  • Stroffolini T, Andreone P, Andriulli A et al. (1998) Characteristics of hepatocellular carcinoma in Italy. J Hepatol 29:944–952

    PubMed  CAS  Google Scholar 

  • Sun Z, Lu P, Gail MH et al. (1999) Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology 30:379–383

    PubMed  CAS  Google Scholar 

  • Tada M, Omata M, Ohto M (1990) Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing. Cancer Res 50:1121–1124

    PubMed  CAS  Google Scholar 

  • Tahara H, Nakanishi T, Kitamoto M et al. (1995) Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res 55:2734–2736

    PubMed  CAS  Google Scholar 

  • Tan SL, Nakao H, He Y et al. (1999) NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homolgy 3 domain/ligand-dependent manner and perturbs mitogenic signaling. Proc Natl Acad Sci USA 96:5533–5538

    PubMed Central  PubMed  CAS  Google Scholar 

  • Tanaka S, Mori M, Sakamoto Y, Makuchi M, Sugimachi K, Wands JR (1999) Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest 103:341–345

    PubMed Central  PubMed  CAS  Google Scholar 

  • Tatsumi T, Takehara T, Kanto T et al. (1999) B7-1 (CD80)gene transfer combined with interleukin-12 administration elicits protective and therapeutic immunity against mouse hepatocellular carcinoma. Hepatology 30:422–429

    PubMed  CAS  Google Scholar 

  • Taylor-Robinson SD, Foster GR, Arora S, Hargreaves S, Thomas HC (1997) Increase in primary liver cancer in the UK, 1979-94. Lancet 350:1142–1143

    Google Scholar 

  • Tennant BC (1992) Hepatocarcinogenesis in experimental woodchuck hepatitis virus infection. In: Sirica AE (ed) The role of cell types in hepatocarcinogenesis. CRC Press, Boca Raton, FL, pp 323–349

    Google Scholar 

  • Tobe T, Arii S (1992) Improving survival after resection of hepatocellular carcinoma: characteristics and current status of surgical treatment of primary liver cancer in Japan. In: Tobe T, Kaneda H, Okudaira M, Ohto M, Endo Y (eds) Primary liver cancer in Japan. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Torimura T, Sata M, Ueno T et al. (1998) Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma. Hum Pathol 29:986–991

    PubMed  CAS  Google Scholar 

  • Torzilli G, Minagawa M, Takayama T et al. (1999) Accurate preoperative evaluation of liver mass lesions without fine-needle biopsy. Hepatology 30:889–893

    PubMed  CAS  Google Scholar 

  • Ueda H, Ullrich SJ, Gangemi JD et al. (1995) Functional inactivation but not structural mutation of p53 causes liver cancer. Nat Genet 9:41–47

    PubMed  CAS  Google Scholar 

  • Vollmer CM Jr, Eilber FC, Butterfield LH et al. (1999) Alphafetoprotein-specific genetic immunotherapy for hepatocellular carcinoma. Cancer Res 59:3064–3067

    PubMed  CAS  Google Scholar 

  • Wands JR, Blum HE (1991) Primary hepatocellular carcinoma. N Engl J Med 325:729–731

    PubMed  CAS  Google Scholar 

  • Wands JR, Liang TJ, Blum HE, Shafritz DA (1992) Molecular pathogenesis of liver disease during persistent hepatitis B virus infection. Semin Liver Dis 12:252–264

    PubMed  CAS  Google Scholar 

  • Wang H-P, Rogler CE (1991) Topoisomerase I-mediated integration of hepadnavirus DNA in vitro. J Virol 65:2381–2392

    PubMed Central  PubMed  CAS  Google Scholar 

  • Wang J, Chenivesse X, Henglein B, Bréchot C (1990) Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 343:555–557

    PubMed  CAS  Google Scholar 

  • Wang J, Zindy F, Chenivesse X, Lamas E, Henglein B, Bréchot C (1992) Modification of cyclin A expression by hepatitis B virus DNA integration in a hepatocellular carcinoma. Oncogene 7:1653–1656

    PubMed  CAS  Google Scholar 

  • Wang X.W., Forrester K, Yeh H, Feitelson MA, Gu J-R, Harris CC (1994) Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci USA 91:2230–2234

    PubMed Central  PubMed  CAS  Google Scholar 

  • Watanabe S, Yamasaki S, Tanae A, Hibi I, Honna T (1994) Three cases of hepatocellular carcinoma among cyproterone users.Ad hoc Committee on Androcur Users. Lancet344:1567–1568

    PubMed  CAS  Google Scholar 

  • Wei Y, Fourel G, Ponzetto A, Silvestro M, Tiollais P, Buendia M-A (1992) Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors. J Virol 66:5265–5276

    PubMed Central  PubMed  CAS  Google Scholar 

  • Xu GW, Sun ZT, Forrester K, Wang X.W., Coursen J, Harris CC (1996) Tissue-specific growth suppression and chemosensitivity promotion in human hepatocellular carcinoma cells by retroviral-mediated transfer of the wildtype p53 gene. Hepatology 24:1264–1268

    PubMed  CAS  Google Scholar 

  • Yakicier MC, Irmak MB, Romano A, Kew M, Ozturk M (1999) Smad2 and Smad4 gene mutations in hepatocellular carcinoma. Oncogene 18:4879–4883

    PubMed  CAS  Google Scholar 

  • Yamada T, De Souza AT, Finkelstein S, Jirtle RL (1997) Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis.Proc Natl Acad Sci USA 94:10351–10355

    PubMed Central  PubMed  CAS  Google Scholar 

  • Yamaguchi R, Yano H, Lemura A, Ogasawara S, Haramaki M, Kojiro M (1998) Expression of vascular endothelial growth factor in human hepatocellular carecinoma. Hepatology 28:68–77

    PubMed  CAS  Google Scholar 

  • Yang Y, Nunes FA, Berencsi K, Furth EE, Gonczol E, Wilson JM (1994) Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 91:4407–4411

    PubMed Central  PubMed  CAS  Google Scholar 

  • Yano M, Asahara T, Dohi K, Mizuno T, Iwamoto KS, Seyama T (1999) Close correlation between a p53 or hMSH2 gene mutation in the tumor and survival of hepatocellular carcinoma patients. Int J Oncol 14:447–451

    PubMed  CAS  Google Scholar 

  • Yoshiji H, Kuriyama S, Yoshii J et al. (1998) Vascular endothelial growth factor tightly regulates in vivo development of murine hepatocellular carcinoma cells. Hepatology 28:1489–1496

    PubMed  CAS  Google Scholar 

  • Zanetti AR, Tanzi E, Paccagnini S et al. (1995) Mother-to-infant transmission of hepatitis C virus. Lancet 345:289–291

    PubMed  CAS  Google Scholar 

  • Zhang X-K, Huang DP, Qiu DK, Chiu JF (1990) The expression of c-myc and c-N-ras in human cirrhotic livers, hepatocellular carcinomas and liver tissue surrounding the tumors. Oncogene 5:909–914

    PubMed  CAS  Google Scholar 

  • Zhang X-K, Egan J.O., Huang D-P, Sun Z-L, Chien V.KY, Chiu J-F (1992) Hepatitis B virus DNA integration and expression of an erb B-like gene in human hepatocellular carcinoma. Biochem Biophys Res Commun 188:344–351

    PubMed  CAS  Google Scholar 

  • Zhang Y-J, Hang W, Chen CJ et al. (1993) Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma. Biochem Biophys Res Commun 196:1010–1016

    PubMed  CAS  Google Scholar 

  • Zhang X-K, Xu H-J, Murakami Y et al. (1994) Deletions of chromosome 13q, mutations in RB1 and RB protein state in human hepatocellular carcinoma. Cancer Res 54:4177–4182

    PubMed  CAS  Google Scholar 

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  1. Darius Moradpour
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  2. Hans-Peter Allgaier
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  3. Heinz G. Linhart
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  4. Hubert E. Blum
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  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str.10, 13122, Berlin-Buch, Germany

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Medizinische Universitätsklinik Knappschaftskrankenhaus, In der Schornau 23-25, 44892, Bochum-Langendreer, Germany

    Stephan A. Hahn  & Wolff Schmiegel  & 

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Moradpour, D., Allgaier, HP., Linhart, H.G., Blum, H.E. (2002). Hepatozelluläres Karzinom. In: Ganten, D., Ruckpaul, K., Hahn, S.A., Schmiegel, W. (eds) Molekularmedizinische Grundlagen von nicht-hereditären Tumorerkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56297-6_7

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