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Molekulare Pathogenese der Malignome des Genitalbereichs

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Part of the Molekulare Medizin book series (MOLMED)

Zusammenfassung

Tumoren des weiblichen Genitaltrakts weisen besondere epidemiologische Verteilungsmuster auf, die für die onkologische Ursachen- und Grundlagenforschung in den letzten Jahrzehnten richtungsweisende Einsichten und Erkenntnisse ergeben haben. Zum einen finden sich bestimmte erbliche Verteilungs muster insbesondere beim Endometrium- und Ovarialkarzinom, die nahe legten, dass erbliche Prädispositionen in der Pathogenese dieser Tumoren eine wesentliche Rolle spielen. Durch diese Beobachtungen konnten u. a. die zentrale Rolle so wesentlicher Tumorsuppressorgene wie der Brust- und Ovarialkrebsgene BRCA1 und BRCA2, aber auch der DNA-Mismatch-Reparaturgene hMLH1, hMSH2 und hMLH6 beim hereditären Endometriumkarzinom charakterisiert werden. Andererseits fanden sich gerade beim Zervixkarzinom, aber auch dem Vulva- und Vaginalkarzinom epidemiologische Anhaltspunkte für einen sexuell übertragbaren Erreger, die letztendlich zur Entdeckung und Charakterisierung der onkogenen humanen Papillomviren geführt haben.

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von Knebel Doeberitz, M. (2002). Molekulare Pathogenese der Malignome des Genitalbereichs. In: Ganten, D., Ruckpaul, K., Hahn, S.A., Schmiegel, W. (eds) Molekularmedizinische Grundlagen von nicht-hereditären Tumorerkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56297-6_12

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