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Pan Vascular Medicine pp 420–440Cite as

Cerebrovascular Ultrasonography

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Abstract

Over three decades ago, continuous-wave (CW) Doppler was introduced as the first ultrasonographic method for evaluation of cerebrovascular disease. Since then the continuous development of new noninvasive ultrasound techniques has resulted in a considerable number of clinical applications for assessment of both extracranial and intracranial arterial diseases. Historical milestones in cerebrovascular ultrasonography include B-mode imaging of blood vessels in a two-dimensional gray-scale display, transcranial pulsed wave (PW) Doppler systems for hemodynamic evaluation of intracranial blood vessels, duplex systems combining B-mode and pulsed wave (PW) Doppler for simultaneous tissue imaging and registration of Doppler spectrums, and color-coded Doppler imaging for real-time visualization of blood flow. More recent advances in cerebrovascular ultrasound encompass power Doppler imaging, transcranial monitoring of microembolic signals, three- and four-dimensional ultrasonography, real-time compound imaging, and contrast agent harmonic perfusion imaging.

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References

  1. International Workshop on Cerebral Embolism (1995) Cerebral embolism. Compilation of papers from the International Workshop, Hennerici M (ed), Gütersloh, Germany, 14–15 Jan 1994. Cere-brovasc Dis 5:66–158

    Google Scholar 

  2. Aaslid R, Markwalder TM, Nornes H (1982) Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal arteries. J Neurosurg 57:769–774

    CAS  PubMed  Google Scholar 

  3. AbuRahma AF, Kyer PD, Robinson PA, Hannay RS (1998) The correlation of ultrasonic carotid plaque morphology and carotid plaque hemorrhage: clinical implications. Surgery 124:721–726

    CAS  PubMed  Google Scholar 

  4. Ackerstaff RG, Hoeneveld H, Slowikowski JM, Moll FL, Eikelboom BC, Ludwig JW (1984) Ultrasonic duplex scanning in atherosclerotic disease of the innominate, subclavian and vertebral arteries: a comparative study with angiography. Ultrasound Med Biol 10: 409–418

    CAS  PubMed  Google Scholar 

  5. Ackerstaff RG, Keunen RW, van Pelt W, Montauban van Swijndregt AD, Stijnen T (1990) Influence of biological factors on changes in mean cerebral blood flow velocity in normal ageing: a transcranial Doppler study. Neurol Res 12:187–191

    CAS  PubMed  Google Scholar 

  6. Ackerstaff RG, Mess WH, Van Zuilen EV, Van der Tweel I (1997) Reliability in the identification of Doppler embolic transient signals: a statistical problem? Stroke 28:876

    CAS  PubMed  Google Scholar 

  7. Aldoori MI, Baird R (1987) Duplex scanning and plaque histology in cerebral ischaemia. Eur J Vasc Surg 1:159–164

    CAS  PubMed  Google Scholar 

  8. Alexandrov AV, Bladin CF, Magissano R, Norris JW (1993) Measuring carotid stenosis. Stroke 24:1292–1296

    CAS  PubMed  Google Scholar 

  9. Arnold JA, Modaresi KB, Thomas N, Taylor PR, Padayachee TS (1999) Carotid plaque characterization by duplex scanning: observer error may undermine current clinical trials. Stroke 30: 61–65

    CAS  PubMed  Google Scholar 

  10. Arnolds BJ, von Reutern GM (1987) Transcranial Doppler sonography. Examination technique and normal reference values. Ultraschall Med 12:115–123

    Google Scholar 

  11. Babikian VL, Hyde C, Pochay V, Winter MR (1994) Clinical correlates of high-intensity transient signals detected on transcranial Doppler sonography in patients with cerebrovascular disease. Stroke 25:1570–1573

    CAS  PubMed  Google Scholar 

  12. Babikian VL, Wijman CA, Hyde C, Cantelmo NL, Winter MR, Baker E, Pochay V (1997) Cerebral microembolism and early recurrent cerebral or retinal ischemic events. Stroke 28:1314–1318

    CAS  PubMed  Google Scholar 

  13. Barry CD, Allott CP, John NW, Mellor PM, Arundel PA, Thomson DS, Waterton JC (1997) Three-dimensional freehand ultrasound: image reconstruction and volume analysis. Ultrasound Med Biol 23:1209–1224

    CAS  PubMed  Google Scholar 

  14. Bartels E (1992) Color-coded Doppler sonography of the vertebral arteries. Comparison with conventional duplex sonography (in German). Ultraschall Med 13:59–66

    CAS  PubMed  Google Scholar 

  15. Bartels E, Flugel KA (1994) Quantitative measurements of blood flow velocity in basal cerebral arteries with transcranial duplex color-flow imaging. A comparative study with conventional transcranial Doppler sonography. J Neuroimaging 4:77–81

    CAS  PubMed  Google Scholar 

  16. Bartels E, Flügel KA (1996) Evaluation of extracranial vertebral artery dissection with duplex color-flow imaging. Stroke 27:290–295

    CAS  PubMed  Google Scholar 

  17. Bassiouny HS, Davis H, Massawa N, Gewertz BL, Glagov S, Zarins CK (1989) Critical carotid stenoses: morphologic and chemical similarity between symptomatic and asymptomatic plaques. J Vasc Surg 9: 202–212

    CAS  PubMed  Google Scholar 

  18. Baumgartner RW, Arnold M, Gonner F, Staikow I, Herrmann C, Rivoir A, Muri RM (1997) Contrast-enhanced transcranial color-coded duplex sonography in ischemic cerebrovascular disease. Stroke 28:2473–2478

    CAS  PubMed  Google Scholar 

  19. Becker GM, Winkler J, Hofmann E, Bogdahn U (1990) Imaging of cerebral arterio-venous malformations by transcranial colour-coded real-time sonography. Neuroradiology 32:280–288

    CAS  PubMed  Google Scholar 

  20. Belkin M, Mackey WC, Pessin MS, Caplan LR, O’Donnell TF (1993) Common carotid artery occlusion with patent internal and external carotid arteries: diagnosis and surgical management. J Vasc Surg 17:1019–1028

    CAS  PubMed  Google Scholar 

  21. Bendick PJ, Glover JL (1990) Hemodynamic evaluation of vertebral arteries by duplex ultrasound. Surg Clin North Am 70:235–244

    CAS  PubMed  Google Scholar 

  22. Bendick PJ, Jackson VP (1986) Evaluation of the vertebral arteries with duplex sonography. J Vasc Surg 3:523–530

    CAS  PubMed  Google Scholar 

  23. Bluth EI, Kay D, Merritt CRB, Sullivan M, Farr G, Mills NL (1986) Sonographic characterization of carotid plaque: detection of hemorrhage. Am J Roentgenol 146:1061–1065

    CAS  Google Scholar 

  24. Bluth EI, McVay LVI, Merritt CR, Sullivan MA (1988) The identification of ulcerative plaque with high resolution duplex carotid scanning. J Ultrasound Med 7:73–76

    CAS  PubMed  Google Scholar 

  25. Bock RW, Lusby RJ (1992) Carotid plaque morphology and interpretation of the echolucent lesion. In: Labs KH, Jäger KA, Fitzgerald DE, Woodcock JP, Neuerburg-Heusler D (eds) Diagnostic vascular imaging. Arnold, London, pp 225–236

    Google Scholar 

  26. Bogdahn U, Becker G, Winkler J, Greiner K, Perez J, Meurers B (1990) Transcranial color-coded real-time sonography in adults. Stroke 21:1680–1688

    CAS  PubMed  Google Scholar 

  27. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE (1997) Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 96:1432–1437

    CAS  PubMed  Google Scholar 

  28. Brass LM, Pavlakis SG, DeVivo D, Piomelli S, Mohr JP (1988) Transcranial Doppler measurements of the middle cerebral artery. Effect of hematocrit. Stroke 19:1466–1469

    CAS  Google Scholar 

  29. Bunegin L, Wahl D, Albin MS (1994) Detection and volume estimation of embolic air in the middle cerebral artery using transcranial Doppler sonography. Stroke 25:593–600

    CAS  PubMed  Google Scholar 

  30. Büdingen HJ, Staudacher T (1987) Die Identifizierung der Arteria basilaris mit der transkraniellen Dopplersonographie. Ultraschall 8:95–101

    Google Scholar 

  31. Büdingen HJ, von Reutern GM (1994) Ultraschalldiagnostik der hirnversorgenden Arterien. Thieme, Stuttgart

    Google Scholar 

  32. Caplan LR, Zarins CK, Hemmatti M (1985) Spontaneous dissection of the extracranial vertebral arteries. Stroke 16:1030–1038

    CAS  PubMed  Google Scholar 

  33. Chan KH, Dearden NM, Miller JD (1993) Transcranial Doppler-sonography in severe head injury. Acta Neurochir Suppl Wien 59:81–85

    CAS  PubMed  Google Scholar 

  34. Chang PH, Shung KK, Levene HB (1996) Quantitative measurements of second harmonic Doppler using ultrasound contrast agents. Ultrasound Med Biol 22:1205–1214

    CAS  PubMed  Google Scholar 

  35. Cher LM, Chambers BR, Smidt V (1992) Comparison of transcranial Doppler with DSA in vertebrobasilar ischaemia. Clin Exp Neurol 29:143–148

    CAS  PubMed  Google Scholar 

  36. Comerota AJ, Cranley A, Cook S (1981) Real-time B-mode imaging in diagnosis of cerebrovascular disease. Surgery 89:718–729

    CAS  PubMed  Google Scholar 

  37. Comerota AJ, Katz ML, White JV, Grosh JD (1990) The preoperative diagnosis of the ulcerated carotid atheroma. J Vasc Surg 11:505–510

    CAS  PubMed  Google Scholar 

  38. Consensus Committee of the Ninth International Cerebral Hemodynamics Symposium (1995) Basic identification criteria of Doppler microembolia signals. Stroke 26:1123

    Google Scholar 

  39. Crouse JR (1997) Sources of arterial wall thickness measurement variability. In: Touboul PJ (ed) Intima media thickness and atherosclerosis: predicting the risk? Parthenon, New York, pp 59–68

    Google Scholar 

  40. Crouse JR, Harpold GH, Kahl FR, Toole JF, McKinney WM (1986) Evaluation of a scoring system for extracranial carotid atherosclerosis extent with B-mode ultrasound. Stroke 17:270–275

    CAS  PubMed  Google Scholar 

  41. Daffertshofer M, Ries S, Schminke U, Hennerici M (1996) High-intensity transient signals in patients with cerebral ischemia. Stroke 27:1844–1849

    CAS  PubMed  Google Scholar 

  42. Dashefsky SM, Cooperberg PL, Harrison PB, Reid JD, Araki DN (1991) Total occlusion of the common carotid artery with patent internal carotid artery. Identification with color flow Doppler imaging. J Ultrasound Med 10:417–421

    CAS  PubMed  Google Scholar 

  43. Davis PC, Nilsen B, Braun IF, Hoffmann JCJ (1986) A prospective comparison of duplex sonography vs angiography of the vertebral arteries. Am J Neuroradiol 7:1059–1064

    CAS  PubMed  Google Scholar 

  44. De Bray JM, Glatt B (1995) Quantification of atheromatous stenosis in the extracranial internal carotid artery. Cerebrovasc Dis 5: 414–426

    Google Scholar 

  45. De Bray JM, Missoum A, Dubas F, Joseph PA, Lhoste P, Emile J, Saumet JL (1994) Doppler transcranial ultrasonography in carotid and vertebral dissections: 36 cases involving angiography (in French). J Mal Vasc 19:35–40

    PubMed  Google Scholar 

  46. De Salles AA, Manchola I (1994) CO2 reactivity in arteriovenous malformations of the brain: a transcranial Doppler ultrasound study. J Neurosurg 80:624–630

    PubMed  Google Scholar 

  47. Delcker A, Diener HC (1992) Die verschiedenen Ultraschallmethoden zur Untersuchung der Arteria vertebralis — eine vergleichende Wertung. Ultraschall Med 13:213–220

    CAS  PubMed  Google Scholar 

  48. Delcker A, Diener HC (1994) Quantification of atherosclerotic plaques in carotid arteries by three-dimensional ultrasound. Br J Radiol 67:672–678

    CAS  PubMed  Google Scholar 

  49. Delcker A, Turowski B (1997) Diagnostic value of three-dimensional transcranial contrast duplex sonography. J Neuroimaging 7: 139–144

    CAS  PubMed  Google Scholar 

  50. Deng J, Gardener JE, Rodeck CH, Lees WR (1996) Fetal echocardiography in three and four dimensions. Ultrasound Med Biol 22: 979–986

    CAS  PubMed  Google Scholar 

  51. Detmer PR, Bashein G, Hodges T, Beach KW, Filer EP, Burns DH, Strandness DEJ (1994) 3D ultrasonic image feature localization based on magnetic scanhead tracking: in vitro calibration and validation. Ultrasound Med Biol 20:923–936

    CAS  PubMed  Google Scholar 

  52. Deverson S, Evans DH, Bouch DC (2000) The effects of temporal bone on transcranial Doppler ultrasound beam shape. Ultrasound Med Biol 26:239–244

    CAS  PubMed  Google Scholar 

  53. Diehl RR, Henkes H, Nahser HC, Kuhne D, Berlit P (1994) Blood flow velocity and vasomotor reactivity in patients with arteriovenous malformations. A transcranial Doppler study. Stroke 25: 1574–1580

    CAS  PubMed  Google Scholar 

  54. Diehl RR, Sliwka U, Rautenberg W, Schwartz A (1993) Evidence for embolization from a posterior cerebral artery thrombus by transcranial Doppler monitoring. Stroke 24:606–608

    CAS  PubMed  Google Scholar 

  55. Droste DW, Karl M, Bohle RM, Kaps M (1997) Comparison of ultrasonic and histopathological features of carotid artery stenosis. Neurol Res 19:380–384

    CAS  PubMed  Google Scholar 

  56. Dwyer JH, Sun P, Kwong-Fu H, Dwyer KM, Selzer RH (1998) Automated intima-media thickness: the Los Angeles Atherosclerosis Study. Ultrasound Med Biol 24:981–987

    CAS  PubMed  Google Scholar 

  57. Eicke BM, Tegeler CH, Dalley G, Myers LG (1994) Angle correction in transcranial Doppler sonography. J Neuroimaging 4:29–33

    CAS  PubMed  Google Scholar 

  58. Eicke BM, von Lorentz J, Paulus W (1995) Embolus detection in different degrees of carotid disease. Neurol Res 17:181–184

    CAS  PubMed  Google Scholar 

  59. Eiho S, Kuwahara M, Asada N (1987) Left ventricular image processing. Med Prog Technol 12:101–115

    CAS  PubMed  Google Scholar 

  60. El Atrozy T, Nicolaides A, Tegos T, Griffin M (1998) The objective characterisation of ultrasonic carotid plaque features. Eur J Vasc Endovasc Surg 16:223–230

    Google Scholar 

  61. Eliasziw M, Strifler JY, Fox AJ, Hachinski VC, Ferguson GG, Barnett HJ (1994) Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. Stroke 25:304–308

    CAS  PubMed  Google Scholar 

  62. Erickson SJ, Mewissen MW, Foley WD, Lawson TL, Middleton WD, Quiroz FA, Macrander SJ, Lipchik EO (1989) Stenosis of the internal carotid artery: assessment using color Doppler imaging compared with angiography. Am J Roentgenol 152:1299–1305

    CAS  Google Scholar 

  63. a. European Carotid Surgery Trialists’ Collaborative Group (1991) MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70–99%) or with mild (0–29%) carotid stenosis. Lancet 337(8752):1235–1243

    Google Scholar 

  64. Fischer CM, Ojemann RJ (1986) A clinico-pathologic study of carotid endarterectomy plaques. Rev Neurol 142:573

    Google Scholar 

  65. Fisher CM, Gore I, Okabe N, White PD (1965) Atherosclerosis of the carotid and vertebral arteries — extracranial and intracranial. Neuropathol Exp Neurol 24:455–476

    Google Scholar 

  66. Fisher M, Blumenfeld AM, Smith TW (1987) The importance of carotid artery plaque disruption and hemorrhage. Arch Neurol 44:1086–1089

    CAS  PubMed  Google Scholar 

  67. Folsom AR, Eckfeldt JH, Weitzman S, Ma J, Chambless LE, Barnes RW, Cram KB, Hutchinson RG (1994) Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Stroke 25:66–73

    CAS  PubMed  Google Scholar 

  68. Forsberg F, Goldberg BB, Liu JB, Merton DA, Rawool NM, Shi WT (1999) Tissue-specific US contrast agent for evaluation of hepatic and splenic parenchyma. Radiology 210:125–132

    CAS  PubMed  Google Scholar 

  69. Forteza AM, Babikian VL, Hyde C, Winter M, Pochay V (1996) Effect of time and cerebrovascular symptoms on the prevalence of microembolic signals in patients with cervical carotid stenosis. Stroke 27:687–690

    CAS  PubMed  Google Scholar 

  70. Franceschi D, Bondi JA, Rubin JR (1992) A new approach for three-dimensional reconstruction of arterial ultrasonography. J Vasc Surg 15:800–804

    CAS  PubMed  Google Scholar 

  71. Fujii K, Heistad D, Faraci FM (1991) Flow mediated dilation of the basilar artery in vivo. Circ Res 69:697–705

    CAS  PubMed  Google Scholar 

  72. Furberg CD, Borhani NO, Byington RP, Gibbons ME, Sowers JR (1993) Calcium antagonists and atherosclerosis. The Multicenter Isradipine/Diuretic Atherosclerosis Study. Am J Hypertens 6:24S–29S

    Google Scholar 

  73. Furst G, Saleh A, Wenserski F, Malms J, Cohnen M, Aulich A, Neu-mann-Haefelin T, Schroeter M, Steinmetz H, Sitzer M (1999) Reliability and validity of noninvasive imaging of internal carotid artery pseudo-occlusion. Stroke 30:1444–1449

    CAS  PubMed  Google Scholar 

  74. Gaunt ME, Martin PJ, Smith JL, Rimmer T, Cherryman G, Ratliff DA, Bell PR, Naylor AR (1994) Clinical relevance of intraoperative embolization detected by transcranial Doppler ultrasonography during carotid endarterectomy: a prospective study of 100 patients. Br J Surg 81:1435–1439

    CAS  PubMed  Google Scholar 

  75. Geiser EA, Christie LGJ, Conetta DA, Conti CR, Gossman GS (1982) A mechanical arm for spatial registration of two-dimensional echocardiographic sections. Cathet Cardiovasc Diagn 8:89–101

    CAS  PubMed  Google Scholar 

  76. Georgiadis D, Baumgartner RW, Karatschai R, Lindner A, Zerkowski HR (1998) Further evidence of gaseous embolic material in patients with artificial heart valves. J Thorac Cardiovasc Surg 115:808–810

    CAS  PubMed  Google Scholar 

  77. Georgiadis D, Grosset DG, Quin RO, Nichol JA, Bone I, Lees KR (1994) Detection of intracranial emboli in patients with carotid disease. Eur J Vasc Surg 8:309–314

    CAS  PubMed  Google Scholar 

  78. Georgiadis D, Kaps M, Siebler M, Hill M, Konig M, Berg J, Kahl M, Zunker P, Diehl B, Ringelstein EB (1995) Variability of Doppler microembolic signal counts in patients with prosthetic cardiac valves. Stroke 26:439–443

    CAS  PubMed  Google Scholar 

  79. Georgiadis D, Mallinson A, Grosset DG, Lees KR (1994) Coagulation activity and emboli counts in patients with prosthetic cardiac valves. Stroke 25:1211–1214

    CAS  PubMed  Google Scholar 

  80. Georgiadis D, Wenzel A, Zerkowski HR, Zierz S, Lindner A (1998) Influence of transducer frequency on Doppler microemboli signals in an in vivo model. Neurol Res 20:198–200

    CAS  PubMed  Google Scholar 

  81. Gerriets T, Seidel G, Fiss I, Modrau B, Kaps M (1999) Contrast-enhanced transcranial color-coded duplex sonography: efficiency and validity. Neurology 52:1133–1137

    CAS  PubMed  Google Scholar 

  82. Glagov S, Bassiouny HS, Giddens DP, Zarins CK (1995) Intimai thickening: morphogenesis, functional significance and detection. J Vasc Invest 1:1–14

    Google Scholar 

  83. Goertler M, Baeumer M, Kross R, Blaser T, Lutze G, Jost S, Wallesch CW (1999) Rapid decline of cerebral microemboli of arterial origin after intravenous acetylsalicylic acid. Stroke 30:66–69

    CAS  PubMed  Google Scholar 

  84. Goes E, Janssens W, Maillet B, Freson M, Steyaert L, Osteaux M (1990) Tissue characterization of atheromatous plaques: correlation between ultrasound image and histological findings. J Clin Ultrasound 18:611–617

    CAS  PubMed  Google Scholar 

  85. Goldberg BB, Merton DA, Liu JB, Forsberg F (1998) Evaluation of bleeding sites with a tissue-specific sonographic contrast agent. J Ultrasound Med 17:609–616

    CAS  PubMed  Google Scholar 

  86. Golledge J, Cuming R, Ellis M, Davies AH, Greenhalgh RM (1997) Carotid plaque characteristics and presenting symptom. Br J Surg 84:1697–1701

    CAS  PubMed  Google Scholar 

  87. Gomez CR, Brass LM, Tegeler CH, Babikian V, Sloan MA, Feldmann E, Wechsler L (1993) The transcranial Doppler standardization project. J Neuroimaging 3:190–192

    CAS  PubMed  Google Scholar 

  88. Greselle JF, Zenteno M, Kien P, Castel JP, Caille JM (1987) Spontaneous dissection of the vertebro-basilar system. A study of 18 cases (15 patients). J Neuroradiol 14:115–123

    CAS  PubMed  Google Scholar 

  89. Griewing B, Morgenstern C, Driesner F, Kallwellis G, Walker ML, Kessler C (1996) Cerebrovascular disease assessed by color-flow and power Doppler ultrasonography: comparison with digital subtraction angiography in internal carotid artery stenosis. Stroke 27:95–100

    CAS  PubMed  Google Scholar 

  90. Griewing B, Schminke U, Morgenstern C, Walker ML, Kessler C (1997) Three-dimensional ultrasound angiography (power mode) for the quantification of carotid artery atherosclerosis. J Neuroimaging 7:40–45

    CAS  PubMed  Google Scholar 

  91. Gronholdt ML, Nordestgaard BG, Wiebe BM, Wilhjelm JE, Sillesen H (1998) Echo-lucency of computerized ultrasound images of carotid atherosclerotic plaques are associated with increased levels of triglyceride-rich lipoproteins as well as increased plaque lipid content. Circulation 97:34–40

    CAS  PubMed  Google Scholar 

  92. Gronholdt ML, Wiebe BM, Laursen H, Nielsen TG, Schroeder TV, Sillesen H (1997) Lipid-rich carotid artery plaques appear echolu-cent on ultrasound B-mode images and may be associated with in-traplaque haemorrhage. Eur J Vasc Endovasc Surg 14:439–445

    CAS  PubMed  Google Scholar 

  93. Grosset DG, Cowburn P, Georgiadis D, Dargie HJ, Faichney A, Lee KR (1994) Ultrasound detection of cerebral emboli in patients with prosthetic heart valves. J Heart Valve Dis 3:128–132

    CAS  PubMed  Google Scholar 

  94. Grosset DG, Georgiadis D, Abdullah I, Bone I, Lees KR (1994) Doppler emboli signals vary according to stroke subtype. Stroke 25:382–384

    CAS  PubMed  Google Scholar 

  95. Grosset DG, Georgiadis D, Kelman AW, Lees KR (1993) Quantification of ultrasound emboli signals in patients with cardiac and carotid disease. Stroke 24:1922–1924

    CAS  PubMed  Google Scholar 

  96. Haggag KJ, Russell D, Brucher R, Dahl A, Jakobsen J, Bakke S, Muan B (1999) Contrast enhanced pulssed Doppler and colour-coded duplex studies on the cranial vasculature. Eur J Neurol 6:443–448

    CAS  PubMed  Google Scholar 

  97. Hallam MJ, Reid JM, Cooperberg PL (1989) Color-flow Doppler and conventional duplex scanning of the carotid bifurcation: prospective, double-blind, correlative study. Am J Roentgenol 152:1101–1105

    CAS  Google Scholar 

  98. Hamper UM, Trapanotto V, Sheth S, DeJong MR, Caskey CI (1994) Three-dimensional US: preliminary clinical experience. Radiology 191:397–401

    CAS  PubMed  Google Scholar 

  99. Harders A (1986) Neurosurgical applications of transcranial Doppler sonography. Springer, Vienna New York

    Google Scholar 

  100. Harders A, Bien S, Eggert HR, Laborde G, Merland JJ, Rufenacht D (1988) Haemodynamic changes in arteriovenous malformations induced by superselective embolization: transcranial Doppler evaluation. Neurol Res 10:239–245

    CAS  PubMed  Google Scholar 

  101. Hart RG (1988) Vertebral artery dissection. Neurology 38:987–989

    CAS  PubMed  Google Scholar 

  102. Hartmann A, Mohr JP, Thompson JL, Ramos O, Mast H (1999) Interrater reliability of plaque morphology classification in patients with severe carotid artery stenosis. Acta Neurol Scand 99:61–64

    CAS  PubMed  Google Scholar 

  103. Hassler W (1986) Hemodynamic aspects of cerebral angiomas. Springer, Vienna New York

    Google Scholar 

  104. Hatsukami TS, Ferguson MS, Beach KW, Gordon D, Detmer PR, Burns DH, Alpers C, Strandness DE Jr (1997) Carotid plaque morphology and clinical events. Stroke 28:95–100

    CAS  PubMed  Google Scholar 

  105. Hell B, Walter FA, Schreiber S, Blase H, Bielke G, Meindl S, Stein G (1993) Three-dimensional ultrasonography in maxillofacial surgery. A new diagnostic tool. Int J Oral Maxillofac Surg 22:173–177

    CAS  PubMed  Google Scholar 

  106. Hennerici M (1994) High intensity transcranial signals (HITS): a questionable “jackpot” for the prediction of stroke risk. J Heart Valve Dis 3:124–125

    CAS  PubMed  Google Scholar 

  107. Hennerici M, Meairs S (2000) Imaging arterial wall disease. Cere-brovasc Dis Suppl 5 [Suppl]:9–20

    Google Scholar 

  108. Hennerici M, Neuerburg-Heusler D (1998) Vascular diagnosis with ultrasound. Thieme, Stuttgart

    Google Scholar 

  109. Hennerici M, Rautenberg W, Schwartz A (1987) Transcranial Doppler ultrasound for the assessment of intracranial arterial flow velocity, part 2. Evaluation of intracranial arterial disease. Surg Neurol 27:523–532

    CAS  PubMed  Google Scholar 

  110. Hennerici M, Rautenberg W, Sitzer G, Schwartz A (1987) Transcranial Doppler ultrasound for the assessment of intracranial arterial flow velocity, part 1. Examination technique and normal values. Surg Neurol 27:439–448

    CAS  PubMed  Google Scholar 

  111. Hennerici M, Reifschneider G, Trockel U, Aulich A (1984) Detection of early atherosclerotic lesions by duplex scanning of the carotid artery. J Clin Ultrasound 12:455–464

    CAS  PubMed  Google Scholar 

  112. Hennerici M, Steinke W (1991) Carotid plaque developments: aspects of hemodynamic and vessel wall-platelet interaction. Cere-brovasc Dis 1:142–148

    Google Scholar 

  113. Hennerici M, Steinke W, Rautenberg W (1989) High-resistance Doppler flow pattern in extracranial carotid dissection. Arch Neurol 46:670–672

    CAS  PubMed  Google Scholar 

  114. Hodges TC, Detmer PR, Burns DH, Beach KW, Strandness DE J (1994) Ultrasonic three-dimensional reconstruction: in vitro and in vivo volume and area measurement. Ultrasound Med Biol 20:719–729

    CAS  PubMed  Google Scholar 

  115. Hoffmann M, Sacco RL, Chan S, Mohr JP (1993) Noninvasive detection of vertebral artery dissection. Stroke 24:815–819

    CAS  PubMed  Google Scholar 

  116. Huber P, Handa J (1967) Effect of contrast material, hypercapnea, hyperventilation, hypotonic glucose and papaverine on the diameter of cerebral arteries. Invest Radiol 2:17–32

    CAS  PubMed  Google Scholar 

  117. Imparato AM, Riles TS, Gostein F (1979) The carotid bifurcation plaque: pathologic findings associated with cerebral ischemia. Stroke 10:238–245

    CAS  PubMed  Google Scholar 

  118. Imparato AM, Riles TS, Mintzer R, Baumann FG (1983) The importance of hemorrhage in the relationship between gross morphologic characteristics and cerebral symptoms in 376 carotid artery plaques. Ann Surg 197:195–203

    CAS  PubMed Central  PubMed  Google Scholar 

  119. Jansen C, Ramos LM, van Heesewijk JP, Moll FL, van Gijn J, Acker-staff RG (1994) Impact of microembolism and hemodynamic changes in the brain during carotid endarterectomy. Stroke 25:992–997

    CAS  PubMed  Google Scholar 

  120. Joakimsen O, Bonaa KH, Stensland-Bugge E (1997) Reproducibility of ultrasound assessment of carotid plaque occurrence, thickness, and morphology. The Tromso Study. Stroke 28:2201–2207

    CAS  PubMed  Google Scholar 

  121. Josien E (1992) Extracranial vertebral artery dissection: nine cases. J Neurol 239:327–330

    CAS  PubMed  Google Scholar 

  122. Keunen RW, Stam CJ, Tavy DL, Mess WH, Titulaer BM, Ackerstaff RG (1998) Preliminary report of detecting microembolic signals in transcranial Doppler time series with nonlinear forecasting. Stroke 29: 1638–1643

    CAS  PubMed  Google Scholar 

  123. King DL, King DL J, Shao MY (1990) Three-dimensional spatial registration and interactive display of position and orientation of real-time ultrasound images. J Ultrasound Med 9:525–532

    CAS  PubMed  Google Scholar 

  124. Klotzsch C, Bozzato A, Lammers G, Mull M, Lennartz B, Noth J (1999) Three-dimensional transcranial color-coded sonography of cerebral aneurysms. Stroke 30:90

    Google Scholar 

  125. Koennecke HC, Mast H, Trocio SHJ, Sacco RL, Ma W, Mohr JP, Thompson JL (1998) Frequency and determinants of microembolic signals on transcranial Doppler in unselected patients with acute carotid territory ischemia. A prospective study. Cerebrovasc Dis 8:107–112

    CAS  PubMed  Google Scholar 

  126. Krishnan S, O’Donnell M (1996) Transmit aperture processing for nonlinear contrast agent imaging. Ultrason Imaging 18:77–105

    CAS  PubMed  Google Scholar 

  127. Langsfeld M, Gray Weale AC, Lusby RJ (1989) The role of plaque morphology and diameter reduction in the development of new symptoms in asymptomatic carotid arteries. J Vasc Surg 9: 548–557

    CAS  PubMed  Google Scholar 

  128. Leen EJ, Feeley TM, Colgan MP, O’Malley MK, Moore DJ, Hourihane DO, Shanik GD (1990) “Haemorrhagic” carotid plaque does not contain haemorrhage. Eur J Vasc Surg 4:123–128

    CAS  PubMed  Google Scholar 

  129. Lennihan L, Kupsky WJ, Mohr JP, Hauser WA, Correli JW, Quest DO (1987) Lack of association between carotid plaque hematoma and ischemic cerebral symptoms. Stroke 18:879–881

    CAS  PubMed  Google Scholar 

  130. Leotta DF, Detmer PR, Martin RW (1997) Performance of a miniature magnetic position sensor for three-dimensional ultrasound imaging. Ultrasound Med Biol 23:597–609

    CAS  PubMed  Google Scholar 

  131. Levine SR, Welch KM (1989) Common carotid artery occlusion. Neurology 39:178–186

    CAS  PubMed  Google Scholar 

  132. Lindegaard KF, Bakke SJ, Aaslid R, Nornes H (1986) Doppler diagnosis of intracranial arterial occlusive disorders. J Neurol Neuro-surg Psychiatry 49:510–518

    CAS  Google Scholar 

  133. Lindegaard KF, Bakke SJ, Grolimund P, Aaslid R, Huber P, Nornes H (1985) Assessment of intracranial hemodynamics in carotid artery disease by transcranial Doppler ultrasound. J Neurosurg 63:890–898

    CAS  PubMed  Google Scholar 

  134. LoGerfo FW, Mason GR (1974) Directional Doppler studies of supraorbital artery flow in internal carotid stenosis and occlusion. Surgery 76:723–728

    CAS  PubMed  Google Scholar 

  135. Lusby RJ, Ferrell LD, Ehrenfeld WK, Stoney RJ, Wylie EJ (1982) Carotid plaque hemorrhage. Its role in production of cerebral ischemia. Arch Surg 117:1479–1488

    CAS  PubMed  Google Scholar 

  136. Manchola IF, De Salles AA, Foo TK, Ackerman RH, Candia GT, Kjellberg RN (1993) Arteriovenous malformation hemodynamics: a transcranial Doppler study. Neurosurgery 33:556–562

    CAS  PubMed  Google Scholar 

  137. Markus H, Bland JM, Rose G, Sitzer M, Siebler M (1996) How good is intercenter agreement in the identification of embolic signals in carotid artery disease? Stroke 27:1249–1252

    CAS  PubMed  Google Scholar 

  138. Markus HS, Ackerstaff R, Babikian V, Bladin C, Droste D, Grosset D, Levi C, Russell D, Siebler M, Tegeler C (1997) Intercenter agreement in reading Doppler embolic signals. A multicenter international study. Stroke 28:1307–1310

    CAS  PubMed  Google Scholar 

  139. Markus HS, Clifton A, Buckenham T, Brown MM (1994) Carotid angioplasty. Detection of embolic signals during and after the procedure. Stroke 25:2403–2406

    CAS  PubMed  Google Scholar 

  140. Markus HS, Droste DW, Brown MM (1994) Detection of asymptomatic cerebral embolic signals with Doppler ultrasound. Lancet 343:1011–1012

    CAS  PubMed  Google Scholar 

  141. Markus HS, Loh A, Israel D, Buckenham T, Clifton A, Brown MM (1993) Microscopic air embolism during cerebral angiography and strategies for avoidance. Lancet 341:784–787

    CAS  PubMed  Google Scholar 

  142. Markus HS, Thomson N, Brown MM (1995) Asymptomatic cerebral embolic signals in symptomatic and asymptomatic carotid artery disease. Brain 118:1005–1011

    PubMed  Google Scholar 

  143. Markus HS, Thomson ND, Brown MM (1995) Asymptomatic cerebral embolic signals in symptomatic and asymptomatic carotid artery disease. Brain 118:1005–1011

    PubMed  Google Scholar 

  144. Maroon JC, Pieroni DW, Campbell RL (1969) Ophthalmosonometry: an ultrasonic method for assessing carotid blood flow. J Neurosurg 30:238–246

    CAS  PubMed  Google Scholar 

  145. Mast H, Mohr JP, Thompson JL, Osipov A, Trocio SH, Mayer S, Young WL (1995) Transcranial Doppler ultrasonography in cerebral arteriovenous malformations. Diagnostic sensitivity and association of flow velocity with spontaneous hemorrhage and focal neurological deficit. Stroke 26:1024–1027

    CAS  PubMed  Google Scholar 

  146. Mattle H, Grolimund P, Huber P, Sturzenegger M, Zurbrugg HR (1988) Transcranial Doppler sonographic findings in middle cerebral artery disease. Arch Neurol 45:289–295

    CAS  PubMed  Google Scholar 

  147. Meairs S, Daffertshofer M, Neff W, Eschenfelder C, Hennerici M (2000) Pulse-inversion contrast harmonic imaging: ultrasonographic assessment of cerebral perfusion. Lancet 355:550–551

    CAS  PubMed  Google Scholar 

  148. Meairs S, Hennerici M (1999) Four-dimensional ultrasonographic characterization of plaque surface motion in patients with symptomatic and asymptomatic carotid artery stenosis. Stroke 30:1807–1813

    CAS  PubMed  Google Scholar 

  149. Meairs S, Steinke W, Mohr JP, Hennerici M (1998) Ultrasound imaging and Doppler sonography. In: Barnett HJM, Mohr JP, Stein BM, Yatsu F, editors. Stroke: pathophysiology, diagnosis and management. Churchill Livingstone, New York, pp 207–326

    Google Scholar 

  150. Meairs S, Timpe L, Beyer J, Hennerici M (2000) Acute aphasia and hemiplegia during karate training. Lancet 356:40

    CAS  PubMed  Google Scholar 

  151. Melis-Kisman E, Mol JMF (1970) L’application de l’effet Doppler à l’exploration cérébrovascular — rapport préliminaire. Rev Neur 122:470–472

    CAS  Google Scholar 

  152. Merritt CR (1987) Doppler color flow imaging. J Clin Ultrasound 15:591–597

    CAS  PubMed  Google Scholar 

  153. Middleton WD, Foley WD, Lawson TL (1988) Color-flow Doppler imaging of carotid artery abnormalities. Am J Roentgenol 150: 419–425

    CAS  Google Scholar 

  154. Middleton WD, Foley WD, Lawson TL (1988) Flow reversal in the normal carotid bifurcation: color Doppler flow imaging analysis. Radiology 167:207–210

    CAS  PubMed  Google Scholar 

  155. Miller JD, Smith RR, Holaday HR (1992) Carbon dioxide reactivity in the evaluation of cerebral ischemia. Neurosurgery 30:518–521

    CAS  PubMed  Google Scholar 

  156. Mintz GS, Pichard AD, Satler LF, Popma JJ, Kent KM, Leon MB (1993) Three-dimensional intravascular ultrasonography: reconstruction of endovascular stents in vitro and in vivo. J Clin Ultrasound 21:609–615

    CAS  PubMed  Google Scholar 

  157. Mohr JP, Duterte DI, Oliveira VR, Dummy S Sr, Dummy S Jr (1988) Recanalization of acute middle cerebral artery occlusion. Neurology 38:215

    Google Scholar 

  158. Mokri B, Houser OW, Sandok BA, Piepgras DG (1988) Spontaneous dissections of the vertebral arteries. Neurology 38:880–885

    CAS  PubMed  Google Scholar 

  159. Montauban-van SA, Elbers HR, Moll FL, de Letter J, Ackerstaff RG (1998) Ultrasonographic characterization of carotid plaques. Ultrasound Med Biol 24:489–493

    Google Scholar 

  160. Moriyasu F, Kono Y, Kamiyama N, Bruns D, Matsumura T, Suginoshita Y, Kobayashi K, Nakamura T, Chiba T (1998) Flash echo imaging of liver tumors using ultrasound contrast agent and intermittent color Doppler scanning. Ultrasound Med 17:S63

    Google Scholar 

  161. Mull M, Aulich A, Hennerici M (1990) Transcranial Doppler ultrasonography versus arteriography for assessment of the vertebrobasilar circulation. J Clin Ultrasound 18:539–549

    CAS  PubMed  Google Scholar 

  162. Mulvagh SL, Foley DA, Aeschbacher BC, Klarich KK, Seward JB (1996) Second harmonic imaging of an intravenously administered echocardiographic contrast agent: visualization of coronary arteries and measurement of coronary blood flow. J Am Coll Cardiol 27:1519–1525

    CAS  PubMed  Google Scholar 

  163. Murphy KJ, Bude RO, Dickinson LD, Rubin JM (1997) Use of intravenous contrast material in transcranial sonography. Acad Radiol 4:577–582

    CAS  PubMed  Google Scholar 

  164. Müller HR (1971) Direktionelle Dopplersonographie der A. frontalis medialis. EEG EMG Z Elektroenzephalogr Elektromyogragr Verwandte Geb 2:816–823

    Google Scholar 

  165. Nabavi DG, Droste DW, Kemeny V, Schulte-Altedorneburg G, Weber S, Ringelstein EB (1998) Potential and limitations of echocontrast-enhanced ultrasonography in acute stroke patients: a pilot study. Stroke 29:949–954

    CAS  PubMed  Google Scholar 

  166. Nabavi DG, Droste DW, Schulte-Altedorneburg G, Kemeny V, Panzica M, Weber S, Ringelstein EB (1999) Diagnostic benefit of echocontrast enhancement for the insufficient transtemporal bone window. J Neuroimaging 9:102–107

    CAS  PubMed  Google Scholar 

  167. Noritomi T, Sigel B, Swami V, Justin J, Gahtan V, Chen X, Feleppa EJ, Roberts AB, Shirouzu K (1997) Carotid plaque typing by multipleparameter ultrasonic tissue characterization. Ultrasound Med Biol 23:643–650

    CAS  PubMed  Google Scholar 

  168. O’Donnell TF, Erdoes L, Mackay WC, McCullough J, Shepard A, Heggerick P (1985) Correlation of B-mode ultrasound imaging and arteriography with pathologic findings at carotid endarterectomy. Arch Surg 120:443–449

    PubMed  Google Scholar 

  169. O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SKJ (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340:14–22

    PubMed  Google Scholar 

  170. O’Leary DH, Polak JF, Kronmal RA, Savage PJ, Borhani NO, Kittner SJ, Tracy R, Gardin JM, Price TR, Furberg CD (1996) Thickening of the carotid wall. A marker for atherosclerosis in the elderly? Cardiovascular Health Study Collaborative Research Group. Stroke 27:224–231

    PubMed  Google Scholar 

  171. Otis S, Rush M, Boyajian R (1995) Contrast-enhanced transcranial imaging. Results of an American phase-two study. Stroke 26:203–209

    CAS  PubMed  Google Scholar 

  172. Padayachee TS, Gosling RG, Bishop CCR, Beurnand K, Browse NL (1986) Monitoring MCA blood velocity during carotid endarterectomy. Br J Surg 73:98–100

    CAS  PubMed  Google Scholar 

  173. Palombo C, Kozakova M, Morizzo C, Andreuccetti F, Tondini A, Palchetti P, Mirra G, Parenti G, Pandian NG (1998) Ultrafast three-dimensional ultrasound: application to carotid artery imaging. Stroke 29:1631–1637

    CAS  PubMed  Google Scholar 

  174. Park AE, McCarthy WJ, Pearce WH, Matsumura JS, Yao JS (1998) Carotid plaque morphology correlates with presenting symptomatology. J Vasc Surg 27:872–878

    CAS  PubMed  Google Scholar 

  175. Petty GW, Massaro AR, Tatemichi TK, Mohr JP, Hilal SK, Stein BM, Solomon RA, Duterte DI, Sacco RL (1990) Transcranial Doppler ultrasonographic changes after treatment for arteriovenous malformations. Stroke 21:260–266

    CAS  PubMed  Google Scholar 

  176. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R (1986) Intimai plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 74:1399–1406

    CAS  PubMed  Google Scholar 

  177. Poli A, Tremoli E, Colombo A, Sirtori M, Pignoli P, Paoletti R (1988) Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients. A new model for the quantitation and follow-up of preclinical atherosclerosis in living human subjects. Atherosclerosis 70:253–261

    CAS  PubMed  Google Scholar 

  178. Porter TR, Xie F, Kricsfeld D, Armbruster RW (1996) Improved myocardial contrast with second harmonic transient ultrasound response imaging in humans using intravenous perfluorocarbon-ex-posed sonicated dextrose albumin. J Am Coll Cardiol 27:1497–1501

    CAS  PubMed  Google Scholar 

  179. Postert T, Braun B, Pfundtner N, Sprengelmeyer R, Meves S, Przuntek H, Buttner T (1998) Echo contrast-enhanced three-dimensional power Doppler of intracranial arteries. Ultrasound Med Biol 24:953–962

    CAS  PubMed  Google Scholar 

  180. Postert T, Hoppe P, Federlein J, Helbeck S, Ermert H, Przuntek H, Büttner T, Wilkening W (2000) Contrast agent-specific imaging modes for the ultrasonic assessment of parenchymal cerebral echo contrast enhancement. J Cereb Blood Flow Metab 20:1709–1716

    CAS  PubMed  Google Scholar 

  181. Postert T, Muhs A, Meves S, Federlein J, Przuntek H, Buttner T (1998) Transient response harmonic imaging: an ultrasound technique related to brain perfusion. Stroke 29:1901–1907

    CAS  PubMed  Google Scholar 

  182. Rautenberg W, Hennerici M (1991) Intracranial hemodynamic measurements in patients with severe asymptomatic extracranial carotid disease. Cerebrovasc Dis 1:216–222

    Google Scholar 

  183. Rautenberg W, Ries S, Bäzner H, Hennerici M (1993) Emboli detection by TCD monitoring. Can J Neurol Sci 20:138–139

    Google Scholar 

  184. Rautenberg W, Schwartz A, Hennerici M (1987) Transkranielle Dopplersonographic während der zerebralen Angiographic In: Widder B (ed) Transkranielle Dopplersonographie bei zerebrovaskulären Erkrankungen. Springer, Berlin Heidelberg New York, pp 144–148

    Google Scholar 

  185. Rautenberg W, Schwartz A, Mull M, Dummy S Sr, Hennerici M (1990) Noninvasive detection of intracranial stenoses and occlusions. Stroke 21:149

    Google Scholar 

  186. Reith W, Pfadenhauer K, Loeprecht H (1990) Significance of transcranial Doppler CO2. Reactivity measurements for the diagnosis of hemodynamically relevant carotid obstructions. Ann Vasc Surg 4:359–364

    CAS  PubMed  Google Scholar 

  187. Ricotta JJ, Bryan FA, Bond MG, Kurtz A, O’Leary DH, Raines JK (1987) Multicenter validation study of real-time (B-mode) ultrasound, arteriography, and pathologic examination. J Vasc Surg 6:512–520

    CAS  PubMed  Google Scholar 

  188. Ries F, Eicke M (1987) Auswirkungen der extrakorporalen Zirkulation auf die intrazerebrale Hämodynamik — Erklärung postoperativer neuropsychiatrischer Komplikationen. In: Widder B (ed) Transkranielle Doppler-Sonographie bei zerebrovaskulären Erkrankungen. Springer, Berlin Heidelberg New York, pp 100–103

    Google Scholar 

  189. Ries F, Honisch C, Lambertz M, Schlief R (1993) A transpulmonary contrast medium enhances the transcranial Doppler signal in humans. Stroke 24:1903–1909

    CAS  PubMed  Google Scholar 

  190. Ries F, Tiemann K, Pohl C, Bauer C, Mundo M, Becher H (1998) High-resolution emboli detection and differentiation by characteristic postembolic spectral patterns. Stroke 29:668–672

    CAS  PubMed  Google Scholar 

  191. Riles TS, Imparato AM, Posner MP, Eikelboom BC (1984) Common carotid occlusion. Ann Surg 199:363–366

    CAS  PubMed Central  PubMed  Google Scholar 

  192. Riley WA, Barnes RW, Applegate WB, Dempsey R, Hartwell T, Davis VG, Bond MG, Furberg CD (1992) Reproducibility of noninvasive ultrasonic measurement of carotid atherosclerosis. The Asymptomatic Carotid Artery Plaque Study. Stroke 23:1062–1068

    CAS  PubMed  Google Scholar 

  193. Ringelstein EB, Droste DW, Babikian VL, Evans DH, Grosset DG, Kaps M, Markus HS, Russell D, Siebler M (1998) Consensus on microembolus detection by TCD. International Consensus Group on Microembolus Detection. Stroke 29:725–729

    CAS  PubMed  Google Scholar 

  194. Ringelstein EB, Droste DW, Babikian VL, Evans DH, Grosset DG, Kaps M, Markus HS, Russell D, Siebler M (1998) Consensus on microembolus detection by TCD. International Consensus Group on Microembolus Detection. Stroke 29:725–729

    CAS  PubMed  Google Scholar 

  195. Ringelstein EB, Sievers C, Ecker S, Schneider PA, Otis SM (1988) Noninvasive assessment of CO2-induced cerebral vasomotor response in normal individuals and patients with internal carotid artery occlusions. Stroke 19:963–969

    CAS  PubMed  Google Scholar 

  196. Ringelstein EB, van Eyck S, Mertens I (1992) Evaluation of cerebral vasomotor reactivity by various vasodilating stimuli: comparison of CO2 to acetazolamide. J Cereb Blood Flow Metab 12:162–168

    CAS  PubMed  Google Scholar 

  197. Robinson ML, Sacks D, Perlmutter GS, Marinelli DL (1988) Diagnostic criteria for carotid duplex sonography. Am J Roentgenol 151:1045–1049

    CAS  Google Scholar 

  198. Rosenfield K, Losordo DW, Ramaswamy K, Pastore JO, Langevin RE, Razvi S, Kosowsky BD, Isner JM (1991) Three-dimensional reconstruction of human coronary and peripheral arteries from images recorded during two-dimensional intravascular ultrasound examination. Circulation 84:1938–1956

    CAS  PubMed  Google Scholar 

  199. Roy E, Abraham P, Montresor S, Baudry M, Saumet JL (1998) The narrow band hypothesis: an interesting approach for high-intensity transient signals (HITS) detection. Ultrasound Med Biol 24:375–382

    CAS  PubMed  Google Scholar 

  200. Röther J, Wentz KU, Rautenberg W, Schwartz A, Hennerici M (1993) Magnetic resonance angiography in vertebrobasilar ischemia. Stroke 24:1310–1315

    PubMed  Google Scholar 

  201. Sabetai MM, Tegos TJ, Nicolaides AN, Dhanjil S, Pare GJ, Stevens JM (2000) Reproducibility of computer-quantified carotid plaque echogenicity: can we overcome the subjectivity? Stroke 31:96

    Google Scholar 

  202. Schmidt C, Wendelhag I (1999) How can the variability in ultrasound measurement of intima-media thickness be reduced? Studies of interobserver variability in carotid and femoral arteries. Clin Physiol 19:45–55

    CAS  PubMed  Google Scholar 

  203. Schneider PA, Rossman ME, Bernstein EF, Torem S, Ringelstein EB, Otis SM (1988) Effect of internal carotid artery occlusion on intracranial hemodynamics. Transcranial Doppler evaluation and clinical correlation. Stroke 19:589–593

    CAS  PubMed  Google Scholar 

  204. Schneider PA, Rossman ME, Torem S, Otis SM, Dillery RB, Bernstein EF (1988) Transcranial Doppler in the management of extracranial cerebrovascular disease: implications in diagnosis and monitoring. J Vasc Surg 7:223–231

    CAS  PubMed  Google Scholar 

  205. Seidel G, Algermissen C, Christoph A, Ciaassen L, Vidal-Lang-wasser M, Katzer T (2000) Harmonic imaging of the human brain. Visualization of brain perfusion with ultrasound. Stroke 31:151–154

    CAS  PubMed  Google Scholar 

  206. Selzer RH, Hodis HN, Kwong-Fu H, Mack WJ, Lee PL, Liu CR, Liu CH (1994) Evaluation of computerized edge tracking for quantifying intima-media thickness of the common carotid artery from B-mode ultrasound images. Atherosclerosis 111:1–11

    CAS  PubMed  Google Scholar 

  207. Siebler M, Kleinschmidt A, Sitzer M, Steinmetz H, Freund HJ (1994) Cerebral microembolism in symptomatic and asymptomatic high-grade internal carotid artery stenosis. Neurology 44:615–618

    CAS  PubMed  Google Scholar 

  208. Siebler M, Sitzer M, Rose G, Bendfeldt D, Steinmetz H (1993) Silent cerebral embolism caused by neurologically symptomatic high-grade carotid stenosis. Event rates before and after carotid endarterectomy. Brain 116:1005–1015

    PubMed  Google Scholar 

  209. Siebler M, Sitzer M, Steinmetz H (1993) Detection of intracranial emboli in patients with symptomatic extracranial carotid artery disease. Stroke 1992:1652–1654

    Google Scholar 

  210. Sitzer M, Fuerst G, Fischer H, Siebler M, Fehlings T, Kleinschmidt A, Kahn T, Steinmetz H (1993) Between-method correlations in quantifying internal carotid stenosis. Stroke 24:1513–1518

    CAS  PubMed  Google Scholar 

  211. Sitzer M, Furst G, Siebler M, Steinmetz H (1994) Usefulness of an intravenous contrast medium in the characterization of high-grade internal carotid stenosis with color Doppler-assisted duplex imaging. Stroke 25:385–389

    CAS  PubMed  Google Scholar 

  212. Sitzer M, Muller W, Siebler M, Hort W, Kniemeyer HW, Jancke L, Steinmetz H (1995) Plaque ulceration and lumen thrombus are the main sources of cerebral microemboli in high-grade internal carotid artery stenosis. Stroke 26:1231–1233

    CAS  PubMed  Google Scholar 

  213. Sitzer M, Rose G, Furst G, Siebler M, Steinmetz H (1997) Characteristics and clinical value of an intravenous echo-enhancement agent in evaluation of high-grade internal carotid stenosis. J Neuroimag-ing 7 [Suppl 1]:S22–S25

    Google Scholar 

  214. Sliwka U, Lingnau A, Stohlmann WD, Schmidt P, Mull M, Diehl RR, Noth J (1997) Prevalence and time course of microembolic signals in patients with acute stroke; a prospective study. Stroke 28:358–363

    CAS  PubMed  Google Scholar 

  215. Sliwka U, Rother J, Steinke W, Hennerici M (1991) Die Bedeutung der Duplexsonographie bei zerebralen Ischämien. (The value of duplex sonography in cerebral ischemia.) Bildgebung 58:182–191

    CAS  PubMed  Google Scholar 

  216. Spencer MP, Cambell SD, Sealy JL, Henry FC, Lindbergh J (1969) Experiments on decompression bubbles in the circulation using ultrasonic and electromagnetic flow meters. J Occup Med 11:238–244

    CAS  PubMed  Google Scholar 

  217. Spencer MP, Thomas GI, Nicholls SC, Sauvage LR (1990) Detection of middle cerebral artery emboli during carotid endarterectomy using transcranial Doppler ultrasonography. Stroke 21:415–423

    CAS  PubMed  Google Scholar 

  218. Spencer MP, Whisler D (1986) Transorbital Doppler diagnosis of intracranial arterial stenosis. Stroke 17:916–921

    CAS  PubMed  Google Scholar 

  219. Steiner H, Staudach A, Spitzer D, Schaffer H (1994) Three-dimensional ultrasound in obstetrics and gynaecology: technique, possibilities and limitations. Hum Reprod 9:1773–1778

    CAS  PubMed  Google Scholar 

  220. Steinke W, Aulich A, Hennerici M (1989) Diagnose und Verlauf von Carotisdissektionen. DMW 114:1869–1875

    CAS  Google Scholar 

  221. Steinke W, Hennerici M (1989) Three-dimensional ultrasound imaging of carotid artery plaques. J Cardiovasc Technol 8:15–22

    Google Scholar 

  222. Steinke W, Hennerici M, Rautenberg W, Mohr JP (1992) Symptomatic and asymptomatic high-grade carotid stenoses in Doppler color-flow imaging. Neurology 42:131–138

    CAS  PubMed  Google Scholar 

  223. Steinke W, Kloetzsch C, Hennerici M (1990) Carotid artery disease assessed by color Doppler flow imaging: correlation with standard Doppler sonography and angiography. Am J Neuroradiol 11:259–266

    CAS  PubMed  Google Scholar 

  224. Steinke W, Kloetzsch C, Hennerici M (1990) Variability of flow patterns in the normal carotid bifurcation. Atherosclerosis 84: 121–127

    CAS  PubMed  Google Scholar 

  225. Steinke W, Meairs S, Ries S, Hennerici M (1996) Sonographic assessment of carotid artery stenosis: comparison of power Doppler imaging and color Doppler flow imaging. Stroke 27:91–94

    CAS  PubMed  Google Scholar 

  226. Steinke W, Rautenberg W, Schwartz A, Hennerici M (1994) Noninvasive monitoring of internal carotid artery dissection. Stroke 25:998–1005

    CAS  PubMed  Google Scholar 

  227. Steinke W, Rautenberg W, Schwartz A, Sliwka U, Hennerici M (1992) Ultrasonographic diagnosis and monitoring of cervicocephalic arterial dissection. Cerebrovasc Dis 2:195

    Google Scholar 

  228. Steinke W, Rautenberg W, Sliwka U, Hennerici M (1993) Common carotid artery occlusion: clinical significance of a patent internal carotid artery. Neurol Sci 20:140

    Google Scholar 

  229. Sterpetti AV, Schultz RD, Feldhaus RJ, Davenport KL, Richardson M, Farina C, Hunter WJ (1988) Ultrasonographic features of carotid plaque and the risk of subsequent neurologic deficits. Surgery 104:652–660

    CAS  PubMed  Google Scholar 

  230. Stolz E, Kaps M, Kern A, Dorndorf W (1999) Frontal bone windows for transcranial color-coded duplex sonography. Stroke 30:814–820

    CAS  PubMed  Google Scholar 

  231. Strandness DE, Eikelboom BC (1998) Carotid artery stenosis-where do we go from here? Eur J Ultrasound 7 [Suppl 3]:S17–S26

    Google Scholar 

  232. Sturzenegger M, Mattle HP, Rivoir A, Rihs F, Schmid C (1993) Ultrasound findings in spontaneous extracranial vertebral artery dissection. Stroke 24:1910–1921

    CAS  PubMed  Google Scholar 

  233. Svindland A, Torvik A (1988) Atherosclerotic carotid disease in asymptomatic individuals: an histological study of 53 cases. Acta Neurol Scand 78:506–517

    CAS  PubMed  Google Scholar 

  234. Taylor DC, Strandness DE Jr (1987) Carotid artery duplex scanning. J Clin Ultrasound 15:635–644

    CAS  PubMed  Google Scholar 

  235. Tegos TJ, Sabetai MM, Nicolaides AN, Pare G, Elatrozy TS, Dhanjil S, Griffin M (2000) Comparability of the ultrasonic tissue characteristics of carotid plaques. J Ultrasound Med 19:407

    Google Scholar 

  236. Tettenborn B, Estol C, DeWitt LD, Kraemer G, Pessin MS, Caplan LR (1990) Accuracy of transcranial Doppler in the vertebrobasilar circulation. J Neurol 237:159

    Google Scholar 

  237. Tong DC, Albers GW (1995) Transcranial Doppler-detected microemboli in patients with acute stroke. Stroke 26:1588–1592

    CAS  PubMed  Google Scholar 

  238. Touboul PJ, Mas JL, Bousser MG, Laplane D (1988) Duplex scanning in extracranial vertebral artery dissection. Stroke 19:116–121

    CAS  PubMed  Google Scholar 

  239. Touboul PJ, Prati P, Scarabin PY, Adrai V, Thibout E, Ducimetière P (1992) Use of monitoring software to improve the measurement of carotid wall thickness by B-mode imaging. J Hypertens Suppl 10: S37–S41

    Google Scholar 

  240. Trattnig S, Schwaighofer B, Hubsch P, Schwarz M, Kainberger F (1991) Color-coded Doppler sonography of vertebral arteries. J Ultrasound Med 10:221–226

    CAS  PubMed  Google Scholar 

  241. Tuteur P, Reivich M, Goldberg HI, Cooper ES, West JW, McHenry LC, Chernik N (1976) Transient responses of cerebral blood flow and ventilation to changes in PaCO2 in normal subjects and patients with cerebrovascular disease. Stroke 7:584–590

    CAS  PubMed  Google Scholar 

  242. Uhlendorf V, Hoffmann C (1994) Nonlinear acoustical response of coated microbubbles in diagnostic ultrasound. Ultrasonics Symp Proc 1559–1562

    Google Scholar 

  243. Valdueza JM, Harms L, Doepp F, Koscielny J, Einhaupl KM (1997) Venous microembolic signals detected in patients with cerebral sinus thrombosis. Stroke 28:1607–1609

    CAS  PubMed  Google Scholar 

  244. Valton L, Larrue V, Arrué P, Géraud G, Bès A (1995) Asymptomatic cerebral embolic signals in patients with carotid stenosis: correlation with appearance of plaque ulceration on angiography. Stroke 26:813–815

    CAS  PubMed  Google Scholar 

  245. Valton L, Larrue V, Le Traon AP, Massabuau P, Géraud G (1998) Microembolic signals and risk of early recurrence in patients with stroke or transient ischemic attack. Stroke 29:2125–2128

    CAS  PubMed  Google Scholar 

  246. Van Zuilen EV, Mess WH, Jansen C, Van der Tweel I, Van Gijn J, Ackerstaff GA (1996) Automatic embolus detection compared with human experts. A Doppler ultrasound study. Stroke 27:1840–1843

    PubMed  Google Scholar 

  247. Van Zuilen EV, Moll FL, Vermeulen FE, Mauser HW, van Gijn J, Ackerstaff RG (1995) Detection of cerebral microemboli by means of transcranial Doppler monitoring before and after carotid en-darterectomy. Stroke 26:210–213

    PubMed  Google Scholar 

  248. Von Birgelen C, de Vrey EA, Mintz GS, Nicosia A, Bruining N, Li W, Slager CJ, Roelandt JR, Serruys PW, de Feyter PJ (1997) ECG-gated three-dimensional intravascular ultrasound: feasibility and reproducibility of the automated analysis of coronary lumen and atherosclerotic plaque dimensions in humans. Circulation 96:2944 – 2952

    Google Scholar 

  249. Wendelhag I, Liang Q, Gustavsson T, Wikstrand J (1997) A new automated computerized analyzing system simplifies readings and reduces the variability in ultrasound measurement of intimamedia thickness. Stroke 28:2195–2200

    CAS  PubMed  Google Scholar 

  250. Widder B, Paulat K, Hackspacher J, Hamann H, Hutschenreiter S, Kreutzer C, Ott F, Vollmar J (1990) Morphological characterization of carotid artery stenoses by ultrasound duplex scanning. Ultrasound Med Biol 16:349–354

    CAS  PubMed  Google Scholar 

  251. Wijman CA, Babikian VL, Matjucha IC, Koleini B, Hyde C, Winter MR, Pochay VE (1998) Cerebral microembolism in patients with retinal ischemia. Stroke 29:1139–1143

    CAS  PubMed  Google Scholar 

  252. Wolverson MK, Bashiti HM, Peterson GJ (1983) Ultrasonic tissue characterisation of atheromatous plaques using high-resolution real-time scanner. Ultrasound Med Biol 9:599–609

    CAS  PubMed  Google Scholar 

  253. Yao J, van Sambeek MR, Dall’Agata A, van Disk LC, Kozakova M, Koudstaal PJ, Roelandt JR (1998) Three-dimensional ultrasound study of carotid arteries before and after endarterectomy; analysis of stenotic lesions and surgical impact on the vessel. Stroke 29: 2026–2031

    CAS  PubMed  Google Scholar 

  254. Zbornikova V, Lassvik C (1991) Common carotid artery occlusion: haemodynamic features. Cerebrovasc Dis 1:136–141

    Google Scholar 

  255. Zwiebel WJ, Austin CW, Sackett JF, Strother CM (1983) Correlation of high-resolution, B-mode and continuous-wave Doppler sonography with arteriography in the diagnosis of carotid stenosis. Radiology 149:523–532

    CAS  PubMed  Google Scholar 

  256. Zwiebel WJ, Knighton R (1990) Duplex examination of the carotid arteries. Semin Ultrasound CT MRI 11:97–135

    CAS  Google Scholar 

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Authors
  1. Stephen Meairs
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  2. Michael Hennerici
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Editor information

Editors and Affiliations

  1. Herz-Zentrum Coswig, Klinik für Kardiologie und Angiologie, Lerchenfeld 1, 06869, Coswig (Anhalt), Germany

    Peter Lanzer MD

  2. The Cleveland Clinic Foundation, One Clinic Center, 9500 Euclid Avenue, Cleveland, 44195, OH, USA

    Eric J. Topol MD

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© 2002 Springer-Verlag Berlin Heidelberg

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Meairs, S., Hennerici, M. (2002). Cerebrovascular Ultrasonography. In: Lanzer, P., Topol, E.J. (eds) Pan Vascular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56225-9_28

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  • DOI: https://doi.org/10.1007/978-3-642-56225-9_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62565-7

  • Online ISBN: 978-3-642-56225-9

  • eBook Packages: Springer Book Archive

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