Zusammenfassung
Der Begriff „Ichthyosen“ leitet sich aus dem griechischen Wort ichthys (Fisch) ab und wird bereits seit dem 18. Jahrhundert verwendet. Darunter wird eine heterogene Gruppe von Genodermatosen zusammengefasst, die eine verdickte Hornschicht aufgrund einer keratinozytären Hyperprolifera-tion oder Hyperretention aufweisen. Diese Verhornungsstörungen sind in der Regel vererbt, wenn auch erworbene Formen vorkommen. Bei den verschiedenen Varianten bestehen Unterschiede im klinischen Bild, im Schweregrad und im Vererbungsmodus.
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Literatur
Abdel ME, el-Awad-Ahmed FR (1994) Salicylate intoxication in an infant with ichthyosis transmitted through skin ointment — a case report. Pediatrics 94: 939–940
Germann R, Schindera I, Kuch M, Seitz U, Altmeyer S, Schindern F (1996) Lebensbedrohliche Salicylatintoxikation durch perkutane Resorption bei einer schweren Ichthyosis vulgaris. Hautarzt 47: 624–627
Happle R, Kerkhof PC van de, Traupe H (1987) Retinoids in disorders of keratinization: their use in adults. Dermatologica 175:107–124
Hoeck HC, Laurberg G, Laurberg P (1994) Hypercalcaemic crisis after excessive topical use of a vitamin D derivative. J Intern Med 235:281–282
Kempers S, Katz HI, Wildnauer R, Green B (1998) An evaluation of the effect of an alpha hydroxy acid-blend skin cream in the cosmetic improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis. Cutis 61:347–350
Kragballe K, Steijlen PM, Ibsen HH, Kerkhof PC van de, Esmann J, Sorensen LH, Axelsen MB (1995) Efficacy, tolerability, and safety of calcipotriol ointment in disorders of keratinization. Results of a randomized, double-blind, vehicle-controlled, right/left comparative study. Arch Dermatol 131:556–560
Kuster W, Bohnsack K, Rippke F, Upmeyer HJ, Groll S, Traupe H (1998) Efficacy of urea therapy in children with ichthyosis. A multicenter randomized, placebo-controlled, double-blind, semilateral study. Dermatology 196:217–222
Lucker GP, Kerkhof PC van de, Dijk MR van, Steijlen PM (1994) Effect of topical calcipotriol on congenital ichthyoses. Br J Dermatol 131: 546–550
Melnik B, Braun FO (1996) Bedeutung der Ölbäder für die adjuvante Basistherapie entzündlicher Dermatosen mit trockener, barrieregestörter Haut. Hautarzt 47: 665–672
Moll I, Traupe H, Voigtlander V, Moll R (1988) Das Zytoskelett der hereditären Ichthyosen. Hautarzt 39: 82–90
Orfanos CE, Zouboulis CC, Almond-Roesler B, Geilen CC (1997) Current use and future potential role of retinoids in dermatology. Drugs 53:358–388
Rubin MG (1994) The clinical use of alpha hydroxy acids. Australas J Dermatol 35: 29–33
Shwayder T, Ott F (1991) All about ichthyosis. Pediatr Clin North Am 38: 835–857
Steijlen PM, Reifenschweiler DO, Ramaekers FC et al. (1993) Topical treatment of ichthyoses and Dariers disease with 13-cis-retinoic acid. A clinical and immunohistochemical study. Arch Dermatol Res 285: 221–226
Thiers BH (1997) The use of topical calcipotriene/calcipotriol in conditions other than plaque-type psoriasis. J Am Acad Dermatol 37: S69–S71
Traupe H (1989) The ichthyoses. A guide to clinical diagnosis, genetic counseling and therapy. Springer, Berlin Heidelberg New York Tokyo
Traupe H (1999) Ichthyosen, Erythrokeratodermien und verwandte Verhornungsstörungen. In: Traupe H, Hamm H (Hrsg) Pädiatrische Dermatologie. Springer, Berlin Heidelberg New York Tokyo, S 47–68
Uthoff D, Gorney M, Teichmann C (1994) Cicatricial ectropion in ichthyosis: a novel approach to treatment. Ophthal Plast Reconstr Surg 10: 92–95
Wang F, Man MQ, Elias PM (1997) A lipid mixture improves skin hydration in ichthyosis vulgaris. Int J Dermatol 36: 876–877
Williams ML (1992) Ichthyosis: mechanisms of disease. Pediatr Dermatol 9:365–368
Buxman M, Hickman J, Ragsdale W et al. (1986) Therapeutic activity of lactate 12% lotion in the treatment of ichthyosis. Active versus vehicle and active versus a petrolatum cream. J Am Acad Dermatol 15:1253–1258
Elsayed Ali H, Barton S, Marks R (1992) Stereological studies of desmosomes in ichthyosis vulgaris. Br J Dermatol 126:24–28
Hofmann B, Stege H, Ruzicka T, Lehmann P (1999) Effect of topical tazarotene in the treatment of congenital ichthyoses. Br J Dermatol 141: 642–646
Just M, Ribera M, Bielsa I, Calatrava A, Ferrandiz C (1999) Keratotsis punctata of the palmar creases: report of two cases associated with ichthyosis vulgaris. Br J Dermatol 141:551–553
Kuster W, Bohnsack K, Rippke F, Upmeyer HJ, Groll S, Traupe H (1998) Efficacy of urea therapy in children with ichthyosis. A multicenter randomized, placebo-controlled, double-blind, semilateral study. Dermatology 196:217–222
Melnik B, Braun FO (1996) Bedeutung der Ölbäder für die adjuvante Basistherapie entzündlicher Dermatosen mit trockener, barrieregestörter Haut. Hautarzt 47: 665–672
Mevorah B, Krayenbuhl A, Bovey EH, Melle GD van (1991) Autosomal dominant ichthyosis and X-linked ichthyosis. Comparison of their clinical and histological phenotypes. Acta Derm Venereol (Stockh) 71:431–434
Petres J, Antal I, Fuzesi S (1990) Klinische Erfahrungen zur Intervallbehandlung mit harnstoffhaltigen Dermatika. Z Hautkr 65:740–745
Rogers RS, Callen J, Wehr R, Krochmal L (1989) Comparative efficacy of 12% ammonium lactate lotion and 5% lactic acid lotion in the treatment of moderate to severe xerosis J Am Acad Dermatol 21:714–716
Schnyder UW (1989) Harnstoff und Harnstoffkombinationen bei Ichthyosen. Hautarzt 40 [Suppl 9]: 51–53
Sybert VP, Dale BA, Holbrook KA (1985) Ichthyosis vulgaris: identification of a defect in synthesis of filaggrin correlated with an absence of keratohyaline granules. J Invest Dermatol 84:191–194
Wehr RF, Kantor I, Jones EL et al. (1991) A controlled comparative efficacy study of 5% ammonium lactate lotion versus an emollient control lotion in the treatment of moderate xerosis. J Am Acad Dermatol 25: 849–851
Ballabio A, Parenti G, Tippett P et al. (1986) X-linked ichthyosis, due to steroid sulphatase deficiency, associated with Kallmann syndrome (hypogonadotropic hypogonadism and anosmia): linkage relationships with Xg and cloned DNA sequences from the distal short arm of the X chromosome. Hum Genet 72: 237–240
Basier E, Grompe M, Parenti G et al. (1992) Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis. Am J Hum Genet 50: 483–491
Bruckner-Tuderman L, Sigg C, Geiger JM, Gilardi S (1988) Acitretin in the symptomatic therapy for severe recessive x-linked ichthyosis. Arch Dermatol 124:529–532
Freiberg RA, Choate KA, Deng H, Alperin ES, Shapiro LJ, Khavari PA (1997) A model of corrective gene transfer in X-linked ichthyosis. Hum Mol Genet 6:927–933
Hernandez MA, Gonzalez SR, De-Unamuno P (1999) X-linked ichthyosis: an update. Br J Dermatol 141:617–627
Jensen TG, Jensen UB, Jensen PK et al. (1993) Correction of steroid sulfatase deficiency by gene transfer into basal cells of tissue-cultured epidermis from patients with recessive X-linked ichthyosis. Exp Cell Res 209: 392–397
Kragballe K, Steijlen PM, Ibsen HH, Kerkhof PC van de, Esmann J, Sorensen LH, Axelsen MB (1995) Efficacy, tolerability, and safety of calcipotriol ointment in disorders of keratinization. Results of a randomized, double-blind, vehicle-controlled, right/left comparative study. Arch Dermatol 131: 556–560
Oyama N, Satoh M, Iwatsuki K, Kaneko F (2000) Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes. J Invest Dermatol 114:1195–1199
Shapiro LJ, Yen P, Pomerantz D et al. (1989) Molecular studies of deletions at the human steroid sulfatase locus. Proc Natl Acad Sci U S A 86: 8477–8481
Traupe H, Happle R (1983) Clinical spectrum of steroid sulfatase deficiency: X-linked recessive ichthyosis, birth complications and cryptorchidism. Eur J Pediatr 140: 19–21
Yen PH, Allen E, Marsh B et al. (1987) Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X-Y interchange. Cell 49: 443–454
Arnold ML, Anton-Lamprecht I, Melz Rothfuss B, Hartschuh W (1988) Ichthyosis congenita type III. Clinical and ultrastructural characteristics and distinction within the heterogeneous ichthyosis congenita group. Arch Dermatol Res 280: 268–278
Choate KA, Kinsella TM, Williams ML, Nolan GP, Khavari PA (1996) Transglutaminase 1 delivery to lamellar ichthyosis keratinocytes. Hum Gene Ther 7: 2247–2253
Ganemo A, Vahlquist A (1997) Lamellar ichthyosis is markedly improved by a novel combination of emollients. Br J Dermatol 137:1017–1018
Ganemo A, Virtanen M, Vahlquist A (1999) Improved topical treatment of lamellar ichthyosis: a double-blind study of four different cream formulations. Br J Dermatol 141: 1027–1032
Ho VC, Gupta AK, Ellis CN et al. (1989) Cyclosporine in lamellar ichthyosis. Arch Dermatol 125:511–514
Hofmann B, Stege H, Ruzicka T, Lehmann P (1999) Effect of topical tazarotene in the treatment of congenital ichthyoses. Br J Dermatol 141: 642–646
Kolde G, Happle R, Traupe H (1985) Autosomal-dominant lamellar ichthyosis: ultrastructural characteristics of a new type of congenital ichthyosis. Arch Dermatol Res 278:1–5
Lucker GP, Heremans AM, Boegheim PJ, Kerkhof PC van de, Steijlen PM (1997) Oral treatment of ichthyosis by the cytochrome P-450 inhibitor liarozole. Br J Dermatol 136: 71–75
Niemi KM, Kanerva L, Kuokkanen K (1991) Recessive ichthyosis congenita type II. Arch Dermatol Res 283:211–218
Niemi KM, Kuokkanen K, Kanerva L, Ignatius J (1993) Recessive ichthyosis congenita type IV. Am J Dermatopathol 15: 224–228
Pena PC, Perez AJ, Becker E, Gutierrez DJ de-, Garcia SM, Valle FJ, Unamuno PP (1998) Differential patterns of filaggrin expression in lamellar ichthyosis. Br J Dermatol 139:958–964
Redondo P, Bauza A (1999) Topical N-acetylcysteine for lamellar ichthyosis. Lancet 354:1880
Stege H, Hofmann B, Ruzicka T, Lehmann P (1998) Topical application of tazarotene in the treatment of non-erythrodermic lamellar ichthyosis. Arch Dermatol 134: 640
Steijlen PM, Dooren-Greebe RJ van, Kerkhof PC van de (1994) Acitretin in the treatment of lamellar ichthyosis. Br J Dermatol 130:211–214
Waisman Y, Rachmel A, Metzker A et al. (1989) Failure of etretinate therapy in twins with severe congenital lamellar ichthyosis. Pediatr Dermatol 6:226–228
Williams ML, Elias PM (1984) Elevated n-alkanes in congenital ichthyosiform erythroderma. Phenotypic differentiation of two types of autosomal recessive ichthyosis. J Clin Invest 74: 296–300
Bale SJ, Compton JG, DiGiovanna JJ (1993) Epidermolytic hyperkeratosis. Semin Dermatol 12:202–209
Bonifas JM, Bare JW, Chen MA et al. (1992) Linkage of the epidermolytic hyperkeratosis phenotype and the region of the type II keratin gene cluster on chromosome 12. J Invest Dermatol 99: 524–527
Cheng J, Syder AJ, Yu QC et al. (1992) The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes. Cell 70: 811–819
Chipev CC, Korge BP, Markova N et al. (1992) A leucine-proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis. Cell 70: 821–828
Kim SC, Hur W, Won JH, Ahn SK (1995) Ichthyosis bullosa of Siemens: report of a sporadic case. J Dermatol 22:283–288
McLean WH, Eady RA, Dopping-Hepenstal PJ et al. (1994): Mutations in the rod 1 A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE). J Invest Dermatol 102: 24–30
Nychay SG, Khorenian SD, Schwartz RA et al. (1991) Epidermolytic hyperkeratosis treated with etretinate. Cutis 47: 277–280
Pulkkinen L, Christiano AM, Knowlton RG, Uitto J (1993) Epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma). Genetic linkage to chromosome 12q in the region of the type II keratin gene cluster. J Clin Invest 91:357–361
Rothnagel JA, Longley MA, Holder RA et al. (1994) Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing. J Invest Dermatol 102:13–16
Sanclemente G, Falabella R, Escobar CE, Arroyave JA (1999) Ichthyosis bullosa of Siemens: a topical therapy option. Arch Dermatol 135: 217–218
Steijlen PM, Perret CM, Schuurmans Stekhoven JH et al. (1990) Ichthyosis bullosa of Siemens: further delineation of the phenotype. Arch Dermatol Res 282:1–5
Steijlen PM, Dooren-Greebe RJ van, Happle R et al. (1991) Ichthyosis bullosa of Siemens responds well to low-dosage oral retinoids. Br J Dermatol 125:469–471
Akiyama M (1999) The pathogenesis of severe congenital ichthyosis of the neonate. J Dermatol Sci 21:96–104
Frenk E, Techtermann F de (1992) Self-healing collodion baby: evidence for autosomal recessive inheritance. Pediatr Dermatol 9: 95–97
Haftek M, Cambazard F, Dhouailly D et al. (1996) A longitudinal study of a harlequin infant presenting clinically as non-bullous congenital ichthyosiform erythroderma. Br J Dermatol 135:448–453
Langer K, Konrad K, Weninger M, Wolff K (1991) Kollodiumbaby mit Übergang in milde lamelläre Ichthyose. Klinischer Verlauf, Histopathologic und ultrastrukturelle Befunde. Hautarzt 42:34–38
Lawlor F, Peiris S (1985) Harlequin fetus successfully treated with etretinate. Br J Dermatol 112:585–590
Lawlor F, Peiris S (1985) Progress of a harlequin fetus treated with etretinate. J R Soc Med 78 [Suppl 11]: 19–20
Nayar M, Chin GY (1992) Harlequin fetus treated with etretinate. Pediatr Dermatol 9:311–314
Ozturk A, Caksen H, Cetin N, Kurtoglu S (1997) A retrospective study on 16 collodion babies. Turk J Pediatr 39:55–59
Pejaver RK, Prasad RS, Garg AK, Jelly A, Shawkat S (1998) Etretinate in the management of harlequin siblings. Indian J Pediatr 65:320–323
Prasad RS, Pejaver RK, Hassan A, al-Dusari S, Wooldridge MA (1994) Management and follow-up of harlequin siblings. Br J Dermatol 130: 650–653
Roberts LJ (1989) Long-term survival of a harlequin fetus. J Am Acad Dermatol 21:335–339
Rogers M, Scraf C (1989) Harlequin baby treated with etretinate. Pediatr Dermatol 6: 216–221
Ward PS, Jones RD (1989) Successful treatment of a harlequin fetus. Arch Dis Child 64:1309–1311
Blaschke S, Moller R, Hausser I, Anton-Lamprecht I, Paul E (1998) Comel-Netherton-Syndrom. Hautarzt 49:499–504
Dale BA, Kimball JR, Fleckman P et al. (1992) CHILD syndrome: lack of expression of epidermal differentiation markers in lesional ichthyotic skin. J Invest Dermatol 98: 442–449
Emami S, Rizzo WB, Hanley KP et al. (1992) Peroxisomal abnormality in fibroblasts from involved skin of CHILD syndrome. Case study and review of peroxisomal disorders in relation to skin disease. Arch Dermatol 128:1213–1222
Greene SL, Muller SA (1985) Netherton’s syndrome. Report of a case and review of the literature. J Am Acad Dermatol 13:329–337
Grob JJ, Breton A, Bonafe JL et al. (1987) Keratitis, ichthyosis, and deafness (KID) syndrome. Vertical transmission and death from multiple squamous cell carcinomas. Arch Dermatol 123:777–782
Happle R, Traupe H, Grobe H, Bonsmann G (1984) The Tay Syndrome (congenital ichthyosis with trichothiodystrophy). Eur J Pediatr 141:147–152
Happle R, Karlic D, Steijlen PM (1990) CHILD-Syndrom bei Mutter und Tochter. Hautarzt 41:105–108
Hartschuh W, Hausser I, Petzoldt D (1989): Erfolgreiche Retinoidtherapie des Netherton-Syndroms. Hautarzt 40: 430–433
Hausser I, Anton-Lamprecht I (1996) Severe congenital generalized exfoliative erythroderma in newborns and infants: a possible sign of Netherton syndrome. Pediatr Dermatol 13:183–199
Hausser I, Anton-Lamprecht I, Hartschuh W, Petzoldt D (1989) Netherton’s syndrome: ultrastructure of the active lesion under retinoid therapy. Arch Dermatol Res 281: 165–172
Hazen PG, Walker AE, Stewart JJ et al. (1992) Keratitis, ichthyosis, and deafness (KID) syndrome: management with chronic oral ketoconazole therapy. Int J Dermatol 31: 58–59
Jagell S, Liden S (1983) Treatment of the ichthyosis of the Sjögren-Larsson syndrome with etretinate (Tigason). Acta Derm Venereol (Stockh) 63: 89–91
Langer K, Konrad K, Wolff K (1990) Keratitis, ichthyosis and deafness (KID)-syndrome: report of three cases and a review of the literature. Br J Dermatol 122: 689–697
Motley RJ, Finlay AY (1989) A patient with Tay’s syndrome. Pediatr Dermatol 6:202–205
Peter C, Meinecke P (1993) CHILD-Syndrom. Fallbericht einer seltenen Genodermatose. Hautarzt 44:590–593
Rizzo WB, Dammann AL, Craft DA (1988) Sjogren-Larsson Syndrome. Impaired fatty alcohol oxidation in cultured fibroblasts due to deficient fatty alcohol:nicotinamide adenine dinucleotide oxidoreductase activity. J Clin Invest 81:738–744
Shiraishi S, Murakami S, Miki Y (1994) Oral fluconazole treatment of fungating candidiasis in the keratitis, ichthyosis and deafness (KID) syndrome. Br J Dermatol 131:904–907
Smith DL, Smith JG, Wong SW, deShazo RD (1995) Netherton’s syndrome: a syndrome of elevated IgE and characteristic skin and hair findings. J Allergy Clin Immunol 95: 116–123
Srebrnik A, Tur E, Perluk C et al. (1987) Dorfman-Chanarin syndrome. A case report and a review. J Am Acad Dermatol 17: 801–808
Suga Y, Tsuboi R, Hashimoto Y, Yoshiike T, Ogawa H (2000) A case of ichthyosis linearis circumflexa successfully treated with topical tacrolimus. J Am Acad Dermatol 42: 520–522
Taube B, Billeaud C, Labreze C, Entressangles B, Fontan D, Taieb A (1999) Sjogren-Larsson syndrome: early diagnosis, dietary management and biochemical studies in two cases. Dermatology 198:340–345
Wehr RF, Hickman J, Krochmal L (1988) Effective treatment of Netherton’s syndrome with 12% lactate lotion. J Am Acad Dermatol 19:140–142
Wenz W, Saleh H, Perlick C (1999) Orthopaedic rehabilitation in a case of Tay-syndrome. Pediatr Rehabil 3:133–135
Wilson GN, Squires RH Jr, Weinberg AG (1991) Keratitis, hepatitis, ichthyosis, and deafness: report and review of KID syndrome. Am J Med Genet 40:255–259
Aram H (1984) Acquired ichthyosis and related conditions. Int J Dermatol 23:458–461
Dilek I, Demirer T, Ustun C et al. (1998) Acquired ichthyosis associated with chronic graft-versus-host disease following allogeneic peripheral blood stem cell transplantation in a patient with chronic myelogenous leukemia. Bone Marrow Transplant 21:1159–1161
Gaveau D, Rotteleur G, Bauters F, Thomas P (1986) Acrokeratose et ichtyose acquises associees a un myelome multiple. Ann Dermatol Venereol 113: 829–832
Kaplan MH, Sadick NS, McNutt NS et al. (1993) Acquired ichthyosis in concomitant HIV-1 and HTLV-II infection: a new association with intravenous drug abuse. J Am Acad Dermatol 29:701–708
Kato N, Yasukuwa K, Kimura K et al. (2000) Anaplastic large-cell lymphoma associated with acquired ichthyosis. J am Acad Dermatol 42:914–920
Lodi A, Betti R, Chiarelli G et al. (1990) Familial pityriasis rotunda. Int J Dermatol 29:483–485
Niederauer HH, Bacharach Buhles M, Altmeyer P (1991) Ichthyose und Alopezie nach Maprotilin: Korneolyse infolge passagerer Keratinisierungsstörung. Hautarzt 42:455–458
Okano M (2001) Assessment of the clinical effect of topical tacalcitol on ichthyoses with retentive hyperkeratosis. Dermatology 202:116–118
Polisky RB, Bronson DM (1986) Acquired ichthyosis in a patient with adenocarcinoma of the breast. Cutis 38:359–360
Roselino AM, Souza CS, Andrade JM, Tone LG, Soares FA, Llorach VM, Foss NT (1997) Dermatomyositis and acquired ichthyosis as paraneoplastic manifestations of ovarian tumor. Int J Dermatol 36: 611–614
Spelman LJ, Strutton GM, Robertson IM, Weedon D (1996) Acquired ichthyosis in bone marrow transplant recipients. J Am Acad Dermatol 35:17–20
Deschamps P, Leroy D, Pedailles S, Mandard JC (1986) Keratoderma climactericum (Haxthausen’s disease): clinical signs, laboratory findings and etretinate treatment in 10 patients. Dermatologica 172:258–262
Gamborg Nielsen P (1984) Dermatophyte infections in hereditary palmo-plantar keratoderma. Frequency and therapy. Dermatologica 168:238–241
Hunziker T, Haudenschild-Falb E, Schmidli J, Krebs A (1987) „Aqua-SUP“ bei chronischen palmoplantaren Dermatosen. Hautarzt 38:165–167
Junge J, Moll I (1995) Multiple Palmoplantarkeratosen, Basaliome und Porokarzinome nach Arsen-Therapie. Hautarzt 46:198–201
Laurent R, Prost O, Nicoliier M et al. (1985) Composite keratohyaline granules in palmoplantar keratoderma: an ultrastructural study. Arch Dermatol Res 277:384–394
Maruyama R, Katoh T, Nishioka K (1999) A case of Unna-Thost disease accompanied by Epidermophyton floccosum infection. J Dermatol 26: 63–66
Schreiber D, Stucker M, Hoffmann K, Bacharach BM, Altmeyer P (1997) Keratosis palmoplantaris maculosa seu papulosa (Davies-Colley) unter dem Bild multipler Cornua cutanea. Hautarzt 48:577–580
Urbina F, Cristobal MC, Sandoval R (1995) Mal de Meleda. Cutis 56: 235–238
Baran R, Juhlin L (1983) Keratodermia palmoplantare papuloverrucoides progressiva: successful treatment with etretinate. J Am Acad Dermatol 8:700–702
Brambilla L, Pigatto PD, Boneschi V et al. (1984) Unusual cases of Meleda keratoderma treated with aromatic retinoid etretinate. Dermatologica 168:283–286
Camisa C, Rossana C (1984) Variant of keratoderma hereditaria mutilans (Vohwinkel’s syndrome). Treatment with orally administered isotretinoin. Arch Dermatol 120:1323–1328
Goldfarb MT, Woo TY, Rasmussen JE (1985) Keratoderma hereditaria mutilans (Vohwinkel’s syndrome): a trial of isotretinoin. Pediatr Dermatol 2: 216–218
Mobacken H, Rosen K, Swanbeck G (1983) Oral psoralen photochemotherapy (PUVA) of hyperkeratotic dermatitis of the palms. Br J Dermatol 109:205–208
Rivers JK, Duke EE, Justus DW (1985) Etretinate: management of keratoma hereditaria mutilans in four family members. J Am Acad Dermatol 13:43–49
Tropet Y, Zultak M, Blanc D et al. (1989) Surgical treatment of epidermolytic hereditary palmoplantar keratoderma J Hand Surg [Am] 14:143–149
Wereide K (1984) Mutilating palmoplantar keratoderma successfully treated with etretinate. Acta Derm Venereol (Stockh) 64:566–569
Bergman R, Bitterman Deutsch O, Fartasch M et al. (1993) Mal de Meleda keratoderma with Pseudoainhum. Br J Dermatol 128: 207–212
Crovato F, Desirello G, Gatti R et al. (1985) Richner-Hanhart syndrome spares a plantar autograft. Arch Dermatol 121: 539–540
Darouti MA el, Al Raubaie SM, Eiada MA (1988) Papillon-Lefevre syndrome. Successful treatment with oral retinoids in three patients. Int J Dermatol 27: 63–66
Gelmetti C, Nazzaro V, Cerri D, Fracasso L (1989) Long-term preservation of permanent teeth in a patient with Papillon-Lefevre syndrome treated with etretinate. Pediatr Dermatol 6: 222–225
Hausser I, Frantzmann Y, Anton-Lamprecht I et al. (1993) Olmsted-Syndrom. Erfolgreiche Therapie durch Behandlung mit Etretinat. Hautarzt 44:394–400
Kellum RE (1989) Papillon-Lefevre syndrome in four siblings treated with etretinate. A nine-year evaluation. Int J Dermatol 28: 605–608
McGovern TW, Gentry RH (1994) Spiny keratoderma: case report, classification, and treatment of music box spine dermatoses. Cutis 54:389–394
Nazzaro V, Blanchet-Bardon C, Mimoz C et al. (1988) Papillon-Lefevre syndrome. Ultrastructural study and successful treatment with acitretin. Arch Dermatol 124: 533–539
Nguyen TQ, Greer KE, Fisher GB Jr, Cooper PH (1986) Papillon-Lefevre syndrome. Report of two patients treated successfully with isotretinoin. J Am Acad Dermatol 15: 46–49
Rabinowitz LG, Williams LR, Anderson CE, Mazur A, Kaplan P (1995) Painful keratoderma and photophobia: hallmarks of tyrosinemia type II. J Pediatr 126: 266–269
Ruiz-Maldonado R, Tamayo-Sanchez L, Orozco-Covar-rubias ML (1998) The use of retinoids in the pediatric patient. Dermatol Clin 16:553–569
Su WP, Chun SI, Hammond DE, Gordon H (1990) Pachyonychia congenita: a clinical study of 12 cases and review of the literature. Pediatr Dermatol 7:33–38
Wehrmann W, Traupe H, Happle R (1985) Papillon-Lefevre-Syndrom (Keratosis palmoplantaris mit Periodonto-pathie). Behandlung mit Etretinat. Hautarzt 36: 173–175
Barron L, Burkhart CG (1987) The treatment of Darier’s disease: an update. Int J Dermatol 26:334
Beier C, Kaufmann R (1999) Efficacy of erbium:YAG laser ablation in Darier disease and Hailey-Hailey disease. Arch Dermatol 135:423–427
Dooren-Greebe RJ van, Kerkhof PC van de, Happle R (1989) Acitretin monotherapy in Darier’s disease. Br J Dermatol 121:375–379
Lauharanta J, Kanerva L, Turjanmaa K, Geiger JM (1988) Clinical and ultrastructural effects of acitretin in Darier’s disease. Acta Derm Venereol (Stockh) 68:492–498
McElroy JA, Mehregan DA, Roenigk RK (1990) Carbon dioxide laser vaporization of recalcitrant symptomatic plaques of Hailey-Hailey disease and Darier’s disease. J Am Acad Dermatol 23: 893–897
Micali G, Nasca MR (1999) Tazarotene gel in childhood Darier disease. Pediatr Dermatol 16:243–244
Oostenbrink JH, Cohen EB, Steijlen PM, Kerkhof PC van de (1996) Oral contraceptives in the treatment of Darier-White disease — a case report and review of the literature. Clin Exp Dermatol 21:442–444
Oster-Schmidt C, Stucker M, Altmeyer P (2000) Dyskeratosis follicularis-erfolgreiche Therapie mit lokalem Retinoid. Hautarzt 51:196–199
Otley CC, Momtaz K (1996) Induction of Darier-White disease with UVB radiation in a clinically photo-insensitive patient. J Am Acad Dermatol 34:931–934
Sakuntabhai A, Ruiz P, V, Carter S et al. (1999) Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet 21: 271–277
Serup J, Thomsen K (1992) A double-blind comparison of acitretin and etretinate in the treatment of Darier’s disease. Acta Derm Venereol (Stockh) 72:150–152
Steijlen PM, Happle R, Muijen GN van, Kerkhof PC van de (1991) Topical treatment with 13-cis-retinoic acid improves Darier’s disease and induces the expression of a unique keratin pattern. Dermatologica 182:178–183
Toombs EL, Peck GL (1989) Electrosurgical treatment of etretinate-resistant Darier’s disease. J Dermatol Surg Oncol 15:1277–1280
Eros N, Kovacs A, Karolyi Z (1998) Successful treatment of transient acantholytic dermatosis with systemic steroids. J Dermatol 25:469–475
Fawcett HA, Miller JA (1983) Persistent acantholytic dermatosis related to actinic damage. Br J Dermatol 109:349–354
Gollnick H (1987) New indications and new retinoids. Dermatologica 175 [Suppl 1]: 182–195
Helfman RJ (1985) Grover’s disease treated with isotretinoin. Report of four cases. J Am Acad Dermatol 12: 981–984
Hu CH, Michel B, Farber EM (1985) Transient acantholytic dermatosis (Grover’s disease). A skin disorder related to heat and sweating. Arch Dermatol 121:1439–1441
Köstier E (1997) Transitorische akantholytische Dermatose (Grover) bei Sarcoptes scabiei-Infektion. Hautarzt 48: 915–917
Luftl M, Degitz K, Plewig G, Röcken M (1999) Bath psoralen-UV-A therapy for persistent Grover disease. Arch Dermatol 135: 606–607
Mota AV, Correia TM, Lopes JM, Guimaraes JM (1998) Successful treatment of Grover’s disease with calcipotriol. Eur J Dermatol 8:33–35
Streit M, Paredes BE, Braathen LR, Brand CU (2000) Transitorische akantholytische Dermatose (M. Grover). Eine Analyse des klinischen Spektrums anhand von 21 histologisch erfassten Fällen. Hautarzt 51: 244–249
Cooper RG, Freemont AJ, Riley M et al. (1992) Bone abnormalities and severe arthritis in pachydermoperiostosis. Ann Rheum Dis 51: 416–419
Hedayati H, Barmada R, Skosey IL (1980) Acrolysis in pachydermoperiostosis. Primary or idiopathic hypertrophic osteoarthropathy. Arch Intern Med 140:1087–1088
Hochmuth WP, Juchems R, Schubert E (1975) Touraine-Solente-Golé-Syndrom (Pachydermoperiostose). Med Klin 70:146–150
Jansen T, Brandi G, Bandmann M, Meurer M (1995) Pachydermoperiostose. Hautarzt 46:429–435
Kaffarnik H, Husmann F, Longin F, Juchems R (1996) Die Pachydermoperiostose, Touraine-Solente-Golé-Syndrom. Dtsch Med Wochenschr 91:1722–1724
Lam SK, Hui WKK, Ho J et al. (1983) Pachydermoperiostosis, hypertrophic gastropathy, and peptic ulcer. Gastroenterology 84: 834–839
Lindmaier A, Raff M, Seidl G, Jurecka W (1989) Pachydermoperiostose. Klinik, Klassifikation und Pathogenese. Hausarzt 40:752–757
Lubach D, Freyschmidt J, Bolten D (1982) Pachydermoperiostose (Touraine-Solente-Golé). Klinische und röntgenologische Differentialdiagnose. Z Hautkr 56:175–186
Matucci-Gerinic M, Lotti T, Jajic I et al. (1991) The clinical spectrum of pachydermoperiostosis (primary hypertrophic osteoarthropathy). Medicine 70: 208–214
Stevanovic DV (1968) Maligne Acanthosis nigricans und Pachydermoperiostose. Dermatol Wochenschr 154:414–417
Emmert S, Küster W, Schauder S et al. (1998) Erythroke-ratodermia progressiva symmetrica Darier-Gottron mit generalisierter Ausprägung. Hautarzt 49:666–671
Nazarro V, Blanchet-Bardon C (1986) Progressive symmetric erythrokeratodermia. Arch Dermatol 122: 434–440
Nir M, Tanzer F (1978) Progressive symmetric erythrokeratodermia. Dermatologica 156:268–273
Orfanos CE, Ehlert R, Gollnick H (1987) The retinoids — a review of their pharmacology and therapeutic use. Drugs 34:459–503
Ruiz-Maldonado RR, Tamago L, Castillo V del, Lozoya I (1982) Erythrokeratodermia progressiva symmetrica: report of 10 cases. Dermatologica 164:133–141
Wateren AR van der, Cormane RH (1977) Oral retinoic acid as a therapy for erythrokeratodermia variabilis. Br J Dermatol 97: 83–85
Appa Y (1999) Retinoid therapy: compatible skin care. Skin Pharmacol Appl Skin Physiol 12:111–119
Archer CB, Elias PM, Lowe NJ, Griffiths WA (1989) Extensive spinal hyperostosis in a patient receiving isotretinoinprogression after 4 years of etretinate therapy. Clin Exp Dermatol 14:319–321
Bleiker TO, Bourke JF, Graham BR, Hutchinson PE (1997) Etretinate may work where acitretin fails. Br J Dermatol 136:368–370
Burge S, Ryan T (1985) Diffuse hyperostosis associated with etretinate. Lancet 2:397–398
Chandraratna RA (1998) Future trends: a new generation of retinoids. J Am Acad Dermatol 39:149–152
DiGiovanna JJ, Sollitto RB, Abangan DL, Steinberg SM, Reynolds JC (1995) Osteoporosis is a toxic effect of long-term etretinate therapy. Arch Dermatol 131: 1263–1267
Ellis CN, Madison KC, Pennes DR et al. (1984) Isotretinoin therapy is associated with early skeletal radiographic changes. J Am Acad Dermatol 10:1024–1029
Ellis CN, Pennes DR, Hermann RC et al. (1988) Long-term radiographic follow-up after isotretinoin therapy. J Am Acad Dermatol 18:1252–1261
Fritsch PO (1992) Retinoids in psoriasis and disorders of keratinization. J Am Acad Dermatol 27: S8–S14
Glover MT, Peters AM, Atherton DJ (1987) Surveillance for skeletal toxicity of children treated with etretinate. Br J Dermatol 116: 609–614
Gollnick H, Rinck G, Bitterling T, Orfanos CE (1990) Pharmakokinetik von Etretinat, Acitretin und 13-cis-Acitretin: neue Ergebnisse und Nutzen der Blutspiegel-orientierten klinischen Anwendung. Z Hautkr 65:40–50
Halkier-Sorensen L, Laurberg G, Andresen J (1987) Bone changes in children on long-term treatment with etretinate. J Am Acad Dermatol 16:999–1006
Haustein UF, Heilmann S (1987) Knochenveränderungen unter Langzeittherapie mit Etretinat (Tigason). Z Hautkr 62:395–396,399–400
Lacour M, Mehta-Nikhar B, Atherton DJ et al. (1996) An appraisal of acitretin therapy in children with inherited disorders of keratinization. Br J Dermatol 134: 1023–1029
Lacour M, Mehta NB, Atherton DJ, Harper JI (1996) An appraisal of acitretin therapy in children with inherited disorders of keratinization. Br J Dermatol 134:1023–1029
Mork NJ, Kolbenstvedt A, Austad J (1992) Efficacy and skeletal side effects of two years’ acitretin treatment. Acta Derm Venereol (Stockh) 72: 445–448
Orfanos CE (1989) Retinoide: der neue Stand. Hautarzt 40: 123–129
Orfanos CE, Zouboulis CC, Almond-Roesler B, Geilen CC (1997) Current use and future potential role of retinoids in dermatology Drugs 53:358–388
Orfanos CE, Ehlert R, Gollnick H (1987) The retinoids. A review of their clinical pharmacology and therapeutic use. Drugs 34:459–503
Paige DG, Judge MR, Shaw DG et al. (1992) Bone changes and their significance in children with ichthyosis on long-term etretinate therapy. Br J Dermatol 127:387–391
Pittsley RA, Yoder FW (1983) Retinoid hyperostosis. Skeletal toxicity associated with long-term administration of 13-cis-retinoic acid for refractory ichthyosis. N Engl J Med 308:1012–1014
Prendiville J, Bingham EA, Burrows D (1986) Premature epiphyseal closure — a complication of etretinate therapy in children. J Am Acad Dermatol 15:1259–1262
Ruiz MR, Tamayo SL, Orozco CM (1998) The use of retinoids in the pediatric patient. Dermatol Clin 16:553–569
Ruiz-Maldonado R, Tamayo-Sanchez L, Orozco-Covar-rubias ML (1998) The use of retinoids in the pediatric patient. Dermatol Clin 16:553–569
Traupe H, Happle R (1985) Etretinate therapy in children with severe keratinization defects. Eur J Pediatr 143: 166–169
Wolverton SE (1992) Monitoring for adverse effects from systemic drugs used in deramtology. J Am Acad Dermatol 26:661–779
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Orfanos, C.E., Garbe, C. (2002). Ichthyosen und andere Verhornungsstörungen. In: Blume-Peytavi, U., et al. Therapie der Hautkrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56219-8_27
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