Abstract
Electron transfer plays a central role in biological energy conversion, e.g. photosynthesis or respiratory chain, and metabolism, e.g. glycolysis or citric acid cycle, and also in the regulation of gene expression where so-called redox switches are involved. The charge transfer is either accomplished by low molecular redox mediators, such as ubiquinone, plastoquinone, oxygen / Superoxide, and the NAD+ / NADH couple, or by the direct interaction of the redox centres of proteins. Both types of biochemical charge transfer reactions have been coupled to redox electrodes:
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(i)
Low molecular redox mediators have been applied for the estimation of the redox potential of biomolecules for a long time. More recently, mediators have served as a key component in many amperometric biosensors.
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(ii)
Since the time of Heyrovski, and Berezin, it has been an attractive goal to achieve “mediatorless” communication between the prosthetic groups of redox proteins and electrodes. This process allows substituting electron sources, i.e. in bioreactors or sensors, thus simplifying technological application. Furthermore, this reaction may improve the basic knowledge of the mechanism of biological redox reactions at interfaces, e.g. at biological membranes.
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Scheller, F.W., Lisdat, F., Lei, C., Ge, B., Wollenberger, U. (2002). Communication between Redox Proteins and Modified Electrodes. In: Hoffmann, KH. (eds) Coupling of Biological and Electronic Systems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56177-1_8
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DOI: https://doi.org/10.1007/978-3-642-56177-1_8
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