Abstract
Proteins can be considered molecular machines, and protein 3D-structures are key to the understanding of these machines and to many applications in biotechnology and medicine. We are developing a method to speed up the time consuming process of structure determination significantly. The method closely couples bioinformatics for protein structure prediction with fast experiments (chemical cross-linking, specific proteolysis, mass spectrometry) for structure validation. For a given protein, the method iterates over cycles of bioinformatics and experiments to collect more and more information on the protein structure, finally resulting in an Experimentally Validated Model (EVAM) of the structure.
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Hoffmann, D., Schnaible, V., Wefing, S., Albrecht, M., Hanisch, D., Zimmer, R. (2002). A New Method for the Fast Solution of Protein-3D-Structures, Combining Experiments and Bioinformatics. In: Hoffmann, KH. (eds) Coupling of Biological and Electronic Systems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56177-1_6
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DOI: https://doi.org/10.1007/978-3-642-56177-1_6
Publisher Name: Springer, Berlin, Heidelberg
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