Ex-vivo Evaluation eines computergestützten 3-D-Simulationsmodells zur interstitiellen Tumorablation bei der Radiofrequenz-Thermotherapie an der Schweineleber
Introduction: Treating liver tumors by in situ ablation techniques like radiofrequency thermotherapy (RF) creates thermal lesions with complex lesion geometry. The aim of this study was to develop and evaluate a computer-simulated 3-D irradiation model for predicting the thermal volume in RF. Material and Methods: Light and heat distribution in the tissue was calculated by using a Monte Carlo Simulation. A 3-D image of the coagulation volume was created and the simulation results were correlated to those ex vivo in 20 porcine livers. The animals were randomized into 2 groups: normal bipolar RF-applicator; internally cooled bipolar RF-applicator. Results: Simulating the coagulation volume required 25.5 (23 – 37) min. Simulated applicator cooling led to a 4-fold increase in lesion volume. The deviation in the diameter between the simulation and ex vivo data was a maximum of 9.2% ± 0.3 (RFmono) and 11.6% ± 0.3 (RFCooled). Conclusion: The developed 3-D irradiation model showed good prediction of the coagulation volume in RF. It is now possible to make a statement about the expected lesion geometry and the application parameters required for reliable tumor destruction during in situ ablation procedures.
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