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Ex-vivo Evaluation eines computergestützten 3-D-Simulationsmodells zur interstitiellen Tumorablation bei der Radiofrequenz-Thermotherapie an der Schweineleber

  • Jörg-Peter Ritz
  • C. Isbert
  • K. Lehmann
  • T. Stein
  • H. J. Buhr
  • C.-T. Germer
Conference paper
Part of the Deutsche Gesellschaft für Chirurgie book series (DTGESCHIR, volume 31)

Abstract

Introduction: Treating liver tumors by in situ ablation techniques like radiofrequency thermotherapy (RF) creates thermal lesions with complex lesion geometry. The aim of this study was to develop and evaluate a computer-simulated 3-D irradiation model for predicting the thermal volume in RF. Material and Methods: Light and heat distribution in the tissue was calculated by using a Monte Carlo Simulation. A 3-D image of the coagulation volume was created and the simulation results were correlated to those ex vivo in 20 porcine livers. The animals were randomized into 2 groups: normal bipolar RF-applicator; internally cooled bipolar RF-applicator. Results: Simulating the coagulation volume required 25.5 (23 – 37) min. Simulated applicator cooling led to a 4-fold increase in lesion volume. The deviation in the diameter between the simulation and ex vivo data was a maximum of 9.2% ± 0.3 (RFmono) and 11.6% ± 0.3 (RFCooled). Conclusion: The developed 3-D irradiation model showed good prediction of the coagulation volume in RF. It is now possible to make a statement about the expected lesion geometry and the application parameters required for reliable tumor destruction during in situ ablation procedures.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Jörg-Peter Ritz
    • 1
    • 3
  • C. Isbert
    • 1
  • K. Lehmann
    • 1
  • T. Stein
    • 2
  • H. J. Buhr
    • 1
  • C.-T. Germer
    • 1
  1. 1.Chirurgische Klinik und Poliklinik IGermany
  2. 2.Institut für Medizinisch-technische Physik und LasermedizinFreie Universität BerlinGermany
  3. 3.Chirurgische Klinik und Poliklinik IUniversitätsklinikum Benjamin FranklinBerlinGermany

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