Oxaliplatin und CPT-11 sind wirksam in der Prävention jedoch nicht in der Behandlung experimentell erzeugter Peritonealkarzinomatose
After surgical resection of colorectal carcinoma, the high local recurrence rate at the original tumor or the peritoneal site remains an unsolved problem. Currently, there are no established standardized therapy protocols for the prevention or treatment of peritoneal carcinomatosis. CPT-11 and Oxaliplatin are novel cytostatic agents, which can provide beneficial effects in the treatment of patients with advanced colorectal cancer. The aim of our study was to investigate whether these substances can inhibit intraperitoneal (i. p.) tumor growth using a rat model of experimental carcinomatosis. Animals were devided into three groups including controls. In group 1, antineoplastic agents were administered directly into the peritoneal cavity following tumor cell transfer, whereas in group 2, substances were given as early postoperative i.p. chemotherapy (d5, 10 & 15 after cell transfer) via port-a-cath. Group 3: i.p. chemotherapy (15 d interval after cell transfer) was administered with the intention of reducing a manifest peritoneal carcinomatosis. The results indicated that CPT-11 and Oxaliplatin were significantly effective in reducing intraperitoneal tumor growth after direct i.p. application during laparotomy for tumor cell transfer. In addition, i.p. administration of CPT-11 or Oxaliplatin also inhibited tumor growth using short postoperative intervals of i.p. chemotherapy. However, the chemotherapeutic protocol was not effective after manifestation of peritoneal carcinomatosis, showing that 1) CPT-11 and Oxaliplatin are potential agents for this setting and 2) it appears to be essential to focus on early administration of chemotherapy in particular for prevention of peritoneal carcinomatosis.
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