Hohe Mutationsfrequenz in der mitochondrialen DNA D-Loop Region bei Adenocarcinomen im Barrett-Ösophagus
Mitochondrial DNA (mtDNA) is known for high mutation rates caused by lack of protective histones, inefficient DNA repair systems, and continuous exposure to mutagenic effects of oxygen radicals.
In the present study, we examined the frequency of mutations in the mtDNA D-loop region in 20 patients with Barrett’s carcinoma and associated Barrett’s epithelium by automated DNA sequencing. Mutations were detected in 8 of 20 (40%) patients in tumor and/or tumor-associated Barrett’s epithelium. There was no association of mtDNA D-loop mutations with histopathological stage of disease (UICC) or tumor grading.
We present the first report on frequent occurrence of mutations in the mtDNA D-loop regions in adenocarcinomas in Barrett’s esophagus. Furthermore, this study strongly supports the hypothesis that oxidative damage is an important mechanism for the induction of adenocarcinoma in Barrett’s esophagus.
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