Analyse der Immunantwort nach neoadjuvanter Immuntherapie mit dem humanen monoklonalen Antikörper SC-1 beim Magenkarzinom
Background: Neoadjuvant therapy for gastric cancer patients with the apoptosis inducing human monoclonal antibody SC-1 might be a new therapeutical approach. For further evaluation of antibody SC-1 the perioperative immune function of patients was explored in this prospective study. Methods: Twenty one gastric cancer patients who underwent total gastrectomy divided into 11 patients (mean (SD) age 64.9 (10.3) years) with neoadjuvant SC-1 antibody therapy (study group) and 10 patients (mean (SD) age 63.6 (9.3) years) without antibody therapy (control group) were investigated for immunologic alterations based on the change of cytokine levels such as tumor necrosis factor (TNF)-α, sFas ligand, interleukin-6 (IL-6), interferon (IFN)-γ, interleukin-12 (IL-12), neopterin and rantes. Additionally, blood lymphocyte subsets were characterized according to the following cluster of differentiation (CD) numbers: CD3, CD4, CD8, CD14, CD19, CD16/56 and quantified as a percentage of total lymphocytes. Results: The level of TNF-α was significantly increased after SC-1 antibody therapy. The perioperative course of other cytokine concentrations were not significantly changed after delivery of SC-1 antibody. There was no significant relationship between change of lymphocyte subsets and antibody therapy. Conclusions: Regarding the data, the delivery of antibody SC-1 leads not to a profound alteration neither in circulating cytokines nor lymphocytes. Especially perioperative immune function in gastric cancer patients with SC-1 antibody therapy seems to be not impaired.
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