Antiangiogenese zur adjuvanten Therapie nach Resektion kolorektaler Lebermetastasen — Erste Ergebnisse einer Phase I/II-Studie mit einem monoklonalen anti-lntegrin- Antikörper

  • Hans-Rudolf Raab
  • G. Riethmüller
Conference paper
Part of the Deutsche Gesellschaft für Chirurgie book series (DTGESCHIR, volume 31)


Introduction: Liver resection offers the only chance of cure for patients with colorectal liver metastases. Nevertheless, recurrences occur in up to 80%. No adjuvant therapy is established. Methods: Within this study 16 patients with high risk of recurrence received an adjuvant treatment after resection of colorectal liver metastases with a chimeric monoclonal antibody against αvβ3 and αIIbβ3 integrins. Main criteria for evaluation were toxicity, tumour-free survival, and overall survival. Results: After a median follow-up of 18 months the only observed toxicity was severe thrombocytopenia in 3 of the 16 patients combined with an anaphylactic reaction in one of these. All recovered without complications, especially without bleeding. Recurrences and deaths were observed in 25% and 6% respectively. Considering the high-risk situation, this was at most half of the expected rate in this group. Discussion and Conclusion: With this regimen acute toxicity in terms of thrombocytopenia was high. Nevertheless, oncologic results are encouraging to further follow up that path.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Hans-Rudolf Raab
    • 1
    • 3
  • G. Riethmüller
    • 2
  1. 1.Klinik für Viszeral- und TransplantationschirurgieMedizinische Hochschule HannoverGermany
  2. 2.Institut für ImmunologieLudwig-Maximilian-Universität MünchenGermany
  3. 3.Klinik für Allgemein- und ViszeralchirurgieKlinikum OldenburgOldenburg (Oldbg.)Germany

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