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Evaluierung einer neuen antiangiogenen Kombinationstherapie für das Pankreaskarzinom: VEGF-Blockade und Matrixmetalloproteinase-Inhibition im Tiermodell

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Book cover Chirurgisches Forum 2002

Part of the book series: Deutsche Gesellschaft für Chirurgie ((FORUMBAND,volume 31))

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Abstract

Blockade of the proangiogenic vascular endothelial growth factor (VEGF) and inhibition of matrix metalloproteinases (MMP) are promising novel treatment strategies for cancer. This study assessed the effects of a neutralizing anti-VEGF antibody (A4.6.1) and a MMP inhibitor (BB-94) on pancreatic cancer (PaCa) in vivo in an orthotopic nude mouse model. Monotherapy with either A4.6.1 and BB-94 significantly reduced tumor size, metastatic spread, and microvessel density in PaCa derived from two cell lines (HPAF-2, AsPC-1), thereby increasing survival. Combined VEGF blockade and MMP inhibition elicited additive effects in tumors derived from moderately differentiated HPAF-2 cells. This study adds further evidence for the therapeutic potential of antiangiogenic VEGF blockade and MMP inhibition in experimental PaCa.

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Authors and Affiliations

  1. Chirurgie I, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany

    Dr. H. G. Hotz, T. Foitzik, B. Hotz & H. J. Buhr

  2. Dept. of Surgery, University of California Los Angeles, USA

    O. J. Hines & H. A. Reber

  3. Chirurgische Klinik I, Universitätsklinikum Benjamin Franklin, FU Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Dr. H. G. Hotz

Authors
  1. Dr. H. G. Hotz
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  2. T. Foitzik
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  3. B. Hotz
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  4. O. J. Hines
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  5. H. A. Reber
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  6. H. J. Buhr
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© 2002 Springer-Verlag Berlin Heidelberg

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Hotz, H.G., Foitzik, T., Hotz, B., Hines, O.J., Reber, H.A., Buhr, H.J. (2002). Evaluierung einer neuen antiangiogenen Kombinationstherapie für das Pankreaskarzinom: VEGF-Blockade und Matrixmetalloproteinase-Inhibition im Tiermodell. In: Chirurgisches Forum 2002. Deutsche Gesellschaft für Chirurgie, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56158-0_10

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  • DOI: https://doi.org/10.1007/978-3-642-56158-0_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43300-2

  • Online ISBN: 978-3-642-56158-0

  • eBook Packages: Springer Book Archive

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