Advertisement

Lokoregionäre Chemotherapie in Kombination mit temporärer Mikroembolisation — eine neue Therapieoption bei Lungentumoren. Erste tierexperimentelle Erfahrungen

  • Paul Schneider
  • S. Kampfer
  • C. Loddenkemper
  • T. Foitzik
  • H. J. Buhr
Conference paper
Part of the Deutsche Gesellschaft für Chirurgie book series (DTGESCHIR, volume 31)

Abstract

The novel method of organ-specific drug application presented here is unilateral chemoembolization of the lung. The pulmonary artery is injected with degradable starch microspheres and cytotoxic drugs to improve tumor control in lung metastases. In a solitary metastasis rat model (CC53l adenocarcinoma), we studied the clinical tumor response. Fourteen days after tumor induction, animals were randomly assigned to four groups. Group I served as the control. Group II received carboplatin intravenously (45 mg/kg). Isolated lung perfusion (ILP) with buffered starch solution and carboplatin (15 mg/kg) was done in group III. Chemoembolization with carboplatin (15 mg/kg) was performed in group IV. Seven days later the difference in the tumor volume before and after treatment was +422 mm3 (±226) in group I, +70 mm3 (±31) in group II, -8 mm3 (±17) in group III and -17 mm3 (±16) in group IV (p <0.05 groups III and IV vs groups I and II).. No pleural spread was observed in groups III and IV. This is the first study to perform chemoembolization of the lung. Compared to intravenous therapy, chemoembolization was more effective and its efficacy was comparable to that of ILP, but less stressful for possible clinical application.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Vogt-Moykopf I, Krysa S, Buelzebruck H, Schirren J (1994) Surgery for pulmonary metastases. The Heidelberg experience. Chest Surg Clin N Am 4(1): 85–112PubMedGoogle Scholar
  2. 2.
    The International Registry of Lung Metastases, Writing Committee: Pastorino, U., Buyse M, Friedel G, Ginsberg RJ, Girard P, Goldstraw P, Johnston M, McCormack P, Pass H, Putnam JB Jr (1997) Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg 113: 37–49CrossRefGoogle Scholar
  3. 3.
    Weksler B, Schneider A, Ng B, Burt M (1993) Isolated single lung perfusion in the rat: an experimental model. J Appl Physiol Jun 74(6): 2736 - 9PubMedGoogle Scholar
  4. 4.
    Burt ME, Liu D, Abolhoda A, Ross HM, Kaneda Y, Jara E, Caspar ES, Ginsberg RJ, Brennan MF (2000) Isolated lung perfusion for patients with unresectable metastases from sarcoma: a phase I trial. Ann Thorac Surg 69: 1542–9PubMedCrossRefGoogle Scholar
  5. 5.
    Ng B, Lenert JT, Weksler B, Port JL, Ellis JL, Burt ME (1995) Isolated lung perfusion with FUDR is an effective treatment for colorectal adenocarcinoma lung metastases in rats. Ann Thorac Surg 59(1): 205–8PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Paul Schneider
    • 1
    • 3
  • S. Kampfer
    • 1
  • C. Loddenkemper
    • 2
  • T. Foitzik
    • 1
  • H. J. Buhr
    • 1
  1. 1.Chirurgische Klinik I, Allgemein-, Gefäß- und ThoraxchirurgieGermany
  2. 2.Institut für Pathologie, Universitätsklinikum Benjamin FranklinFreie Universität BerlinGermany
  3. 3.Chirurgische Klinik I, UK Benjamin FranklinFreie Universität BerlinBerlinGermany

Personalised recommendations