Lokoregionäre Chemotherapie in Kombination mit temporärer Mikroembolisation — eine neue Therapieoption bei Lungentumoren. Erste tierexperimentelle Erfahrungen
The novel method of organ-specific drug application presented here is unilateral chemoembolization of the lung. The pulmonary artery is injected with degradable starch microspheres and cytotoxic drugs to improve tumor control in lung metastases. In a solitary metastasis rat model (CC53l adenocarcinoma), we studied the clinical tumor response. Fourteen days after tumor induction, animals were randomly assigned to four groups. Group I served as the control. Group II received carboplatin intravenously (45 mg/kg). Isolated lung perfusion (ILP) with buffered starch solution and carboplatin (15 mg/kg) was done in group III. Chemoembolization with carboplatin (15 mg/kg) was performed in group IV. Seven days later the difference in the tumor volume before and after treatment was +422 mm3 (±226) in group I, +70 mm3 (±31) in group II, -8 mm3 (±17) in group III and -17 mm3 (±16) in group IV (p <0.05 groups III and IV vs groups I and II).. No pleural spread was observed in groups III and IV. This is the first study to perform chemoembolization of the lung. Compared to intravenous therapy, chemoembolization was more effective and its efficacy was comparable to that of ILP, but less stressful for possible clinical application.
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