Skip to main content
SpringerLink
Log in

Habituelle Abortneigung

Abklärungund Therapie

  • Chapter
Gynäkologie upgrade 2002

  • 39 Accesses

Zusammenfassung

Aborte sind Schwangerschaftsverluste vor der Lebensfähigkeit des Kindes. Die WHO- Definition von 1977 lautet: “the expulsion or extraction from its mother of an embryo or fetus weighing 500 g or less” [73]. Die Gewichtsdefinition entspricht etwa der 20.-22. SSW. Unterschieden werden Früh- von Spataborten. Die Grenze zwischen Friih- und Spätaborten liegt im Bereich der 16. SSW. Diese Differenzierung ist hinsichtlich der Abortursachen und eventueller prophylaktischer Maßnahmen von Bedeutung. Innerhalb der Gruppe der Friihaborte werden in neuerer Zeit noch Frühestaborte (nur biochemisch nachweisbar) von klinischen Aborten unterschieden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 74.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Acien P (1993) Reproductive performance of women with uterine malformations. Hum Reprod 8: 122–126

    PubMed  CAS  Google Scholar 

  2. Alberman E (1988) The epidemiology of repeated abortion. In: Beard RW, Sharp F (eds) Early pregnancy loss: mechanisms and treatment. RCOG, London, pp 9–17

    Chapter  Google Scholar 

  3. Armstrong BG, McDonald AD, Sloan M (1992) Cigarette, alcohol, and coffee consumption and spontaneous abortion. Am J Public Health 82: 85–87

    Article  PubMed  CAS  Google Scholar 

  4. Beer AE, Quebbeman JF, Ayers JW, Haines RF (1981) Major histocompatibility complex antigens, maternal and paternal immune responses, and chronic habitual abortions in humans. Am J Obstet Gynecol 141: 987–999

    PubMed  CAS  Google Scholar 

  5. Belanger K, Leaderer B, Hellenbrand K, Holford TR, McSharry J, Power ME, Bracken MB (1998) Spontaneous abortion and exposure to electric blankets and heated water beds. Epidemiology 9: 36–42

    Article  PubMed  CAS  Google Scholar 

  6. Breckwoldt M, Runnebaum B, Müller OA (1993) Weibliche Gonaden (Gynakologie und Geburtshilfe). In: Ziegler R, Pickardt CR, Willig R-P (Hrsg) Rationelle Diagnostik in der Endokrino-logie einschlie Blich Diabetologie und Stoffwechsel. Thieme, Stuttgart, S 213–221

    Google Scholar 

  7. Bussen S, Sutterlin M, Steck T (1999) Endocrine abnormalities during the follicular phase in women with recurrent spontaneous abortion. Hum Reprod 14: 18–20

    Article  PubMed  CAS  Google Scholar 

  8. Buttram VC Jr, Gibbons WE (1979) Mullerian anomalies: a proposed classification. (An analysis of 144 cases). Fertil Steril 32: 40–46

    PubMed  Google Scholar 

  9. Buttram VC Jr, Reiter RC (1981) Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril 36: 433–445

    PubMed  Google Scholar 

  10. Capella-Allouc S, Morsad F, Rongieres-Bertrand C, Taylor S, Fernandez H (1999) Hysteroscopic treatment of severe Asherman’s syndrome and subsequent fertility. Hum Reprod 14: 1230–1233

    Article  PubMed  CAS  Google Scholar 

  11. Christiansen OB (1997) Epidemiological, immunogenetic and immunotherapeutic aspects of unexplained recurrent miscarriage. Dan Med Bull 44: 396–424

    PubMed  CAS  Google Scholar 

  12. Clifford K, Rai R, Regan L (1997) Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Hum Reprod 12: 387–389

    Article  PubMed  CAS  Google Scholar 

  13. Clifford K, Rai R, Watson H, Franks S, Regan L (1996) Does suppressing luteinising hormone secretion reduce the miscarriage rate? Results of a randomised controlled trial. BMJ 312: 1508–1511

    Article  PubMed  CAS  Google Scholar 

  14. Clifford K, Rai R, Watson H, Regan L (1994) An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases. Hum Reprod 9: 1328–1332

    PubMed  CAS  Google Scholar 

  15. Cowchock FS, Reece EA, Balaban D, Branch DW, Plouffe L (1992) Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am J Obstet Gynecol 166: 1318–1323

    PubMed  CAS  Google Scholar 

  16. Csapo Al, Pulkkinen M (1978) Indispensability of the human corpus luteum in the maintenance of early pregnancy. Luteectomy evidence. Obstet Gynecol Surv 33: 69–68

    Article  PubMed  CAS  Google Scholar 

  17. Daya S (1989) Efficacy of progesterone support for pregnancy in women with recurrent miscarriage. A meta-analysis of controlled trials. Br J Obstet Gynaecol 96: 275–280

    Article  PubMed  CAS  Google Scholar 

  18. Deichert U, van de Sandt M, Lauth G, Daume E (1988) Dietransvaginale Hysterokontrast-sonographie (HKSG). Ein neuesVerfahren zur Differenzierung intrauteriner und myometraler Befunde. Geburtshilfe Frauenheilkd 48: 835–844

    Article  PubMed  CAS  Google Scholar 

  19. Doyle P, Maconochie N, Roman E, Davies G, Smith PG, Beral V (2000) Fetal death and congenital malformation in babies born to nuclear industry employees: report from the nuclear industry family study. Lancet 356: 1293–1299

    Article  PubMed  CAS  Google Scholar 

  20. Fenster L, Hubbard AE, Swan SH, Windham GC, Waller K, Hiatt RA, Benowitz N (1997) Caffeinated beverages, decaffeinated coffee, and spontaneous abortion. Epidemiology 8: 515–523

    Article  PubMed  CAS  Google Scholar 

  21. Filicori M, Butler JR, Crowley WF (1984): Neuroendocrine regulation of the corpus luteum in the human: evidence for pulsatile progesterone secretion. J Gin Invest 73: 1638–1647

    CAS  Google Scholar 

  22. Goldstein P, Berrier J, Rosen S, Sacks HS, Chalmers TC (1989) A meta-analysis of randomized control trials of progestational agents in pregnancy. Br J Obstet Gynaecol 96: 265–274

    Article  PubMed  CAS  Google Scholar 

  23. Greaves M, Cohen H, MacHin SJ, Mackie I (2000) Guidelines on the investigation and management of the antiphospholipid syndrome. Br J Haematol 109: 704–715

    Article  PubMed  CAS  Google Scholar 

  24. Harlap S, Shiono PH (1980) Alcohol, smoking, and incidence of spontaneous abortions in the first and second trimester. Lancet 26: 173–176

    Article  Google Scholar 

  25. Heidam LZ (1984) Spontaneous abortions among laboratory workers; a follow up study. J Epidemiol Community Health 38: 36–41

    Article  PubMed  CAS  Google Scholar 

  26. Hinney B, Henze C, Kuhn W, Wuttke W (1996) The corpus luteum insufficiency: a multifactorial disease. J Clin Endocrinol Metab 81: 565–570

    Article  PubMed  CAS  Google Scholar 

  27. Hinney B, Neumeyer H (1999) Immuntherapie habitueller Aborte. Reproduktionsmedizin 15: 200–211

    Article  Google Scholar 

  28. Homer HA, Li TC, Cooke ID (2000) The septate uterus: a review of management and reproductive outcome. Fertil Steril 73: 1–14

    Article  PubMed  CAS  Google Scholar 

  29. The German RSA/IVIG Group (1994) Intravenous immunoglobulin in the prevention of recurrent miscarriage. Br J ObstetGynaecol 101: 1072–1077

    Article  Google Scholar 

  30. Jivraj S, Anstie B, Cheong YC, Fairlie FM, Laird SM, Li TC (2001) Obstetric and neonatal outcome in women with a history of recurrent miscarriage: a cohort study. Hum Reprod 16: 102–106

    Article  PubMed  CAS  Google Scholar 

  31. Jones GS (1949) Some newer aspects of the management of infertility. JAMA 141: 1123–1129

    Article  CAS  Google Scholar 

  32. Kirk EP, Chuong CJ, Coulam CB, Williams TJ (1993) Pregnancy after metroplasty for uterine anomalies. Fertil Steril 59: 1164–1168

    PubMed  CAS  Google Scholar 

  33. Koike T, Minakami H, Kosuge S, Usui R, Matsubara S, Izumi A, Sato I (1999) Uterine leiomyoma in pregnancy: its influence on obstetric performance. J Obstet Gynaecol Res 25: 309–313

    Article  PubMed  CAS  Google Scholar 

  34. Kutteh WH (1996) Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol 174: 1584–1589

    Article  PubMed  CAS  Google Scholar 

  35. Lammer EJ, Chen DT, Hoar RM et al. (1985) Retinoic acid embryopathy. N Engl J Med 313: 837–841

    Article  PubMed  CAS  Google Scholar 

  36. Laskin CA, Bombardier C, Hannah ME et al. (1997) Prednisone and aspirin in women with autoantibodiesand unexplained recurrent fetal loss. N Engl J Med 337: 148–153

    Article  PubMed  CAS  Google Scholar 

  37. Li TC (1998) Recurrent miscarriage: principles of management. Hum Reprod 13: 478–482

    Article  PubMed  CAS  Google Scholar 

  38. Lutjen PJrounson A, Leeton J, Findlay J, Wood C, Renou P (1984) The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure. Nature 307: 174–171

    Article  Google Scholar 

  39. Macdonald RR(1989) Does treatment with progesterone prevent miscarriage? Br J Obstet Gynaecol 96: 257–260

    Google Scholar 

  40. Malik E, Berg C, Sterzik K, Stoz F, Rossmanith WG (2000) Reproductive outcome of 32 patients with primary or secondary infertility and uterine pathology. Arch Gynecol Obstet 264: 24–26

    Article  PubMed  CAS  Google Scholar 

  41. Medawar PB (1953) Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Experim Biol 7: 320–338

    Google Scholar 

  42. Mowbray JF, Gibbings C, Liddell H, Reginald PW, Underwood JL, Beard RW (1985) Controlled trial of treatment of recurrent spontaneous abortion by immunisation with paternal cells. Lancet i: 941–943

    Article  Google Scholar 

  43. Mueller-Eckhardt G, Heine O, Neppert J, Kunzel W, Mueller-Eckhardt C (1989) Prevention of recurrent spontaneous abortion by intravenous immunoglobulin. Vox Sang 56: 151–154

    Article  PubMed  CAS  Google Scholar 

  44. Nakajima ST, Nason FG, Badger GJ, Gibson M (1991) Progesterone production in early pregnancy. Fertil Steril 55: 516–521

    PubMed  CAS  Google Scholar 

  45. Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M (2000) Maternal age and fetal loss: population based register linkage study. BMJ 320: 1708–1712

    Article  PubMed  CAS  Google Scholar 

  46. Ogasawara M, Aoki K, Okada S, Suzumori K (2000) Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril 73: 300–304

    Article  PubMed  CAS  Google Scholar 

  47. Ogasawara M, Kajiura S, Katano K, Aoyama T, Aoki K (1997) Are serum progesterone levels predictive of recurrent miscarriage in future pregnancies? Fertil Steril 68: 806–809

    Article  PubMed  CAS  Google Scholar 

  48. Patton PE (1994) Anatomic uterine defects. Gin Obstet Gynecol 37: 705–721

    CAS  Google Scholar 

  49. Pauer HU, Hinney B, Voigt-Tschirschwitz T, Neesen J, Engel W (2001) Die Bedeutung von Faktor V G1691A-,FaktorllG20210A-und der Methylentetrahydrofolat-Reduktase-Mutationin der Diagnostik habitueller Aborte. Reproduktionsmedizin 17: 42–47

    Article  Google Scholar 

  50. Prentice RL, Gatenby PA, Loblay RH, Shearman RP, Kronenberg H, Basten A (1984) Lupus anticoagulant in pregnancy. Lancet ii: 464

    Article  Google Scholar 

  51. Rabinerson D, Johar M, Pomerantz M, Haimovich L (1992) Persistence of a normal pregnancy after an early luteectomy. A report of two cases. J Reprod Med 37: 749–752

    PubMed  CAS  Google Scholar 

  52. Rai R, Cohen H, Dave M, Regan L (1997) Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies. BMJ 314: 253–257

    Article  PubMed  CAS  Google Scholar 

  53. Rand JH, Wu XX, Andree HA, Lockwood CJ, Guller S, Scher J, Harpel PC (1997) Pregnancy loss in the antiphospholipid-antibody syndrome-a possible thrombogenic mechanism. N Engl J Med 337: 154–160

    Article  PubMed  CAS  Google Scholar 

  54. Regan L, Owen EJ, Jacobs HS (1990) Hypersecretion of luteinising hormone, infertility, and miscarriage. Lancet 336: 1141–1144

    Article  PubMed  CAS  Google Scholar 

  55. Rock JA, Schlaff WD (1985) The obstetric consequences of uterovaginal anomalies. Fertil Steril 43: 681–692

    PubMed  CAS  Google Scholar 

  56. Scott JR, Rote NS, Branch DW (1987) Immunologic aspects of recurrent abortion and fetal death. Obstet Gynecol 70: 645–656

    PubMed  CAS  Google Scholar 

  57. Scott JR (2000) Immunotherapy for recurrent miscarriage (cochrane review). Cochrane Library, Oxford

    Google Scholar 

  58. Simon C, Martinez L, Pardo F, Jortajada M, Pellicer A (1991) Mullerian defects in women with normal reproductive outcome. Fertil Steril 56: 1192–1193

    PubMed  CAS  Google Scholar 

  59. Speroff L, Glass RH, Kase NG (1999) Clinical gynecologic endocrinology and infertility. Lippincott Williams&Wilkins, Baltimore, pp 1043–1055

    Google Scholar 

  60. Stephenson MD (1996) Frequency of factors associated with habitual abortion in 197 couples. Fertil Steril 66: 24–29

    PubMed  CAS  Google Scholar 

  61. Stern JJ, Dorfmann AD, Gutierrez-Najar AJ, Cerrillo M, Coulam CB (1996) Frequency of abnormal karyotypes among abortuses from women with and without a history of recurrent spontaneous abortion. Fertil Steril 65: 250–253

    PubMed  CAS  Google Scholar 

  62. Stray-Pedersen B, Stray-Pedersen S (1984) Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion. Am J Obstet Gynecol 148: 140–146

    PubMed  CAS  Google Scholar 

  63. Stirrat GM (1990) Recurrent miscarriage I: Definition and epidemiology. Lancet 336: 673–675

    Article  PubMed  CAS  Google Scholar 

  64. Soliman S, Daya S, Collins J, Hughes EG (1994) The role of luteal phase support in infertility treatment: a meta-analysis of randomized trials. Fertil Steril 61: 1068–1076

    PubMed  CAS  Google Scholar 

  65. Sutherland HW, Pritchard CW (1987) Increased incidence of spontaneous abortion in pregnancies complicated by maternal diabetes mellitus. Am J Obstet Gynecol 156: 135–138

    PubMed  CAS  Google Scholar 

  66. Taskinen H, Lindbohm ML, Hemminki K (1986) Spontaneous abortions among women working in the pharmaceutical industry. Br J Ind Med 43: 199–205

    PubMed  CAS  Google Scholar 

  67. Taylor C, Faulk WP (1981) Prevention of recurrent abortion with leucocyte transfusions. Lancet ii: 68–70

    Article  Google Scholar 

  68. The American Fertility Society (1988) The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, mullerian anomalies and intrauterine adhesions. Fertil Steril 49: 944–955

    Google Scholar 

  69. Thornton CA, Ballow M (1993) Safety of intravenous immunoglobulin. Arch Neurol 50: 135–136

    Article  PubMed  CAS  Google Scholar 

  70. Tulppala M, Marttunen M, Soderstrom-Anttila V et al. (1997) Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. Hum Reprod 12: 1567–1572

    Article  PubMed  CAS  Google Scholar 

  71. Tulppala M, Stenman UH, Cacciatore B, Ylikorkala O (1993) Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage: prospective study in 50 women. Br J Obstet Gynaecol 100: 348–352

    Article  PubMed  CAS  Google Scholar 

  72. Tulppala M, Viinikka L, Ylikorkala O (1991) Thromboxane dominance and prostacyclin deficiency in habitual abortion. Lancet 337: 879–881

    Article  PubMed  CAS  Google Scholar 

  73. WHO (1977) WHO recommended definitions, terminology and format for statistical tables related to the perinatal period. Act Obstet Gynecol Scand 56: 247–253

    Google Scholar 

  74. Windham GC, Swan SH (1997) Moderate maternal drinking and infant birthweight. Epidemiology 8: 112–123

    Article  PubMed  CAS  Google Scholar 

  75. Recurrent Miscarriage Immunotherapy Trialists Group (1994) Worldwide collaborative observational study and meta-analysis on allogenic leukocyte immunotherapy for recurrent spontaneous abortion. Am J Reprod Immunol 32: 55–72

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universitäts-Frauenklinik Göttingen, Germany

    B. Hinney

Authors
  1. B. Hinney
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Universitäts-Frauenklinik, Moorenstraße 5, 40225, Düsseldorf, Germany

    L. Beck

  2. Schwaigerstraße 33, 92224, Amberg, Germany

    D. Berg

  3. Eichbergstraße 34, 79117, Freiburg, Germany

    A. Pfleiderer

  4. Abteilung Gynäkologische Endokrinologie und Fertilitätsstörungen, Universitäts-Frauenklinik, Voßstraße 2, 69115, Heidelberg, Germany

    T. Strowitzki

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hinney, B. (2002). Habituelle Abortneigung. In: Beck, L., Berg, D., Pfleiderer, A., Strowitzki, T. (eds) Gynäkologie upgrade 2002. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56142-9_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-56142-9_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43398-9

  • Online ISBN: 978-3-642-56142-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation