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Vulvakarzinom

Diagnostik und Therapie

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Gynäkologie upgrade 2002

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Zusammenfassung

Das invasive Vulvakarzinom gehört zu den seltenen Malignomen der Frau. Die Inzidenz liegt bei 2/105 Frauen/Jahr; sie steigt von 0,4 bei 30-jährigen auf 20 bei über 70-jährigen Frauen. Die Inzidenz nimmt stetig weiter zu [52,33]. Von den 1987-89 in den 11 deutschen Berichtskliniken fur den Annual Report behandelten 275 Patientinnen mit einem invasiven Vulvakarzinom lebten nach 5 Jahren noch 47% [37]. Da sehr viele Patientinnen mit einem Vulvakarzinom nicht in den zentralen Kliniken behandelt werden, ist das Gesamtergebnis schlechter [52]. Vulva re intraepitheliale Neoplasien (VIN) werden immer häufiger diagnostiziert und dies besonders bei 35-40-jährigen Frauen, Inzidenz: 0,2-0,3/105 Frauen. Als Risikofaktoren gelten Genitalwarzen und der Nachweis von Papillomaviren in Hautbiopsaten, meist HPV16. In der Folge eines Lichen sclerosus tritt ein Vulvakarzinom in < 5% auf [47]. HPV 16/18 findet man dagegen nicht selten bei der gemischten und der hypertrophischen Dystrophie [42) und bei alien VIN-Formen [25]. Risikofaktoren sind Immunsuppression, besonders eine ▸ HIV-lnfektion [36], und möglicherweise der Nikotinabusus.

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Authors and Affiliations

  1. Frauenklinik, Lukaskrankenhaus, Neuss, Germany

    H.-G. Schnürch

  2. Freiburg, Germany

    A. Pfleiderer

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  1. H.-G. Schnürch
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  2. A. Pfleiderer
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Editors and Affiliations

  1. Universitäts-Frauenklinik, Moorenstraße 5, 40225, Düsseldorf, Germany

    L. Beck

  2. Schwaigerstraße 33, 92224, Amberg, Germany

    D. Berg

  3. Eichbergstraße 34, 79117, Freiburg, Germany

    A. Pfleiderer

  4. Abteilung Gynäkologische Endokrinologie und Fertilitätsstörungen, Universitäts-Frauenklinik, Voßstraße 2, 69115, Heidelberg, Germany

    T. Strowitzki

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Schnürch, HG., Pfleiderer, A. (2002). Vulvakarzinom. In: Beck, L., Berg, D., Pfleiderer, A., Strowitzki, T. (eds) Gynäkologie upgrade 2002. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56142-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-56142-9_10

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