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Biosafety Issues in Lentivector Production

  • C. Delenda
  • M. Audit
  • O. Danos
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 261)

Abstract

The development of efficient lentivectors brings about exciting possibilities for novel therapeutic interventions. Still, as new biologicals intended to be used in the clinic, these vectors will have to comply with a complete set of requirements regarding their mode of preparation and characterization. Over the past 50 years, there has been an increasing awareness of the safety issues surrounding the manufacturing of medicinal products. Regulatory authorities and agencies regularly publish guidelines and coordinate international conferences on harmonization (ICH), whose goal is to define common standards for biotechnological and biological products to be administered to human patients (SCHULTZ 1998).

Keywords

Ciency Virus Rous Sarcoma Virus Packaging System Human Immunode Gene Transfer Vector 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • C. Delenda
    • 1
  • M. Audit
    • 1
  • O. Danos
    • 1
  1. 1.Genethon IIIEvry Cedex 02France

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