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Organ-Organ Interactions in Multiple Organ Failure

  • Chapter
Mechanisms of Organ Dysfunction in Critical Illness

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICMSOFT,volume 38))

Abstract

Multiple organ failure (MOF) is just thirty years old. Tilney and colleagues were the first to describe the syndrome as a lethal consequence of surgery to repair abdominal aortic aneurysms [2]. Despite the timely and appropriate application of organ support, affected patients could not be rescued. Frustration in this field persists. The purpose of this chapter is to explore how interactions among the vital organs may regulate function and, reciprocally, how functions may regulate those interactions.

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Author information

Authors and Affiliations

  1. Department of Surgery, Washington University School of Medicine, Box 8109, 660 South Euclid Avenue, St. Louis, MO, USA

    J. J. Wizorek & T. G. Buchman

Authors
  1. J. J. Wizorek
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  2. T. G. Buchman
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Editor information

Editors and Affiliations

  1. Intensive Care Unit, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Timothy W. Evans

  2. Division of Critical Care Medicine, University of Pittsburgh Medical Center, Scaife Hall, Room 606, 3550 Terrace Street, Pittsburgh, PA, 15264, USA

    Mitchell P. Fink

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© 2002 Springer-Verlag Berlin Heidelberg

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Wizorek, J.J., Buchman, T.G. (2002). Organ-Organ Interactions in Multiple Organ Failure. In: Evans, T.W., Fink, M.P. (eds) Mechanisms of Organ Dysfunction in Critical Illness. Update in Intensive Care and Emergency Medicine, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56107-8_11

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  • DOI: https://doi.org/10.1007/978-3-642-56107-8_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42692-9

  • Online ISBN: 978-3-642-56107-8

  • eBook Packages: Springer Book Archive

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