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LCMV and the Central Nervous System: Uncovering Basic Principles of CNS Physiology and Virus-Induced Disease

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Arenaviruses II

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 263))

Abstract

Our understanding of the normal functions of the central nervous system (CNS) and of the mechanisms underlying neuroimmunological responses have greatly benefited from the use of lymphocytic choriomeningitis virus (LCMV) infection of its natural host, the mouse. One of the strengths of the LCMV system is its flexibility: infection can result in dramatically distinct outcomes in mice depending on variables such as host age, immunological competence, host genetic background, virus dosage, virus strain and route of inoculation (reviewed in Borrow 1997; Buchmeier and Zajac 1999). Depending on how these variables are combined, the consequences of infection range from rapid onset, immune-mediated mortality to lifelong persistent infection in the absence of overt illness. While all of these outcomes can be induced in laboratory mice, mother-to-offspring transmission resulting in persistent LCMV infection predominates in the wild.

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Author notes

  1. C. F. Evans

    Present address: Digital Gene Technologies, 11149 N. Torrey Pines Road, La Jolla, CA, 92037, USA

  2. J. M. Redwine

    Present address: Neurome, 11149 N. Torrey Pines Road, La Jolla, CA, 92037, USA

Authors and Affiliations

  1. Department of Neuropharmacology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    C. F. Evans & J. M. Redwine

  2. Division of Basic Science, The Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA, 19111, USA

    C. E. Patterson, S. Askovic & G. F. Rall

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Editors and Affiliations

  1. Division of Virology Department of Neuropharmacology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone

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© 2002 Springer-Verlag Berlin Heidelberg

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Evans, C.F., Redwine, J.M., Patterson, C.E., Askovic, S., Rall, G.F. (2002). LCMV and the Central Nervous System: Uncovering Basic Principles of CNS Physiology and Virus-Induced Disease. In: Oldstone, M.B.A. (eds) Arenaviruses II. Current Topics in Microbiology and Immunology, vol 263. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56055-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-56055-2_9

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