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Cerebral Blood Flow pp 72–95Cite as

Coupling and Compartmentation of Cerebral Blood Flow and Metabolism

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Part of the book series: Update in Intensive Care Medicine ((UICMSOFT,volume 37))

Abstract

Is there a link between brain function and brain energy metabolism? If there is a link, is it important to the understanding of brain function and its organization? To answer these general questions, we must understand at least four relationships which reasonable considerations suggest underlie the link between brain function and brain energy metaboHsm. These relationships link:

  • The function of the brain to the work carried out in the brain (the function-work couple),

  • the work of the brain to the cells which carry out the work (cellular compartmentation),

  • the cells which carry out the work to the relative and absolute magnitudes of oxidative and non-oxidative energy metabolism of brain (work-metabolism couple), and

  • the energy metabolism of the brain to its blood supply (metabolism-flow couple).

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  1. The Pathophysiology and Experimental Tomography Center, Aarhus University Hospital Aarhus, Denmark

    Albert Gjedde MD, DM, FAAAS

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Gjedde, A. (2003). Coupling and Compartmentation of Cerebral Blood Flow and Metabolism. In: Cerebral Blood Flow. Update in Intensive Care Medicine, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56036-1_7

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