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Cerebral Blood Flow pp 7–16Cite as

Neural Regulation of the Cerebral Circulation

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Part of the book series: Update in Intensive Care Medicine ((UICMSOFT,volume 37))

Abstract

It was once believed that cerebral blood vessels could not dilate and constrict independently and that the cerebral circulation was entirely under the control of the systemic circulation [see ref 1 for a historical review]. However, evidence accumulated over the past 100 years indicates that cerebral blood vessels are in a dynamic state. Thus, the cerebral vasculature is endowed with complex regulatory systems that allow the brain to finely regulate its own blood supply. One of the major factors that regulates cerebral blood flow (CBF) is neuronal activity. In this chapter, we will focus on the mechanisms governing the relationship between neural activity and blood flow with emphasis on the role of nitric oxide (NO) and cyclooxygenase-2 (COX-2).

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Authors and Affiliations

  1. Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA

    Costantino Iadecola MD (Professor) & Kiyoshi Niwa MD, PhD (Research Associate)

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  1. Costantino Iadecola MD
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  2. Kiyoshi Niwa MD, PhD
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© 2003 Kluwer Academic/Plenum Publishers, New York

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Iadecola, C., Niwa, K. (2003). Neural Regulation of the Cerebral Circulation. In: Cerebral Blood Flow. Update in Intensive Care Medicine, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56036-1_2

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  • DOI: https://doi.org/10.1007/978-3-642-56036-1_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42684-4

  • Online ISBN: 978-3-642-56036-1

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