Abstract
Ventilator-associated pneumonia (VAP) is a major challenge in the intensive care unit (ICU), with an incidence varying between 5 and 50% in mechanically ventilated patients [1, 2]. Because of its high mortality rate (around 30%) [3, 4], aggressive evaluation of patients who fail to improve during the first days of treatment is indicated.
Keywords
- Systemic Inflammatory Response Syndrome
- Acute Respiratory Distress Syndrome
- Ventilator Associate Pneumonia
- Respir Crit
- Nosocomial Pneumonia
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Celis R, Torres A, Gatell JM, Almela M, Rodriguez-Roisin R, Aqusti-Vidal A (1988) Nosocomial pneumonia: A multivariate analysis of risk and prognosis. Chest 93:318–324
Fagon JY, Chastre J, Domart Y, et al (1989) Nosocomial pneumonia in patients receiving continuous mechanical ventilation. Prospective analysis of 52 episodes with use of a protected specimen brush and quantitative culture techniques. Am Rev Respir Dis 139:877–884
Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gibert C (1993) Nosocomial pneumonia in ventilated patients: A cohort study evaluating attributable mortality and hospital stay. Am J Med 94:281–288
Leu HS, Kaiser DL, Mori M, Woolson RF, Wenzel RP (1989) Hospital-acquired pneumonia. Attributable mortality and morbidity. Am J Epidemiol 129:1258–1267
Montravers P, Fagon JY, Chastre J, et al (1993) Follow-up protected specimen brushes to assess treatment in nosocomial pneumonia. Am Rev Respir Dis 147:38–44
Fabregas N, Ewig S, Torres A, et al (1999) Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate postmortem lung biopsies. Thorax 54:867–873
Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew PD, Suter PM (1991) Diagnosis of ventilator associated pneumonia by bacteriologic analysis of bronchoscopic and non-broncho-scopic “blind” bronchoalveolar lavage fluid. Am Rev Respir Dis 143:1121–1129
Garrad ChS, A Court ChD (1995) The diagnosis of pneumonia in the critically ill. Chest 108:17s-25s
Torres A, Aznar R, Gatell JM, et al (1990) Incidence, risk, and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am Rev Respir Dis 142:523–528
Trouillet JL, Chastre J, Vuagnat A, et al (1998) Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am Rev Respir Dis 157:531–539
American Thoracic Society (1996) Hospital-acquired pneumonia in adults: Diagnosis, assessment, initial therapy, and prevention: A consensus statement. Am J Respir Crit Care Med 153:1711–1725
Kollef MH, Ward S (1998) The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia. Chest 113:412–420
Nava S, Ambrosino N, Bruschi C, Confalonieri M, Rampulla C (1997) Physiological effects of flow and pressure triggering during non-invasive mechanical ventilation in patients with chronic obstructive pulmonary disease. Thorax 52:249–254
Rello J, Ausina V, Castella J, Net A, Prats G (1992) Nosocomial respiratory tract infections in multiple trauma patients. Influence of level of consciousness with implications for therapy. Chest 102:525–529
Ravindra M, Niederman MS (2000) Adequate empirical therapy minimizes the impact of diagnostic methods in patients with ventilator-associated pneumonia. Crit Care Med 28:3092–3093
Singh N (2000) Infection in solid organ transplant recipient. Curr Opin Infect Dis 13:343–347
Donnelly JP (2000) Infection in the neutropenic and haematopoietic stem cell transplant recipient. Curr Opin Infect Dis 13:337–342
Petri MG, König J, Moecke HP, et al (1997) Epidemiology of invasive mycosis in ICU patients: a prospective multicenter study in 435 non-neutropenic patients. Intensive Care Med 23:317–325
Bert F, Lambert-Zechovsky N (1996) Sinusitis in mechanically ventilated patients and its role in the pathogenesis of nosocomial pneumonia. Eur J Clin Microbiol Infect Dis 15:533–544
Le Moal G, Lemerre D, Grollier G, Desmont C, Klossek JM, Robert R (1999) Nosocomial sinusitis with isolation of anaerobic bacteria in ICU. Intensive Care Med 25:1066–1071
Rouby JJ, Laurent P, Gosnach M, et al (1994) Risk factors and clinical relevance of nosocomial maxillary sinisitis in the critically ill. Am J Respir Crit Care Med 150:776–783
Holzapfel L, Chastang C, Demingeon G, Bohe J, Piralla B, Coupry A (1999) Randomized study assessing the systematic search for maxillary sinusitis in nasotracheal mechanically ventilated patients. Am J Respir Crit Care Med 159:695–701
Berglof A, Norlander T, Feinstein R, Otori N, Stierna P, Sandstedt K (2000) Association of bronchopneumonia with sinusitis due to Bordetella bronchiseptica in an experimental rabbit model. Am J Rhinol 14:125–130
Elliott TSJ (1997) Catheter-associated infections: new developments in prevention. Current Topics in Intensive Care 4:182–205
Elliott TSJ (1993) Line-associated bacteraemias. Commun Dis Rep CDR Rev 3:R91-R96
Orlando R, Gleason E, Drezner AD (1983) Acute acalculous cholecystitis in the critically ill patient. Am J Surg 145:472–476
Barie PS, Fischer E (1995) Acute acalculous cholecystitis. J Am Coll Surg 180:232–244
Kiviniemi H, Makela JT, Autio R, et al (1998) Percutanous cholecystostomy in acute cholecystitis in high risk patients: an analysis of 69 cases. Int Surg 83:299–302
Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334–1349
Lai KK, Melvin ZS, Menard MJ, Kotilainen MR, Baker S (1997) Clostridium difficile-associated diarrhea: epidemiology, risk factors and infection control. Infect Control Hosp Epidemiol 18:628–632
Pear SM, Williamson TH, Bettin KM, Gerding DN, Galgiani JN (1994) Decrease in nosocomial Clostridium difficile-associated diarrhea by restricting clindamycin use. Ann Intern Med 120:272–277
Paradisi F, Corti G, Mangani V (1998) Urosepsis in the critical care unit. Crit Care Clin 114:165–180
Winer-Muram HT, Rubin SA, Ellis JV, et al (1993) Pneumonia and ARDS in patients receiving mechanical ventilation: diagnostic accuracy of chest radiography. Chest 188:479–485
Meduri GU, Belenchia JM, Estes RJ, Wunderink RG, el Torky M, Leeper KV Jr (1991) Proliferative phase of ARDS. Clinical findings and effects of corticosteroids. Chest 100:943–952
Sutherland KR, Steinberg PS, Maunder RJ, Millberg JA, Allen DL, Hudson LD (1995) Pulmonary infection during the acute respiratory distress syndrome. Am J Respir Crit Care Med 152:550–556
Delclaux C, Roupie E, Blot F, Brochard L, Lemaire F, Brun-Buisson C (1997) Lower respiratory tract colonization and infection during severe acute respiratory distress syndrome. Am J Respir Crit Care Med 156:1092–1098
Brun-Buisson C (2000) The epidemiology of the systemic inflammatory response. Intensive Care Med 26 (suppl 1):S64-S74
Engoren M (1995) Lack of association between atelectasis and fever. Chest 107:81–84
Wright L, King TE (1997) Cryptogenic organizing pneumonia (Idiopathic bronchilitis obliterans organizing pneumonia): An update. Clin Pulm Med 4:152–158
Xaubet A, Torres A, Marco F, Puig-De la Bellacasa J, Faus R, Aqusti-Vidal A (1989) Pulmonary infiltrates in immunocompromised patients. Diagnostic value of telescoping plugged catheter and bronchoalveolar lavage. Chest 95:130–135
Kahn FW, Jones JH (1988) Analysis of bronchoalveolar lavage specimens from immunocompromised patients with a protocol applicable in the microbiology laboratory. J Clin Microbiol 26:1150–1155
Jordan S, Mitchell, Quinlan GJ, Goldstraw P, Evans TW (2000) The pathogenesis of lung injury following pulmonary resection. Eur Respir J 15:790–799
Waller DA, Gebitekin C, Saunders NR, Walker DR (1993) Non-cardiogenic pulmonary edema complicating lung resection. Ann Thorac Surg 55:140–143
Turnage WS, Lunn JJ (1993) Postpneumonectomy pulmonary edema. A retrospective analysis of associated variables. Chest 103:1646–1650
Wunderink RG (1995) Ventilator-associated pneumonia: failure to response to antibiotic therapy. Clin Chest Med 16:173–193
Fagon JY, Chastre J, Wolff M (2000) Invasive and non-invasive strategies for management of suspected ventilator-associated pneumonia. Ann Intern Med 132:612–630
Sanchez-Nieto JM, Torres A, Garcia-Cordoba F, et al (1998) Impact of invasive and noninvasive quantitative culture sampling on outcome of ventilator-associated pneumonia: a pilot study. Am J Respir Crit Care Med 157:371–376
Cunha BA (1998) Fever in the critical care unit. Crit Care Clin 14:1–14
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Ferrer, M., Ioanas, M., Torres, A. (2002). Evaluation of Non-responding Patients with Ventilator-associated Pneumonia. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2002. Yearbook of Intensive Care and Emergency Medicine 2002, vol 2002. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56011-8_33
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