Skip to main content

Vasopressin and its Analogs

  • Conference paper
  • 136 Accesses

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 2002 ((YEARBOOK,volume 2002))

Abstract

Hypotension due to peripheral vasodilation and reduced responsiveness to vasopressor therapy are cardinal features of septic, and other forms of vasodilatory, shock. The nonosmotic release of the peptide hormone arginine-vasopressin in response to hypotension and hypovolemia, is an important defense mechanism to counteract systemic hypotension and maintain adequate tissue perfusion. Despite an initial appropriate response, vasopressin plasma levels fall and are inappropriately low in later stages of septic shock [1].

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Landry DW, Levin HR, Gallant EM, et al (1997) Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation 95:1122–1125

    Article  PubMed  CAS  Google Scholar 

  2. Malay MB, Ashton RC, Landry DW, Townsend RN (1999) Low-dose vasopressin in the treatment of vasodilatory septic shock. J Trauma 47:699–703

    Article  PubMed  CAS  Google Scholar 

  3. Argenziano M, Choudhri AF, Oz MC, Rose EA, Smith CR, Landry DW (1997) A prospective randomized trial of arginine vasopressin in the treatment of vasodilatory shock after left ventricular assist device placement. Circulation 96:II 286–290

    CAS  Google Scholar 

  4. Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:2002–2012

    Article  Google Scholar 

  5. Cobb JP, Danner RJ (1996) Nitric oxide and septic shock. JAMA 275:1192–1196

    Article  PubMed  CAS  Google Scholar 

  6. Grover R, Zaccardelli D, Colice G, Guntupalli K, Watson D, Vincent JL (1999) An open label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-arginine hydrochloride (546C88), in patients with septic shock. Crit Care Med 27:913–922

    Article  PubMed  CAS  Google Scholar 

  7. Kirov MY, Evgenov OV, Evgenov NV, et al (2001) Infusion of methylene blue in human septic shock: A pilot, randomized, controlled study. Crit Care Med 29:1860–1867

    Article  PubMed  CAS  Google Scholar 

  8. Grover R, Lopez A, Lorente J, et al (1999) Multicenter, randomized, placebo-controlled, double blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients in septic shock. Crit Care Med 27:A33 (Abst)

    Article  Google Scholar 

  9. Landry DW, Oliver JA (1992) The ATP-sensitive K+ channel mediates hypotension in endo-toxemia and hypoxic lactic acidosis in dog. J Clin Invest 89:2071–2074

    Article  PubMed  CAS  Google Scholar 

  10. Davies NW (1990) Modulation of ATP-sensitive K+ channels in skeletal muscle by intracellular protons. Nature 343:375–377

    Article  PubMed  CAS  Google Scholar 

  11. Keung EC, Li Q (1991) Lactate activates ATP-sensitive potassium channels in guinea pig ventricular myocytes. J Clin Invest 88:1772–1777

    Article  PubMed  CAS  Google Scholar 

  12. Morales D, Madigan J, Cullinane, et al (1999) Reversal by vasopressin of intractable hypotension in the late phase of hemorrhagic shock. Circulation 100:226–229

    Article  PubMed  CAS  Google Scholar 

  13. Morales DL, Gregg D, Helman DN, et al (2000) Arginine vasopressin in the treatment of 50 patients with postcardiotomy vasodilatory shock. Ann Thorac Surg 69:102–106

    Article  PubMed  CAS  Google Scholar 

  14. Cooke CR, Wall BM, Jones GV, Presley DN, Share L (1993) Reversible vasopressin deficiency in severe hypernatremia. Am J Kidney Dis 22:44–52

    PubMed  CAS  Google Scholar 

  15. Reid IA (1994) Role of nitric oxide in the regulation of renin and vasopressin secretion. Front Neuroendocrinol 15:351–383

    Article  PubMed  CAS  Google Scholar 

  16. Mohring J, Glanzer K, Maciel JA Jr, et al (1980) Greatly enhanced pressor response to antidiuretic hormone in patients with impaired cardiovascular reflexes due to idiopathic orthostatic hypotension. J Cardiovasc Pharmacol 2:367–376

    Article  PubMed  CAS  Google Scholar 

  17. Wagner HN Jr, Braunwald E (1956) The pressor effect of the antidiuretic principle of the posterior pituitary in orthostatic hypotension. J Clin Invest 35:1412–1418

    Article  PubMed  CAS  Google Scholar 

  18. Bartelstone HJ, Nasmyth PA (1965) Vasopressin potentiation of catecholamine actions in dog, rat, cat and rat aortic strip. Am J Physiol 208:754–762

    PubMed  CAS  Google Scholar 

  19. Wakatsuki T, Nakaya Y, Inoue I (1992) Vasopressin modulates K+-channel activities of cultured smooth muscle cells from porcine coronary artery. Am J Physiol 263:H491–H496

    PubMed  CAS  Google Scholar 

  20. Umino T, Kusano E, Muto S, et al (1999) AVP inhibits LPS- and IL- 1ß- stimulated NO and cGMP via V1 receptor in cultured rat mesangial cells. Am J Physiol 276:F433–F441

    PubMed  CAS  Google Scholar 

  21. Cowley AW Jr, Monos E, Guyton AC (1974) Interaction of vasopressin and the baroreceptor reflex system in the regulation of arterial blood pressure in the dog. Circ Res 34:505–514

    Article  PubMed  CAS  Google Scholar 

  22. Garrard CS, Kontoyannis DA, Piepoli M (1993) Spectral analysis of heart rate variability in the sepsis syndrome. Clin Auton Res 3:5–13

    Article  PubMed  CAS  Google Scholar 

  23. Chen JM, Cullinane S, Spanier TB, et al (1999) Vasopressin deficiency and pressor hypersensitivity in hemodynamically unstable organ donors. Circulation 100:II 244–246

    CAS  Google Scholar 

  24. Tsuneyoshi I, Yamada H, Kakihana Y, Nakamura M, Nakano Y, Boyle WA (2001) Hemodynamic and metabolic effects of low-dose vasopressin infusion in vasodilatory septic shock. Crit Care Med 29:487–493

    Article  PubMed  CAS  Google Scholar 

  25. Landry DW, Levin Hr, Gallant EM, et al (1997) Vasopressin pressor hypersensitivity in vasodilatory septic shock. Crit Care Med 25:1279–1282

    Article  PubMed  CAS  Google Scholar 

  26. Rosenzweig EB, Starc TJ, Chen JM, et al (1999) Intravenous arginine-vasopressin in children with vasodilatory shock after cardiac surgery. Circulation 100: II 182–186

    Article  CAS  Google Scholar 

  27. Gold JA, Cullinane S, Chen J, Oz MC, Oliver JA, Landry DW (2000) Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension. Crit Care Med 28:249–252

    Article  PubMed  CAS  Google Scholar 

  28. Argenziano M, Chen JM, Cullinane S, et al (1999) Arginine vasopressin in the management of vasodilatory hypotension after cardiac transplantation. J Heart Lung Transplant 18:814–817

    Article  PubMed  CAS  Google Scholar 

  29. Holmes CL, Walley KR, Chittock DR, Lehman T, Russell JA (2001) The effects of vasopressin on hemodynamics and renal function in severe septic shock: a case series. Intensive Care Med 27:1416–1421

    Article  PubMed  CAS  Google Scholar 

  30. Duenser MW, Mayr AJ, Ulmer H, et al (2001) The effects of vasopressin on systemic hemodynamics in catecholamine-resistant septic and postcardiotomy shock: a retrospective analysis. Anesth Analg 93:7–13

    Article  Google Scholar 

  31. Lamarre P, Perreault B, Lesur O (2001) Vasopressin and blood pressure support for pancreatitis-induced systemic inflammatory response syndrome with circulatory shock. Pharmacotherapy 21:506–508

    Article  PubMed  CAS  Google Scholar 

  32. Varga C, Pavo I, Lamarque D, et al (1998) Endogenous vasopressin increases acute endotoxin provoked gastrointestinal mucosal injury in the rat. Eur J Pharmacol 352:257–261

    Article  PubMed  CAS  Google Scholar 

  33. Erwald R, Wiechel KL, Strandell T (1976) Effect of vasopressin on regional splanchnic blood flows in conscious man. Acta Chir Scand 142:36–42

    PubMed  CAS  Google Scholar 

  34. Lambert M, de Peyer R, Muller AF (1982) Reversible ischemic colitis after intravenous vasopressin therapy. JAMA 247:666–667

    Article  PubMed  CAS  Google Scholar 

  35. Willems MG, Schoenemann J, Rey C, Schafer H, Lindecken KD (1985) Ischemia of the cecum caused by glycylpressin. Leber Magen Darm 15:165–168

    PubMed  CAS  Google Scholar 

  36. Schmitt W, Wagner-Thiessen E, Lux G (1987) Ischemic colitis in a patient treated with glypressin for bleeding oesophageal varices. Hepatogastroenterology 34:134–136

    PubMed  CAS  Google Scholar 

  37. Escorsell A, Del Arbol LR, Planas R, et al (2000) Multicenter randomized controlled trial of terlipressin versus sclerotherapy in the treatment of acute variceal bleeding: The TEST study. Hepatology 32:471–476

    Article  PubMed  CAS  Google Scholar 

  38. Uriz J, Gines P, Cardenas A, et al (2000) Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome. J Hepatol 33:43–48

    Article  PubMed  CAS  Google Scholar 

  39. D’Amico G, Traina M, Vizzini G, et al (1994) Terlipressin or vasopressin plus transdermal nitroglycerin in a treatment strategy for digestive bleeding in cirrhosis. A randomized clinical trial. J Hepatol 20:206–212

    Article  PubMed  Google Scholar 

  40. Barriere E, Tazi KA, Poirel O, Lebrec D, Moreau R (2001) Terlipressin administration decreases iNOS expression and improves circulatory and liver dysfunction in endotoxin-challenged rats with cirrhosis. J Heptol 34 (Suppl 1):A519 (Abst)

    Google Scholar 

  41. Scharte M, Meyer J, Van Aken H, Bone HG (2001) Hemodynamic effects of terlipressin (a synthetic analog of vasopressin) in healthy and endotoxemic sheep. Crit Care Med 29:1756–1760

    Article  PubMed  CAS  Google Scholar 

  42. O’Brian AJ, Clapp LH, Singer M (2001) The use of glypressin in norepinephrine-resistant septic shock. Intensive Care Med 27 (Suppl 2):A110 (Abst)

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Auzinger, G., Wendon, J. (2002). Vasopressin and its Analogs. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2002. Yearbook of Intensive Care and Emergency Medicine 2002, vol 2002. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56011-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-56011-8_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43149-7

  • Online ISBN: 978-3-642-56011-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics