Skip to main content

Antioxidants and Endothelial Function: Therapeutic Implications

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 2002

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 2002 ((YEARBOOK,volume 2002))

Abstract

Endothelial function may be impaired in critically ill patients [1]. The endothelium actively regulates vascular tone, platelet aggregation, coagulation, fibrinolysis, and leukocyte activation [2]. Endothelial dysfunction may, therefore, be important in the pathophysiology of some of the conditions encountered in the intensive care unit (ICU).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cardigan R, McGloin H, Macki I, Machin S, Singer M (1998) Endothelial dysfunction in critically ill patients: the effect of haemofiltration. Intensive Care Med 24:1264–1271

    Article  PubMed  CAS  Google Scholar 

  2. De Caterina R (2000) Endothelial dysfunctions: common denominators in vascular disease. Curr Opin Clin Nutr Metab Care 3:453–467

    Article  PubMed  Google Scholar 

  3. Oldham KM, Bowen PE (1998) Oxidative stress in critical care: is antioxidant supplementation beneficial? J Am Diet Assoc 98:1001–1008

    Article  PubMed  CAS  Google Scholar 

  4. Goode HF, Webster NR (1993) Anti-oxidants in intensive care medicine. Clin Intensive Care 4:265–270

    Google Scholar 

  5. Carr A, Frei B (2000) The role of natural antioxidants in preserving the biological activity of endothelium-derived nitric oxide. Free Radic Biol Med 28:1806–1814

    Article  PubMed  CAS  Google Scholar 

  6. Vallance P, Chan N (2001) Endothelial function and nitric oxide: clinical relevance. Heart 85:342–350

    Article  PubMed  CAS  Google Scholar 

  7. Haji-Michael PG (2000) Antioxidant therapy in the critically ill. Br J Intensive Care 10:88–93

    Google Scholar 

  8. Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:2002–2012

    Article  PubMed  CAS  Google Scholar 

  9. Cockcroft JR, Wilkinson IB, Webb DJ (1997) Age, arterial stiffness and the endothelium. Age Ageing 26:53–60

    Article  PubMed  Google Scholar 

  10. Nichols WW, O’Rourke MF (1998) McDonald’s Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. 4th edn. Arnold, London

    Google Scholar 

  11. Wilkinson IB, Cockcroft JR, Webb DJ (1998) Pulse wave analysis and arterial stiffness. J Cardiovasc Pharmacol 32 Suppl 3:S33–S37

    Google Scholar 

  12. Cheeseman KH, Salter TF (1993) An introduction to free radical biochemistry. Br Med Bull 49:481–493

    PubMed  CAS  Google Scholar 

  13. Gryglewski RJ, Palmer RMJ, Moncada S (1986) Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320:454–456

    Article  PubMed  CAS  Google Scholar 

  14. Cosentino F, Luscher TF (1998) Tetrahydrobiopterin and endothelial function. Eur Heart J 19(Suppl G):G3–G8

    PubMed  CAS  Google Scholar 

  15. Cosentino F, Katusic ZS (1995) Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries. Circulation 91:139–144

    Article  PubMed  CAS  Google Scholar 

  16. Keaney JF, Guo Y, Cunningham D, Shwaery GT, Xu AM, Vita JA (1996) Vascular incorporation of a-tocopherol prevents endothelial dysfunction due to oxidised LDL by inhibiting protein kinase C stimulation. J Clin Invest 98:386–394

    Article  PubMed  CAS  Google Scholar 

  17. Weber C, Erl W (2000) Modulation of vascular cell activation, function, and apoptosis: role of antioxidants and nuclear factor-kappa B. Curr Topics Cell Regul 36:217–235

    Article  CAS  Google Scholar 

  18. Altavilla D, Saitta A, Guarini S, et al (2001) Oxidative stress causes nuclear factor-kappa В activation in acute hypovolemic hemorrhagic shock. Free Radic Biol Med 30:1055–1066

    Article  PubMed  CAS  Google Scholar 

  19. Abello PA, Fidler SA, Buckley GB, Buchman TG (1994) Antioxidants modulate induction of programmed endothelial cell death (apoptosis) by endotoxin. Arch Surg 129:134–140

    Article  PubMed  CAS  Google Scholar 

  20. Browry VW, Mohr D, Clearly J, Stocker R (1995) Prevention of tocopherol-mediated peroxidation in ubiquinol-20-free human low density lipoprotein. J Biol Chem 270:5756–5763

    Article  Google Scholar 

  21. Halliwell B (1996) Vitamin C: antioxidant or pro-oxidant in vivo. Free Radic Res 25:439–454

    Article  PubMed  CAS  Google Scholar 

  22. Maxwell SRJ (1995) Prospects for the use of antioxidant therapies. Drugs 49:345–361

    Article  PubMed  CAS  Google Scholar 

  23. Stehouwer CDA (1999) Is measurement of endothelial dysfunction clinically useful? Eur J Clin Invest 29:459–461

    Article  PubMed  CAS  Google Scholar 

  24. Smith FCT, Gosling P, Sanghera K, Green MA, Paterson IS, Shearman CP (1994) Micropro-teinuria predicts the severity of systemic effects of reperfusion injury following infrarenal aortic aneurysm surgery. Ann Vase Surg 8:1–5

    Article  Google Scholar 

  25. Shearman CP, Gosling P, Walker KJ (1989) Is low proteinuria an early predictor of severity of acute pancreatitis? J Clin Pathol 42:1132–1135

    Article  PubMed  CAS  Google Scholar 

  26. De Gaudio AR, Spina R, Di Filippo A, Feri M (1999) Glomerular permeability and trauma: a correlation between microalbuminuria and injury severity score. Crit Care Med 27:2105–2108

    Article  PubMed  Google Scholar 

  27. Hack Ce, Zeerleder S (2001) The endothelium in sepsis: source of and target for inflammation. Crit Care Med 29(Suppl):S21–S27

    Article  Google Scholar 

  28. Yamamoto K, Saito H (1998) A pathological role of increased expression of plasminogen activator inhibitor-1 in human or animal disorders. Int J Hematol 68:371–385

    Article  PubMed  CAS  Google Scholar 

  29. Hasdai D, Gibbons RJ, Holmes DR, Higano ST, Lerman A (1997) Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. Circulation 96:3390–3395

    Article  PubMed  CAS  Google Scholar 

  30. McAuliffe AV, Brooks BA, Fisher EJ, Molyneaux LM, Yue DK (1998) Administration of ascorbic acid and an aldose reductase inhibitor (tolrestat) in diabetes: effect on urinary albumin excretion. Nephron 80:277–284

    Article  PubMed  CAS  Google Scholar 

  31. Duffy S J, Gokce N, Holbrook M, et al (1999) Treatment of hypertension with ascorbic acid. Lancet 354:2048–2049

    Article  PubMed  CAS  Google Scholar 

  32. Rossig L, Hoffmann J, Hugel B, et al (2001) Vitamin C inhibits endothelial cell apoptosis in congestive heart failure. Circulation 104:2182–2187

    Article  PubMed  CAS  Google Scholar 

  33. Ceriello A (1997) Acute hyperglycaemia and oxidative stress generation. Diabetic Med 14:S45–S49

    Article  PubMed  Google Scholar 

  34. Beckman JA, Goldfine AB, Gordon MB, Creager MA (2001) Ascorbate restores endothe-lium-dependent vasodilation impaired by acute hyperglycemia in humans. Circulation 103:1618–1623

    Article  PubMed  CAS  Google Scholar 

  35. Marfella R, Verrazzo G, Acampora R, et al (1995) Glutathione reverses systemic hemodynamic changes induced by acute hyperglycemia in healthy subjects. Am J Physiol 268:E1167–E1173

    PubMed  CAS  Google Scholar 

  36. Ceriello A, Curcio F, dello Russo P, et al (1995) The defence against free radicals protects endothelial cells from hyperglycemia-induced plasminogen activator inhibitor-1 over-production. Blood Coagul Fibrinolysis 6:133–137

    Article  PubMed  CAS  Google Scholar 

  37. Ceriello A, Falleti E, Motz E, et al (1998) Hyperglycemia-induced circulating ICAM-1 increase in diabetes mellitus: the possible role of oxidative stress. Horm Metab Res 30:146–149

    Article  PubMed  CAS  Google Scholar 

  38. De Mattia G, Bravi MC, Laurenti O, et al (1998) Reduction of oxidative stress by oral N-acetyl-L-cysteine treatment decreases plasma soluble vascular cell adhesion molecule-1 concentrations in non-obese, non-dyslipidaemic, normotensive patients with non-insulin-dependent diabetes. Diabetologia 41(11):1392–1396

    Article  PubMed  Google Scholar 

  39. Goudev A, Kyurkchiev S, Gergova V, et al (2000) Reduced concentrations of soluble adhesion moleculs after antioxidant supplementation in postmenopausal women with high cardiovascular risk profiles — a randomised double-blind study. Cardiology 94:227–232

    Article  PubMed  CAS  Google Scholar 

  40. Schmidt H, Schmidt W, Müller T, Bohrer H, Gebhard MM, Martin E (1997) N-acetylcysteine attenuates endotoxin-induced leukocyte-endothelial cell adhesion and macromolecular leakage in vivo. Crit Care Med 25:858–863

    Article  PubMed  CAS  Google Scholar 

  41. Porter JM, Ivatury RR, Azimuddin K, Swami R (1999) Antioxidant therapy in the prevention of organ dysfunction syndrome and infections complications after trauma: early results of a prospective randomised study. Am Surg 65:478–483

    PubMed  CAS  Google Scholar 

  42. Tanaka H, Matsuda T, Miyagantani Y, Yukioka T, Matsuda H, Shimazaki S (2000) Reduction of resuscitation fluid volumes in severely burned patients using ascrobic acid administration. Arch Surg 135:326–331

    Article  PubMed  CAS  Google Scholar 

  43. Jackson TS, Xu A, Vita JA, Keaney JFJ (1998) Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res 83:916–922

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Mullan, B.A., McCloskey, B.V. (2002). Antioxidants and Endothelial Function: Therapeutic Implications. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2002. Yearbook of Intensive Care and Emergency Medicine 2002, vol 2002. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56011-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-56011-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43149-7

  • Online ISBN: 978-3-642-56011-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics