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Immunological Mechanisms of Anti-lgE Treatment

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New Trends in Allergy V

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Abstract

Non-anaphylactogenic anti-IgE mAb have been developed over the past decade to treat atopic allergies. These antibodies neutralize circulating IgE molecules, and thus prevent IgE from binding to its receptors, FCERI and CD23. Efficacy of anti-IgE treatment has been shown in several clinical trials,and new, unanticipated, mechanisms by which anti-IgE exerts its clinical effect are being discovered. Here we summarize a number of studies on the immunological mechanisms underlying anti-IgE treatment.

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Authors
  1. R. J. J. van Neerven
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  2. C. P. A. A. van Roomen
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  3. E. F. Knol
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Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein Klinikum Rechts der Isar, Technische Universität München, Biedersteiner Straße 29, 80802, München, Germany

    Johannes Ring (Prof. Dr. Dr.) (Prof. Dr. Dr.)

  2. ZAUM—Zentrum für Allergie und Umwelt, Klin. Kooperationsgruppe Umweltdermatologie und Allergologie GSF, Technische Universität München, Biedersteiner Straße 29, 80802, München, Germany

    Heidrun Behrendt (Prof. Dr.) (Prof. Dr.)

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van Neerven, R.J.J., van Roomen, C.P.A.A., Knol, E.F. (2002). Immunological Mechanisms of Anti-lgE Treatment. In: Ring, J., Behrendt, H. (eds) New Trends in Allergy V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55994-5_36

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  • DOI: https://doi.org/10.1007/978-3-642-55994-5_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62768-2

  • Online ISBN: 978-3-642-55994-5

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