Skip to main content
SpringerLink
Log in

Medikamentöse und toxische Leberschäden

  • Chapter
Klinische Hepatologie

  • 104 Accesses

Zusammenfassung

Die Entwicklung einer Fülle neuer Wirkstoffe in den letzten Jahrzehnten hat zu einer Zunahme unerwünschter Reaktionen der Leber auf Pharmaka geführt. Wenngleich arzneimittelbedingte Leberschäden insgesamt eher selten vorkommen, sollen doch ca. 2% aller im Krankenhaus auftretenden Ikterusfälle und bis zu 25% der fulminanten Hepatitiden medikamentös induziert sein. Auch pflanzliche Präparate und „natürliche“ Heilkräuter sind potenziell hepatotoxisch. Das breite Spektrum medikamentös-toxischer Läsionen erfordert, derartige Schäden differenzialdiagnostisch immer in Erwägung zu ziehen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Banks AT, Zimmerman HJ, Ishak KG et al. (1995) Diclofenac-associated hepatotoxicity: analysis of 180 cases reported to the Food and Drug Administration as adverse reactions. Hepatology 22: 820–827

    Article  PubMed  CAS  Google Scholar 

  • Bass NM, Delmer RK (1996) Drug induced liver disease. In: Zakim D, Boyer TD (eds) Hepatology. A textbook of liver disease, 3rd ed. Saunders, Philadelphia, pp 962–1017

    Google Scholar 

  • Chitturi S, Farrell GC (2000) Herbal hepatotoxicity: an expanding but poorly defined problem. J Gastroenterol Hepatol 15: 1093–1099

    Article  PubMed  CAS  Google Scholar 

  • Consensus Meeting (1990) Criteria of drug-induced liver disorders. J Hepatol 11: 272–276

    Article  Google Scholar 

  • Dancygier H (2001) Medikamentöse/toxische Leberschäden und alkoholische Leberkrankheiten. In: Caspary WF, Leuschner U, Zeuzem S (Hrsg) Therapie von Leber-und Gallekrankheiten, 2. Aufl. Springer, Berlin Heidelberg New York, S 147–164

    Chapter  Google Scholar 

  • Dancygier H, Frühauf H (1997) Klinische Pharmakologie der Leberkrankheiten. In: Kuemmerle HP (Hrsg) Klinische Pharmakologie, 4. Aufl. eco-med, IV-4.11.1, pp 1–77

    Google Scholar 

  • Farrell GC (1994) Drug induced liver disease. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Floersheim GL (1987) Treatment of human amatoxin mushroom poisoning: myths and advances in therapy. Med Toxicol 2: 1–9

    PubMed  CAS  Google Scholar 

  • Gennis MA, Vemuri R, Burns EA et al. (1991) Familial occurrence of hypersensitivity to phenytoin. Am J Med 91: 631–634

    Article  PubMed  CAS  Google Scholar 

  • Geubel AP, Sempoux CL (2000) Drug and toxin-induced bile duct disorders. J Gastroenterol Hepatol 15: 1232–1238

    PubMed  CAS  Google Scholar 

  • Gillette JR, Stripp B (1975) Pre-and postnatal enzyme capacity for drug metabolic production. Fed Proc 34: 172–178

    PubMed  CAS  Google Scholar 

  • Hoft RH, Bunker JP, Goodman HI et al. (1981) Halothan hepatitis in three pairs of closely related women. N Engl J Med 304: 1023–1024

    Article  PubMed  CAS  Google Scholar 

  • Karliova M, Treichel U, Malaga M et al. (2000) Interaction of hypericum perforatum (St. John’s wort) with cyclosporin A metabolism in a patient after liver transplantation. J Hepatol 33:853–855

    Article  Google Scholar 

  • Klein AS, Hart J, Brems JJ et al. (1989) Amanita poisoning: treatment and the role of liver transplantation. Am J Med 86: 187–193

    Article  PubMed  CAS  Google Scholar 

  • Kluge F (1995) Leberschäden durch Fremdstoffe. In: Gerok W, Blum HE (Hrsg) Hepatologie, 2. Aufl. Urban & Schwarzenberg. München Wien Baltimore, S 463–480

    Google Scholar 

  • Kraft M, Spahn TW, Menzel J et al. (2001) Fulminantes Leberversagen nach Einnahme des pflanzlichen Antidepressivums Kava-Kava. Dtsch Med Wochenschr 126: 970–972

    Article  PubMed  CAS  Google Scholar 

  • Larrey D (1997) Hepatotoxicity of herbal remedies. J Hepatol 26 [suppl 1]: 47–51

    Article  PubMed  CAS  Google Scholar 

  • Larrey D, Pageaux GP (1997) Genetic predisposition to druginduced hepatotoxicity. J Hepatol 26 [suppl 2]: 12–21

    Article  PubMed  CAS  Google Scholar 

  • Lee WM (1995) Drug-induced hepatotoxicity. N Engl J Med 333: 1118–1127

    Article  PubMed  CAS  Google Scholar 

  • Lipp HP, Schuler U (1995) Die menschlichen Cytochrom-P-450-Isoenzyme. Arzneimitteltherapie 13: 272–280

    Google Scholar 

  • Makin AJ, Wendon J, Williams R (1995) A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987–1993). Gastroenterology 109: 1907–1916

    Article  PubMed  CAS  Google Scholar 

  • Martin-Facklam M, Drewe J, Haefeli WE (2000) ArzneimittelInteraktionen am Cytochrom-P-450-System. Dtsch Med Wochenschr 125: 63–67

    Article  PubMed  CAS  Google Scholar 

  • Moertel CG, Fleming TR, Macdonald JS et al. (1993) Hepatic toxicity associated with fluorouracil plus levamisole adjuvant therapy. J Clin Oncol 11: 2386–2390

    PubMed  CAS  Google Scholar 

  • Paneitz A, Meissner K, Kroemer HK (2000) Arzneimittelinteraktionen: Neue Mechanismen und klinische Relevanz. Internist 41: 338–343

    Article  PubMed  CAS  Google Scholar 

  • Pelekonen O, Kalhala EH, Lormi TKJ et al. (1973) Comparison of activities of drug metabolizing enzymes in human fetal and adult livers. Clin Pharmacol Ther 14: 840–844

    Google Scholar 

  • Schenker S, Bay M (1994) Drug disposition and hepatotoxicity in the elderly. J Clin Gastroenterol 18: 232–237

    Article  PubMed  CAS  Google Scholar 

  • Schulze J, Endres S (1999) Genotyp, Phänotyp und unerwünschte Arzneimittelreaktionen. Arzneimitteltherapie 17: 196–200

    Google Scholar 

  • Strohmeyer G, Weik C (1999) Leberschädigung durch Medikamente. Z Gastroenterol 37: 367–378

    PubMed  CAS  Google Scholar 

  • Weik C, Strohmeyer G (1999) Hepatobiliäre Erkrankungen im Alter. Dtsch Med Wochenschr 124: 466–471

    Article  PubMed  CAS  Google Scholar 

  • Woodhouse KW, Mutch E, Williams FM et al. (1984) The effect of age on pathways of drug metabolism in human liver. Age Ageing 13: 328–334

    Article  PubMed  CAS  Google Scholar 

  • Zimmerman HJ (1999) Hepatotoxicity. The adverse effects of drugs and other chemicals on the liver, 2nd ed. Lippincott Williams & Wilkins, Baltimore

    Google Scholar 

  • Zimmerman HJ, Maddrey WC (1995) Acetaminophen (Paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventures. Hepatology 22:767–773

    Article  Google Scholar 

Download references

Authors
  1. H. Dancygier
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Dancygier, H. (2003). Medikamentöse und toxische Leberschäden. In: Klinische Hepatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55902-0_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-55902-0_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67559-4

  • Online ISBN: 978-3-642-55902-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation