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Leberzirrhose und Folgeerkrankungen

  • H. Dancygier
  • W. Nagell
Chapter

Zusammenfassung

Die Leberzirrhose stellt das Spätstadium chronisch progredienter Lebererkrankungen unterschiedlicher Åtiologie dar. Sie ist durch Leberzelluntergang, Bindegewebevermehrung und einen knotigen Organumbau mit Verlust der normalen Läppchenarchitektur gekennzeichnet.

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Literatur

  1. Anthony PP, Ishak KG, Nayak NC et al. (1978) The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization. J Clin Pathol 31: 395–414PubMedGoogle Scholar
  2. Bergasa NY, Jones EA (1995) The pruritus of cholestasis: potential pathogenic and therapeutic implications of opioids. Gastroenterology 108: 1582–1588PubMedGoogle Scholar
  3. Butt AK, Khan AA, Alam A et al. (1998) Predicting hospital mortality in cirrhotic patients: comparison of Child-Pugh and acute physiology, age and chronic health evaluation (APACHE III) scoring systems. Am J Gastroenterol 93: 2469–2475PubMedGoogle Scholar
  4. Collier J, Sherman M (1998) Screening for hepatocellular carcinoma. Hepatology 27: 273–278PubMedGoogle Scholar
  5. Cordoba J, Cabréra J, Lataif Let al. (1998) High prevalence of sleep disturbance in cirrhosis. Hepatology 27: 339–345PubMedGoogle Scholar
  6. Delhaye M, Louis H, Degraef C et al. (1999) Hepatocyte proliferative activity in human liver cirrhosis. J Hepatol 30: 461–471PubMedGoogle Scholar
  7. Gaiani S, Gramantieri L, Venturoli N et al. (1997) What is the criterion for differentiating chronic hepatitis from compensated cirrhosis? A prospective study comparing ultrasonography and percutaneous liver biopsy. J Hepatol 6: 979–985Google Scholar
  8. Greeve M, Ferrell L, Kim M et al. (1993) Cirrhosis of undefined pathogenesis: absence of evidence for unknown viruses or autoimmune processes. Hepatology 17: 593–598PubMedGoogle Scholar
  9. Lichtinghagen R, Breitenstein K, Arndt B et al. (1998) Comparison of matrix metalloproteinase expression in normal and cirrhotic liver. Virchows Arch 432: 153–158PubMedGoogle Scholar
  10. Ludwig I, Hashimoto E, Porayko MK et al. (1997) Hemosiderosis in cirrhosis. A study of 447 native livers. Gastroenterology 112: 882–888PubMedGoogle Scholar
  11. Madden AM, Bradbury W, Morgan MY (1997) Taste perception in cirrhosis: its relationship to circulating micronutrients and food preferences. Hepatology 26: 40–48PubMedGoogle Scholar
  12. Maharaj B, Maharaj RJ, Leary WP et al. (1986) Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver. Lancet I: 523–525Google Scholar
  13. Pagliaro L, Rinaldi F, Craxi A et al. (1983) Percutaneous blind biopsy versus laparoscopy with guided biopsy in diagnosis of cirrhosis. A prospective, randomized trial. Dig Dis Sci 28: 39–43PubMedGoogle Scholar
  14. Pateron D, Ganne N, Trinchet IC et al. (1994) Prospective study of screening for hepatocellular carcinoma in Caucasian patients with cirrhosis. J Hepatol 20: 65–71PubMedGoogle Scholar
  15. Scheuer PI (1970) Liver biopsy in the diagnosis of cirrhosis. Gut 11: 275–278PubMedGoogle Scholar
  16. Sciot R, Staessen D, van Damme B et al. (1988) Incomplete septal cirrhosis: histopathological aspects. Histopathology 13: 593–603PubMedGoogle Scholar
  17. Soloway RD, Baggenstoss AH, Schoenfield LI et al. (1971) Observer error and sampling variability tested in evaluation of hepatitis and cirrhosis by liver biopsy. Dig Dis Sci 16: 1082–1086Google Scholar
  18. Taourel P, Blanc P, Dauzat M et al. (1998) Doppler study of mesenteric, hepatic, and portal circulation in alcoholic cirrhosis: relationship between quantitative doppler measurements and the severity of portal hypertension and hepatic failure. Hepatology 28: 932–936PubMedGoogle Scholar
  19. Tanner MS, Portmann B (1981) Indian childhood cirrhosis. Arch Dis Child 56: 4–6PubMedGoogle Scholar
  20. Tradati F, Colombo M, Mannucci PM et al. (1998) A prospective multicenter study of hepatocellular carcinoma in Italian hemophiliacs with chronic hepatitis C. Blood 91: 1173–1177PubMedGoogle Scholar
  21. Trey C, Burns DG, Saunders SJ (1966) Treatment of hepatic coma by exchange blood transfusion. N Engl J Med 274: 473–481PubMedGoogle Scholar

Aszites

  1. Arroyo V, Ginès P, Gerbes A et al. (1996) Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. Hepatology 23: 164–176PubMedGoogle Scholar
  2. Bataller R, Ginès P, Arroyo V (1997) Practical recommendations for the treatment of ascites and ist complications. Drugs 54: 571–580PubMedGoogle Scholar
  3. Fernández-Esparrach G, Sanchez-Fueyo A, Ginès P et al. (2000) A prognostic model for predicting survival in cirrhosis with ascites. J Hepatol 34: 46–52Google Scholar
  4. Gentilini P, Casini-Raggi V, Di Fiore G et al. (1999) Albumin improves the response to diuretics in patients with cirrhosis and ascites: results of a randomized, controlled trial. J Hepatol 30: 639–645PubMedGoogle Scholar
  5. Ginès A, Fernández-Esparrach, Monescillo A et al. (1996) Randomized trial comparing albumin, dextran 70, and polygeline in cirrhotic patients with ascites treated by paracentesis. Gastroenterology 111: 1002–10 10PubMedGoogle Scholar
  6. Ginès P, Arroyo V, Quintero E et al. (1987) Comparison of paracentesis and diuretics in the treatment of cirrhotics with tense ascites: results of a randomised study. Gastroenterology 93: 234–241PubMedGoogle Scholar
  7. Ginès P, Tito LI, Arroyo V et al. (1988) Randomized comparative study of therapeutic paracentesis with and without intravenous albumin in cirrhosis. Gastroenterology 94: 1493–1502PubMedGoogle Scholar
  8. Ginès P, Arroyo V, Vargas V et al. (1991) Paracentesis with intravenous infusion of albumin as compared with peritoneovenous shunting in cirrhosis with refractory ascites. N Engl J Med 325: 829–835PubMedGoogle Scholar
  9. Ginès P, Arroyo V, Rodés J (1999) Ascites, hepatorenal syndrome, and sponateneous bacterial peritonitis: prevention and treatment. In: McDonald JWD, Burroughs AK, Feagan BG (eds) Evidence based gastroenterology and hepatology, BMJ Books, pp 427–442Google Scholar
  10. Lebrec D, Giuily N, Hadengue A et al. (1996) Transjugular intrahepatic portosystemic shunts: comparison with paracentesis in patients with cirrhosis and refractory ascites: a randomized trial. J Hepatol 25: 135–144PubMedGoogle Scholar
  11. Luca A, Garcia-Pagan JC, Bosch J et al. (1995) Beneficial effects of intravenous albumin infusion on the hemodynamic and humoral changes after total paracentesis. Hepatology 22: 753–758PubMedGoogle Scholar
  12. Ochs A, Rössle M, Haag K et al. (1995) The transjugular intrahepatic portosystemic stent-shunt procedure for refractory ascites. N Engl J Med 332: 1192–1197PubMedGoogle Scholar
  13. Roberts LR, Kamath PS (1996) Ascites and hepatorenal syndrome: pathophysiology and management. Mayo Clin Proc 71: 874–881PubMedGoogle Scholar
  14. Rössle M (1996) The transjugular intrahepatic portosystemic shunt. J Hepatol 25: 224–231PubMedGoogle Scholar
  15. Rössle M, Ochs A, Gulberg V et al. (2000) A comparison of paracentesis and transjugular intrahepatic porto systemic shunting in patients with ascites. N Engl J Med 342: 1701–1707PubMedGoogle Scholar
  16. Runyon BA (1997) Treatment of patients with cirrhosis and ascites. Semin Liver Dis 17: 249–260PubMedGoogle Scholar
  17. Runyon BA (1998) AASLD practice guidelines. Management of adult patients with ascites caused by cirrhosis. Hepatology 27:264–272Google Scholar
  18. Vila MC, Sola R, Molina L et al. (1998) Hemodynamic changes in patients developing effective hypovolemia after total paracentesis. J Hepatol 28: 639–645PubMedGoogle Scholar

Gastroösophageale Varizen

  1. Armonis A, Patch D, Burroughs AK (1997) Hepatic venous pressure measurement: an old test as a new prognostic marker in cirrhosis? Hepatology 25: 245–248PubMedGoogle Scholar
  2. Bernard B, Lebrec D, Mathurin P et al. (1997) Beta-adrenergic antagonists in the prevention of gastrointestinal rebleeding in patients with cirrhosis: a meta-analysis. Hepatology 25: 63–70PubMedGoogle Scholar
  3. Boyer TD (1997) Natural history of portal hypertension. Clin Liver Dis 1: 31–44PubMedGoogle Scholar
  4. Boyer TD (2001) Pharmacologic treatment of portal hypertension: past, present, and future. Hepatology 34: 834–839PubMedGoogle Scholar
  5. Chalasani N, Imperiale TF, Ismail A et al. (1999) Predictors of large esophageal varices in patients with cirrhosis. Am J Gastroenterol 94: 3285–3291PubMedGoogle Scholar
  6. D’Amico G, Pagliaro L, Bosch J (1995) The treatment of portal hypertension. A meta-analytic review. Hepatology 22: 332–353PubMedGoogle Scholar
  7. D’Amico G, Pagliaro L, Bosch J (1999) Pharmacological treatment of portal hypertension: an evidence-based approach. Semin Liver Dis 19: 475–505PubMedGoogle Scholar
  8. De Franchis R (1988) Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices — a prospective multicenter study. N Engl J Med 319: 983–989Google Scholar
  9. De Franchis R (2000) Updating consensus in portal hypertension: report of the Baveno III consensus workshop on definitions, methodology and therapeutic strategies in portal hypertension. J Hepatol 33: 846–852PubMedGoogle Scholar
  10. Escorsell A, Bordas JP, Castaneda B et al. (2000) Predictive value of the variceal pressure response to continued pharmacological therapy in patients with cirrhosis and portal hypertension. Hepatology 31: 1061–1067PubMedGoogle Scholar
  11. Garcia-Tsao G, Grace ND, Groszmann RJ et al. (1986) Shortterm effects of propranolol on portal venous pressure. Hepatology 6: 101–106PubMedGoogle Scholar
  12. Goulis J, Armonis A, Patch D et al. (1998) Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage. Hepatology 27: 1207–1212PubMedGoogle Scholar
  13. Goulis J, Burroughs AK (1999) Portal hypertesnsive bleeding: prevention and treatment. In: McDonald JWD, Burroughs AK, Feagan BG (eds) Evidence based gastroenterology and hepatology. BMJ Books, pp 389–426Google Scholar
  14. Gotzsche PC (2000) Somatostatin or octreotide for acute bleeding oesophageal varices. Cochrane Database Syst Rev 2: CD000193Google Scholar
  15. Gournay J, Masliah C, Martin T et al. (2000) Isosorbide mononitrate and propranolol compared with propranolol alone for the prevention of variceal rebleeding. Hepatology 31: 1239–1245PubMedGoogle Scholar
  16. Grace ND, Groszmann RJ, Garcia-Tsao G et al. (1998) Portal hypertension and variceal bleeding: an AASLD single topic symposium. Hepatology 28: 868–880PubMedGoogle Scholar
  17. Hadengue A (1999) Somatostatin or octreotide in acute variceal bleeding. Digestion 60 [suppl 2]: 31–41PubMedGoogle Scholar
  18. Hartigan PM, Gebhard RL, Gregory PB et al. (1997) Sclerotherapy for actively bleeding esophageal varices in male alcoholics with cirrhosis. Gastrointest Endosc 46: 1–7PubMedGoogle Scholar
  19. Hosking SW, Johnson AG, Smart HL et al. (1989) Anorectal varices, hemorrhoids, and portal hypertension. Lancet 1: 349–352PubMedGoogle Scholar
  20. Jalan R, Hayes PC (2000) UK guidelines for the management of variceal hemorrhage in cirrhotic patients. Gut 46 [suppl 3]: 1–15Google Scholar
  21. Lay CS, Tsai YT, Teg CY et al. (1997) Endoscopic variceal ligation in prophylaxis of first variceal bleeding in cirrhotic patients with high risk esophageal varices. Hepatology 25: 1346–1350PubMedGoogle Scholar
  22. Lebrec D (2001) Drug therapy for portal hypertension. Gut 49: 441–442PubMedGoogle Scholar
  23. Lebrec D, Poynard T, Hillon P et al. (1981) Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis. N Engl J Med 305: 1371–1374PubMedGoogle Scholar
  24. Lo GH, Lai KH, Cheng JS et al. (1997) Emergency banding ligation versus sclerotherapy for the control of active bleeding from esophageal varices. Hepatology 25: 1101–1104PubMedGoogle Scholar
  25. Lo GH, Lai KH, Cheng JS et al. (2000) Endoscopic variceal ligation plus nadolol and sucralfate compared with ligation alone for the prevention of variceal bleeding: a prospective, randomized trial. Hepatology 32: 461–465PubMedGoogle Scholar
  26. Merkel C, Marin R, Sacerdoti D et al. (2000) Long-term results of a clinical trial of nadolol with or without isosorbid mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 31: 324–329PubMedGoogle Scholar
  27. Nevens F, Bustami R, Scheys I et al. (1998) Variceal pressure is a factor predicting the risk of a first variceal bleeding: a prospective cohort study in cirrhotic patients. Hepatology 27: 15–19PubMedGoogle Scholar
  28. North Italian Endoscopic Club for the study and treatment of esophageal varices (1988) Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices: a prospective multicenter study. N Engl J Med 319: 983–989Google Scholar
  29. Pauwels A, Mostefa-Kara N, Debenes B et al. (1996) Systemic antibiotic prophylaxis after gastrointestinal hemorrhage in cirrhotic patients with a high risk of infection. Hepatology 24:802–806Google Scholar
  30. Polio J, Groszmann RJ (1986) Hemodynamic factors involved in the development and rupture of esophageal varices: a pathophysiologic approach to treatment. Semin Liver Dis 6: 318–331PubMedGoogle Scholar
  31. Poynard T, Calès P, Pasta L et al. (1991) Beta-adrenergic-antagonist drugs in the prevention of gastrointestinal bleeding in patients with cirrhosis and esophageal varices. N Engl J Med 324: 1532–1538PubMedGoogle Scholar
  32. Sarin SK, Guptan RKC, Jain AK et al. (1996) A randomized controlled trial of variceal band ligation for primary prophylaxis of variceal bleeding. Eur J Gastroenterol Hepatol 8: 337–342PubMedGoogle Scholar
  33. Sarin SK, Lamba GS, Kumar M et al. (1999) Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding. N Engl J Med 340: 988–993PubMedGoogle Scholar
  34. Schepke M, Reichel C, Ziske C et al. (2001) Leberzirrhose — Teil 2: Komplikationen und Therapie. Dtsch Med Wochenschr 126: 978–981PubMedGoogle Scholar
  35. Sharara AI, Rockey DC (2001) Gastroesophageal variceal hemorrhage. N Engl J Med 345: 669–681PubMedGoogle Scholar
  36. Teran JC, Imperiale TF, Mullen KD et al. (1997) Primary prophylaxis of variceal bleeding in cirrhosis: a cost effectiveness analysis. Gastroenterology 112: 473–482PubMedGoogle Scholar
  37. Villanueva C, Balanzo J, Novella MT et al. (1996) Nadolol plus isosorbide mononitrate compared with sclerotherapy for the prevention of variceal bleeding. N Engl J Med 334: 1624–1629PubMedGoogle Scholar
  38. Villanueva C, Minana J, Ortiz J et al. (2001) Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. N Engl J Med 345: 647–655PubMedGoogle Scholar
  39. Walker S (1988) Behandlung der Ösophagusvarizenblutung mit vasoaktiven Substanzen. Dtsch Med Wochenschr 113: 26–31PubMedGoogle Scholar
  40. Westaby D, Hayes PC, Gimson AE et al. (1989) Controlled clinical trial of injection sclerotherapy for active variceal bleeding. Hepatology 9: 274–277PubMedGoogle Scholar

Portal hypertensive Gastroenteropathie und Biliopathie

  1. Balan KK, Jones AT, Roberts NB et al. (1996) The effects of he licobacter pylori colonization on gastric function and the incidence of portal hypertensive gastropathy in patients with cirrhosis of the liver. Am J Gastroenterol 91: 1400–1406PubMedGoogle Scholar
  2. Burak KW, Lee SS, Beck PL (2001) Portal hypertensive gastropathy and gastric antral vascular ectasia (GAVE) syndrome. Gut 49: 866–872PubMedGoogle Scholar
  3. Chandra R, Kapoor D, Tharakan A et al. (2001) Portal biliopathy. J Gastroenterol Hepatol 16: 1086–1092PubMedGoogle Scholar
  4. D’Amico G, Montalbano L, Traina M et al. (1990) Natural history of congestive gastropathy in cirrhosis. Gastroenterology 99: 1558–1564PubMedGoogle Scholar
  5. Hashizume M, Tanaka K, Mokuchi K (1983) Morphology of gastric microcirculation in cirrhosis. Hepatology 6: 1008–1012Google Scholar
  6. Kawanaka H, Tomikawa M, Jones MK et al. (2001) Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications. Hepatology 34: 990–999PubMedGoogle Scholar
  7. McCormack TT, Sim J, Eyre-Brook I et al. (1985) Gastric lesions in portal hypertension: inflammatory gastritis or congestive gastropathy? Gut 26: 1226–1232PubMedGoogle Scholar
  8. Papazian A, Braillon A, Dupas JL et al. (1986) Portal hypertensive gastric mucosa: an endoscopic study. Gut 27: 1199–1203PubMedGoogle Scholar
  9. Perez-Ayuso RM, Piquet JM, Bosch JM et al. (1991) Propranolol in prevention of recurrent bleeding from severe portal hypertensive gastropathy in cirrhosis. Lancet 337: 1431–1434PubMedGoogle Scholar
  10. Primignani M, Carpinelli L, Preatoni P et al. (2000) Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. Gastroenterology 119: 181–187PubMedGoogle Scholar
  11. Sarin SK, Shahi HM, Jain M et al. (2000) The natural history of portal hypertensive gastropathy: influence of variceal eradication. Am J Gastroenterol 95: 2888–2893PubMedGoogle Scholar
  12. Smart HL, Triger DR (1991) Clinical features, pathophysiology and relevance of portal hypertensive gastropathy. Endoscopy 23: 224–228PubMedGoogle Scholar
  13. Viggiano TR, Gostout CJ (1992) Portal hypertensive intestinal vasculopathy. A review of the clinical, endoscopic, and histopathologic features. Am J Gastroenterology 87: 944–954Google Scholar
  14. West MS, Garra BS, Horti SC et al. (1991) Gallbladder varices: imaging findings in patients with portal hypertension. Radiology 179: 179–182PubMedGoogle Scholar
  1. Andreu M, Sola R, Sitges-Serra A et al. (1993) Risk factors for spontaneous bacterial peritonitis in cirrhotic patients with ascites. Gastroenterology 104: 1133–1138PubMedGoogle Scholar
  2. Bahr JM, Manns MP (2001) Funktion des Immunsystems bei Leberzirrhose. Z Gastroenterol 39: 601–607PubMedGoogle Scholar
  3. Bernard B, Grange JD, Khac NE et al. (1999) Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis. Hepatology 29: 1655–1661PubMedGoogle Scholar
  4. Cirera I, Bauer TM, Navasa Met al. (2001) Bacterial translocation of enteric organisms in patients with cirrhosis. J Hepatol 34: 32–37PubMedGoogle Scholar
  5. Gilbert JA, Kamath PS (1995) Spontaneous bacterial peritonitis: an update. Mayo Clin Proc 70: 365–370PubMedGoogle Scholar
  6. Ginès P, Rimola A, Planas R et al. (1990) Norfloxacin prevents spontaneous bacterial peritonitis recurrence in cirrhosis: results of a double blind, placebo-controlled trial. Hepatology 12: 716–724PubMedGoogle Scholar
  7. Ginès P, Navasa M (1998) Antibiotic prophylaxis for spontaneous bacterial peritonitis: how and whom? J Hepatol 29: 490–494PubMedGoogle Scholar
  8. Grange JD, Roulot D, Pelletier G et al. (1998) Norfloxacin prophylaxis of bacterial infections in cirrhotic patients with ascites: a double blind randomized trial. J Hepatol 29: 430–436PubMedGoogle Scholar
  9. Guarner C, Soriano G (1997) Spontaneous bacterial peritonitis. Semin Liver Dis 17: 203–217PubMedGoogle Scholar
  10. Guarner C, Sola R, Soriano G et al. (1999) Risk of a first community-acquired spontaneous bacterial peritonitis in cirrhotics with low ascitic fluid protein levels. Gastroenterology 117: 414–419PubMedGoogle Scholar
  11. Inadomi J, Sonnenberg A (1997) Cost-analysis of prophylactic antibiotics in spontaneous bacterial peritonitis. Gastroenterology 113: 1289–1294PubMedGoogle Scholar
  12. Navarro VJ (1999) Spontaneous bacterial peritonitis. Curr Treat Opt Gastroenterol 2: 457–462Google Scholar
  13. Navasa M, Follo A, Llovet JM et al. (1996) Randomized, comparative study of oral ofloxacin versus intravenous cefotaxim in spontaneous bacterial peritonitis. Gastroenterology 111: 1011–1017PubMedGoogle Scholar
  14. Navasa M, Rimola A, Rodés J (1997) Bacterial infections in liver disease. Semin Liver Dis 17: 323–333PubMedGoogle Scholar
  15. Ramachandran A, Balasubramanian KA (2001) Intestinal dysfunction in liver cirrhosis: its role in spontaneous bacterial peritonitis. J Gastroenterol Hepatol 16: 607–612PubMedGoogle Scholar
  16. Rimola A, Garcia-Tsao G, Navasa M et al. (2000) Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. J Hepatol 32: 142–153PubMedGoogle Scholar
  17. Rolachon A, Cordier L, Bacq Y et al. (1995) Ciprofloxacin and long-term prevention of spontaneous bacterial peritonitis: results of a prospective controlled trial. Hepatology 22: 117l–1174Google Scholar
  18. Runyon BA (1993) Bacterial infections in patients with cirrhosis. J Hepatol 18: 272–272Google Scholar
  19. Schölmerich J, Glück T (1998) Spontane bakterielle Peritonitis. Internist 39: 263–271PubMedGoogle Scholar
  20. Singh N, Gayowski T, Yu VL et al. (1995) Trimethoprim-sulfamethoxazole for the precention of spontaneous bacterial peritonitis in cirrhosis: a randomized trial. Ann Intern Med 122:595–598Google Scholar
  21. Sort P, Navasa M, Arroyo V et al. (1999) Effect of intravenous albumin or renal impairment on mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 341: 403–409PubMedGoogle Scholar
  22. Such J, Runyon BA (1998) Spontaneous bacterial peritonitis. Clin Infect Dis 27: 669–676PubMedGoogle Scholar
  23. Thuluvath PJ, Morss S, Thompson R (2001) Spontaneous bacterial peritonitis — in-hospital mortality, predictors of survival, and health care costs from 1988 to 1998. Am J Gastroenterol 96: 1232–1236PubMedGoogle Scholar
  24. Baktir G, Fisch HU, Karlaganis G (1987) Mechanisms of the excessive sedative response of cirrhotics to benzodiazepines: model experiment with triazolam. Hepatology 7: 629–368Google Scholar
  25. Basile AS, Jones EA (1997) Ammonia and GABA-ergic neurotransmission: interrelated factors in the pathogenesis of hepatic encephalopathy. Hepatology 25: 1303–1305PubMedGoogle Scholar
  26. Blei AT, Cordoba J and The Practice Parameters Committee of the American College of Gastroenterology (2001) Hepatic encephalopathy. Am J Gastroenterol 96: 1968–1975PubMedGoogle Scholar
  27. Conn HO, Bircher J (eds) (1994) Hepatic encephalopathy: syndromes and therapies. Medi-Ed, Bloomington, IllinoisGoogle Scholar
  28. Eriksson LS, Conn HO (1989) Branched chain amino acids in the management of hepatic encephalopathy: an analysis of variants. Hepatology 10: 228–246PubMedGoogle Scholar
  29. Ferenci P (1991) Hepatische Enzephalopathie, Klinik der Gegenwart. Urban & Schwarzenberg, München Wien BaltimoreGoogle Scholar
  30. Ferenci P (1998) Therapie der akuten und chronischen hepatischen Enzephalopathie bei Patienten mit Leberzirrhose. Z Gastroenterol 36: 909–916PubMedGoogle Scholar
  31. Ferenci P (2001) Hepatische Enzephalopathie. Dtsch Med Wochenschr 126: S76–80Google Scholar
  32. Ferenci P, Püspük A, Steidl P (1992) Current concepts in the pathophysiology of hepatic encephalopathy. Eur J Clin Invest 22: 573–581PubMedGoogle Scholar
  33. Groeneweg M, Quero JC, De Bruijn I et al. (1998) Subclinical hepatic encephalopathy impairs daily functioning. Hepatology 28: 45–49PubMedGoogle Scholar
  34. Häussinger D, Maier KP (1996) Hepatische Enzephalopathie. Thieme, Stuttgart New YorkGoogle Scholar
  35. Jalan R, Seery JP, Taylor-Robinson SD (1996) Review article: pathogenesis and treatment of chronic hepatic encephalopathy. Aliment Pharmacol Ther 10: 681–697PubMedGoogle Scholar
  36. Kircheis G, Nilius R, Held C et al. (1997) Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study. Hepatology 25: 1351–1360PubMedGoogle Scholar
  37. Kuhlbusch R, Enck P, Häussinger D (1998) Hepatische Enzephalopathie: neuropsychologische und neurophysiologische Diagnostik. Z Gastroenterol 36: 1075–1083PubMedGoogle Scholar
  38. Kullmann F, Hollerbach S, Holstege A et al. (1995) Subclinical hepatic encephalopathy: the diagnostic value of evoked potentials. J Hepatol 22: 101–110PubMedGoogle Scholar
  39. Norenberg MD (1990) Astrocytes in hepatic encephalopathy. In: Grisolia S, Felipo V, Minana D (eds) Cirrhosis, hepatic encephalopathy and ammonium toxicity. Plenum, New YorkGoogle Scholar
  40. Platell C, Kong SE, McCauley R et al. (2000) Branched-chain amino acids. J Gastroenterol Hepatol 15: 706–717PubMedGoogle Scholar
  41. Plauth M, Egberts EH, Hamster et al. (1993) Long-term treatment of latent portosystemic encephalopathy with branched-chain amino acids. A double-blind placebo controlled crossover study. J Hepatol 17: 308–314PubMedGoogle Scholar
  42. Riordan SM, Williams R (1997) Treatment of hepatic encephalopathy. N Engl J Med 337: 473–479PubMedGoogle Scholar
  43. Staedt U, Leweling H, Gladisch R et al. (1993) Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomised study using a four-fold crossover design. J Hepatol 19: 424–430PubMedGoogle Scholar
  44. Stahl J (1963) Studies of the blood ammonia in liver disease: its diagnostic, prognostic and therapeutic significance. Ann Intern Med 58: 1–24PubMedGoogle Scholar
  45. Stauch S, Kircheis G, Adler G et al. (1998) Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study. J Hepatol 28: 856–864PubMedGoogle Scholar
  46. Watanabe A (1998) Cerebral changes in hepatic encephalopathy. J Gastroenterol Hepatol 13: 752–760PubMedGoogle Scholar
  47. Weissenborn K (1992) Recent developments in the pathophysiology and treatment of hepatic encephalopathy. Bailliere’s Clin Gastroenterol 6: 609–630Google Scholar
  48. Zullo A, Rinaldi V, Meddi P et al. (1999) Helicobacter pylori infection, plasma ammonia levels, and psychometric testing in cirrhotic patients. Am J Gastroenterol 94: 2214–2218PubMedGoogle Scholar
  49. Angeli P, Volpin R, Gerunda G et al. (1999) Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide. Hepatology 29: 1690–1697PubMedGoogle Scholar
  50. Arroyo V, Ginès P, Gerbes A et al. (1996) Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. Hepatology 23: 164–176PubMedGoogle Scholar
  51. Bataller R, Ginès P, Guevara M et al. (1997) Hepatorenal syndrome. Semin Liver Dis 17: 233–247PubMedGoogle Scholar
  52. Bataller R, Ginès P, Arroyo V et al. (2000) Hepatorenal syndrome. Clin Liver Dis 4: 487–507PubMedGoogle Scholar
  53. Biecker E, Brensing K-A, Perz J et al. (1999) Therapie des hepatorenalen Syndroms bei Leberzirrhose. Dtsch Med Wochenschr 124: 1039–1042PubMedGoogle Scholar
  54. Brensing K-A, Textor J, Perz J et al. (2000) Long term outcome after transjugular intrahepatic porto systemic stent-shunt in non-transplant cirrhotics with hepatorenal syndrome: a phase II study. Gut 47: 288–295PubMedGoogle Scholar
  55. Dagher L, Moore (2001) The hepatorenal syndrome. Gut 49: 729–737PubMedGoogle Scholar
  56. Gentilini P, Laffi G, La Villa G et al. (1999) Ascites and hepatorenal syndrome during cirrhosis: two entities or the continuation of the same complication? J Hepatol 31: 1088–1097PubMedGoogle Scholar
  57. Gerbes AL (1992) Medical treatment of ascites and hepatorenal syndrome in cirrhosis. In: Rodès J, Arroyo V (eds) Therapy in liver diseases. Ediciones Doyma, Barcelona, pp 143–148Google Scholar
  58. Ginès A, Escorsell A, Ginès P et al. (1993) Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis. Gastroenterology 105: 229–236PubMedGoogle Scholar
  59. Gonwa TA, Klintmalm GB, Levy Met al. (1995) Impact of pretransplant renal function on survival after liver transplantation. Transplantation 59: 361–365PubMedGoogle Scholar
  60. Guevara M, Ginès P, Bandi JC et al. (1998) Transjugular intrahepatic portosystemic shunt in hepatorenal syndrome: effects on renal function and vasoactive systems. Hepatology 28: 416–422PubMedGoogle Scholar
  61. Guevara M, Ginès P, Fernandez-Esparrach G et al. (1998) Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion. Hepatology 27: 35–41PubMedGoogle Scholar
  62. Gulberg V, Bilzer M, Gerbes AL (1999) Long-term therapy and retreatment of hepatorenal syndrome type 1 with ornipressin and dopamine. Hepatology 30: 870–875PubMedGoogle Scholar
  63. Jeyarajah DR, Gonwa DA, McBride M et al. (1997) Hepatorenal syndrome: combined liver-kidney transplants versus isolated liver transplant. Transplantation 27: 1760–1765Google Scholar
  64. Roberts LR, Kamath PS (1996) Ascites and hepatorenal syndrome: pathophysiology and management. Mayo Clin Proc 71:874–881Google Scholar
  65. Sort P, Navasa M, Arroyo V et al. (1999) Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 341: 403–409PubMedGoogle Scholar
  66. Uriz J, Gines P, Cardenas A et al. (2000) Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome. J Hepatol 33: 43–48PubMedGoogle Scholar
  67. Abrams GA, Nanda NC, Dubovsky EV et al. (1998) Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: a new approach. Gastroenterology 114: 305–310PubMedGoogle Scholar
  68. Alberts WM, Salem AJ, Solomon DA et al. (1991) Hepatic hydrothorax: cause and management. Arch Intern Med 151: 2383–2388PubMedGoogle Scholar
  69. Allgaier HP, Haag K, Blum HE (1998) Das hepatopulmonale Syndrom. Z Gastroenterol 36: 247–251PubMedGoogle Scholar
  70. Castro M, Krowka MJ, Schroeder DR et al. (1996) Frequency and clinical implications of increased pulmonary artery pressures in liver transplant patients. Mayo Clin Proc 71: 543–551PubMedGoogle Scholar
  71. Fallon MB, Abrams GA, Luo B et al. (1997) The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome. Gastroenterology 113: 606–615PubMedGoogle Scholar
  72. Fallon MB, Abrams GA (2000) Pulmonary dysfunction in chronic liver disease. Hepatology 32: 859–865PubMedGoogle Scholar
  73. Hadengue A, Benhayoun MK, Lebrec D (1991) Pulmonary hypertension complicating portal hypertension: prevalence and relation to splanchnic hemodynamics. Gastroenterology 100: 520–528PubMedGoogle Scholar
  74. Herve P, Lebrec D, Brenot F et al. (1998) Pulmonary vascular disorders in portal hypertension. Eur Respir J 11: 1153–1166PubMedGoogle Scholar
  75. Johnston RF, Loo RV (1964) Hepatic hydrothorax. Ann Intern Med 61: 385–401PubMedGoogle Scholar
  76. Krowka MJ, Cortese DA (1994) Hepatopulmonary syndromecurrent concepts in diagnostic and therapeutic considerations. Chest 105: 1528–1537PubMedGoogle Scholar
  77. Krowka MJ, Porayko MK, Plevak DJ et al. (1997) Hepatopulmonary syndrome with progressive hypoxemia as an indication for liver transplantation: case reports and literature review. Mayo Clin Proc 72: 44–53PubMedGoogle Scholar
  78. Krowka MJ, Frantz RP, McGoon MD et al. (1999) Improvement in pulmonary hemodynamics during intravenous epoprostenol (prostacyclin): a study of 15 patients with moderate to severe portopulmonary hypertension. Hepatology 30: 641–648PubMedGoogle Scholar
  79. Kuo PC, Plotkin JS, Gaine S et al. (1999) Portopulmonary hypertension and the liver transplantation candidate. Transplantation 67: 1087–1093PubMedGoogle Scholar
  80. Lange PA, Stoller KJ (1995) The hepatopulmonary syndrome. Ann Intern Med 122: 521–529PubMedGoogle Scholar
  81. Lazaridis KN, Frank JW, Krowka MJ et al. (1999) Hepatic hydrothorax: pathogenesis, diagnosis, and management. Am J Med 107: 262–267PubMedGoogle Scholar
  82. Mandell MS, Groves BM (1996) Pulmonary hypertension in chronic liver disease. Clin Chest Med 17: 17–34PubMedGoogle Scholar
  83. Martinez GP, Barbera JA, Visa J et al. (2001) Hepatopulmonary syndrome in candidates for liver transplantation. J Hepatol 34:651–657Google Scholar
  84. Rodriguez-Roisin R, Agusti AGN, Roca J (1992) The hepatopulmonary syndrome: new name, old complexities. Thorax 47:897–902Google Scholar
  85. Rössle M, Siegerstetter V (1998) Der hepatische Hydrothorax. Empfehlungen für eine rationelle Therapie. Dtsch Med Wochenschr 123: 1485–1489PubMedGoogle Scholar
  86. Schenk P, Madl C, Rezaie-Majd S et al. (2000) Methylene blue improves hepatopulmonary syndrome. Ann Intern Med 133: 701–706PubMedGoogle Scholar
  87. Ahah A, Variyam E (1988) Pericardial effusion and left ventricular dysfunction associated with ascites secondary to hepatic cirrhosis. Arch Intern Med 148: 585–588Google Scholar
  88. Bernardi M, Calandra S, Colantoni A et al. (1998) Q-T interval prolongation in cirrhosis: prevalence, relationship with severity, and etiology of the disease and possible pathogenetic factors. Hepatology 27: 28–34PubMedGoogle Scholar
  89. Brohee D, Franken P, Fievaz M et al. (1984) High-output heart failure secondary to hepatic arteriovenous micro fistulae. Selective arterial embolization treatment. Arch Intern Med 144: 1282–1284PubMedGoogle Scholar
  90. Liu H, Lee SS (1999) Cardiopulmonary dysfunction in cirrhosis. J Gastroenterol Hepatol 14: 600–608PubMedGoogle Scholar
  91. Ma Z, Lee SS (1996) Cirrhotic cardiomyopathy: getting to the heart of the matter. Hepatology 24: 451–459PubMedGoogle Scholar
  92. Naschitz JE, Slobodin G, Lewis RJ et al. (2000) Heart diseases affecting the liver and liver diseases affecting the heart. Am Heart J 140: 111–120PubMedGoogle Scholar
  93. Panos MZ, Moore K, Vlavianos P et al. (1990) Single, total paracentesis for tense ascites: sequential hemodynamic changes and right atrial size. Hepatology 11: 662–667PubMedGoogle Scholar
  94. Pozzi M, Carugo S, Boari G et al. (1997) Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites. Hepatology 26: 1131–1137PubMedGoogle Scholar
  95. Valeriano V, Funaro S, Lionetti R et al. (2000) Modification of cardiac function in cirrhotic patients with and without ascites. Am J Gastroenterol 95: 3200–3205PubMedGoogle Scholar
  96. Bach N, Schaffner F, Kapelman B (1989) Sexual behavior in women with nonalcoholic liver diseases. Hepatology 9: 698–703PubMedGoogle Scholar
  97. Bannister P, Oakes J, Sheridan P et al. (1987) Sex hormone changes in chronic liver disease: a matched study of alcoholic versus non-alcoholic liver disease. Q J Med 63: 305–313PubMedGoogle Scholar
  98. Caronia S, Taylor K, Pagliaro L et al. (1999) Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection. Hepatology 30: 1059–1063PubMedGoogle Scholar
  99. Häussinger D (1995) Leber und endokrines System. In: Gerok W, Blum HE (Hrsg) Hepatologie, 2. Aufl. Urban & Schwarzenberg. München Wien Baltimore, S 789–809Google Scholar
  100. Madersbacher S, Ludvik G, Stulnig T et al. (1996) The impact of liver transplantation on endocrine status in man. Clin Endocrinol 44: 461–466Google Scholar
  101. Merli M, Leonetti F, Riggio O et al. (1999) Glucose intolerance and insulin resistance in cirrhosis are normalized after liver transplantation. Hepatology 30: 649–654PubMedGoogle Scholar
  102. Nolte W, Hartmann H, Ramadori G (1995) Glucose metabolism and liver cirrhosis. Exp Clin Endocrinol 103: 63–74Google Scholar
  103. Petrides AS, Stanley T, Matthews DE et al. (1998) Insulin resistance in cirrhosis: prolonged reduction of hyperinsulinemia normalizes insulin sensitivity. Hepatology 28: 141–149PubMedGoogle Scholar
  104. Siegel EG, Gallwitz B, Schmidt WE et al. (1999) Der hepatogene Diabetes — Aktuelle Konzepte zu Pathophysiologie und Therapie. Dtsch Med Wochenschr 124: 1530–5PubMedGoogle Scholar
  105. Cowan DH (1980) Effect of alcoholism on hemostasis. Semin Hematol 2: 137–147Google Scholar
  106. Kaul V, Munoz SJ (2000) Coagulopathy of liver disease. Curr Treat Op Gastroenterol 3: 433–437Google Scholar
  107. Kelly DA, Tuddenham EG (1986) Haemostatic problems in liver disease. Gut 27: 339–349PubMedGoogle Scholar
  108. Mammen EF (1994) Coagulation defects in liver disease. Med Clin North Am 78: 545–554PubMedGoogle Scholar
  109. Violi F, Ferro D, Basili S et al. (1993) Hyperfibrinolysis resulting from clotting activation in patients with different degrees of cirrhosis. Hepatology 17: 78–83PubMedGoogle Scholar
  110. Compston JE (1986) Hepatic osteodystrophy: vitamin D metabolism in patients with liver disease. Gut 27: 1073–1090PubMedGoogle Scholar
  111. Diamond TH, Stiel D, Lunzer M et al. (1990) Osteoporosis and skeletal fractures in chronic liver disease. Gut 31: 82–87PubMedGoogle Scholar
  112. Rouillard S, Lane NE (2001) Hepatic osteodystrophy. Hepatology 33: 301–307PubMedGoogle Scholar
  113. Walter E, Gerok W (1995) Leber und Bewegungsapparat (Skelett, Gelenke, Muskulatur). In: Gerok W, Blum HE (Hrsg) Hepatologie, 2. Aufl. Urban & Schwarzenberg, Miinchen Wien Baltimore, S 771–785Google Scholar
  114. Angeli P, Albino G, Carraro P et al. (1996) Cirrhosis and muscle cramps: evidence of a causal relationship. Hepatology 23: 264–273PubMedGoogle Scholar
  115. Morrison WL, Bouchier IAD, Gibson JNA et aI. (1990) Skeletal muscle and whole-body protein turnover in cirrhosis. Clin Sci 78: 613–619PubMedGoogle Scholar
  116. Cabré E, Gonzalez-Huix F, Abad Lacruz A et al. (1990) Effect of total enteral nutrition on the short-term outcome of severely malnourished cirrhotics: a randomized controlled trial. Gastroenterology 98: 715–720PubMedGoogle Scholar
  117. Cabré E, Gassull MA (1995) Nutritional support in liver disease. Eur J Gastroenterol Hepatol 7: 528–532PubMedGoogle Scholar
  118. Campillo B, Bories PN, Leluen M et al. (1995) Short term changes in energy metabolism after 1 month of a regular oral diet in severely malnourished cirrhotic patients. Metabolism 44: 765–770PubMedGoogle Scholar
  119. Crawford DH, Shepherd RW, Halliday JW et al. (1994) Body composition in non alcoholic cirrhosis: the effect of disease etiology and severity on nutritional compartments. Gastroenterology 106: 1611–1617PubMedGoogle Scholar
  120. McCullough AJ, Bugianesi E (1997) Protein-calorie malnutrition and the etiology of cirrhosis. Am J Gastroenterol 92: 734–738PubMedGoogle Scholar
  121. Merli M, Riggio O, Dally Let al. (1996) Does malnutrition affect survival in cirrhosis? Hepatology 23: 1041–1046PubMedGoogle Scholar
  122. Muller MJ (1998) Ernührung bei Leberzirrhose. Internist 39: 247–253PubMedGoogle Scholar
  123. Nielson K, Kondrup J, Martinsen L et al. (1995) Long term oral refeeding of patients with cirrhosis of the liver. Br J Nutri 74: 557–567Google Scholar
  124. Pierlich M, SchUtz T, Spachos T et al. (2000) Bioelectrical impedance analysis is a useful bedside technique to assess malnutrition in cirrhotic patients with and without ascites. Hepatology 32: 1208–1215Google Scholar
  125. Platell C, Kong SE, McCauley R et al. (2000) Branched-chain amino acids. J Gastroenterol Hepatol 15: 706–717PubMedGoogle Scholar
  126. Plauth M, Weimann A, Holm E et al. (1999) Leitlinien der GASL zur Erniihrungstherapie bei Leberkrankheiten und Lebertransplantation. Z Gastroenterol 37: 301–312PubMedGoogle Scholar
  127. Sarin SK, Dhingra N, Bansai A et al. (1997) Dietary and nutritional abnormalities in alcoholic liver disease: a comparison with chronic alcoholics without liver disease. Am J Gastroenterol 92: 777–783PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • H. Dancygier
  • W. Nagell

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