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Leberzirrhose und Folgeerkrankungen

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Klinische Hepatologie

Zusammenfassung

Die Leberzirrhose stellt das Spätstadium chronisch progredienter Lebererkrankungen unterschiedlicher Åtiologie dar. Sie ist durch Leberzelluntergang, Bindegewebevermehrung und einen knotigen Organumbau mit Verlust der normalen Läppchenarchitektur gekennzeichnet.

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Literatur

  • Anthony PP, Ishak KG, Nayak NC et al. (1978) The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization. J Clin Pathol 31: 395–414

    PubMed  CAS  Google Scholar 

  • Bergasa NY, Jones EA (1995) The pruritus of cholestasis: potential pathogenic and therapeutic implications of opioids. Gastroenterology 108: 1582–1588

    PubMed  CAS  Google Scholar 

  • Butt AK, Khan AA, Alam A et al. (1998) Predicting hospital mortality in cirrhotic patients: comparison of Child-Pugh and acute physiology, age and chronic health evaluation (APACHE III) scoring systems. Am J Gastroenterol 93: 2469–2475

    PubMed  CAS  Google Scholar 

  • Collier J, Sherman M (1998) Screening for hepatocellular carcinoma. Hepatology 27: 273–278

    PubMed  CAS  Google Scholar 

  • Cordoba J, Cabréra J, Lataif Let al. (1998) High prevalence of sleep disturbance in cirrhosis. Hepatology 27: 339–345

    PubMed  CAS  Google Scholar 

  • Delhaye M, Louis H, Degraef C et al. (1999) Hepatocyte proliferative activity in human liver cirrhosis. J Hepatol 30: 461–471

    PubMed  CAS  Google Scholar 

  • Gaiani S, Gramantieri L, Venturoli N et al. (1997) What is the criterion for differentiating chronic hepatitis from compensated cirrhosis? A prospective study comparing ultrasonography and percutaneous liver biopsy. J Hepatol 6: 979–985

    Google Scholar 

  • Greeve M, Ferrell L, Kim M et al. (1993) Cirrhosis of undefined pathogenesis: absence of evidence for unknown viruses or autoimmune processes. Hepatology 17: 593–598

    PubMed  CAS  Google Scholar 

  • Lichtinghagen R, Breitenstein K, Arndt B et al. (1998) Comparison of matrix metalloproteinase expression in normal and cirrhotic liver. Virchows Arch 432: 153–158

    PubMed  CAS  Google Scholar 

  • Ludwig I, Hashimoto E, Porayko MK et al. (1997) Hemosiderosis in cirrhosis. A study of 447 native livers. Gastroenterology 112: 882–888

    PubMed  CAS  Google Scholar 

  • Madden AM, Bradbury W, Morgan MY (1997) Taste perception in cirrhosis: its relationship to circulating micronutrients and food preferences. Hepatology 26: 40–48

    PubMed  CAS  Google Scholar 

  • Maharaj B, Maharaj RJ, Leary WP et al. (1986) Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver. Lancet I: 523–525

    Google Scholar 

  • Pagliaro L, Rinaldi F, Craxi A et al. (1983) Percutaneous blind biopsy versus laparoscopy with guided biopsy in diagnosis of cirrhosis. A prospective, randomized trial. Dig Dis Sci 28: 39–43

    PubMed  CAS  Google Scholar 

  • Pateron D, Ganne N, Trinchet IC et al. (1994) Prospective study of screening for hepatocellular carcinoma in Caucasian patients with cirrhosis. J Hepatol 20: 65–71

    PubMed  CAS  Google Scholar 

  • Scheuer PI (1970) Liver biopsy in the diagnosis of cirrhosis. Gut 11: 275–278

    PubMed  CAS  Google Scholar 

  • Sciot R, Staessen D, van Damme B et al. (1988) Incomplete septal cirrhosis: histopathological aspects. Histopathology 13: 593–603

    PubMed  CAS  Google Scholar 

  • Soloway RD, Baggenstoss AH, Schoenfield LI et al. (1971) Observer error and sampling variability tested in evaluation of hepatitis and cirrhosis by liver biopsy. Dig Dis Sci 16: 1082–1086

    CAS  Google Scholar 

  • Taourel P, Blanc P, Dauzat M et al. (1998) Doppler study of mesenteric, hepatic, and portal circulation in alcoholic cirrhosis: relationship between quantitative doppler measurements and the severity of portal hypertension and hepatic failure. Hepatology 28: 932–936

    PubMed  CAS  Google Scholar 

  • Tanner MS, Portmann B (1981) Indian childhood cirrhosis. Arch Dis Child 56: 4–6

    PubMed  CAS  Google Scholar 

  • Tradati F, Colombo M, Mannucci PM et al. (1998) A prospective multicenter study of hepatocellular carcinoma in Italian hemophiliacs with chronic hepatitis C. Blood 91: 1173–1177

    PubMed  CAS  Google Scholar 

  • Trey C, Burns DG, Saunders SJ (1966) Treatment of hepatic coma by exchange blood transfusion. N Engl J Med 274: 473–481

    PubMed  CAS  Google Scholar 

  • Andreu M, Sola R, Sitges-Serra A et al. (1993) Risk factors for spontaneous bacterial peritonitis in cirrhotic patients with ascites. Gastroenterology 104: 1133–1138

    PubMed  CAS  Google Scholar 

  • Bahr JM, Manns MP (2001) Funktion des Immunsystems bei Leberzirrhose. Z Gastroenterol 39: 601–607

    PubMed  CAS  Google Scholar 

  • Bernard B, Grange JD, Khac NE et al. (1999) Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis. Hepatology 29: 1655–1661

    PubMed  CAS  Google Scholar 

  • Cirera I, Bauer TM, Navasa Met al. (2001) Bacterial translocation of enteric organisms in patients with cirrhosis. J Hepatol 34: 32–37

    PubMed  CAS  Google Scholar 

  • Gilbert JA, Kamath PS (1995) Spontaneous bacterial peritonitis: an update. Mayo Clin Proc 70: 365–370

    PubMed  CAS  Google Scholar 

  • Ginès P, Rimola A, Planas R et al. (1990) Norfloxacin prevents spontaneous bacterial peritonitis recurrence in cirrhosis: results of a double blind, placebo-controlled trial. Hepatology 12: 716–724

    PubMed  Google Scholar 

  • Ginès P, Navasa M (1998) Antibiotic prophylaxis for spontaneous bacterial peritonitis: how and whom? J Hepatol 29: 490–494

    PubMed  Google Scholar 

  • Grange JD, Roulot D, Pelletier G et al. (1998) Norfloxacin prophylaxis of bacterial infections in cirrhotic patients with ascites: a double blind randomized trial. J Hepatol 29: 430–436

    PubMed  CAS  Google Scholar 

  • Guarner C, Soriano G (1997) Spontaneous bacterial peritonitis. Semin Liver Dis 17: 203–217

    PubMed  CAS  Google Scholar 

  • Guarner C, Sola R, Soriano G et al. (1999) Risk of a first community-acquired spontaneous bacterial peritonitis in cirrhotics with low ascitic fluid protein levels. Gastroenterology 117: 414–419

    PubMed  CAS  Google Scholar 

  • Inadomi J, Sonnenberg A (1997) Cost-analysis of prophylactic antibiotics in spontaneous bacterial peritonitis. Gastroenterology 113: 1289–1294

    PubMed  CAS  Google Scholar 

  • Navarro VJ (1999) Spontaneous bacterial peritonitis. Curr Treat Opt Gastroenterol 2: 457–462

    Google Scholar 

  • Navasa M, Follo A, Llovet JM et al. (1996) Randomized, comparative study of oral ofloxacin versus intravenous cefotaxim in spontaneous bacterial peritonitis. Gastroenterology 111: 1011–1017

    PubMed  CAS  Google Scholar 

  • Navasa M, Rimola A, Rodés J (1997) Bacterial infections in liver disease. Semin Liver Dis 17: 323–333

    PubMed  CAS  Google Scholar 

  • Ramachandran A, Balasubramanian KA (2001) Intestinal dysfunction in liver cirrhosis: its role in spontaneous bacterial peritonitis. J Gastroenterol Hepatol 16: 607–612

    PubMed  CAS  Google Scholar 

  • Rimola A, Garcia-Tsao G, Navasa M et al. (2000) Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. J Hepatol 32: 142–153

    PubMed  CAS  Google Scholar 

  • Rolachon A, Cordier L, Bacq Y et al. (1995) Ciprofloxacin and long-term prevention of spontaneous bacterial peritonitis: results of a prospective controlled trial. Hepatology 22: 117l–1174

    Google Scholar 

  • Runyon BA (1993) Bacterial infections in patients with cirrhosis. J Hepatol 18: 272–272

    Google Scholar 

  • Schölmerich J, Glück T (1998) Spontane bakterielle Peritonitis. Internist 39: 263–271

    PubMed  Google Scholar 

  • Singh N, Gayowski T, Yu VL et al. (1995) Trimethoprim-sulfamethoxazole for the precention of spontaneous bacterial peritonitis in cirrhosis: a randomized trial. Ann Intern Med 122:595–598

    Google Scholar 

  • Sort P, Navasa M, Arroyo V et al. (1999) Effect of intravenous albumin or renal impairment on mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 341: 403–409

    PubMed  CAS  Google Scholar 

  • Such J, Runyon BA (1998) Spontaneous bacterial peritonitis. Clin Infect Dis 27: 669–676

    PubMed  CAS  Google Scholar 

  • Thuluvath PJ, Morss S, Thompson R (2001) Spontaneous bacterial peritonitis — in-hospital mortality, predictors of survival, and health care costs from 1988 to 1998. Am J Gastroenterol 96: 1232–1236

    PubMed  CAS  Google Scholar 

  • Baktir G, Fisch HU, Karlaganis G (1987) Mechanisms of the excessive sedative response of cirrhotics to benzodiazepines: model experiment with triazolam. Hepatology 7: 629–368

    Google Scholar 

  • Basile AS, Jones EA (1997) Ammonia and GABA-ergic neurotransmission: interrelated factors in the pathogenesis of hepatic encephalopathy. Hepatology 25: 1303–1305

    PubMed  CAS  Google Scholar 

  • Blei AT, Cordoba J and The Practice Parameters Committee of the American College of Gastroenterology (2001) Hepatic encephalopathy. Am J Gastroenterol 96: 1968–1975

    PubMed  CAS  Google Scholar 

  • Conn HO, Bircher J (eds) (1994) Hepatic encephalopathy: syndromes and therapies. Medi-Ed, Bloomington, Illinois

    Google Scholar 

  • Eriksson LS, Conn HO (1989) Branched chain amino acids in the management of hepatic encephalopathy: an analysis of variants. Hepatology 10: 228–246

    PubMed  CAS  Google Scholar 

  • Ferenci P (1991) Hepatische Enzephalopathie, Klinik der Gegenwart. Urban & Schwarzenberg, München Wien Baltimore

    Google Scholar 

  • Ferenci P (1998) Therapie der akuten und chronischen hepatischen Enzephalopathie bei Patienten mit Leberzirrhose. Z Gastroenterol 36: 909–916

    PubMed  CAS  Google Scholar 

  • Ferenci P (2001) Hepatische Enzephalopathie. Dtsch Med Wochenschr 126: S76–80

    Google Scholar 

  • Ferenci P, Püspük A, Steidl P (1992) Current concepts in the pathophysiology of hepatic encephalopathy. Eur J Clin Invest 22: 573–581

    PubMed  CAS  Google Scholar 

  • Groeneweg M, Quero JC, De Bruijn I et al. (1998) Subclinical hepatic encephalopathy impairs daily functioning. Hepatology 28: 45–49

    PubMed  CAS  Google Scholar 

  • Häussinger D, Maier KP (1996) Hepatische Enzephalopathie. Thieme, Stuttgart New York

    Google Scholar 

  • Jalan R, Seery JP, Taylor-Robinson SD (1996) Review article: pathogenesis and treatment of chronic hepatic encephalopathy. Aliment Pharmacol Ther 10: 681–697

    PubMed  CAS  Google Scholar 

  • Kircheis G, Nilius R, Held C et al. (1997) Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study. Hepatology 25: 1351–1360

    PubMed  CAS  Google Scholar 

  • Kuhlbusch R, Enck P, Häussinger D (1998) Hepatische Enzephalopathie: neuropsychologische und neurophysiologische Diagnostik. Z Gastroenterol 36: 1075–1083

    PubMed  CAS  Google Scholar 

  • Kullmann F, Hollerbach S, Holstege A et al. (1995) Subclinical hepatic encephalopathy: the diagnostic value of evoked potentials. J Hepatol 22: 101–110

    PubMed  CAS  Google Scholar 

  • Norenberg MD (1990) Astrocytes in hepatic encephalopathy. In: Grisolia S, Felipo V, Minana D (eds) Cirrhosis, hepatic encephalopathy and ammonium toxicity. Plenum, New York

    Google Scholar 

  • Platell C, Kong SE, McCauley R et al. (2000) Branched-chain amino acids. J Gastroenterol Hepatol 15: 706–717

    PubMed  CAS  Google Scholar 

  • Plauth M, Egberts EH, Hamster et al. (1993) Long-term treatment of latent portosystemic encephalopathy with branched-chain amino acids. A double-blind placebo controlled crossover study. J Hepatol 17: 308–314

    PubMed  CAS  Google Scholar 

  • Riordan SM, Williams R (1997) Treatment of hepatic encephalopathy. N Engl J Med 337: 473–479

    PubMed  CAS  Google Scholar 

  • Staedt U, Leweling H, Gladisch R et al. (1993) Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomised study using a four-fold crossover design. J Hepatol 19: 424–430

    PubMed  CAS  Google Scholar 

  • Stahl J (1963) Studies of the blood ammonia in liver disease: its diagnostic, prognostic and therapeutic significance. Ann Intern Med 58: 1–24

    PubMed  CAS  Google Scholar 

  • Stauch S, Kircheis G, Adler G et al. (1998) Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study. J Hepatol 28: 856–864

    PubMed  CAS  Google Scholar 

  • Watanabe A (1998) Cerebral changes in hepatic encephalopathy. J Gastroenterol Hepatol 13: 752–760

    PubMed  CAS  Google Scholar 

  • Weissenborn K (1992) Recent developments in the pathophysiology and treatment of hepatic encephalopathy. Bailliere’s Clin Gastroenterol 6: 609–630

    CAS  Google Scholar 

  • Zullo A, Rinaldi V, Meddi P et al. (1999) Helicobacter pylori infection, plasma ammonia levels, and psychometric testing in cirrhotic patients. Am J Gastroenterol 94: 2214–2218

    PubMed  CAS  Google Scholar 

  • Angeli P, Volpin R, Gerunda G et al. (1999) Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide. Hepatology 29: 1690–1697

    PubMed  CAS  Google Scholar 

  • Arroyo V, Ginès P, Gerbes A et al. (1996) Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. Hepatology 23: 164–176

    PubMed  CAS  Google Scholar 

  • Bataller R, Ginès P, Guevara M et al. (1997) Hepatorenal syndrome. Semin Liver Dis 17: 233–247

    PubMed  CAS  Google Scholar 

  • Bataller R, Ginès P, Arroyo V et al. (2000) Hepatorenal syndrome. Clin Liver Dis 4: 487–507

    PubMed  CAS  Google Scholar 

  • Biecker E, Brensing K-A, Perz J et al. (1999) Therapie des hepatorenalen Syndroms bei Leberzirrhose. Dtsch Med Wochenschr 124: 1039–1042

    PubMed  CAS  Google Scholar 

  • Brensing K-A, Textor J, Perz J et al. (2000) Long term outcome after transjugular intrahepatic porto systemic stent-shunt in non-transplant cirrhotics with hepatorenal syndrome: a phase II study. Gut 47: 288–295

    PubMed  CAS  Google Scholar 

  • Dagher L, Moore (2001) The hepatorenal syndrome. Gut 49: 729–737

    PubMed  CAS  Google Scholar 

  • Gentilini P, Laffi G, La Villa G et al. (1999) Ascites and hepatorenal syndrome during cirrhosis: two entities or the continuation of the same complication? J Hepatol 31: 1088–1097

    PubMed  CAS  Google Scholar 

  • Gerbes AL (1992) Medical treatment of ascites and hepatorenal syndrome in cirrhosis. In: Rodès J, Arroyo V (eds) Therapy in liver diseases. Ediciones Doyma, Barcelona, pp 143–148

    Google Scholar 

  • Ginès A, Escorsell A, Ginès P et al. (1993) Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis. Gastroenterology 105: 229–236

    PubMed  Google Scholar 

  • Gonwa TA, Klintmalm GB, Levy Met al. (1995) Impact of pretransplant renal function on survival after liver transplantation. Transplantation 59: 361–365

    PubMed  CAS  Google Scholar 

  • Guevara M, Ginès P, Bandi JC et al. (1998) Transjugular intrahepatic portosystemic shunt in hepatorenal syndrome: effects on renal function and vasoactive systems. Hepatology 28: 416–422

    PubMed  CAS  Google Scholar 

  • Guevara M, Ginès P, Fernandez-Esparrach G et al. (1998) Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion. Hepatology 27: 35–41

    PubMed  CAS  Google Scholar 

  • Gulberg V, Bilzer M, Gerbes AL (1999) Long-term therapy and retreatment of hepatorenal syndrome type 1 with ornipressin and dopamine. Hepatology 30: 870–875

    PubMed  CAS  Google Scholar 

  • Jeyarajah DR, Gonwa DA, McBride M et al. (1997) Hepatorenal syndrome: combined liver-kidney transplants versus isolated liver transplant. Transplantation 27: 1760–1765

    Google Scholar 

  • Roberts LR, Kamath PS (1996) Ascites and hepatorenal syndrome: pathophysiology and management. Mayo Clin Proc 71:874–881

    Google Scholar 

  • Sort P, Navasa M, Arroyo V et al. (1999) Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 341: 403–409

    PubMed  CAS  Google Scholar 

  • Uriz J, Gines P, Cardenas A et al. (2000) Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome. J Hepatol 33: 43–48

    PubMed  CAS  Google Scholar 

  • Abrams GA, Nanda NC, Dubovsky EV et al. (1998) Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: a new approach. Gastroenterology 114: 305–310

    PubMed  CAS  Google Scholar 

  • Alberts WM, Salem AJ, Solomon DA et al. (1991) Hepatic hydrothorax: cause and management. Arch Intern Med 151: 2383–2388

    PubMed  CAS  Google Scholar 

  • Allgaier HP, Haag K, Blum HE (1998) Das hepatopulmonale Syndrom. Z Gastroenterol 36: 247–251

    PubMed  CAS  Google Scholar 

  • Castro M, Krowka MJ, Schroeder DR et al. (1996) Frequency and clinical implications of increased pulmonary artery pressures in liver transplant patients. Mayo Clin Proc 71: 543–551

    PubMed  CAS  Google Scholar 

  • Fallon MB, Abrams GA, Luo B et al. (1997) The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome. Gastroenterology 113: 606–615

    PubMed  CAS  Google Scholar 

  • Fallon MB, Abrams GA (2000) Pulmonary dysfunction in chronic liver disease. Hepatology 32: 859–865

    PubMed  CAS  Google Scholar 

  • Hadengue A, Benhayoun MK, Lebrec D (1991) Pulmonary hypertension complicating portal hypertension: prevalence and relation to splanchnic hemodynamics. Gastroenterology 100: 520–528

    PubMed  CAS  Google Scholar 

  • Herve P, Lebrec D, Brenot F et al. (1998) Pulmonary vascular disorders in portal hypertension. Eur Respir J 11: 1153–1166

    PubMed  CAS  Google Scholar 

  • Johnston RF, Loo RV (1964) Hepatic hydrothorax. Ann Intern Med 61: 385–401

    PubMed  CAS  Google Scholar 

  • Krowka MJ, Cortese DA (1994) Hepatopulmonary syndromecurrent concepts in diagnostic and therapeutic considerations. Chest 105: 1528–1537

    PubMed  CAS  Google Scholar 

  • Krowka MJ, Porayko MK, Plevak DJ et al. (1997) Hepatopulmonary syndrome with progressive hypoxemia as an indication for liver transplantation: case reports and literature review. Mayo Clin Proc 72: 44–53

    PubMed  CAS  Google Scholar 

  • Krowka MJ, Frantz RP, McGoon MD et al. (1999) Improvement in pulmonary hemodynamics during intravenous epoprostenol (prostacyclin): a study of 15 patients with moderate to severe portopulmonary hypertension. Hepatology 30: 641–648

    PubMed  CAS  Google Scholar 

  • Kuo PC, Plotkin JS, Gaine S et al. (1999) Portopulmonary hypertension and the liver transplantation candidate. Transplantation 67: 1087–1093

    PubMed  CAS  Google Scholar 

  • Lange PA, Stoller KJ (1995) The hepatopulmonary syndrome. Ann Intern Med 122: 521–529

    PubMed  CAS  Google Scholar 

  • Lazaridis KN, Frank JW, Krowka MJ et al. (1999) Hepatic hydrothorax: pathogenesis, diagnosis, and management. Am J Med 107: 262–267

    PubMed  CAS  Google Scholar 

  • Mandell MS, Groves BM (1996) Pulmonary hypertension in chronic liver disease. Clin Chest Med 17: 17–34

    PubMed  CAS  Google Scholar 

  • Martinez GP, Barbera JA, Visa J et al. (2001) Hepatopulmonary syndrome in candidates for liver transplantation. J Hepatol 34:651–657

    Google Scholar 

  • Rodriguez-Roisin R, Agusti AGN, Roca J (1992) The hepatopulmonary syndrome: new name, old complexities. Thorax 47:897–902

    Google Scholar 

  • Rössle M, Siegerstetter V (1998) Der hepatische Hydrothorax. Empfehlungen für eine rationelle Therapie. Dtsch Med Wochenschr 123: 1485–1489

    PubMed  Google Scholar 

  • Schenk P, Madl C, Rezaie-Majd S et al. (2000) Methylene blue improves hepatopulmonary syndrome. Ann Intern Med 133: 701–706

    PubMed  CAS  Google Scholar 

  • Ahah A, Variyam E (1988) Pericardial effusion and left ventricular dysfunction associated with ascites secondary to hepatic cirrhosis. Arch Intern Med 148: 585–588

    Google Scholar 

  • Bernardi M, Calandra S, Colantoni A et al. (1998) Q-T interval prolongation in cirrhosis: prevalence, relationship with severity, and etiology of the disease and possible pathogenetic factors. Hepatology 27: 28–34

    PubMed  CAS  Google Scholar 

  • Brohee D, Franken P, Fievaz M et al. (1984) High-output heart failure secondary to hepatic arteriovenous micro fistulae. Selective arterial embolization treatment. Arch Intern Med 144: 1282–1284

    PubMed  CAS  Google Scholar 

  • Liu H, Lee SS (1999) Cardiopulmonary dysfunction in cirrhosis. J Gastroenterol Hepatol 14: 600–608

    PubMed  CAS  Google Scholar 

  • Ma Z, Lee SS (1996) Cirrhotic cardiomyopathy: getting to the heart of the matter. Hepatology 24: 451–459

    PubMed  CAS  Google Scholar 

  • Naschitz JE, Slobodin G, Lewis RJ et al. (2000) Heart diseases affecting the liver and liver diseases affecting the heart. Am Heart J 140: 111–120

    PubMed  CAS  Google Scholar 

  • Panos MZ, Moore K, Vlavianos P et al. (1990) Single, total paracentesis for tense ascites: sequential hemodynamic changes and right atrial size. Hepatology 11: 662–667

    PubMed  CAS  Google Scholar 

  • Pozzi M, Carugo S, Boari G et al. (1997) Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites. Hepatology 26: 1131–1137

    PubMed  CAS  Google Scholar 

  • Valeriano V, Funaro S, Lionetti R et al. (2000) Modification of cardiac function in cirrhotic patients with and without ascites. Am J Gastroenterol 95: 3200–3205

    PubMed  CAS  Google Scholar 

  • Bach N, Schaffner F, Kapelman B (1989) Sexual behavior in women with nonalcoholic liver diseases. Hepatology 9: 698–703

    PubMed  CAS  Google Scholar 

  • Bannister P, Oakes J, Sheridan P et al. (1987) Sex hormone changes in chronic liver disease: a matched study of alcoholic versus non-alcoholic liver disease. Q J Med 63: 305–313

    PubMed  CAS  Google Scholar 

  • Caronia S, Taylor K, Pagliaro L et al. (1999) Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection. Hepatology 30: 1059–1063

    PubMed  CAS  Google Scholar 

  • Häussinger D (1995) Leber und endokrines System. In: Gerok W, Blum HE (Hrsg) Hepatologie, 2. Aufl. Urban & Schwarzenberg. München Wien Baltimore, S 789–809

    Google Scholar 

  • Madersbacher S, Ludvik G, Stulnig T et al. (1996) The impact of liver transplantation on endocrine status in man. Clin Endocrinol 44: 461–466

    CAS  Google Scholar 

  • Merli M, Leonetti F, Riggio O et al. (1999) Glucose intolerance and insulin resistance in cirrhosis are normalized after liver transplantation. Hepatology 30: 649–654

    PubMed  CAS  Google Scholar 

  • Nolte W, Hartmann H, Ramadori G (1995) Glucose metabolism and liver cirrhosis. Exp Clin Endocrinol 103: 63–74

    CAS  Google Scholar 

  • Petrides AS, Stanley T, Matthews DE et al. (1998) Insulin resistance in cirrhosis: prolonged reduction of hyperinsulinemia normalizes insulin sensitivity. Hepatology 28: 141–149

    PubMed  CAS  Google Scholar 

  • Siegel EG, Gallwitz B, Schmidt WE et al. (1999) Der hepatogene Diabetes — Aktuelle Konzepte zu Pathophysiologie und Therapie. Dtsch Med Wochenschr 124: 1530–5

    PubMed  CAS  Google Scholar 

  • Cowan DH (1980) Effect of alcoholism on hemostasis. Semin Hematol 2: 137–147

    Google Scholar 

  • Kaul V, Munoz SJ (2000) Coagulopathy of liver disease. Curr Treat Op Gastroenterol 3: 433–437

    Google Scholar 

  • Kelly DA, Tuddenham EG (1986) Haemostatic problems in liver disease. Gut 27: 339–349

    PubMed  CAS  Google Scholar 

  • Mammen EF (1994) Coagulation defects in liver disease. Med Clin North Am 78: 545–554

    PubMed  CAS  Google Scholar 

  • Violi F, Ferro D, Basili S et al. (1993) Hyperfibrinolysis resulting from clotting activation in patients with different degrees of cirrhosis. Hepatology 17: 78–83

    PubMed  CAS  Google Scholar 

  • Compston JE (1986) Hepatic osteodystrophy: vitamin D metabolism in patients with liver disease. Gut 27: 1073–1090

    PubMed  CAS  Google Scholar 

  • Diamond TH, Stiel D, Lunzer M et al. (1990) Osteoporosis and skeletal fractures in chronic liver disease. Gut 31: 82–87

    PubMed  CAS  Google Scholar 

  • Rouillard S, Lane NE (2001) Hepatic osteodystrophy. Hepatology 33: 301–307

    PubMed  CAS  Google Scholar 

  • Walter E, Gerok W (1995) Leber und Bewegungsapparat (Skelett, Gelenke, Muskulatur). In: Gerok W, Blum HE (Hrsg) Hepatologie, 2. Aufl. Urban & Schwarzenberg, Miinchen Wien Baltimore, S 771–785

    Google Scholar 

  • Angeli P, Albino G, Carraro P et al. (1996) Cirrhosis and muscle cramps: evidence of a causal relationship. Hepatology 23: 264–273

    PubMed  CAS  Google Scholar 

  • Morrison WL, Bouchier IAD, Gibson JNA et aI. (1990) Skeletal muscle and whole-body protein turnover in cirrhosis. Clin Sci 78: 613–619

    PubMed  CAS  Google Scholar 

  • Cabré E, Gonzalez-Huix F, Abad Lacruz A et al. (1990) Effect of total enteral nutrition on the short-term outcome of severely malnourished cirrhotics: a randomized controlled trial. Gastroenterology 98: 715–720

    PubMed  Google Scholar 

  • Cabré E, Gassull MA (1995) Nutritional support in liver disease. Eur J Gastroenterol Hepatol 7: 528–532

    PubMed  Google Scholar 

  • Campillo B, Bories PN, Leluen M et al. (1995) Short term changes in energy metabolism after 1 month of a regular oral diet in severely malnourished cirrhotic patients. Metabolism 44: 765–770

    PubMed  CAS  Google Scholar 

  • Crawford DH, Shepherd RW, Halliday JW et al. (1994) Body composition in non alcoholic cirrhosis: the effect of disease etiology and severity on nutritional compartments. Gastroenterology 106: 1611–1617

    PubMed  CAS  Google Scholar 

  • McCullough AJ, Bugianesi E (1997) Protein-calorie malnutrition and the etiology of cirrhosis. Am J Gastroenterol 92: 734–738

    PubMed  CAS  Google Scholar 

  • Merli M, Riggio O, Dally Let al. (1996) Does malnutrition affect survival in cirrhosis? Hepatology 23: 1041–1046

    PubMed  CAS  Google Scholar 

  • Muller MJ (1998) Ernührung bei Leberzirrhose. Internist 39: 247–253

    PubMed  CAS  Google Scholar 

  • Nielson K, Kondrup J, Martinsen L et al. (1995) Long term oral refeeding of patients with cirrhosis of the liver. Br J Nutri 74: 557–567

    Google Scholar 

  • Pierlich M, SchUtz T, Spachos T et al. (2000) Bioelectrical impedance analysis is a useful bedside technique to assess malnutrition in cirrhotic patients with and without ascites. Hepatology 32: 1208–1215

    Google Scholar 

  • Platell C, Kong SE, McCauley R et al. (2000) Branched-chain amino acids. J Gastroenterol Hepatol 15: 706–717

    PubMed  CAS  Google Scholar 

  • Plauth M, Weimann A, Holm E et al. (1999) Leitlinien der GASL zur Erniihrungstherapie bei Leberkrankheiten und Lebertransplantation. Z Gastroenterol 37: 301–312

    PubMed  CAS  Google Scholar 

  • Sarin SK, Dhingra N, Bansai A et al. (1997) Dietary and nutritional abnormalities in alcoholic liver disease: a comparison with chronic alcoholics without liver disease. Am J Gastroenterol 92: 777–783

    PubMed  CAS  Google Scholar 

Aszites

  • Arroyo V, Ginès P, Gerbes A et al. (1996) Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. Hepatology 23: 164–176

    PubMed  CAS  Google Scholar 

  • Bataller R, Ginès P, Arroyo V (1997) Practical recommendations for the treatment of ascites and ist complications. Drugs 54: 571–580

    PubMed  CAS  Google Scholar 

  • Fernández-Esparrach G, Sanchez-Fueyo A, Ginès P et al. (2000) A prognostic model for predicting survival in cirrhosis with ascites. J Hepatol 34: 46–52

    Google Scholar 

  • Gentilini P, Casini-Raggi V, Di Fiore G et al. (1999) Albumin improves the response to diuretics in patients with cirrhosis and ascites: results of a randomized, controlled trial. J Hepatol 30: 639–645

    PubMed  CAS  Google Scholar 

  • Ginès A, Fernández-Esparrach, Monescillo A et al. (1996) Randomized trial comparing albumin, dextran 70, and polygeline in cirrhotic patients with ascites treated by paracentesis. Gastroenterology 111: 1002–10 10

    PubMed  Google Scholar 

  • Ginès P, Arroyo V, Quintero E et al. (1987) Comparison of paracentesis and diuretics in the treatment of cirrhotics with tense ascites: results of a randomised study. Gastroenterology 93: 234–241

    PubMed  Google Scholar 

  • Ginès P, Tito LI, Arroyo V et al. (1988) Randomized comparative study of therapeutic paracentesis with and without intravenous albumin in cirrhosis. Gastroenterology 94: 1493–1502

    PubMed  Google Scholar 

  • Ginès P, Arroyo V, Vargas V et al. (1991) Paracentesis with intravenous infusion of albumin as compared with peritoneovenous shunting in cirrhosis with refractory ascites. N Engl J Med 325: 829–835

    PubMed  Google Scholar 

  • Ginès P, Arroyo V, Rodés J (1999) Ascites, hepatorenal syndrome, and sponateneous bacterial peritonitis: prevention and treatment. In: McDonald JWD, Burroughs AK, Feagan BG (eds) Evidence based gastroenterology and hepatology, BMJ Books, pp 427–442

    Google Scholar 

  • Lebrec D, Giuily N, Hadengue A et al. (1996) Transjugular intrahepatic portosystemic shunts: comparison with paracentesis in patients with cirrhosis and refractory ascites: a randomized trial. J Hepatol 25: 135–144

    PubMed  CAS  Google Scholar 

  • Luca A, Garcia-Pagan JC, Bosch J et al. (1995) Beneficial effects of intravenous albumin infusion on the hemodynamic and humoral changes after total paracentesis. Hepatology 22: 753–758

    PubMed  CAS  Google Scholar 

  • Ochs A, Rössle M, Haag K et al. (1995) The transjugular intrahepatic portosystemic stent-shunt procedure for refractory ascites. N Engl J Med 332: 1192–1197

    PubMed  CAS  Google Scholar 

  • Roberts LR, Kamath PS (1996) Ascites and hepatorenal syndrome: pathophysiology and management. Mayo Clin Proc 71: 874–881

    PubMed  CAS  Google Scholar 

  • Rössle M (1996) The transjugular intrahepatic portosystemic shunt. J Hepatol 25: 224–231

    PubMed  Google Scholar 

  • Rössle M, Ochs A, Gulberg V et al. (2000) A comparison of paracentesis and transjugular intrahepatic porto systemic shunting in patients with ascites. N Engl J Med 342: 1701–1707

    PubMed  Google Scholar 

  • Runyon BA (1997) Treatment of patients with cirrhosis and ascites. Semin Liver Dis 17: 249–260

    PubMed  CAS  Google Scholar 

  • Runyon BA (1998) AASLD practice guidelines. Management of adult patients with ascites caused by cirrhosis. Hepatology 27:264–272

    Google Scholar 

  • Vila MC, Sola R, Molina L et al. (1998) Hemodynamic changes in patients developing effective hypovolemia after total paracentesis. J Hepatol 28: 639–645

    PubMed  CAS  Google Scholar 

Gastroösophageale Varizen

  • Armonis A, Patch D, Burroughs AK (1997) Hepatic venous pressure measurement: an old test as a new prognostic marker in cirrhosis? Hepatology 25: 245–248

    PubMed  CAS  Google Scholar 

  • Bernard B, Lebrec D, Mathurin P et al. (1997) Beta-adrenergic antagonists in the prevention of gastrointestinal rebleeding in patients with cirrhosis: a meta-analysis. Hepatology 25: 63–70

    PubMed  CAS  Google Scholar 

  • Boyer TD (1997) Natural history of portal hypertension. Clin Liver Dis 1: 31–44

    PubMed  CAS  Google Scholar 

  • Boyer TD (2001) Pharmacologic treatment of portal hypertension: past, present, and future. Hepatology 34: 834–839

    PubMed  CAS  Google Scholar 

  • Chalasani N, Imperiale TF, Ismail A et al. (1999) Predictors of large esophageal varices in patients with cirrhosis. Am J Gastroenterol 94: 3285–3291

    PubMed  CAS  Google Scholar 

  • D’Amico G, Pagliaro L, Bosch J (1995) The treatment of portal hypertension. A meta-analytic review. Hepatology 22: 332–353

    PubMed  Google Scholar 

  • D’Amico G, Pagliaro L, Bosch J (1999) Pharmacological treatment of portal hypertension: an evidence-based approach. Semin Liver Dis 19: 475–505

    PubMed  Google Scholar 

  • De Franchis R (1988) Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices — a prospective multicenter study. N Engl J Med 319: 983–989

    Google Scholar 

  • De Franchis R (2000) Updating consensus in portal hypertension: report of the Baveno III consensus workshop on definitions, methodology and therapeutic strategies in portal hypertension. J Hepatol 33: 846–852

    PubMed  Google Scholar 

  • Escorsell A, Bordas JP, Castaneda B et al. (2000) Predictive value of the variceal pressure response to continued pharmacological therapy in patients with cirrhosis and portal hypertension. Hepatology 31: 1061–1067

    PubMed  CAS  Google Scholar 

  • Garcia-Tsao G, Grace ND, Groszmann RJ et al. (1986) Shortterm effects of propranolol on portal venous pressure. Hepatology 6: 101–106

    PubMed  CAS  Google Scholar 

  • Goulis J, Armonis A, Patch D et al. (1998) Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage. Hepatology 27: 1207–1212

    PubMed  CAS  Google Scholar 

  • Goulis J, Burroughs AK (1999) Portal hypertesnsive bleeding: prevention and treatment. In: McDonald JWD, Burroughs AK, Feagan BG (eds) Evidence based gastroenterology and hepatology. BMJ Books, pp 389–426

    Google Scholar 

  • Gotzsche PC (2000) Somatostatin or octreotide for acute bleeding oesophageal varices. Cochrane Database Syst Rev 2: CD000193

    Google Scholar 

  • Gournay J, Masliah C, Martin T et al. (2000) Isosorbide mononitrate and propranolol compared with propranolol alone for the prevention of variceal rebleeding. Hepatology 31: 1239–1245

    PubMed  CAS  Google Scholar 

  • Grace ND, Groszmann RJ, Garcia-Tsao G et al. (1998) Portal hypertension and variceal bleeding: an AASLD single topic symposium. Hepatology 28: 868–880

    PubMed  CAS  Google Scholar 

  • Hadengue A (1999) Somatostatin or octreotide in acute variceal bleeding. Digestion 60 [suppl 2]: 31–41

    PubMed  CAS  Google Scholar 

  • Hartigan PM, Gebhard RL, Gregory PB et al. (1997) Sclerotherapy for actively bleeding esophageal varices in male alcoholics with cirrhosis. Gastrointest Endosc 46: 1–7

    PubMed  CAS  Google Scholar 

  • Hosking SW, Johnson AG, Smart HL et al. (1989) Anorectal varices, hemorrhoids, and portal hypertension. Lancet 1: 349–352

    PubMed  CAS  Google Scholar 

  • Jalan R, Hayes PC (2000) UK guidelines for the management of variceal hemorrhage in cirrhotic patients. Gut 46 [suppl 3]: 1–15

    Google Scholar 

  • Lay CS, Tsai YT, Teg CY et al. (1997) Endoscopic variceal ligation in prophylaxis of first variceal bleeding in cirrhotic patients with high risk esophageal varices. Hepatology 25: 1346–1350

    PubMed  CAS  Google Scholar 

  • Lebrec D (2001) Drug therapy for portal hypertension. Gut 49: 441–442

    PubMed  CAS  Google Scholar 

  • Lebrec D, Poynard T, Hillon P et al. (1981) Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis. N Engl J Med 305: 1371–1374

    PubMed  CAS  Google Scholar 

  • Lo GH, Lai KH, Cheng JS et al. (1997) Emergency banding ligation versus sclerotherapy for the control of active bleeding from esophageal varices. Hepatology 25: 1101–1104

    PubMed  CAS  Google Scholar 

  • Lo GH, Lai KH, Cheng JS et al. (2000) Endoscopic variceal ligation plus nadolol and sucralfate compared with ligation alone for the prevention of variceal bleeding: a prospective, randomized trial. Hepatology 32: 461–465

    PubMed  CAS  Google Scholar 

  • Merkel C, Marin R, Sacerdoti D et al. (2000) Long-term results of a clinical trial of nadolol with or without isosorbid mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 31: 324–329

    PubMed  CAS  Google Scholar 

  • Nevens F, Bustami R, Scheys I et al. (1998) Variceal pressure is a factor predicting the risk of a first variceal bleeding: a prospective cohort study in cirrhotic patients. Hepatology 27: 15–19

    PubMed  CAS  Google Scholar 

  • North Italian Endoscopic Club for the study and treatment of esophageal varices (1988) Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices: a prospective multicenter study. N Engl J Med 319: 983–989

    Google Scholar 

  • Pauwels A, Mostefa-Kara N, Debenes B et al. (1996) Systemic antibiotic prophylaxis after gastrointestinal hemorrhage in cirrhotic patients with a high risk of infection. Hepatology 24:802–806

    Google Scholar 

  • Polio J, Groszmann RJ (1986) Hemodynamic factors involved in the development and rupture of esophageal varices: a pathophysiologic approach to treatment. Semin Liver Dis 6: 318–331

    PubMed  CAS  Google Scholar 

  • Poynard T, Calès P, Pasta L et al. (1991) Beta-adrenergic-antagonist drugs in the prevention of gastrointestinal bleeding in patients with cirrhosis and esophageal varices. N Engl J Med 324: 1532–1538

    PubMed  CAS  Google Scholar 

  • Sarin SK, Guptan RKC, Jain AK et al. (1996) A randomized controlled trial of variceal band ligation for primary prophylaxis of variceal bleeding. Eur J Gastroenterol Hepatol 8: 337–342

    PubMed  CAS  Google Scholar 

  • Sarin SK, Lamba GS, Kumar M et al. (1999) Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding. N Engl J Med 340: 988–993

    PubMed  CAS  Google Scholar 

  • Schepke M, Reichel C, Ziske C et al. (2001) Leberzirrhose — Teil 2: Komplikationen und Therapie. Dtsch Med Wochenschr 126: 978–981

    PubMed  CAS  Google Scholar 

  • Sharara AI, Rockey DC (2001) Gastroesophageal variceal hemorrhage. N Engl J Med 345: 669–681

    PubMed  CAS  Google Scholar 

  • Teran JC, Imperiale TF, Mullen KD et al. (1997) Primary prophylaxis of variceal bleeding in cirrhosis: a cost effectiveness analysis. Gastroenterology 112: 473–482

    PubMed  CAS  Google Scholar 

  • Villanueva C, Balanzo J, Novella MT et al. (1996) Nadolol plus isosorbide mononitrate compared with sclerotherapy for the prevention of variceal bleeding. N Engl J Med 334: 1624–1629

    PubMed  CAS  Google Scholar 

  • Villanueva C, Minana J, Ortiz J et al. (2001) Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. N Engl J Med 345: 647–655

    PubMed  CAS  Google Scholar 

  • Walker S (1988) Behandlung der Ösophagusvarizenblutung mit vasoaktiven Substanzen. Dtsch Med Wochenschr 113: 26–31

    PubMed  CAS  Google Scholar 

  • Westaby D, Hayes PC, Gimson AE et al. (1989) Controlled clinical trial of injection sclerotherapy for active variceal bleeding. Hepatology 9: 274–277

    PubMed  CAS  Google Scholar 

Portal hypertensive Gastroenteropathie und Biliopathie

  • Balan KK, Jones AT, Roberts NB et al. (1996) The effects of he licobacter pylori colonization on gastric function and the incidence of portal hypertensive gastropathy in patients with cirrhosis of the liver. Am J Gastroenterol 91: 1400–1406

    PubMed  CAS  Google Scholar 

  • Burak KW, Lee SS, Beck PL (2001) Portal hypertensive gastropathy and gastric antral vascular ectasia (GAVE) syndrome. Gut 49: 866–872

    PubMed  CAS  Google Scholar 

  • Chandra R, Kapoor D, Tharakan A et al. (2001) Portal biliopathy. J Gastroenterol Hepatol 16: 1086–1092

    PubMed  CAS  Google Scholar 

  • D’Amico G, Montalbano L, Traina M et al. (1990) Natural history of congestive gastropathy in cirrhosis. Gastroenterology 99: 1558–1564

    PubMed  Google Scholar 

  • Hashizume M, Tanaka K, Mokuchi K (1983) Morphology of gastric microcirculation in cirrhosis. Hepatology 6: 1008–1012

    Google Scholar 

  • Kawanaka H, Tomikawa M, Jones MK et al. (2001) Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications. Hepatology 34: 990–999

    PubMed  CAS  Google Scholar 

  • McCormack TT, Sim J, Eyre-Brook I et al. (1985) Gastric lesions in portal hypertension: inflammatory gastritis or congestive gastropathy? Gut 26: 1226–1232

    PubMed  CAS  Google Scholar 

  • Papazian A, Braillon A, Dupas JL et al. (1986) Portal hypertensive gastric mucosa: an endoscopic study. Gut 27: 1199–1203

    PubMed  CAS  Google Scholar 

  • Perez-Ayuso RM, Piquet JM, Bosch JM et al. (1991) Propranolol in prevention of recurrent bleeding from severe portal hypertensive gastropathy in cirrhosis. Lancet 337: 1431–1434

    PubMed  CAS  Google Scholar 

  • Primignani M, Carpinelli L, Preatoni P et al. (2000) Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. Gastroenterology 119: 181–187

    PubMed  CAS  Google Scholar 

  • Sarin SK, Shahi HM, Jain M et al. (2000) The natural history of portal hypertensive gastropathy: influence of variceal eradication. Am J Gastroenterol 95: 2888–2893

    PubMed  CAS  Google Scholar 

  • Smart HL, Triger DR (1991) Clinical features, pathophysiology and relevance of portal hypertensive gastropathy. Endoscopy 23: 224–228

    PubMed  CAS  Google Scholar 

  • Viggiano TR, Gostout CJ (1992) Portal hypertensive intestinal vasculopathy. A review of the clinical, endoscopic, and histopathologic features. Am J Gastroenterology 87: 944–954

    CAS  Google Scholar 

  • West MS, Garra BS, Horti SC et al. (1991) Gallbladder varices: imaging findings in patients with portal hypertension. Radiology 179: 179–182

    PubMed  CAS  Google Scholar 

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Dancygier, H., Nagell, W. (2003). Leberzirrhose und Folgeerkrankungen. In: Klinische Hepatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55902-0_27

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