Zusammenfassung
Trotz erheblicher Fortschritte in der Intensivmedizin ist das Versagen eines oder mehrerer Organe (Multiorganversagen) mit einer hohen Mortalität verbunden. Dem Versagen vitaler Organe nach schweren Verletzungen, Schock, Verbrennungen und Immunsuppression geht regelmäßig eine generalisierte Entzündungsreaktion voraus, die auf infektiöse (Sepsis) oder nichtinfektiöse Ursachen zurückgeführt werden kann. Die hämodynamischen Auswirkungen bei Schock führen im Gastrointestinaltrakt zu einer Beeinträchtigung der intestinalen Durchblutung, in deren Folge eine Störung der intestinalen Barrierefunktion entsteht, die zur Invasion von Bakterien und Toxinen aus dem Darmlumen in den Blutkreislauf führt.
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Literatur
Adam S, Batson S (1997) A study of problems associated with the delivery of enteral feed in critically ill patients in five ICUs in the UK. Intensive Care Med 23:261–266
Adolph M (1999) Lipid emulsions in parenteral nutrition. Ann Nutr Metab 43:1–13
Alexander JW (1999) is early enteral feeding of benefit? Intensiv Care Med 25:129–130
Beale RJ, Bryg DJ, Bihari DJ (1999) Immunonutrition in the critically ill: a systematic review of clinical outcome. Crit Care Med 27:2799–2805
Behrendt W, Raumanns J (2002) Stoffwechselveränderungen und Ernährung. In: Schuster HP, Werdan K (Hrsg.) Intensivtherapie bei Sepsis und Multiorganversagen. Springer, Berlin Heidelberg New York, S.311–332
Boelens PG, Nijveldt RJ, Houdijk AP et al. (2001) Glutamine alimentation in catabolic state. J Nutr 131:S2569–S2767
Bone RC, Balk RA, Cerra FB et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644–1655
Brathwaite CE, Ross SE, Nagele R et al. (1993) Bacterial translocation occurs in humans after traumatic injury: evidence using immunifluorescence. J Trauma 34:586–590
Cerra FB, Benitez MR, Blackburn GL et al. (1997) Applied nutrition in ICU patients. A consensus statement of the American College of Chest Physicians. Chest 111:769–778
Heyland DK, Cook DJ, Guyatt GH (1993) Enteral nutrition in the critically ill patient: a critical review of the evidence. Intensive Care Med 19:435–442
Heyland DK, MacDonald S, Keefe L, Drover JW (1998) Total parenteral nutrition in the critically ill patient: a meta-analysis. JAMA 80:2013–2019
Heyland DK (2000) Parenteral nutrition in the critically ill patient: more harm than good? Proc Nutr Soc 59:457–466
Heyland DK, Novak F, Drover et al. (2001) Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA 286:944–953
Hyslop PA, Hinshaw DP, Halsey WA (1988) Mechanism of oxidant-mediated cell injury: the glycolytic and mitochondrial pathways of ADP phosphorylation are majorintracellular targets inactivated by hydrogen peroxyde. J Biol Chem 253:1665–1675
Hutcheson IR, Whittle BJ, Boughton-Smith NK (1990) Role of nitric oxide in maintaining vascular integrity in endotoxin-induced intestinal damage in the rat. Br J Pharmacol 101:815–820
Jeevanandam M, Young DH, Schiller WR (1990) Glucose turnover, oxidation, and indices of recycling in severely traumatized patients. J Trauma 30:582–589
Kompan L, Kremzar B, Gadzijev E, Prosek M (1999) Effects of early enteral nutrition on intestinal permeability and the development of multiple organ failure after multiple injury. Intensive Care Med 25:157–161
Kompan L, Kompan D (2001) Importance of increased intestinal permeability after multiple injuries. Eur J Surg 167:57057–57064
Kudsk KA, Croce MA, Fabian TC et al. (1992) Enteral versus parenteral feeding — effects on septic morbidity after blunt and penetrating abdominal trauma. Ann Surg 215:503–603
Leidig P, Gerding W, Arns W, Ortmann M (2001) Renal oxalosis with renal failure after infusion of xylitol. Dtsch Med Wochenschr 126:1357–1360
Madara J (1989) Loosening the tight junctions: lessons from the intestine. J Clin Invest 83:1089–1094
Marik PE, Zaloga GP (2001) Early enteral nutrition in acutely ill patients: a systematic review. Crit Care Med 29:2264–2270
Marshall JC, Christou NV, Meakins JL (1993) The gastrointestinal tract — the undrained abscess of multiple organ failure. Ann Surg 218:111–119
Marzi I, Bauer M (2001) Multiorganversagen. In: Burchardi H, Larsen R, Schuster HP, Suter PM (Hrsg.) Intensivmedizin. Springer, Berlin Heidelberg New York, S. 1087–1098
Mayer K, Grimm H, Grimminger F, Seeger W (2002) Parenteral nutrition with ω-3 lipids in sepsis. Br J Nutr 87:S69–S75
Montejo JC (1999) Enteral nutrition-related gastrointestinal complications in critically ill patients: a multicenter study. The Nutritional and Metabolic Working Group of the Spanish Society of Intensive Care Medicine and Coronary Units. Crit Care Med 27:1447–1453
Montejo JC, Grau T, Acosta J et al. (2002) Multicenter, prospective, randomized, single-blind study comparing the efficacy and gastrointestinal complications of early jejunal feeding with early gastric feeding in critically ill patients. Crit Care Med 30:796–800
Moore FA, Feliciano DV, Andrassy RJ et al. (1992) Early enteral feeding, compared with parenteral, reduces postoperative septic complications. The results of a metaanalysis. Ann Surg 216:172–183
Moore FA (2000) Common mucosal immunity: a novel hypothesis. Ann Surg 231:9–10
Moseley RH, Wang W, Takeda H et al. (1996) Effect of endotoxin on bile acid transport in rat liver: a potential for sepsis associated cholestasis. Am J Physiol 271:G137–G146
Nieuwenhuijzen GAP, Deitch EA, Goris RJA (1996) Infection, the gut and the development of the multiple organ dysfunction syndrome. Eur J Surg 162:259–273
Obled C, Papet I, Breuille D (2002) Metabolic bases of amino acid requirements in acute diseases. Curr Opin Clin Nutr Metab Care 5:189–197
O’Riordain MG, Fearon KC, Ross et al. (1994) Glutamine-supplemented total parenteral nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal resection. Ann Surg 220:212–221
Reeds PJ, Jahoor F (2001) The amino acid requirements of disease. Clin Nutrition 20:S15–S22
Pacitti AJ, Inoue Y, Souba WW (1993) Tumor necrosis factor stimulates amino acid transport in plasma membrane vesicles from rat liver. J Clin Invest 91:474–483
Riehl TE, Stenson WF (1994) Mechanisms of transit of lipid mediators of inflammation and bacterial peptides across intestinal epithelia. Am J Physiol 267:G687–G695
Sax HC, Illig KA, Ryan CK, Hardy DJ (1996) Low-dose enteral feeding is beneficial during total parenteral nutrition. Am J Surg 17:587–590
Schmeck J, Kraft P (1998) Die Leber als Zielorgan im Multiorganversagen — pathophysiologische Aspekte und therapeutische Ansätze. Anästh Intens Notf 11:549–558
Schricker T, Geisser W, Georgieff M (1997) Parenteral nutrition therapy. Energy and non-energy actions of carbohydrates and fats. Anästhesist 46:371–384
Souba WW, Copeand EM (1992) Cytokine Modulation of Na+-dependent Glutamine transport across the brush border membrane of monolayers of human intestinal Caco-2 Cells. Ann Surg 215:536–545
Stein J, Bolder U (2000) Pathophysiologie intestinaler Funktionen beim kritisch Kranken. Chir Gastroenterol 16:13–22
Stein J (2002) Resorptionstests In: Stein J, Wehrmann T (Hrsg.) Funktionsdiagnostik in der Gastroenterologie. Springer, Berlin Heidelberg New York, S. 125–180
Streat SJ, Beddoe AH, Hill GL (1987) Aggressive nutritional support does not prevent protein loss despite fat gain in septic intensive care patients. J Trauma 127:262–266
Suchner U, Felbinger TW (2001) Enterale, minimal-enterale, parenterale Ernährung — Vorteile einer enteralen Ernährungstherapie. In: Löser C, Keymling M (Hrsg.) Praxis der enteralen Ernährung.Thieme, Stuttgart, S. 32–40
Suchner U, Heyland DK, Peter K (2002) Immune-modulatory actions of arginine in the critically ill. Br J Nutr 87:S121–S132
Teppermann BL, Brown JF, Korolkiewicz R, Whittle BJ (1994) Nitric oxide synthetase activity, viability and cyclic GMP levels in rat colonic epithelial cells: effects of endotoxin challange. J Pharmacol Exp Ther 271:1477–1482
Tremel H, Kienle B, Weilermann LS et al. (1994) Glutamine dipeptide — supplemented parenteral nutrition maintains intestinal function in the critically ill. Gastroenterology 107:1595–1601
Unno N, Menconi MJ, Smith M, Fink MP (1995) Nitric oxide mediates interferon-γ-induced hyperpermeability in cultured human intestinal epithelial monolayers. Crit Care Med 23:1170–1176
Valero MA, Leon-Sanz M, Escobar I et al. (2001) Evaluation of non glucose carbohydrates in parenteral nutrition for diabetic patients. Eur J Clin Nutr 55:1111–1116
Waitzberg DL, Lotierzo PH, Logullo AF et al. (2002) Parenteral lipid emulsions and phagocytic systems. Br J Nutr 87:S49–S57
Wolfe RR, Herndon DN, Jahoor F et al. (1987) Effect of severe burn injury on substrate cycling by glucose and fatty acids. N Engl J Med 31:403–408
Wolfe RR (1999) Sepsis as a modulator of adaptation to low and high carbohydrate and low and high fat intakes. Eur J Clin Nutr 53:S36–S42
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Stein, J. (2003). Ernährung und Stoffwechsel bei SIRS und Sepsis. In: Stein, J., Jauch, KW. (eds) Praxishandbuch klinische Ernährung und Infusionstherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55896-2_35
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DOI: https://doi.org/10.1007/978-3-642-55896-2_35
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