Skip to main content

The Consequences of a Gastrectomy

  • Chapter
Gastric Substitutes

Abstract

A healthy stomach functions as a reservoir and it transports food after mechanical breakdown and preliminary digestion, secretes juices and enzymes and controls the emptying of chyme into the duodenum (Fig. 2.1). The lower oesophageal sphincter (LOS) protects against gastroesophageal reflux. After a total gastrectomy when the LOS has probably been resected (transhiatal oesophagojejunostomy), this protection is lost. The proximal stomach holds chyme (large-volume reservoir) and then propels it toward the distal stomach.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aaronson N.K., Ahmedzai S, Bergman B et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 8: 365–376

    Article  Google Scholar 

  2. Aaronson N.K., Bullinger M, Ahmedzai S (1988) A modular approach to quality-of-life assessment in cancer clinical trials. Recent Results Cancer Res 111:231–249

    Article  PubMed  CAS  Google Scholar 

  3. Adachi Y., Suematsu T, Shiraishi N et al (1999) Quality of life after laparoscopy-assis ted Billroth I gastrectomy. Ann Surg 229:49–54

    Article  PubMed  CAS  Google Scholar 

  4. Adams J.F. (1968) The clinical and metabolic consequences of total gastrectomy. 3. Noteson metabolic functions, deficiency states, changes in intestinal histology, and radiology. Scand J Gastroenterol 3: 152–159

    Article  PubMed  CAS  Google Scholar 

  5. Adams J.F. (1968) The clinical and metabolic consequences of total gastrectomy. II. Anaemia. Metabolism of iron, vitamin B12 andfolic acid. Scand J Gastroenterol 3: 145–151

    PubMed  CAS  Google Scholar 

  6. Ahlering T.E., Weinberg AC, Razor B (1991) Modified Indiana pouch. J Urolo 145: 1156–1158

    CAS  Google Scholar 

  7. Alexander-Williams J.A. (1981) Duodenogastric reflux after gastric operations. Br J Surg 68:685–687

    Article  PubMed  CAS  Google Scholar 

  8. Alexander-Williams J.A. (1982) Alkaline reflux gastritis: a myth or a disease? Am J Surg 143:17–21

    Article  PubMed  CAS  Google Scholar 

  9. Almind K., Ambye L., Urhammer S.A. et al (1998) Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells. Diabetologia 41: 1194–1198

    Article  PubMed  CAS  Google Scholar 

  10. Amdrup E (1966) Postgastrectomy syndromes. Am J Dig Dis 11: 432–446

    Article  PubMed  CAS  Google Scholar 

  11. Andreasen J.J., Orskov C., Holst J.J. (1994) Secretion of glucagon-like peptide-1 and reactive hypoglycemia after partial gastrectomy. Digestion 55: 221–228

    Article  PubMed  CAS  Google Scholar 

  12. Anvari M., Dent J., Malbert C.H. et al (1996) Preservation of normal gastric emptying following gastric surgery by use of a muscle bridge. Am J Surg 172: 345–349

    Article  PubMed  CAS  Google Scholar 

  13. Attwood S.E., Ball C.S., Barlow A.P. et al (1993) Role of intragastric and intraoesophageal alkalinisation in the genesis of complications in Barrett’s columnar lined lower oesophagus. Gut 34: 11–15

    Article  PubMed  CAS  Google Scholar 

  14. Baldini F., Falciai R., Scheggi A.M. (1988) A new fibreoptic sensor for bile reflux. In: Proceedings Optical Fibres and Sensors 1988. New Orleans, Louisiana. Artech, Norwood, Massachusetts, pp 353–356

    Google Scholar 

  15. Basso, D.E. (1951) The efficacy and applicability of an intussuscepted conical valve in preventing regurgitation and leakage of intestinal contents. Ann Surg l33: 477–485

    Google Scholar 

  16. Bechi P., Balzi M, Becciolini A et al (1991) Gastric cell proliferation kinetics and bile reflux after partial gastrectomy. Am J Gastroenterol 86: 1424–1432

    PubMed  CAS  Google Scholar 

  17. Bechi P., Falciai R, Baldini F (1993) Ambulatory assessment of enterogastric and nonacid gastroesophageal reflux by means of a fiberoptic sensor (abstract). Gastroenterology 104:751

    Google Scholar 

  18. Bechi P., Pucciani F, Baldini F et al (1993) Long-term ambulatory enterogastric reflux monitoring. Validation of a new fiberoptic technique. Dig Dis Sci 38: 1297–l306

    Article  PubMed  CAS  Google Scholar 

  19. Becker H.D. (1977) Pathogenese, Diagnostik und Therapie des Dumping-Syndroms. Chirurg 48:247–253

    PubMed  CAS  Google Scholar 

  20. Becker H.D. (1985) Maintenance of duodenal passage-yes or no? Langenbecks Arch Chir 366:241–247

    Article  PubMed  CAS  Google Scholar 

  21. Begemann F., Schumpelick V. (1981) Problems in duodenogastric reflux assessment, using bile acid and lysolecithin measurement. Scand J Gastroenterol Suppl 67: 51–53

    PubMed  CAS  Google Scholar 

  22. Berglund B., Liedman B., Olbe L. et al (1991) Reservoir function after subtotal or total gastrectomy with or without gastric substitute. Eur J Surg 157:201–204

    PubMed  CAS  Google Scholar 

  23. Blazeby J.M., Alderson D. (1999) Quality of life In: Daly JM, Hennessy TPJ, Reynolds JV (eds) Management of upper gastrointestinal cancer. WB Saunders Company LTD, London, pp 58–80

    Google Scholar 

  24. Blazeby J.M., Williams M.H., Alderson D. et al (1995) Observer variation in assessment of uality of life in patients with oesophageal cancer. Br J Surg 82: 1200–1203

    Article  PubMed  CAS  Google Scholar 

  25. Boren C.H., Way L.W. (1980) Alkaline reflux gastritis: a reevaluation. Am J Surg 140: 40–46

    Article  PubMed  CAS  Google Scholar 

  26. Borger H.W., Schafmayer A., Becker H.D. (1977) Gastrointestinal hormone release in dumping syndrome before and after reconstruction of duodenal passage. Chir Forum Exp Klin Forsch 224–227

    Google Scholar 

  27. Breetvelt I.S., Van Dam F.S. (1991) Underreporting by cancer patients: the case of response-shift. Soc Sci Med 32: 981–987

    Article  PubMed  CAS  Google Scholar 

  28. Bugge-Asperheim B., Skaland K., Myren J. et al (1966) Changes of jejunal mucosa in relation to clinical findings and intestinal absorption in patients with total gastrectomy. Acta Chir Scand 131: 135–144

    PubMed  CAS  Google Scholar 

  29. Burge H.W., Rizk A.R., Tompkin A.M.B. (1961) Selective vagotomy in the prevention of postvagotomy diarrhoea. Lancet 2: 897–901

    Article  PubMed  CAS  Google Scholar 

  30. Caldwell M.T., Lawlor P., Byrne P.J. et al (1995) Ambulatory oesophageal bile reflux monitoring in Barrett’s oesophagus. Br J Surg 82:657–660

    Article  PubMed  CAS  Google Scholar 

  31. Carlson H.C., Code C.F., Nelson R.A. (1966) Motor action of the canine gastroduodenal junction: a cineradiographic, pressure, and electric study. Am J Dig Dis 11: 155–172

    Article  PubMed  CAS  Google Scholar 

  32. Champion G., Richter J.E., Vaezi M.F. et al (1994) Duodenogastroesophageal reflux: relationship to pH and importance in Barrett’s esophagus. Gastroenterology 107: 747–754

    Article  PubMed  CAS  Google Scholar 

  33. Cheadle W.G., Baker P.R., Cuschieri A. (1985) Pyloric reconstruction for severe vasomotor dumping after vagotomy and pyloroplasty. Ann Surg 202: 568–572

    Article  PubMed  CAS  Google Scholar 

  34. Christiansen P.M., Hansen O.H., Pedersen T. (1974) Reconstruction of the pylorus for postvagotomy diarrhoea and dumping. Br J Surg 61: 519–520

    Article  PubMed  CAS  Google Scholar 

  35. Christofides N.D., Bloom S.R., Besterman H.S. et al (1979) Release of motilin by oral and intravenous nutrients in man. Gut 20: 102–106

    Article  PubMed  CAS  Google Scholar 

  36. Clark G.W., Ireland A.P., DeMeester T.R. (1996) Dysplasia in Barrett’s esophagus: diagnosis, surveillance and treatment. Dig Dis 14:213–227

    Article  PubMed  CAS  Google Scholar 

  37. Clark G.W., Smyrk T.C., Burdiles P. et al (1994) Is Barrett’s metaplasia the source of adenocarcinomas of the cardia? Arch Surg 129:609–614

    Article  PubMed  CAS  Google Scholar 

  38. Clark G.W., Smyrk T.C., Mirvish S.S. et al (1994) Effect of gastroduodenal juice and dietary fat on the development of Barrett’s esophagus and esophageal neoplasia: an experimental rat model. Ann Surg Oncol 1:252–261

    Article  PubMed  CAS  Google Scholar 

  39. Crowne D.P., Marlowe D. (1964) The approval motive. John Wiley: 1048–1055

    Google Scholar 

  40. De Haes J.C., van Knippenberg F.C. (1985) The quality of life of cancer patients: a review of the literature. Soc Sci Med 20: 809–817

    Article  PubMed  Google Scholar 

  41. Delcore R., Cheung L.Y. (1991) Surgical options in postgastrectomy syndromes. Surg Clin North Am 71:57–75

    PubMed  CAS  Google Scholar 

  42. DeMeester S.R., Campos G.M.R., DeMeester T.R. et al (1998) The impact of an antireflux procedure on intestinal metaplasia of the cardia. Ann Surg 4: 547–556

    Article  Google Scholar 

  43. DeMeester S.R., DeMeester T.R. (2000) Columnar mucosa and intestinal metaplasia of the esophagus. Ann Surg 231:303–321

    Article  PubMed  CAS  Google Scholar 

  44. DeMeester T.R., Fuchs K.H., Ball C.S. et al (1987) Experimental and clinical results with proximal end-to-end duodenojejunostomy for pathologic duodenogastric reflux. Ann Surg 206:414–426

    Article  PubMed  CAS  Google Scholar 

  45. Donahue P.E., Bombeck C.T., Condon R.E. et al (1984) Proximal gastric vagotomy versus selective vagotomy with antrectomy: results of a prospective, randomized clinical trial after four to twelve years. Surgery 96: 585–591

    PubMed  CAS  Google Scholar 

  46. Drapanas T., McDonald J.C., Stewart J.D. (1962) Serotonin release following instillation of hypertonic glucose into the proximal intestine. Ann Surg 156: 528–536

    Article  PubMed  CAS  Google Scholar 

  47. Dupre J., Ross S.A., Watson D. et al (1973) Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab 37: 826–828

    Article  PubMed  CAS  Google Scholar 

  48. Eagon J.C., Miedema B.W., Kelly K.A. (1992) Postgastrectomy syndromes. Surg Clin North Am 72: 445–465

    PubMed  CAS  Google Scholar 

  49. Ebied F.H., Ralphs D.N., Hobsley M. et al (1982) Dumping symptoms after vagotomy treated by reversal of pyloroplasty. Br J Surg 69:527–528

    Article  PubMed  CAS  Google Scholar 

  50. Eloff S.J. (1992) Neopylorus: a functional reflux-free gastroenteral anastomosis. J R Coll Surg Edinb 37:313–318

    PubMed  CAS  Google Scholar 

  51. Eypasch E., Williams J.I., Wood-Dauphinee S. et al (1995) Gastrointestinal Quality of Life Index: development, validation and application of a new instrument. Br J Surg 82: 216–222

    Article  PubMed  CAS  Google Scholar 

  52. Eypasch E., Wood-Dauphinee S., Williams J.I. et al (1993) The Gastrointestinal Quality of Life Index. A clinical index for measuring patient status in gastroenterologic surgery. Chirurg 64: 264–274

    PubMed  CAS  Google Scholar 

  53. Eyre-Brook I.A., Holroyd A.M., Johnson A.G. (1984) Is bile reflux at endoscopy a significant finding? Scand J Gastroenterol Suppl 92:203–205

    PubMed  CAS  Google Scholar 

  54. Fass, J. (1998) Der gastrektomierte Patient. In: Schumpelick V, Schippers E (eds) Pouch: Grundlagen, Funktion, Technik, Ergebnisse. Springer Verlag, Berlin, Heidelberg, New York, pp 35–52

    Google Scholar 

  55. Fenger H.J. (1967) Clinical and experimental studies of dumping disposition. A method for preoperative evaluation of individual dumping disposition. Acta Chir Scand Suppl 371: 1–128

    PubMed  CAS  Google Scholar 

  56. Fischermann K., Harly S., Worning H. et al (1967) Pancreatic function and the absorption of fat, iron, vitamin B12, and calcium after total gastrectomy for gastric cancer. Gut 8: 260–266

    Article  PubMed  CAS  Google Scholar 

  57. Fox J.A. (1989) Control of gastrointestinal motility by peptides: old peptides, new tricks-new peptides, old tricks. Gastroenterol Clin North Am 18: 163–177

    PubMed  CAS  Google Scholar 

  58. Fuchs K.H., De Meester T.R., Hinder R.A. et al (1991) Computerized identification of pathologic duodenogastric reflux using 24-hour gastric pH monitoring. Ann Surg 213: 13–20

    Article  PubMed  CAS  Google Scholar 

  59. Fuchs K.H., Maroske J., Fein M. et al (2000) Erhalt der Duodenalpassage nach Gastrektomie. Chir Gastroenterol 16 (Suppl 2): 20–24

    Article  Google Scholar 

  60. Gasslander T., Mukaida H., Herrington M.K. et al (1995) Profound duodenogastric reflux causes pancreatic growth in rats. Gut 36:137–141

    Article  PubMed  CAS  Google Scholar 

  61. Germann G., Hottenrott C., Maul F.D. (1984) Duodeno-gastraler Reflux nach Magenresektionen. Akta Chirurgica 19: 133–135

    Google Scholar 

  62. Giarelli L., Melato M., Stanta G. et al (1983) Gastric resection. A cause for high frequency of gastric carcinoma. Cancer 52: 1113–1116

    Article  Google Scholar 

  63. Gillen P., Keeling P., Byrne.PJ et al (1988) Experimental columnar metaplasia in the canine oesophagus. Br J Surg 75: 113–115

    Article  PubMed  CAS  Google Scholar 

  64. Glassmann J.A. (1942) An artificial ileocolic valve. Surg Gyn Obstetr 74:92–98

    Google Scholar 

  65. Gotley D.C., Morgan A.P., Ball D. et al (1991) Composition of gastro-oesophageal refluxate. Gut 32: 1093–1099

    Article  PubMed  CAS  Google Scholar 

  66. Green D.W., Gomez G., Greeley G.H. Jr (1989) Gastrointestinal peptides. Gastroenterol Clin North Am 18:695–733

    PubMed  CAS  Google Scholar 

  67. Gustavsson S., Ilstrup D.M., Morrison P. et al (1988) Roux-Y stasis syndrome after gastrectomy. Am J Surg 155: 490–494

    Article  PubMed  CAS  Google Scholar 

  68. Haggitt R.C., Tryzelaar J., Ellis F.H. et al (1978) Adenocarcinoma complicating columnar epithelium-lined (Barrett’s) esophagus. Am J Clin Pathol 70: 1–5

    PubMed  CAS  Google Scholar 

  69. Hamilton S.R., Smith R.R., Cameron J.L. (1988) Prevalence and characteristics of Barrett esophagus in patients with adenocarcinoma of the esophagus or esophagogastric junction. Hum Pathol 19:942–948

    Article  PubMed  CAS  Google Scholar 

  70. Herrington J.L. Jr, Edwards W.H., Carter J.H. et al (1968) Treatment of severe postvagotomy diarrhea by reversed jejunal segment. Ann Surg 168: 522–541

    Article  PubMed  Google Scholar 

  71. Herrington J.L. Jr, Sawyers J.L. (1972) A new operation for the dumping syndrome and post-vagotomy diarrhea. Ann Surg 175: 790–801

    Article  PubMed  Google Scholar 

  72. Hinder R.A. (1992) Duodenal switch: a new form of pancreaticobiliary diversion. Surg Clin North Am 72:487–499

    PubMed  CAS  Google Scholar 

  73. Hinder R.A., Bremner C.G. (1987) The uses and consequences of the Roux-en-Y operation. In: Nyhus L (ed) Surgery Annual. Appleton-Century-Croft, Norwalk, Connecticut, pp 151–174

    Google Scholar 

  74. Hoare A.M., Jones E.L., Alexander-Williams J. et al (1977) Symptomatic significance of gastric mucosal changes after surgery for peptic ulcer. Gut 18: 295–300

    Article  PubMed  CAS  Google Scholar 

  75. Hobsley M. (1988) Reconstruction of the pylorus. Langenbecks Arch Chir 373: 131–135

    Article  PubMed  CAS  Google Scholar 

  76. Hocking M.P., Sninsky C.A., Howard R.J. (1988) Normal and abnormal gastrointestinal motility. Surg Annu 20:227–255

    PubMed  CAS  Google Scholar 

  77. Hocking M.P., Vogel S.B. (1991) Physiology of gastric secretion and motility in normal and postgastrectomy states. In Hocking MP, Vogel SB (eds) Woodward’s postgastrectomy syndromes, 2nd edn, Philadelphia, WB Saunders, pp 29–46

    Google Scholar 

  78. Hollands M.J., Filipe I., Edwards S. et al (1989) Clinical and histological sequelae of Rouxen-Y diversion. Br J Surg 76:481–484

    Article  PubMed  CAS  Google Scholar 

  79. Hom S., Sarr M.G., Kelly K.A. (1989) Postoperative gastric atony after vagotomy for obstructing peptic ulcer. Am J Surg 157: 282–286

    Article  PubMed  CAS  Google Scholar 

  80. Hopmann W.P.M., Wolbernik R.G.J., Lamers C.B. et al (1988) Treatment of the dumping syndrome with the somatostation analogue SMS 201-995. Ann Surg 207: 155–159

    Google Scholar 

  81. Houghton P.W., Mortensen N.J., Williamson R.C. (1987) Effect of duodenogastric reflux on gastric mucosal proliferation after gastric surgery. Br J Surg 74:288–291

    Article  PubMed  CAS  Google Scholar 

  82. Iftikhar S.Y., Evans D.F., Steele R.J.C. et al (1991) Bile reflux in Barrett’s oesophagus. Gut 32:1554–1558

    Article  Google Scholar 

  83. Iftikhar S.Y., Ledingham S., Steele R.J. et al (1993) Bile reflux in columnar-lined Barrett’s oesophagus. Ann R Coll Surg Engl 75:411–416

    PubMed  CAS  Google Scholar 

  84. Johnston D. (1975) Operative mortality and postoperative morbidity of highly selective vagotomy. Br J Surg 62: 160

    PubMed  CAS  Google Scholar 

  85. Johnston G.W., Spencer E.F.A., Wilkinson A.J. (1991) Proximal gastric vagotomy: Followup at 10-20 years. Br J Surg 78: 20–23

    Article  PubMed  CAS  Google Scholar 

  86. Johnston M.H., Hammond A.S., Laskin W. et al (1996) The prevalence and clinical characteristics of short segments of specialized intestinal metaplasia in the distal esophagus on routine endoscopy. Am J Gastroenterol 91: 1507–1511

    PubMed  CAS  Google Scholar 

  87. Karnofski D.A., Abermann W.A., Craver LF et al (1948) The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer 1: 634–643

    Article  Google Scholar 

  88. Katada N, Hinder RA, Smyrk TC et al (1999) Duodenoesophageal reflux induces apoptosis in rat esophageal epithelium. Dig Dis Sci 44:301–310

    Article  PubMed  CAS  Google Scholar 

  89. Kauer W.K., Burdiles P., Ireland A.P. et al (1995) Does duodenal juice reflux into the esophagus of patients with complicated GERD Evaluation of a fiberoptic sensor for bilirubin. Am J Surg 169:98–103

    Article  PubMed  CAS  Google Scholar 

  90. Kauer W.K., Peters J.H., De Meester T.R. et al (1995) Mixed reflux of gastric and duodenal juices is more harmful to the esophagus than gastric juice alone. The need for surgical therapy re-emphasized. Ann Surg 222: 525–523

    PubMed  CAS  Google Scholar 

  91. Keane F.B., DiMagno E.P., Malagelada J.R. (1981) Duodenogastric reflux in humans: its relationship to fasting antroduodenal motility and gastric, pancreatic, and biliary secretion. Gastroenterology 81: 726–731

    PubMed  CAS  Google Scholar 

  92. Keighley MR, Asquith P, Alexander-Williams J (1975) Duodenogastric reflux: a cause of gastric mucosal hyperaemia and symptoms after operations for peptic ulceration. Gut 16: 28–32

    Article  PubMed  CAS  Google Scholar 

  93. Kelly KA (1981) Motility of the stomach and gastroduodenal junction. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven Press, New York, pp 393–410

    Google Scholar 

  94. Kelly KA, Becker JM, van Heerden JA (1981) Reconstructive gastric surgery. Br J Surg 68:687–691

    Article  PubMed  CAS  Google Scholar 

  95. Klingler PJ, Perdikis G, Wilson P et al (1999) Indications, technical modalities and results of the duodenal switch operation for pathologic duo de no gastric reflux. Hepatogastroenterology 46: 97–102

    PubMed  CAS  Google Scholar 

  96. Koller M, Heitmann K, Kussmann J et al (1999) Symptom reporting in cancer patients II: relations to social desirability, negative affect, and self-reported health behaviors. Cancer 86: 1609–1620

    Article  PubMed  CAS  Google Scholar 

  97. Koller M, Kussman J, Lorenz W et al (1996) Symptom reporting in cancer patients: the role of negative affect and experienced social stigma. Cancer 77: 983–995

    Article  PubMed  CAS  Google Scholar 

  98. Kondo K, Kojima H, Akiyama S et al (1995) Pathogenesis of adenocarcinoma induced by gastrojejunostomy in Wistar rats: role of duodenogastric reflux. Carcinogenesis 16:1747–1751

    Article  PubMed  CAS  Google Scholar 

  99. Korenaga D, Orita H, Okuyama T et al (1992) Quality of life after gastrectomy in patients with carcinoma of the stomach. Br J Surg 79: 248–250

    Article  PubMed  CAS  Google Scholar 

  100. Koussidis A, Apsokardou-Koussidou M (1990) Treatment of alkaline gastritis and recurrent ulcer following Roux-en-Y gastrectomy and construction of a Rumpf antireflux valve. Zentralbl Chir 115: 95–102

    PubMed  CAS  Google Scholar 

  101. Kuznetsov VA, Fedorov IV (1991) Bilateral exclusion of the duodenum in reconstructive surgery of the stomach. Khirurgiia (Mosk) 60–64

    Google Scholar 

  102. Lin KM, Ueda RK, Hinder RA et al (1991) Etiology and importance of alkaline esophageal reflux. Am J Surg 162: 553–557

    Article  PubMed  CAS  Google Scholar 

  103. Linehan IP, Weiman J, Hobsley M (1986) The IS-minute dumping provocation test. Br J Surg 73: 810–812

    Article  PubMed  CAS  Google Scholar 

  104. Locke GR III, Talley NJ, Carpenter HA et al (1995) Changes in the site-and histologyspecific incidence of gastric cancer during a 50-year period. Gastroenterology 109: 1750–1756

    Article  PubMed  Google Scholar 

  105. Long RG, Adrian TE, Bloom SR (1985) Somatostatin and the dumping syndrome. Br Med J (Clin Res Ed) 290: 886–888

    Article  CAS  Google Scholar 

  106. MacGregor I, Parent J, Meyer JH (1977) Gastric emptying of liquid meals and pancreatic and biliary secretion after subtotal gastrectomy or truncal vagotomy and pyloroplasty in man. Gastroenterology 72: 195–205

    PubMed  CAS  Google Scholar 

  107. Machella TE (1949) The mechanism of the post-gastrectomy “dumping” syndrome. Ann Surg 130: 145–159

    Article  PubMed  CAS  Google Scholar 

  108. MacKay C (1970) Postgastrectomy steatorrhea. Am J Surg 120: 324–328

    PubMed  CAS  Google Scholar 

  109. Mackie CR, Wisbey ML, Cuschieri A (1982) Milk 99Tcm-EHID: a test for enterogastric bile reflux. Br J Surg 69: 101–104

    Article  PubMed  CAS  Google Scholar 

  110. Madura JA, Grosfeld JL (1997) Biliary diversion. A new method to prevent enterogastric reflux and reverse the Roux stasis syndrome. Arch Surg 132: 245–249

    Article  PubMed  CAS  Google Scholar 

  111. Marshall REK, Anggiansah A, Owen WJ (1997) Bile in the oesophagus: clinical relevance and ambulatory detection. Br J Surg 84:21–28

    Article  PubMed  CAS  Google Scholar 

  112. Martin CJ, Kennedy T (1982) Reconstruction of the pylorus. World J Surg 6:221–225

    Article  PubMed  CAS  Google Scholar 

  113. Mason RC (1986) Duodenogastric reflux in rat gastric carcinoma. Br J Surg 73: 801–803

    Article  PubMed  CAS  Google Scholar 

  114. Mathias JR, Fernandez A, Sninsky CA et al (1985) Nausea, vomiting, and abdominal pain after Roux-en-Y anastomosis: motility of the jejunal limb. Gastroenterology 88:101–107

    PubMed  CAS  Google Scholar 

  115. McAlhany JC Jr, Hanover TM, Taylor SM et al (1994) Long-term follow-up of patients with Roux-en-Y gastrojejunostomy for gastric disease. Ann Surg 219:451–457

    Article  PubMed  Google Scholar 

  116. Mendes de Almeida JC, Chaves P, Pereira AD et al (1997) Is Barrett’s esophagus the precursor of most adenocarcinomas of the esophagus and cardia? A biochemical study. Ann Surg 6:725–735

    Article  Google Scholar 

  117. Meyer JH, Thomson JB, Cohen MB et al (1979) Sieving of solid food by the canine stomach and sieving after gastric surgery. Gastroenterology 76: 804–813

    PubMed  CAS  Google Scholar 

  118. Meyer W, Vollmar F, Bar W (1979) Barrettesophagus following total gastrectomy. A contribution to its pathogenesis. Endoscopy 11: 121–126

    Article  PubMed  CAS  Google Scholar 

  119. Miedema BW, Kelly KA (1992) The Roux stasis syndrome. Treatment by pacing and prevention by use of an ‘uncut’ Roux limb. Arch Surg 127: 295–300

    Article  PubMed  CAS  Google Scholar 

  120. Miholic J, Meyer HJ, Kotzerke J et al (1989) Emptying of the gastric substitute after total gastrectomy. Jejunal interposition versus Roux-y esophagojejunostomy. Ann Surg 210:165–172

    Article  PubMed  CAS  Google Scholar 

  121. Miholic J, Orskov C, Holst JJ et al (1991) Emptying of the gastric substitute, glucagonlike peptide-1 (GLP-1) and reactive hypoglycemia after total gastrectomy. Dig Dis Sci 36: 1361–1370

    Article  PubMed  CAS  Google Scholar 

  122. Miholic J, Reilmann L, Meyer HJ et al (1990) Extracellular space, blood volume, and the early dumping syndrome after total gastrectomy. Gastroenterology 99: 923–929

    PubMed  CAS  Google Scholar 

  123. Mirvish SS, Huang Q, Chen SC et al (1993) Metabolism of carcinogenic nitrosamines in the rat and human esophagus and induction of esophageal adenocarcinoma in rats. Endoscopy 25: 627–631

    Article  PubMed  CAS  Google Scholar 

  124. Misumi A, Harada K, Murakami A et al (1989) Postoperative results of distal partial gastrectomy, selective vagotomy plus antrectomy, and selective proximal vagotomy for duodenal ulcers. Jpn J Surg 19: 708–717

    Article  PubMed  CAS  Google Scholar 

  125. Miwa K, Fujimura T, Hasegawa H et al (1992) Is bile or are pancreaticoduodenal secretions related to gastric carcinogenesis in rats with reflux through the pylorus? J Cancer Res Clin Oncol 118: 570–574

    Article  PubMed  CAS  Google Scholar 

  126. Miwa K, Hattori T, Miyazaki I(1995) Duodenogastric reflux and foregut carcinogenesis. Cancer 75: 1426–1432

    Article  PubMed  CAS  Google Scholar 

  127. Mix CL (1922) “Dumping stomach” following gastrojejunostomy. Surg Clin North Am 2:617–622

    Google Scholar 

  128. Morales TG, Sampliner RE, Bhattacharyya A (1997) Intestinal metaplasia of the gastric cardia. Am J Gastroenterol 92:414–418

    PubMed  CAS  Google Scholar 

  129. Morrison P, Miedema BW, Kohler L et al (1990) Electrical dysrhythmias in the Roux jejunal limb: cause and treatment. Am J Surg 160:252–256

    Article  PubMed  CAS  Google Scholar 

  130. Muller-Lissner SA, Fimmel Cj, Sonnenberg A et al (1983) Novel approach to quantify duodenogastric reflux in healthy volunteers and in patients with type I gastric ulcer. Gut 24:510–518

    Article  PubMed  CAS  Google Scholar 

  131. Muller-Lissner SA, Fraass C (1985) Dissociation of duodenogastric marker reflux and bile salt reflux. Dig Dis Sci 30: 733–738

    Article  PubMed  CAS  Google Scholar 

  132. Mummendey HD, Eifler S (1993) Eine neue Skala zur Messung Sozialer Erwiinschtheit. Bielefelder Arbeiten zur Sozialpsychologie 8: 1–10

    Google Scholar 

  133. O'Harte FP, Abdel-Wahab YH, Conlon JM et al (1998) Glycation of glucagon-like peptide-1(7-36)amide: characterization and impaired action on rat insulin secreting cells. Diabetologia 41: 1187–1193

    Article  PubMed  Google Scholar 

  134. Oberg S, Peters JH, DeMeester TR et al (1997) Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastroesophageal reflux disease. Ann Surg 226: 522–530

    Article  PubMed  CAS  Google Scholar 

  135. Panis Y, Fekete F (1994) Total duodenal diversion in reoperations for gastroesophageal reflux. Indications and results in 29 patients. Ann Chir 48:27–30

    PubMed  CAS  Google Scholar 

  136. Perl JI (1949) Intussuscepted conical valve formation in jejunostomies. Surgery 25: 297–301

    PubMed  CAS  Google Scholar 

  137. Peters FT, Kleibeuker JH (1993) Barrett’s oesophagus and carcinoma. Recent insights into its development and possible prevention. Scand J Gastroenterol Suppl 200: 59–64

    Article  PubMed  CAS  Google Scholar 

  138. Poth EJ, Smith LB (1966) Gastric pouches: their evaluation. Am J Surg 112:721–727

    Article  PubMed  CAS  Google Scholar 

  139. Pryor JP, O’shea MJ, Brooks PL et al (1971) The long-term metabolic consequences of partial gastrectomy. Am J Med 51: 5–10

    Article  PubMed  CAS  Google Scholar 

  140. Rau B, Koop H (2000) Mechanismen der Mangelernahrung nach Gastrektomie. Chir Gastroenterol 16 (Suppl 2): 1–7

    Google Scholar 

  141. Ritchie WP Jr (1980) Alkaline reflux gastritis. An objective assessment of its diagnosis and treatment. Ann Surg 192:288–298

    Article  PubMed  Google Scholar 

  142. Roberts KE, Randall HT, Farr HW (1954) Cardiovascular and blood volume alterations resulting from intrajejunal administration of hypertonic solutions to gastrectomized patients: the relationship of these changes to the dumping syndrome. Ann Surg 140:631–640

    Article  PubMed  CAS  Google Scholar 

  143. Robles Campos R, Parrilla Paricio P, Lujan Mompean JA et al (1990) Quantification of duodenogastric reflux in gastroduodenal peptic ulcer and in gastric operation patients, using a 24-h gastric pH measurement as a quantification technique. Br J Surg 77:428–431

    Article  PubMed  CAS  Google Scholar 

  144. Rumpf P, Mahmud H, Kremer K (1980) Operative Technik zur Verhinderung des alkalischen Refluxes nach Magenresektionen. Chirurg 51: 534–535

    PubMed  CAS  Google Scholar 

  145. Sagor GR, Bryant MG, Ghatei MA et al (1981) Release of vasoactive intestinal peptide in the dumping syndrome. Br Med J (Clin Res Ed) 282: 507–510

    Article  CAS  Google Scholar 

  146. Sawchuk A, Canal D, Grosfeld JL et al (1987) Electrical pacing of the Roux limb resolves delayed gastric emptying. J Surg Res 42:635–641

    Article  PubMed  CAS  Google Scholar 

  147. Schippers E, Willis S, Ruckdeschl G et al (1996) Small intestinal myoelectrical activity and bacterial flora after Roux-en-Y reconstruction. Br J Surg 83:127l–1272

    Article  Google Scholar 

  148. Schwarz A, Beger HG (2000) Veranderungen im gastrointestinalen Hormonhaushalt nach Gastrektomie: Was ist klinisch relevant? Chir Gastroenterol 16 (SuppI2):25–30

    Article  Google Scholar 

  149. Sears RJ, Champion GL, Richter JE (1995) Characteristics of distal partial gastrectomy patients with esophageal symptoms of duodenogastric reflux. Am J Gastroenterol 90:211–215

    PubMed  CAS  Google Scholar 

  150. Shultz KT, Neelon FA, Nilsen LB et al (1971) Mechanism of postgastrectomy hypoglycemia. Arch Intern Med 128: 240–246

    Article  PubMed  CAS  Google Scholar 

  151. Sigstad H (1970) A clinical diagnostic index in the diagnosis of the dumping syndrome. Acta Med Scand 188: 479–486

    Article  PubMed  CAS  Google Scholar 

  152. Sipponen P, Kekki M, Siurala M (1981) Atrophic gastritis and intestinal metaplasia in gastric carcinoma. Cancer 52: 1062–1068

    Article  Google Scholar 

  153. Sirinek KR, O'Dorisio TM, Howe B et al (1985) Neurotensin, vasoactive intestinal peptide, and Roux-en-Y gastrojejunostomy. Their role in the dumping syndrome. Arch Surg 120: 605–609

    Article  PubMed  CAS  Google Scholar 

  154. Smout AJPM, Akkermans LMA, Roelofs JMM (1987) Gastric emptying and postbrandial symptoms after Billroth II resection. Surgery 101:27–34

    PubMed  CAS  Google Scholar 

  155. Spitzer WO, Dobson AJ, Hall J et al (1981) Measuring the quality of life of cancer patients: a concise QL-index for use by physicians. J Chronic Dis 34: 585–597

    Article  PubMed  CAS  Google Scholar 

  156. Stalnikowicz R, Benbassat J (1990) Risk of gastric cancer after gastric surgery for benign disorders. Arch Intern Med 150: 2022–2026

    Article  PubMed  CAS  Google Scholar 

  157. Stalsberg H, Taksdal S (1971) Stomach cancer following gastric surgery for benign conditions. Lancet 2: 1175–1177

    Article  PubMed  CAS  Google Scholar 

  158. Stier A, Holscher AH, Schwaiger M et al (1994) Jejunum pouch after total gastrectomy-clinical and scintigraphic studies of function and quality of life. Zentralbl Chir 1:838–844

    Google Scholar 

  159. Storer EH (1976) Postvagotomy diarrhea. Surg Clin North Am 56: 1461–1468

    PubMed  CAS  Google Scholar 

  160. Summers GEJ, Hocking MP (1992) Preoperative and postoperative motility disorders of the stomach. Surg Clin North Am 72:467–486

    PubMed  Google Scholar 

  161. Svedlund J, Sullivan M, Liedmann B et al (1997) Quality of life after gastrectomy for gastric carcinoma: controlled study of reconstructive procedures. World J Surg 21: 422–433

    Article  PubMed  CAS  Google Scholar 

  162. Szurewski JH (1984) Smooth muscle electrophysiology. In: Bennett A, Velo G (eds) Mechanisms of GI motility and secretion. Raven Press, New York, pp 55–70

    Chapter  Google Scholar 

  163. Takahashi T, Yamamura T, J (1990) Pathogenesis of acute cholecystitis after gastrectomy. Br J Surg 77: 536–539

    Article  PubMed  CAS  Google Scholar 

  164. Takahashi T, Yamamura T, Yokoyama E et al (1986) Impaired contractile motility of the gallbladder after gastrectomy. Am J Gastroenterol 81: 672–677

    PubMed  CAS  Google Scholar 

  165. Tersmette AC, Offerhaus GJ, Tersmette KW et al (1990) Meta-analysis of the risk of gastric stump cancer: detection of high-risk patient subsets for stomach cancer after remote partial gastrectomy for benign conditions. Cancer Res 50: 6486–6489

    PubMed  CAS  Google Scholar 

  166. Thomas H, Heimbucher J, Fuchs KH et al (1996) The mode of Roux-en-Y reconstruction affects motility in the efferent limb. Arch Surg 131:63–66

    Article  PubMed  CAS  Google Scholar 

  167. Thybusch-Bernhardt A, Schmidt C, Küchler Th et al (1999) Quality of life following radical surgical treatment of gastric carcinoma. World J Surg 23: 503–508

    Article  PubMed  CAS  Google Scholar 

  168. Toubanakis G, Economou GC, JA et al (2000) Replacement of the pyloric sphincter with the ileocecal valve: an experimental study. Mt Sinai J Med 67: 152–158

    PubMed  CAS  Google Scholar 

  169. Troidl H, Kusche J, Vestweber KH et al (1987) Quality of life: an important endpoint both in surgical practice and research. J Chronic Dis 40: 523–528

    Article  PubMed  CAS  Google Scholar 

  170. Tu BN, Kelly KA (1995) Elimination of the Roux stasis syndrome using a new type of “uncut Roux” limb. Am J Surg 170: 381–386

    Article  PubMed  CAS  Google Scholar 

  171. Vaezi MF, Richter JE (1995) Synergism of acid and duodenogastroesophageal reflux in complicated Barrett’s esophagus. Surgery 117: 699–704

    Article  PubMed  CAS  Google Scholar 

  172. Valenzuela JE, Defilippi C (1981) Inhibition of gastric emptying in humans by secretion, the octapeptide of cholecystokinin, and intraduodenal fat. Gastroenterology 81: 898–902

    PubMed  CAS  Google Scholar 

  173. Van der Mijle HC, Beekhuis H, Bleichrodt RP et al (1993) Transit disorders of the gastric remnant and Roux limb after Roux-en-Y gastrojejunostomy: relation to symptomatology and vagotomy. Br J Surg 80: 60–64

    Article  Google Scholar 

  174. Van der Mijle HC, Kleibeuker JH, Limburg AJ et al (1993) Manometric and scintigraphic studies of the relation between motility disturbances in the Roux limb and the Rouxen-Y syndrome. Am J Surg 166: 11–17

    Article  Google Scholar 

  175. Van Knippenberg FC, de Haes JC (1988) Measuring the quality of life of cancer patients: psychometric properties of instruments. J Clin Epidemiol 41: 1043–1053

    Article  PubMed  CAS  Google Scholar 

  176. Vecht J, Masclee AA, Lamers CB (1997) The dumping syndrome. Current insights into pathophysiology, diagnosis and treatment. Scand J Gastroenterol Suppl 223: 21–27

    PubMed  CAS  Google Scholar 

  177. Visick AH (1948) A study of the failures after gastrectomy. Ann R Coll Surg Engl 3:266–284

    PubMed  CAS  Google Scholar 

  178. Waring JP, Legrand J, Chinichian A et al (1990) Duodenogastric reflux in patients with Barrett’s esophagus. Dig Dis Sci 35:759–762

    Article  PubMed  CAS  Google Scholar 

  179. Warshaw AL (1981) Intragastric alkali infusion: a simple, accurate provocative test for diagnosis of symptomatic alkaline reflux gastritis. Ann Surg 194: 297–304

    Article  PubMed  CAS  Google Scholar 

  180. Watanapa P, Flaks B, Oztas H et al (1992) Duodenogastric reflux enhances growth and carcinogenesis in the rat pancreas. Br J Surg 79:791–794

    Article  PubMed  CAS  Google Scholar 

  181. Watson D, Pennebaker JW (1989) Health complaints, stress, and distress: exploring the central role of negative affectivity. Psychol Rev 96: 234–254

    Article  PubMed  CAS  Google Scholar 

  182. Weisbrodt NW, Green GM, Levan VH et al (1985) Effect of pancreatic secretions on transit in bypassed loops of intestine in rats. Dig Dis Sci 31: 78–81

    Article  Google Scholar 

  183. Welch NT, Yasui A, Kim CB et al (1992) Effect of duodenal switch procedure on gastric acid production, intragastric pH, gastric emptying, and gastrointestinal hormones. Am J Surg 163:37–35

    Article  PubMed  CAS  Google Scholar 

  184. Wickremesinghe PC, Dayrit PQ, Manfredi OL et al (1983) Quantitative evaluation of bile diversion surgery utilizing 99mTc HIDA scintigraphy. Gastroenterology 84: 354–363

    PubMed  CAS  Google Scholar 

  185. Williams NS, Miller J, Elashoff J et al (1986) Canine resistances to gastric emptying of liquid nutrients after ulcer surgery. Dig Dis Sci 31:273–280

    Article  PubMed  CAS  Google Scholar 

  186. Woodward ER, Hocking MP (1987) Postgastrectomy syndromes. Surg Clin North Am 67:509–520

    PubMed  CAS  Google Scholar 

  187. Wu, CW, Hsieh, MC, Lo, SS, Lui, WY, P'eng, FK (1997) Quality of life of patients with gastric adenocarcinoma after curative gastrectomy. World J Surg 21:777–782

    Article  PubMed  CAS  Google Scholar 

  188. Zherlov GK, Dambaev GT, Bogomolov NI (1983) Gastric resection with creation of a sphincter in the region of the anastomosis in peptic ulcer. Klin Khir 8: 33–36

    PubMed  Google Scholar 

  189. Zieren HU, Zippel K, Zieren J et al (1998) Quality of life after surgical treatment of gastric carcinoma. Eur J Surg 164: 119–125

    Article  PubMed  CAS  Google Scholar 

  190. Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Metzger, J., Harder, F., Von Flüe, M. (2003). The Consequences of a Gastrectomy. In: Gastric Substitutes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55880-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-55880-1_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62497-1

  • Online ISBN: 978-3-642-55880-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics