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Autoantigene

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Molekularmedizinische Grundlagen von rheumatischen Erkrankungen

Part of the book series: Molekulare Medizin ((MOLMED))

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Zusammenfassung

Antigene sind Substanzen, welche eine Immunantwort auslösen und mit den Immunzellen (T- und B-Lymphozyten) bzw. den von ihnen gebildeten Produkten (Antikörpern, s. Kapitel 7 „Autoantikörper bei rheumatischen Erkrankungen“) in spezifischer Weise interagieren. Immunantwort auslösende komplette Antigene werden auch als Immunogene bezeichnet. Inkomplette Antigene (Haptene) können allein keine Antwort induzieren, sondern wirken nur nach Kopplung mit bestimmten Trägermolekülen (Carrier) immunogen, reagieren dann aber mit den für sie spezifischen Antikörpern. Komplette Antigene können natürlicher, artifizieller oder synthetischer Herkunft sein (Tabelle 6.1).

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Literatur

  • Aikoh T, Tomokuni A, Matsukii T et al. (1998) Activation-induced cell death in human peripheral blood lymphocytes after stimulation with silieate in vitro. Int J Oncol 12: 1355–1359

    PubMed  CAS  Google Scholar 

  • Alarcon Segovia D, Cabral AR (2000) The anti-phospholipid antibody syndrome: clinical and serologieal aspects. Baillieres Best Pract Res Clin Rheumatol 14:139–150

    Google Scholar 

  • Amoura Z, Piette JC, Bach JF, Koutouzov S (1999) The key role of nucleosomes in lupus. Arthritis Rheum 42:833–843

    PubMed  CAS  Google Scholar 

  • Anthony DD, Haqqi TM (1999) Collagen-induced arthritis in miee: an animal model to study the pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol 17:240–244

    PubMed  CAS  Google Scholar 

  • Arbuckle MR, James JA, Kohlhase KF, Rubertone MV, Dennis GJ, Hadey JB (2001) Development of anti-dsDNA autoantibodies prior to clinieal diagnosis of systemie lupus erythematosus. Scand J Immunol 54:211–219

    PubMed  CAS  Google Scholar 

  • Amett FC, Reveille JD, Goldstein R et al. (1996) Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetie, serologie, and clinieal analysis. Arthritis Rheum 39:1151–1160

    Google Scholar 

  • Arribas J, Luz Rodriguez M, Alvarez Do Fomo R, Castano JG (1991) Autoantibodies against the multieatalytie proteinase in patients with systemie lupus erythematosus. J Exp Med 173:423–427

    PubMed  CAS  Google Scholar 

  • Asaga H, Yamada M, Senshu T (1998) Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages. Biochem Biophys Res Commun 243:641–666

    PubMed  CAS  Google Scholar 

  • Astaldi Ricotti GC, Bestagno M, Cerino A et al. (1989) Antibodies to hnRNP core protein Al in connective tissue diseases. J Cell Biochem 40:43–47

    Google Scholar 

  • Axford JS (1999) Glycosylation and rheumatic disease. Biochim Biophys Acta 1455:219–229

    PubMed  CAS  Google Scholar 

  • Bachmann M (2000) Somatic mutations, a mechanism for induction of autoimmunity. In: Conrad K, Humbel RL, Meurer M, Shoenfeld Y, Tan EM (eds) Autoantigens and autoantibodies: diagnostic tools and clues to understanding autoimmunity. Pabst Science Publishers, Lengerich, pp 187–241

    Google Scholar 

  • Baeten D, Boots AM, Steenbakkers PG et al. (2000) Human cartilage gp-39+,CDl6+ monocytes in peripheral blood and synovium: correlation with joint destruction in rheumatoid arthritis. Arthritis Rheum 43:1233–1243

    PubMed  CAS  Google Scholar 

  • Barker RN, Wells AD, Ghoraishian M et al. (1996) Expression of mammalian 60-kD heat shock protein in the joints of mice with pristane-induced arthritis. Clin Exp Immunol 103:83–88

    PubMed  CAS  Google Scholar 

  • Benoist C, Mathis D (2000) A revival of the B cell paradigm for rheumatoid /arthritis pathogenesis? Arthritis Res 2:90–94

    PubMed  CAS  Google Scholar 

  • Billaut Mulot O, Cocude C, Kolesnitchenko V et al. (2001) SS-56, a novel cellular target of autoantibody responses in Sjogren syndrome and systemic lupus erythematosus. J Clin Invest 108:861–869

    Google Scholar 

  • Bläß S, Union A, Raymackers J et al. (2001) The stress protein BiP is overexpressed and is a major Band T cell target in rheumatoid arthritis. Arthritis Rheum 44:761–771

    PubMed  Google Scholar 

  • Bockenstedt LK, Gee RJ, Mamula MJ (1995) Self-peptides in the initiation of lupus autoimmunity. J Immunol 154:3516–3524

    PubMed  CAS  Google Scholar 

  • Boire G, Gendron M, Monast N, Bastin B, Menard HA (1995) Purification of antigenically intact Ro ribonucleoproteins; biochemical and immunological evidence that the 52-kD protein is not a Ro protein. Clin Exp Immunol 100:489–498

    PubMed  CAS  Google Scholar 

  • Borregaard N, Kjeldsen L, Lollike K, Sengelov H (1995) Granules and secretory vesicles of the human neutrophil. Clin Exp Immunol 101:16–19

    Google Scholar 

  • Bouffard P, Laniel MA, Boire G (1996) Anti-Ro (SSA) antibodies: clinical significance and biological relevance. J Rheumatol 23:1838–1841

    PubMed  CAS  Google Scholar 

  • Bouffard P, Barbar E, Briere F, Boire G (2000) Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins. RNA 6:66–78

    PubMed  CAS  Google Scholar 

  • Brahms H, Raymackers J, Union A, Keyser F de, Meheus L, Luhrmann R (2000) The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies. J Biol Chem 275:17.122–17.129

    Google Scholar 

  • Brockstedt E, Rickers A, Kostka S et al. (1998) Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein Al by caspase 3. J Biol Chem 273:28.057–28.064

    Google Scholar 

  • Brouwer R, Hengstman GJ, Vree Egberts W et al. (2000) Autoantibody profIles in the sera of European patients with myositis. Ann Rheum Dis 60:116–123

    Google Scholar 

  • Brouwer R, Pruijn GJ, Venrooij WJ van (2001) The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma. Arthritis Res 3:102–106

    PubMed  CAS  Google Scholar 

  • Bruns A, Blass S, Hausdorf G, Burmester GR, Hiepe F (2000) Nucleosomes are major T and B cell auto antigens in systemic lupus erythematosus. Arthritis Rheum 43:2307–2315

    PubMed  CAS  Google Scholar 

  • Bui N, Strub K (1999) New insights into signal recognition and elongation arrest activities of the signal recognition particle. Biol Chem 380:135–145

    PubMed  CAS  Google Scholar 

  • Bunn CC, Denton CP, Shi Wen X, Knight C, Black CM (1998) Anti-RNA polymerases and other autoantibody specificities in systemic sclerosis. Br J Rheumatol 37:15–20

    PubMed  CAS  Google Scholar 

  • Burd CG, Dreyfuss G (1994) Conserved structures and diversity of functions of RNA-binding proteins. Science 265:615–621

    PubMed  CAS  Google Scholar 

  • Buyon JP (1994) Neonatal lupus syndromes. Curr Opin Rheumatol 6:523–529

    PubMed  CAS  Google Scholar 

  • Buyon JP, Tseng CE, Di Donato F, Rashbaum W, Morris A, Chan EK (1997) Cardiac expression of 52beta, an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro auto antigen, is maximal during fetal development. Arthritis Rheum 40:655–660

    PubMed  CAS  Google Scholar 

  • Buyon JP, Kim MY, Copel JA, Friedman DM (2001) Anti-Ro/ SSA antibodies and congenital heart block: necessary but not sufficient. Arthritis Rheum 44:1723–1727

    PubMed  CAS  Google Scholar 

  • Casciola Rosen L, Rosen A (1997) Ultraviolet light-induced keratinocyte apoptosis: a potential mechanism for the induction of skin lesions and autoantibody production in LE. Lupus 6:175–180

    Google Scholar 

  • Casciola Rosen LA, Miller DK, Anhalt GJ, Rosen A (1994) Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J Biol Chem 269:30.757–30.760

    Google Scholar 

  • Casciola Rosen L, Wigley F, Rosen A (1997) Scleroderma auto antigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis. J Exp Med 185:71–79

    Google Scholar 

  • Casiano CA, Ochs RL, Tan EM (1998) Distinct cleavage products of nuclear pro teins in apoptosis and necrosis revealed by autoantibody probes. Cell Death Differ 5:183–190

    PubMed  CAS  Google Scholar 

  • Casiano CA, Wu X, Molinaro C (2000) Apoptosis, necrosis and the genesis of autoantibodies: an integral overview. In: Conrad K, Humbel RL, Meurer M, Shoenfeld Y, Tan EM (eds) Autoantigens and autoantibodies: diagnostic tools and clues to understanding autoimmunity. Pabst Science Publishers, Lengerich, pp 152–186

    Google Scholar 

  • Chabre H, Amoura Z, Piette JC, Godeau P, Bach JF, Koutouzov S (1995) Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus. Arthritis Rheum 38:1485–1491

    PubMed  CAS  Google Scholar 

  • Cheng ST, Nguyen TQ, Yang YS, Capra JD, Sontheimer RD (1996) Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein auto antigen. J Immunol 156:4484–4491

    PubMed  CAS  Google Scholar 

  • Chen X, Quinn AM, Wolin SL (2000) Ro ribonucleoproteins contribute to the resistance of Deinococcus radiodurans to ultraviolet irradiation. Genes Dev 14:777–782

    PubMed  CAS  Google Scholar 

  • Chiang SY, Swenberg JA, Weisman WH, Skopek TR (1997) Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line. Carcinogenesis 18:31–36

    PubMed  CAS  Google Scholar 

  • Chindalore V, Neas B, Reichlin M (1998) The association between anti-ribosomal Pantibodies and active nephritis in systemic lupus erythematosus. Clin Immunol Immunopathol 87:292–296

    PubMed  CAS  Google Scholar 

  • Cohen IR (2001) Antigenic mlmlcry, clonal selection and autoimmunity. J Autoimmun 16:337–340

    PubMed  CAS  Google Scholar 

  • Conrad K, Mehlhorn J (2000) Diagnostic and prognostic relevance of autoantibodies in uranium miners. Int Arch Allergy Immunol 123:77–91

    PubMed  CAS  Google Scholar 

  • Conroy SE, Faulds GB, Williams W, Latchman DS, Isenberg DA (1994) Detection of autoantibodies to the 90 kDa heat shock protein in systemic lupus erythematosus and other autoimmune diseases. Br J Rheumatol 33:923–926

    PubMed  CAS  Google Scholar 

  • Cook AD, Rowley MJ, Mackay IR, Gough A, Emery P (1996) Antibodies to type 11 collagen in early rheumatoid arthritis. Correlation with disease progression. Arthritis Rheum 39:1720–1727

    PubMed  CAS  Google Scholar 

  • Cooley HM, Melny BJ, Gleeson R, Greco T, Kay TW (1999) Clinical and serological assoeiations of anti-Ku antibody. J Rheumatol 26:563–567

    PubMed  CAS  Google Scholar 

  • Cope AP, Sonderstrup G (1998) Evaluating candidate autoantigens in rheumatoid arthritis. Springer Semin Immunopathol 20:23–39

    PubMed  CAS  Google Scholar 

  • Corrigall VM, Bodman Smith MD, Fife MS et al. (2001) The human endoplasmic reticulum molecular chaperone BiP is an auto antigen for rheumatoid arthritis and prevents the induction of experimental arthritis. J Immunol 166: 1492–1498

    PubMed  CAS  Google Scholar 

  • Craft J, Fatenejad S (1997) Self antigens and epitope spreading in systemic autoimmunity. Arthritis Rheum 40:1374–1382

    PubMed  CAS  Google Scholar 

  • Craig JM, Earnshaw WC, Vagnarelli P (1999) Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression. Exp Cell Res 246:249–262

    PubMed  CAS  Google Scholar 

  • Cremer MA, Rosloniec EF, Kang AH (1998) The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease. J Mol Med 76:275–288

    PubMed  CAS  Google Scholar 

  • Datta SK, Kaliyaperumal A, Mohan C, Desai Mehta A (1997) T helper cells driving pathogenic anti-DNA autoantibody production in lupus: nucleosomal epitopes and CD40 ligand signals. Lupus 6:333–336

    PubMed  CAS  Google Scholar 

  • De Graeff Meeder ER, Eden W van, Rijkers GT et al. (1995) Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis. J Clin Invest 95:934–940

    Google Scholar 

  • De Wildt RM, Finnern R, Ouwehand WH, Griffiths AD, Venrooij WJ van, Hoet RM (1996) Characterization of human variable domain antibody fragments against the U1 RNA-assoeiated A protein, selected from a synthetic and patient-derived combinatorial V gene library. Eur J Immunol 26:629–639

    PubMed  Google Scholar 

  • De Wildt RM, Steenbakkers PG, Pennings AH, Hoogen FH van den, Venrooij WJ van, Hoet RM (1997) A new method for the analysis and production of monoclonal antibody fragments originating from single human B cells. J Immunol Methods 207:61–67

    PubMed  Google Scholar 

  • Decker P, Briand JP, Mureia G de, Pero RW, Isenberg DA, Muller S (1998) Zinc is an essential cofactor for recognition of the DNA binding domain of poly(ADP-ribose) polymerase by antibodies in auto immune rheumatic and bowel diseases. Arthritis Rheum 41:918–926

    PubMed  CAS  Google Scholar 

  • Decker P, Isenberg D, Muller S (2000) Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase (PARP) apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis. J Biol Chem 275:9043–9046

    PubMed  CAS  Google Scholar 

  • Despres N, Boire G, Lopez Longo FJ, Menard HA (1994) The Sa system: a novel antigen-antibody system speeific for rheumatoid arthritis. J Rheumatol 21:1027–1033

    PubMed  CAS  Google Scholar 

  • Dick T, Mierau R, Sternfeld R, Weiner EM, Genth E (1995) Clinical relevance and HLA assoeiation of autoantibodies against the nucleolus organizer region (NOR-90). J Rheumatol 22:67–72

    PubMed  CAS  Google Scholar 

  • Dighiero G (1997) Natural autoantibodies, tolerance, and autoimmunity. Ann N Y Acad Sci 815:182–192

    PubMed  CAS  Google Scholar 

  • Dighiero G, Rose NR (1999) Critical self-epitopes are key to the understanding of self-tolerance and autoimmunity. Immunol Today 20:423–428

    PubMed  CAS  Google Scholar 

  • Ditzel HJ, Masaki Y, Nielsen H, Farnaes L, Burton DR (2000) Cloning and expression of a novel human antibody-antigen pair assoeiated with Felty’s syndrome. Proc Natl Acad Sei USA 97:9234–9239

    CAS  Google Scholar 

  • Dominguez M, Cacoub P, Gareia de la Torre I et al. (2001) Autoantibodies to receptor induced neoepitopes of fibrinolytic pro teins in rheumatic and vascular diseases. J Rheumatol 28:302–308

    PubMed  CAS  Google Scholar 

  • Dorner T, Hucko M, Mayet WJ, Trefzer U, Burmester GR, Hiepe F (1995) Enhanced membrane expression of the 52 kDa Ro(SS-A) and La(SS-B) antigens by human keratinocytes induced by TNF alpha. Ann Rheum Dis 54:904–909

    PubMed  CAS  Google Scholar 

  • Dreyfuss G, Matunis MJ, Pinol Roma S, Burd CG (1993) hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem 62:289–321

    PubMed  CAS  Google Scholar 

  • Earnshaw WC, Tomkiel JE (1992) Centromere and kinetochore structure. Curr Opin Cell Biol 4:86–93

    PubMed  CAS  Google Scholar 

  • Eden W van, Zee R van der, Paul AG et al. (1998) Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases? Immunol Today 19:303–307

    PubMed  Google Scholar 

  • Eden W van, Wendling U, Paul L, Prakken B, Kooten P van, Zee R van der (2000) Arthritis protective regulatory potential of self-heat shock protein cross-reactive T cells. Cell Stress Chaperones 5:452–457

    PubMed  Google Scholar 

  • Eenennaam H van, Jarrous N, Venrooij WJ van, Pruijn GJ (2000) Architecture and function of the human endonucleases RNAse P and RNAse MRP. IUBMB Life 49:265–272

    PubMed  Google Scholar 

  • Eftekhari P, Salle L, Lezoualc’h F et al. (2000) Anti-SSA/R052 autoantibodies blocking the cardiac 5-HT4 serotoninergic receptor could explain neonatal lupus congenital heart block. Eur J Immunol 30:2782–2790

    PubMed  CAS  Google Scholar 

  • Eftekhari P, Roegel JC, Lezoualc’h F, Fischmeister R, Imbs JL, Hoebeke J (2001) Induction of neonatallupus in pups of mice immunized with synthetic peptides derived from amino acid sequences of the serotoninergic 5-HT4 receptor. Eur J Immunol 31:573–579

    PubMed  CAS  Google Scholar 

  • Elkon KB, Bonfa E, Weissbach H, Brot N (1994) Antiribosomal antibodies in SLE, infection, and following deliberate immunization. Adv Exp Med Biol 347:81–92

    PubMed  CAS  Google Scholar 

  • Fabini G, Rutjes SA, Zimmermann C, Pruijn GJ, Steiner G (2000) Analysis of the niolecular composition of Ro ribonucleoprotein complexes. Identification of novel Y RNAbinding proteins. Eur J Biochem 267:2778–2789

    PubMed  CAS  Google Scholar 

  • Fabini G, Raijmakers R, Hayer S, Fouraux MA, Pruijn GJ, Steiner G (2001) The heterogeneous nuclear ribonucleoproteins land K interact with a subset of the ro ribonucleoprotein-associated Y RNAs in vitro and in vivo. J Biol Chem 276:20.711–20.718

    Google Scholar 

  • Feist E, Dorner T, Kuckelkorn U et al. (1996) Proteasome alpha-type subunit C9 is a primary target of autoantibodies in sera of patients with myositis and systemic lupus erythematosus. J Exp Med 184:1313–1318

    PubMed  CAS  Google Scholar 

  • Feist E, Kuckelkorn U, Dorner T et al. (1999) Autoantibodies in primary Sjogren’s syndrome are directed against proteasomal subunits of the alpha and beta type. Arthritis Rheum 42:697–702

    PubMed  CAS  Google Scholar 

  • Feist E, Dorner T, Kuckelkorn U, Scheffler S, Burmester G, Kloetzel P (2000) Diagnostie importance of anti-proteasome antibodies. Int Arch Allergy Immunol 123:92–97

    PubMed  CAS  Google Scholar 

  • Fritzler MJ, Chan EKL (2000) Autoantibodies to endosomes and the Golgi complex. In: Conrad K, Humbel RL, Meurer M, Shoenfeld Y, Tan EM (eds) Autoantigens and autoantibodies: diagnostie tools and dues to understanding autoimmunity. Pabst Seience Publishers, Lengerieh, pp 339–361

    Google Scholar 

  • Fritzler M, Rattner JB (2000) Autoantibodies to the mitotie apparatus: Biologieal breakthroughs, dinieal applieation, etiologieal complexity. In: Conrad K, Humbel RL, Meurer M, Shoenfeld Y, Tan EM (eds) Autoantigens and autoantibodies: diagnostie tools and dues to understanding autoimmunity. Pabst Seience Publishers, Lengerieh, pp 58–86

    Google Scholar 

  • Furuta K, Hildebrandt B, Matsuoka S et al. (1998) Immunological characterization of heterochrornatin protein p25beta autoantibodies and relationship with centromere autoantibodies and pulmonary fibrosis in systemie sderoderma. J Mol Med 76:54–60

    PubMed  CAS  Google Scholar 

  • Gallucei S, Matzinger P (2001) Danger signals: SOS to the immune system. Curr Opin Immunol 13:114–119

    Google Scholar 

  • Gause A, Berek C (2001) Role of B cells in the pathogenesis of rheumatoid arthritis: potential implieations for treatment. Biodrugs 15:73–79

    PubMed  CAS  Google Scholar 

  • Ge Q, Wu Y, James JA, Targoff IN (1996) Epitope analysis of the major reactive region of the 100-kd protein of PM-Sd auto antigen. Arthritis Rheum 39:1588–1595

    PubMed  CAS  Google Scholar 

  • Geld YM van der, Limburg PC, Kallenberg CG (2001) Proteinase 3, Wegener’s auto antigen: from gene to antigen. J Leukoc Biol 69:177–190

    PubMed  Google Scholar 

  • Genth E, Mierau R (1995) Diagnostische Bedeutung Sklerodermie-und Myositis-assoziierter Autoantikorper. Z Rheumatol 54:39–49

    PubMed  CAS  Google Scholar 

  • George J, Afek A, Gilburd B et al. (1998) Induction of early atherosderosis in LDL-receptor-defieient miee immunized with beta2-g1ycoprotein 1. Circulation 98: 1108–1115

    PubMed  CAS  Google Scholar 

  • Georgescu L, Mevorach D, Arnett FC, Reveille JD, Elkon KB (1997) Anti-P antibodies and neuropsychiatrie lupus erythematosus. Ann N Y Acad Sci 14:823:263–269

    Google Scholar 

  • Gething MJ (1999) Role and regulation of the ER chaperone BiP. Semin Cell Dev Biol 10:465–472

    PubMed  CAS  Google Scholar 

  • Girbal Neuhauser E, Durieux JJ, Arnaud M et al. (1999) The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro )filaggrin by deimination of arginine residues. J Immunol 162:585–594

    Google Scholar 

  • Goldbach Mansky R, Lee J, McCoy A et al. (2000) Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res 2:236–243

    Google Scholar 

  • Gong H, Zolzer F, Recklinghausen G von, Havers W, Schweigerer L (2000) Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cyde arrest and apoptosis. Leukemia 14:826–829

    PubMed  CAS  Google Scholar 

  • Greidinger EL, Hoffman RW (2001) The appearance of U1 RNP antibody specificities in sequential autoimmune human antisera follows a characteristic order that implicates the UI-70 kd and B’/B proteins as predominant U1 RNP immunogens. Arthritis Rheum 44:368–375

    PubMed  CAS  Google Scholar 

  • Greidinger EL, Casciola Rosen L, Morris SM, Hoffman RW, Rosen A (2000) Autoantibody recognition of distinctly modified forms of the Ul-70-kd antigen is associated with different dinieal disease manifestations. Arthritis Rheum 43:881–888

    PubMed  CAS  Google Scholar 

  • Grodzieky T, Elkon KB (2000) Apoptosis in rheumatie diseases. Am J Med 108:73–82

    Google Scholar 

  • Gross WL, Csernok E (1995) Immunodiagnostie and pathophysiologie aspects of antineutrophil cytoplasmie antibodies in vasculitis. Curr Opin Rheumatol 7:11–19

    PubMed  CAS  Google Scholar 

  • Guerassimov A, Zhang Y, Banerjee S et al. (1998) Autoimmunity to cartilage link protein in patients with rheumatoid arthritis and ankylosing spondylitis. J Rheumatol 25:1480–1484

    PubMed  CAS  Google Scholar 

  • Guerassimov A, Zhang Y, Cartman A et al. (1999) Immune responses to cartilage link protein and the GI domain of proteoglycan aggrecan in patients with osteoarthritis [published erratum appears in Arthritis Rheum 1999 Jun;42(6):1303. Arthritis Rheum 42:527–533

    PubMed  CAS  Google Scholar 

  • Guldner HH, Netter HJ, Szostecki C, Jaeger E, Will H (1990) Human anti-p68 autoantibodies recognize a common epitope of Ul RNA containing small nudear ribonudeoprotein and influenza B virus. J Exp Med 171:819–829

    PubMed  CAS  Google Scholar 

  • Haaheim LR, Halse AK, Kvakestad R, Stern B, Normann O, Jonsson R (1996) Serum antibodies from patients with primary Sjogren’s syndrome and systemie lupus erythematosus recognize multiple epitopes on the La(SS-B) auto antigen resembling viral protein sequences. Scand J Immunol 43:115–121

    PubMed  CAS  Google Scholar 

  • Harley JB, James JA (1999) Epstein-Barr virus infection may be an environmental risk factor for systemie lupus erythematosus in children and teenagers. Arthritis Rheum 42:1782–1783

    PubMed  CAS  Google Scholar 

  • Harvey G, Black C, Maddison P, McHugh N (1997) Characterization of antinudeolar antibody reactivity in patients with systemie sderosis and their relatives. J Rheumatol 24:477–484

    PubMed  CAS  Google Scholar 

  • Harvey GR, Butts S, Rands AL, Patel Y, McHugh NJ (1999) Clinical and serological assoeiations with anti-RNA polymerase antibodies in systemie sderosis. Clin Exp Immunol 117:395–402

    PubMed  CAS  Google Scholar 

  • Hassfeld W, Steiner G, Graninger W, Witzmann G, Schweitzer H, Smolen JS (1993) Autoantibody to the nudear antigen RA33: a marker for early rheumatoid arthritis. Br J Rheumatol 32:199–203

    PubMed  CAS  Google Scholar 

  • Hassfeld W, Steiner G, Studnieka Benke A et al. (1995) Autoimmune response to the spliceosome. An immunologie link between rheumatoid arthritis, mixed connective tissue disease, and systemic lupus erythematosus. Arthritis Rheum 38:777–785

    PubMed  CAS  Google Scholar 

  • Hasunuma Y, Matsuura E, Makita Z, Katahira T, Nishi S, Koike T (1997) Involvement of beta 2-glycoprotein land anticardiolipin antibodies in oxidatively modified lowdensity lipoprotein uptake by macrophages. Clin Exp Immunol 107:569–573

    PubMed  CAS  Google Scholar 

  • Hausmann S, Wucherpfennig KW (1997) Activation of autoreactive T cells by peptides from human pathogens. Curr Opin Immunol 9:831–838

    PubMed  CAS  Google Scholar 

  • Hayem G, De Bandt M, Palazzo E et al. (1999) Anti-heat shock protein 70 kDa and 90 kDa antibodies in serum of patients with rheumatoid arthritis. Ann Rheum Dis 58:291–296

    PubMed  CAS  Google Scholar 

  • Hemmerieh P, Neu E, Macht M, Peter HH, Krawinkel U, Mikecz A von (1998) Correlation between chlamydial infection and auto immune response: molecular mimiery between RNA polymerase major sigma subunit from Chlamydia trachomatis and human L7. Eur J Immunol 28:3857–3866

    Google Scholar 

  • Hiepe F (2000) The partide nature of intracellular autoantigens. In: Conrad K, Humbel RL, Meurer M, Shoenfeld Y, Tan EM (eds) Autoantigens and autoantibodies: Diagnostic tools and dues to understanding autoimmunity. Pabst Science Publishers, Lengerich, pp 26–38

    Google Scholar 

  • Hoch SO (1994) The Sm antigens. In: Venrooij WJ van, Maini RN (eds) Manual of biological markers of disease, vol B. Kluwer Academic Publishers, Dordrecht Boston London, pp 2.4/1–2.4/23

    Google Scholar 

  • Holmdahl R (1998) Genetics of susceptibility to chronic experimental encephalomyelitis and arthritis. Curr Opin Immunol 10:710–717

    PubMed  CAS  Google Scholar 

  • Holmdahl R, Andersson EC, Andersen CB, Svejgaard A, Fugger L (1999) Transgenic mouse models of rheumatoid arthritis. Immunol Rev 169:161–173

    PubMed  CAS  Google Scholar 

  • Horvath L, Czirjak L, Fekete B et al. (2001) Levels of antibodies against Clq and 60 kDa family of heat shock proteins in the sera of patients with various auto immune diseases. Immunol Lett 75:103–109

    PubMed  CAS  Google Scholar 

  • Hueber W, Hassfeld W, Smolen JS, Steiner G (1999) Sensitivity and specificity of anti-Sa autoantibodies for rheumatoid arthritis. Rheumatology Oxford 38:155–159

    PubMed  CAS  Google Scholar 

  • Hultman P, Enestrom S, Tudey SJ, Pollard KM (1994) Selective induction of anti-fibrillarin autoantibodies by silver nitrate in mice. Clin Exp Immunol 96:285–291

    PubMed  CAS  Google Scholar 

  • Hultman P, Hansson-Georgiadis H (1999) Methyl mercuryinduced autoimmunity in mice. Toxicol Appl Pharmacol 154:203–211

    PubMed  CAS  Google Scholar 

  • Ieko M, Ichikawa K, Triplett DA et al. (1999) Beta2-glycoprotein I is necessary to inhibit protein C activity by monodonal anticardiolipin antibodies. Arthritis Rheum 42:167–174

    PubMed  CAS  Google Scholar 

  • Ioannou Y, Sultan S, Isenberg DA (1999) Myositis ovedap syndromes. Curr Opin Rheumatol 11:468–474

    PubMed  CAS  Google Scholar 

  • Isenberg DA (1995) Humoral immunity and glycosylation abnormalities in rheumatoid arthritis. Clin Exp Rheumatol 13:12s17–20

    Google Scholar 

  • Iyer R, Holian A (1997) Involvement of the ICE family of proteases in siliea-indueed apoptosis in human alveolar macrophages. Am J Physiol 273:L760–L767

    PubMed  CAS  Google Scholar 

  • Iyer R, Hamilton RF, Li L, Holian A (1996) Silica-induced apoptosis mediated via seavenger receptor in human alveolar macrophages. Toxicol Appl Pharmacol 141:84–92

    PubMed  CAS  Google Scholar 

  • James JA, Hadey JB (1998) B-cell epitope spreading in autoimmunity. Immunol Rev 16:185–200

    Google Scholar 

  • James JA, Gross T, Scofield RH, Hadey JB (1995) Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B’-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. J Exp Med 181:453–461

    PubMed  CAS  Google Scholar 

  • James JA, Kaufman KM, Farris AD et al. (1997) An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus. J Clin Invest 100:3019–3026

    PubMed  CAS  Google Scholar 

  • James JA, Hadey JB, Scofield RH (2001) Role of virus es in systemic lupus erythematosus and Sjogren syndrome. Curr Opin Rheumatol 13:370–376

    PubMed  CAS  Google Scholar 

  • Jefferis R (1995) Rheumatoid factors, B cells and immunoglobulin genes. Br Med Bull 51:312–331

    PubMed  CAS  Google Scholar 

  • Jefferis R, Lund J, Pound JD (1998) IgG-Fc-mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation. Immunol Rev 16:359–376

    Google Scholar 

  • Ji H, Korganow AS, Mangialaio S et al. (1999) Different modes of pathogenesis in T-cell-dependent autoimmunity: dues from two TCR transgenic systems. Immunol Rev 16:139–146

    Google Scholar 

  • Kallenberg CG (1998) Autoantibodies to myeloperoxidase: dinical and pathophysiological significance. J Mol Med 76:682–687

    PubMed  CAS  Google Scholar 

  • Karwan RM (1998) Further characterization of human RNAse MRP/RNAse P and related autoantibodies. Mol Biol Rep 25:95–101

    PubMed  CAS  Google Scholar 

  • Keech CL, Gordon TP, McCluskey J (1996) The immune response to 52-kDa Ro and 60-kDa Ro is linked in experimental autoimmunity. J Immunol 157:3694–3699

    PubMed  CAS  Google Scholar 

  • Khan MF, Wu X, Ansari GA (2001) Anti-malondialdehyde antibodies in MRL+I+ mice treated with trichloroethene and dichloroacetyl chloride: possible role of lipid peroxidation in autoimmunity. Toxicol Appl Pharmacol 170:88–92

    PubMed  CAS  Google Scholar 

  • Kindas Mugge I, Steiner G, Smolen JS (1993) Similar frequency of autoantibodies against 70-kD dass heat-shock proteins in healthy subjects and systemic lupus erythematosus patients. Clin Exp Immunol 92:46–50

    Google Scholar 

  • Kishore U, Reid KB (2000) Clq: structure, function, and receptors. Immunopharmacology 49:159–170

    PubMed  CAS  Google Scholar 

  • Klein Gunnewick JMT, Venrooij WJ van (1994) Autoantigens contained in the U1 small nudear ribonudeoprotein complex. In: Venrooij WJ van, Maini RN (eds) Manual of biological markers of disease, vol B. Kluwer Academic Publishers, Dordrecht Boston London, pp 3.1/1–20

    Google Scholar 

  • Koike T (2000) Anticardiopilin antibody — specificity and pathogenesis. In: Conrad K, Humbel RL, Meurer M, Shoenfeld Y, Tan EM (eds) Autoantigens and autoantibodies: diagnostic tools and dues to understanding autoimmunity. Pabst Science Publishers, Lengerich, pp 383–396

    Google Scholar 

  • Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C, Mathis D (1996) Organ-specific disease provoked by systemic autoimmunity. Cell 87:811–822

    PubMed  CAS  Google Scholar 

  • Kramer A (1996) The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu Rev Biochem 65:367–409

    PubMed  CAS  Google Scholar 

  • Kreeic AM, Swanson MS (1999) hnRNP complexes: composition, structure, and function. Curr Opin Cell Biol 11:363–371

    Google Scholar 

  • Kuwana M, Okano Y, Kaburaki J, Medsger TA, Wright TM (1999) Autoantibodies to RNA polymerases recognize multiple subunits and demonstrate cross-reactivity with RNA polyrnerase complexes. Arthritis Rheum 42:275–284

    PubMed  CAS  Google Scholar 

  • Labbe JC, Hekimi S, Rokeach LA (1999) Assessing the function of the Ro ribonudeoprotein complex using Caenorhabditis elegans as a biological tool. Biochem Cell Biol 77:349–354

    PubMed  CAS  Google Scholar 

  • Labbe JC, Burgess J, Rokeach LA, Hekimi S (2001) ROP-1, an RNA quality-control pathway component, affects Caenorhabditis elegans dauer formation. Proc Natl Acad Sci USA 97:13.233–13.238

    Google Scholar 

  • Lacroix-Desmazes S, Kaveri SV, Mouthon L et al. (1998) Self-reactive antibodies (natural autoantibodies) in healthy individuals. J Irnmunol Methods 216:117–137

    CAS  Google Scholar 

  • Lan MS, Madaren NK (1998) Cryptic epitope and autoimrnunity. Diabetes Metab Rev 14:333–334

    PubMed  CAS  Google Scholar 

  • Latchman DS, Isenberg DA (1994) The role of hsp90 in SLE. Autoimmunity 19:211–218

    PubMed  CAS  Google Scholar 

  • Lee B, Craft JE (1995) Molecular structure and function of auto antigens in systemic sc1erosis. Int Rev Immunol 12:129–144

    PubMed  CAS  Google Scholar 

  • Lockshin MD, Letendre CH (1992) Antiphospholipid antibody/ lupus anticoagulant workshop. Arthritis Rheum 35:1234–1237

    PubMed  CAS  Google Scholar 

  • Lorenz HM, Herrmann M, Winkler T, Gaipl U, Kalden JR (2000) Role of apoptosis in autoimmunity. Apoptosis 5:443–449

    PubMed  CAS  Google Scholar 

  • Lu L, Kaliyaperumal A, Boumpas DT, Datta SK (1999) Major peptide autoepitopes for nuc1eosome-speeific T cells of human lupus. J Clin Invest 104:345–355

    PubMed  CAS  Google Scholar 

  • Luross JA, Williams NA (2001) The genetic and immunopathological pro ces ses underlying collagen-induced arthritis. Immunology 103:407–416

    PubMed  CAS  Google Scholar 

  • Macario AJ (1995) Heat-shock proteins and molecular chaperones: implications for pathogenesis, diagnostics, and therapeutics. Int J Clin Lab Res 25:59–70

    PubMed  CAS  Google Scholar 

  • Mageed RA, Borretzen M, Moyes SP, Thompson KM, Natvig JB (1997) Rheumatoid factor autoantibodies in health and disease. Ann N Y Acad Sci 5:815.296–815.311

    Google Scholar 

  • Mahler M, Mierau R, Bluthner M (2000) Fine-speeifieity of the anti-CENP-A B-cell auto immune response. J Mol Med 78:460–467

    PubMed  CAS  Google Scholar 

  • Mallard K, Jones DB, Richmond J, McGill M, Foulis AK (1996) Expression of the human heat shock pro tein 60 in thyroid, pancreatic, hepatic and adrenal autoimmunity. J Autoimmun 9:89–96

    PubMed  CAS  Google Scholar 

  • Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E et al. (2001) The major synovial targets of the rheumatoid arthritis-speeific antifllaggrin autoantibodies are deiminated forms of the alpha-and beta-chains of fibrin. J Immunol 166

    Google Scholar 

  • Matsumoto I, Staub A, Benoist C, Mathis D (1999) Arthritis provoked by linked T and Beeil recognition of a glycolytic enzyme. Science 286:1732–1735

    PubMed  CAS  Google Scholar 

  • Mavragani CP, Tzioufas AG, Moutsopoulos HM (2000) Sjogren’s syndrome: autoantibodies to cellular antigens. Clinical and molecular aspects. Int Arch Allergy Immunol 123:46–57

    PubMed  CAS  Google Scholar 

  • McCluskey J, Farris AD, Keech CL et al. (1998) Determinant spreading: lessons from animal models and human disease. Immunol Rev 16:4209–4229

    Google Scholar 

  • Menard HA, Lapointe E, Rochdi MD, Zhou ZJ (2000) Insights into rheumatoid arthritis derived from the Sa immune system. Arthritis Res 2:429–432

    PubMed  CAS  Google Scholar 

  • Meroni PL, Raschi E, Testoni C, Tincani A, Balestrieri G (2001) Antiphospholipid antibodies and the endothelium. Rheum Dis Clin North Am 27:587–602

    PubMed  CAS  Google Scholar 

  • Mevoraeh D, Zhou JL, Song X, Elkon KB (1998) Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med 188:387–392

    Google Scholar 

  • Mimori T (1996) Structures targeted by the immune system in myositis. Curr Opin Rheumatol 8:521–527

    PubMed  CAS  Google Scholar 

  • Miranda Carus ME, Boutjdir M, Tseng CE, DiDonato F, Chan EK, Buyon JP (1998) Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model. J Immunol 161:5886–5892

    Google Scholar 

  • Mocei S, Lafferty K, Howard M (2000) The role of auto antigens in autoimmune disease. Curr Opin Immunol 12:725–730

    Google Scholar 

  • Mohan C, Datta SK (1995) Lupus: key pathogenic mechanisms and contributing factors. Clin Immunol Immunopathol 77:209–220

    PubMed  CAS  Google Scholar 

  • Montecucco C, Caporali R, Cobianchi F, Biamonti G (1996) Identification of autoantibodies to the I protein of the heterogeneous nuc1ear ribonuc1eoprotein complex in patients with systemic sc1erosis. Arthritis Rheum 39:1669–1676

    PubMed  CAS  Google Scholar 

  • Morgan K (1990) What do anti-collagen antibodies mean? Ann Rheum Dis 49:62–65

    PubMed  CAS  Google Scholar 

  • Moseley P (2000) Stress proteins and the immune response. Immunopharmacology 48:299–302

    PubMed  CAS  Google Scholar 

  • Muhlen CA von, Tan EM (1995) Autoantibodies in the diagnosis of systemic rheumatic diseases. Semin Arthritis Rheum 24:323–358

    Google Scholar 

  • Nagaraju K, Cox A, Caseiola-Rosen L, Rosen A (2001) Novel fragments of the Sjögren’s syndrome autoantigens alphafodrin and type 3 muscarinic acetylcholine receptor generated during cytotoxic Iymphocyte granule-induced cell death. Arthritis Rheum 44:2376–2386

    PubMed  CAS  Google Scholar 

  • Neugebauer KM, Merrill JT, Wener MH, Lahita RG, Roth MB (2000) SR proteins are autoantigens in patients with systemic lupus erythematosus. Importanee of phosphoepitopes. Arthritis Rheum 43: 1768–1778

    PubMed  CAS  Google Scholar 

  • Nietert PJ, Sutherland SE, Silver RM et al. (1998) Is occupational organic solvent exposure a risk factor for sc1eroderma? Arthritis Rheum 41:1111–1118

    PubMed  CAS  Google Scholar 

  • O’Brien CA, Wolin SL (1994) A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors. Genes Dev 8:2891–2903

    PubMed  Google Scholar 

  • Pierangeli SS, Gharavi AE, Harris EN (2000) Experimental thrombosis and antiphospholipid antibodies: new insights. J Autoimmun 15:241–247

    PubMed  CAS  Google Scholar 

  • Pockley AG, Bulmer J, Hanks BM, Wright BH (1999) Identification of human heat shock protein 60 (Hsp60) and anti-Hsp60 antibodies in the peripheral eirculation of normal individuals. Cell Stress Chaperones 4:29–35

    PubMed  CAS  Google Scholar 

  • Pollard KM, Pearson DL, Bluthner M, Tan EM (2000) Proteolytic c1eavage of a self-antigen following xenobiotic-induced cell death produces a fragment with novel immunogenic properties. J Immunol 165:2263–2270

    PubMed  CAS  Google Scholar 

  • Pommier Y (1998) Diversity of DNA topoisomerases land inhibitors. Biochimie 80:255–270

    PubMed  CAS  Google Scholar 

  • Pritzker LB, Joshi S, Gowan JJ, Harauz G, Moscarello MA (2000) Deimination of myelin basic protein. 1. Effect of deimination of arginyl residues of myelin basic protein on its strueture and susceptibility to digestion by cathepsin D. Biochemistry 39:5374–5381

    PubMed  CAS  Google Scholar 

  • Prockop DJ, Kivirikko KI (1995) Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Bioehern 64:403–434

    CAS  Google Scholar 

  • Pruijn GJM (2000) Autoantigens in the nuc1eolus of human cells. In: Conrad K, Humbel RL, Meurer M, Shoenfeld Y, Tan EM (eds) Autoantigens and autoantibodies: diagnostic tools and clues to understanding autoimmunity. Pabst Seience Publishers, Lengerich, pp 41–57

    Google Scholar 

  • Pruijn GJ, Simons FH, Venrooij WJ van (1997) Intraeellular loealization and nucleoeytoplasmic transport of Ro RNP components. Eur J Cell Biol 74:123–132

    PubMed  CAS  Google Scholar 

  • Rattner JB, Rees J, Arnett FC, Reveille JD, Goldstein R, Fritzier MJ (1996) The centromere kinesin-like protein, CENP-E. An auto antigen in systemic sclerosis. Arthritis Rheum 39:1355–1361

    PubMed  CAS  Google Scholar 

  • Rattner JB, Rees J, Whitehead CM et al. (1997) High frequency of neoplasia in patients with autoantibodies to centromere protein CENP-F. Clin Invest Med 20:308–319

    PubMed  CAS  Google Scholar 

  • Reichlin M, Van Venrooij WJ (1991) Autoantibodies to the URNP particles: relationship to clinical diagnosis and nephritis. Clin Exp Irnrnunol 83:286–290

    CAS  Google Scholar 

  • Reichlin M, Wolfson Reichlin M (1999) Evidence for the participation of anti-ribosomal P antibodies in lupus nephritis. Arthritis Rheum 42:2728–2729

    PubMed  CAS  Google Scholar 

  • Riemekasten G, Marell J, Trebeljahr G et al. (1998) A novel epitope on the C-terminus of SmDI is recognized by the majority of sera from patients with systemic lupus erythematosus. J Clin Invest 102:754–763

    PubMed  CAS  Google Scholar 

  • Rose NR (1998) The role of infection in the pathogenesis of autoimmune disease. Semin Immunol 10:5–13

    PubMed  CAS  Google Scholar 

  • Rothfield N, Whitaker D, Bordwell B, Weiner E, Senecal JL, Earnshaw W (1987) Detection of anticentromere antibodies using cloned autoantigen CENP-B. Arthritis Rheum 30:1416–1419

    PubMed  CAS  Google Scholar 

  • Roux S, Seelig HP, Meyer O (1998) Significance of Mi-2 autoantibodies in polymyositis and dermatomyositis. J Rheumatol 25:395–396

    PubMed  CAS  Google Scholar 

  • Rowley MJ, Cook AD, Mackay IR, Teuber SS, Gershwin ME (1996) Comparative epitope mapping of antibodies to collagen in women with silicone breast implants, systemic lupus erythematosus and rheumatoid arthritis. Curr Top Microbiol Immunol 210:307–316

    PubMed  CAS  Google Scholar 

  • Rubin RL (1999) Etiology and mechanisms of drug-induced lupus. Curr Opin Rheumatol 11:357–363

    PubMed  CAS  Google Scholar 

  • Rutjes SA, Vree Egberts WT, Jongen P, Van Den Hoogen F, Pruijn GJ, Van Venrooij WJ (1997) Anti-R052 antibodies frequently co-occur with anti-Jo-1 antibodies in sera from patients with idiopathic inflammatory myopathy. Clin Exp Irnrnunol 109:32–40

    CAS  Google Scholar 

  • Rutjes SA, Utz PJ, Heijden A van der, Broekhuis C, Venrooij WJ van, Pruijn GJ (1999) The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Cell Death Differ 6:976–986

    PubMed  CAS  Google Scholar 

  • Sabbatini A, Bombardieri S, Migliorini P (1993) Autoantibodies from patients with systemic lupus erythematosus bind a shared sequence of SmD and Epstein-Barr virusencoded nuclear antigen EBNA 1. Eur J Immunol 23:1146–1152

    PubMed  CAS  Google Scholar 

  • Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N (2000) Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 191:423–434

    PubMed  CAS  Google Scholar 

  • Savici D, He B, Geist LJ, Monick MM, Hunninghake GW (1994) Silica increases tumor necrosis factor (TNF) production, in part, by upregulating the TNF promoter. Exp Lung Res 20:613–625

    PubMed  CAS  Google Scholar 

  • Schaller M, Burton DR, Ditzel HJ (2001) Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease. Nat Immunol 2:746–753

    PubMed  CAS  Google Scholar 

  • Schellekens GA, Jong BA de, Hoogen FH van den, Putte LB van de, Venrooij WJ van (1998) Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 101:273–281

    PubMed  CAS  Google Scholar 

  • Schett G, Redlich K, Xu Q et al. (1998a) Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSFI) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and HSFI activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J Clin Invest 102:302–311

    PubMed  CAS  Google Scholar 

  • Schett G, Steiner G, Smolen JS (1998b) Nuclear antigen histone Hl is primarily involved in lupus erythematosus cell formation. Arthritis Rheum 41:1446–1455

    PubMed  CAS  Google Scholar 

  • Schwartz M, Cohen IR (2000) Autoimmunity can benefit self-maintenance. Immunol Today 21:265–268

    PubMed  CAS  Google Scholar 

  • Scofield RH, Farris AD, Horsfall AC, Harley JB (1999) Fine specificity of the auto immune response to the RolSSA and La/SSB ribonucleoproteins. Arthritis Rheum 42:199–209

    PubMed  CAS  Google Scholar 

  • Scott DL (2000) Prognostic factors in early rheumatoid arthritis. Rheumatology 12:4–9

    Google Scholar 

  • Segelmark M, Westman K, Wieslander J (2000) How and why should we detect ANCA? Clin Exp Rheumatol 18:629–635

    PubMed  CAS  Google Scholar 

  • Selak S, Chan EK, Schoenroth L, Senecal JL, Fritzler MJ (1999) Early endosome antigen. 1: An autoantigen associated with neurological diseases. J Invest Med 47:311–318

    CAS  Google Scholar 

  • Selak S, Woodman RC, Fritzler MJ (2000) Autoantibodies to early endosome antigen (EEAI) produce a staining pattern resembling cytoplasmic anti-neutrophil cytoplasmic antibodies (C-ANCA). Clin Exp Immunol 122:493–498

    PubMed  CAS  Google Scholar 

  • Sherer Y, Shoenfeld Y (2001) Antiphospholipid syndrome, antiphospholipid antibodies, and atherosclerosis. Curr Atheroscler Rep 3:328–333

    PubMed  CAS  Google Scholar 

  • Shingai R, Maeda T, Onishi S, Yamamoto Y (1995) Autoantibody against 70 kD heat shock protein in patients with autoimmune liver diseases. J Hepatol 23:382–390

    PubMed  CAS  Google Scholar 

  • Shoenfeld Y, Sherer Y, Harats D (2001) Artherosclerosis as an infectious, inflammatory and auto immune disease. Trends Immunol 22:293–295

    PubMed  CAS  Google Scholar 

  • Siegert CE, Daha MR (1998) Clq as antigen in humoral autoimmune responses. Immunobiology 199:295–302

    PubMed  CAS  Google Scholar 

  • Simon M, Girbal E, Sebbag M et al. (1993) The cytokeratin filament-aggregating protein filaggrin is the target of the so-called “antikeratin antibodies,” autoantibodies specific for rheumatoid arthritis. J Clin Invest 92:1387–1393

    PubMed  CAS  Google Scholar 

  • Skriner K, Sommergruber WH, Tremmel V et al. (1997) Anti-A2IRA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease. J Clin Invest 100:127–135

    PubMed  CAS  Google Scholar 

  • Slobbe RL, Pluk W, Venrooij WJ van, Pruijn GJ (1992) Roribonucleoprotein assembly in vitro. Identification of RNAprotein and protein-protein interactions. J Mol Biol 227:361–366

    PubMed  CAS  Google Scholar 

  • Smolen JS (1996) Autoantibodies in rheumatoid arthritis. In: Venrooij WJ van, Maini RN (eds) Manual of biological markers of disease, vol C. Kluwer Academic Publishers, Dordrecht Boston London, pp 1.111–18

    Google Scholar 

  • Smolen JS, Steiner G (1998) Are autoantibodies active players or epiphenomena? Curr Opin Rheumatol 10:201–206

    PubMed  CAS  Google Scholar 

  • Spronk PE, Limburg PC, Kallenberg CG (1995) Serological markers of disease activity in systemic lupus erythematosus. Lupus 4:86–94

    PubMed  CAS  Google Scholar 

  • Steiner G, Hartmuth K, Skriner K et al. (1992) Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. J Clin Invest 90:1061–1066

    PubMed  CAS  Google Scholar 

  • Steiner G, Skriner K, Smolen JS (1996) Autoantibodies to the AIB proteins of the heterogeneous nuclear ribonucleoprotein complex: novel tools for the diagnosis of rheumatie diseases. Int Arch Allergy Immunol 111:314–319

    PubMed  CAS  Google Scholar 

  • Stemmer C, Muller S (1996) Histone autoantibodies other than (H2A-H2B)-DNA autoantibodies. In: Peter JB, Shoenfeld Y (eds) Autoantibodies. Elsevier Science, Amsterdam, pp 373–384

    Google Scholar 

  • Sugimoto K, Kuriyama K, Shibata A, Himeno M (1997) Characterization of internal DNA-binding and C-terminal dimerization domains of human centromere/kinetochore auto antigen CENP-C in vitro: role of DNA-binding and self-associating activities in kinetochore organization. Chromosome Res 5:132–141

    PubMed  CAS  Google Scholar 

  • Sugimoto K, Kuriyama K, Himeno M, Muro Y (1998) Epitope mapping of human centromere auto antigen centromere protein C (CENP-C); heterogeneity of anti-CENP-C response in rheumatie diseases. J Rheumatol 25:474–481

    PubMed  CAS  Google Scholar 

  • Suzuki N, Mihara S, Sakane T (1997) Development of pathogenie anti-DNA antibodies in patients with systemie lupus erythematosus. FASEB J 11:1033–1038

    PubMed  CAS  Google Scholar 

  • Takasaki Y, Kaneda K, Takeuchi K, Yano T, Hashimoto H (2000) Antibodies to PCNA and Ki-a linked set of autoimmune response associated with cellular function of target antigens. In: Conrad K, Humbel RL, Meurer M, Shoenfeld Y, Tan EM (eds) Autoantigens and autoantibodies: diagnostie tools and c1ues to understanding autoimmunity. Pabst Science Publishers, Lengerich, pp 88–109

    Google Scholar 

  • Takasaki Y, Kogure T, Takeuchi K et al. (2001) Reactivity of anti-proliferating cell nuc1ear antigen (PCNA) murine monoc1onal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation. J Immunol 166:4780–4787

    PubMed  CAS  Google Scholar 

  • Takeda Y, Dynan WS (2001) Autoantibodies against DNA double-strand break repair proteins. Front Biosci 6:D1335–D1345

    CAS  Google Scholar 

  • Tan EM, Chan EK (1993) Molecular biology of auto antigens and new insights into autoimmunity. Clin Invest 71:327–330

    CAS  Google Scholar 

  • Targoff IN (1993) Humoral immunity in polymyositis/dermatomyositis. J Invest DermatoL 100:116s–123s

    PubMed  CAS  Google Scholar 

  • Targoff IN (2000) Update on myositis-specific and myositisassociated autoantibodies. Curr Opin Rheumatol 12:475–481

    PubMed  CAS  Google Scholar 

  • Tishler M, Shoenfeld Y (1996) Anti-heat-shock protein antibodies in rheumatie and autoimmune diseases. Semin Arthritis Rheum 26:558–563

    PubMed  CAS  Google Scholar 

  • Utz PJ, Hottelet M, Venrooij WJ van, Anderson P (1998) Association of phosphorylated serine/arginine (SR) splicing factors with the U1-small ribonuc1eoprotein (snRNP) auto antigen complex accompanies apoptotie cell death. J Exp Med 187:547–560

    PubMed  CAS  Google Scholar 

  • Van Bruggen MC, Kramers C, Berden JH (1996) Autoimmunity against nuc1eosomes and lupus nephritis. Ann Med Interne (Paris) 147:485–489

    Google Scholar 

  • Vazquez Abad D, Rothfield NF (1995) Autoantibodies in systemic sc1erosis. Int Rev Immunol 12:145–157

    Google Scholar 

  • Venrooij W van, Pruijn GJM (1995) Ribonuc1eoprotein complexes as autoantigens. Curr Opin Immunol 7:819–824

    PubMed  Google Scholar 

  • Venrooij WJ van, Pruijn GJ (2000) Citrullination: a small change for a protein with great consequences for rheumatoid arthritis. Arthritis Res 2:249–251

    PubMed  Google Scholar 

  • Verhasselt V, Goldman M (2001) From autoimmune responses to autoimmune disease: what is needed? J Autoimmun 16:327–330

    PubMed  CAS  Google Scholar 

  • Verheijen R (1994) DNA topoisomerase I. In: Venrooij WJ van, Maini RN (eds) Manual of biologieal markers of dis-ease, vol B. Kluwer Academie Publishers, Dordrecht Boston London, pp 5.113–5.1116

    Google Scholar 

  • Verheijden GF, Rijnders AW, Bos E et al. (1997) Human cartilage glycoprotein-39 as a candidate auto antigen in rheumatoid arthritis. Arthritis Rheum 40:1115–1125

    PubMed  CAS  Google Scholar 

  • Wahren Herlenius M, Muller S, Isenberg D (1999) Analysis of B-cell epitopes of the Ro/SS-A autoantigen. Immunol Today 20:234–240

    Google Scholar 

  • Walport MJ, Davies KA, Botto M (1998) Clq and systemie lupus erythematosus. Immunobiology 199:265–285

    PubMed  CAS  Google Scholar 

  • Wang J, Dong X, Stojanov L, Kimpel D, Satoh M, Reeves WH (1997) Human autoantibodies stabilize the quaternary structure of Ku antigen. Arthritis Rheum 40:1344–1353

    PubMed  CAS  Google Scholar 

  • Wang D, Buyon JP, Zhu W, Chan EK (1999) Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies. J Clin Invest 104:1265–1275

    PubMed  CAS  Google Scholar 

  • Warburton PE, Cooke CA, Bourassa S et al. (1997) Immunolocalization of CENP-A suggests a distinct nuc1eosome structure at the inner kinetochore plate of active centromeres. Curr Biol 7:901–904

    PubMed  CAS  Google Scholar 

  • Watanabe T, Sato T, Uchiumi T, Arakawa M (1996) Neuropsychiatrie manifestations in patients with systemie lupus erythematosus: diagnostie and predietive value of longitudinal examination of anti-ribosomal P antibody. Lupus 5:178–183

    PubMed  CAS  Google Scholar 

  • Weighardt F, Biamonti G, Riva S (1996) The roles of heterogeneous nuc1ear ribonuc1eoproteins (hnRNP) in RNA metabolism. Bioessays 18:747–756

    PubMed  CAS  Google Scholar 

  • Weyand CM, Klimiuk PA, Goronzy JJ (1998) Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes. Springer Semin Immunopathol 20:5–22

    PubMed  CAS  Google Scholar 

  • Whitehead CM, Fritzler MJ, Rattner JB (1998) The relationship of ASE-1 and NOR-90 in autoimmune sera. J Rheumatol 25:2126–2130

    PubMed  CAS  Google Scholar 

  • Will CL, Luhrmann R (2001) Spliceosomal UsnRNP biogenesis, structure and function. Curr Opin Cell Biol 13:290–301

    PubMed  CAS  Google Scholar 

  • Wolin SL, Matera AG (1999) The trials and travels of tRNA. Genes Dev 13:1–10

    PubMed  CAS  Google Scholar 

  • Wu R, Lefvert AK (1995) Autoantibodies against oxidized low density lipoproteins (oxLDL): characterization of antibody isotype, subc1ass, affinity and effect on the macrophage uptake of oxLDL. Clin Exp Immunol 102:174–180

    PubMed  CAS  Google Scholar 

  • Wu X, Molinaro C, Johnson N, Casiano CA (2001) Secondary necrosis is a source of proteolytieally modified forms of specific intracellular autoantigens: implications for systemie autoimmunity. Arthritis Rheum 44:2642–2652

    PubMed  CAS  Google Scholar 

  • Wucherpfennig KW (2001) Structural basis of molecular mimiery. J Autoimmun 16:293–302

    PubMed  CAS  Google Scholar 

  • Xiao GQ, Qu Y, Hu K, Boutjdir M (2001) Down-regulation of L-type calcium channel in pups born to 52 kDa SSAI Ro immunized rabbits. Faseb J 15:1539–1545

    PubMed  CAS  Google Scholar 

  • Xu W, Seiter K, Feldman E, Ahmed T, Chiao JW (1996) The differentiation and maturation mediator for human myeloid leukemia cells shares homology with neuroleukin or phosphoglucose isomerase. Blood 87:4502–4506

    PubMed  CAS  Google Scholar 

  • Xue D, Rubinson DA, Pannone BK, Yoo Q, Wolin SL (2000) U snRNP assembly in yeast involves the La protein. EMBO J 19:1650–1660

    PubMed  CAS  Google Scholar 

  • Youinou P, Serre G (1995) The antiperinuc1ear factor and antikeratin antibody systems. Int Arch Allergy Immunol 107:508–518

    PubMed  CAS  Google Scholar 

  • Zee R van der, Anderton SM, Prakken AB, Liesbeth Paul AG, van Eden W (1998) T cell responses to conserved bacterial heat-shock-protein epitopes induce resistance in experimental autoimmunity. Semin Immunol 10:35–41

    PubMed  Google Scholar 

  • Zhang Y, Guerassimov A, Leroux JY et al. (1998) Induction oE arthritis in BALB/c mice by cartilage link protein: involvement oE distinct regions recognized by T and B lymphocytes. Am J Pathol 153:1283–1291

    PubMed  CAS  Google Scholar 

  • Zimmerman R, Radhakrishnan J, Valeri A, Appel G (2001) Advances in the treatment oE lupus nephritis. Annu Rev Med 2001:5263–5278

    Google Scholar 

  • Zugel U, Kaufmann SH (1999) Role of heat shock proteins in protection from and pathogenesis of infectious diseases. Clin Microbiol Rev 12:19–39

    PubMed  CAS  Google Scholar 

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Authors
  1. Günter Steiner
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  2. Karsten Conrad
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Editor information

Editors and Affiliations

  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10, 13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Center of Experimental Rheumatology, University Hospital, Gloriastraße 25, 8091, Zürich, Schweiz

    Steffen Gay

  3. Institut für Klinische Immunologie Medizinische Klinik III, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glückstraße 4a, 91054, Erlangen, Deutschland

    Jochen R. Kalden

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© 2003 Springer-Verlag Berlin Heidelberg

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Steiner, G., Conrad, K. (2003). Autoantigene. In: Ganten, D., Ruckpaul, K., Gay, S., Kalden, J.R. (eds) Molekularmedizinische Grundlagen von rheumatischen Erkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55803-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-55803-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62855-9

  • Online ISBN: 978-3-642-55803-0

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