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Die Komponenten der extrazellulären Matrix, ihre Struktur und Funktion

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Molekularmedizinische Grundlagen von rheumatischen Erkrankungen

Part of the book series: Molekulare Medizin ((MOLMED))

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Zusammenfassung

Ursprünglich wurden das Bindegewebe oder die extrazelluläre Matrix (ECM) vorwiegend unter dem Gesichtspunkt einer Gerüst- und Stützsubstanz gesehen, welche die biomechanische Stabilität des Organismus gewährleistet. Typische Beispiele dafür sind Knochen, Knorpel, Sehnen und Haut sowie die elastischen Gefäßwände. In den letzten Jahrzehnten ist ein zusätzlicher wichtiger Aspekt, die Wechselwirkung der ECM mit Zellen und der Einfluss auf ihr Verhalten, in den Vordergrund gerückt. So wirkt die ECM als Substrat für Adhäsion, Ausbreitung, Wanderung und Teilung von Zellen und kontrolliert ihre Differenzierung.

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  1. Klaus Kühn
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  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10, 13122, Berlin-Buch, Deutschland

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    Steffen Gay

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    Jochen R. Kalden

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Kühn, K. (2003). Die Komponenten der extrazellulären Matrix, ihre Struktur und Funktion. In: Ganten, D., Ruckpaul, K., Gay, S., Kalden, J.R. (eds) Molekularmedizinische Grundlagen von rheumatischen Erkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55803-0_3

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