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N-CoR-HDAC Corepressor Complexes: Roles in Transcriptional Regulation by Nuclear Hormone Receptors

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Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 274)

Abstract

Many nuclear hormone receptors (NHRs) actively repress the expression of their primary response genes through the recruitment of transcriptional corepressor complexes to regulated promoters. N-CoR and the highly related SMRT were originally isolated and characterized by their ability to interact exclusively with the unliganded forms ofNHRs and confer transcriptional repression. Recently, both the N-CoR and SMRT corepressors have been found to exist in vivo in multiple, distinct macromolecular complexes. While these corepressor complexes differ in overall composition, a general theme is that they contain histone deacetylase enzymatic activity. Several of these complexes contain additional transcriptional corepressor proteins with functional ties to chromatin structure. Together, these data suggest that modulation of chromatin structure plays a central role in N-CoR mediated transcriptional repression from unliganded NHRs.

Keywords

Thyroid Hormone Receptor Nuclear Hormone Receptor HDAC Activity Corepressor Complex Amphibian Metamorphosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aasland R, Stewart AF, Gibson T (1996) The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADAcomplexes, the transcriptional co-repressor N-CoR and TFIIIB. Trends Biochem Sci 21:87–8PubMedGoogle Scholar
  2. Alland L, Muhle R, Hou H JR, Potes J, Chin L, Schreiber-Agus N, Depinho RA (1997) Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387:49–55PubMedCrossRefGoogle Scholar
  3. Almouzni G, Wolffe AP (1993) Nuclear assembly, structure, and function: the use of Xenopus in vitro systems. Exp Cell Res 205:1–15PubMedCrossRefGoogle Scholar
  4. Aranda A, Pascual A (2001) Nuclear hormone receptors and gene expression. Physiol Rev 81:1269–304PubMedGoogle Scholar
  5. Archer TK, Fryer CJ, Lee HL, Zaniewski E, Liang T, Mymryk JS (1995) Steroid hormone receptor status defines the MMTV promoter chromatin structure in vivo. J Steroid Biochem Mol Biol 53:421–9PubMedCrossRefGoogle Scholar
  6. Asano K, Merrick WC, Hershey JW (1997) The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome. J Biol Chem 272:23477–80PubMedCrossRefGoogle Scholar
  7. Ayer DE, Lawrence QA, Eisenman RN (1995) Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80:767–76PubMedCrossRefGoogle Scholar
  8. Baniahmad A, Ha I, Reinberg D, Tsai S, Tsai MJ, O’malley BW (1993) Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone. Proc Natl Acad Sci USA 90:8832–6PubMedCrossRefGoogle Scholar
  9. Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A, Borsani G (1999) X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. Am J Hum Genet 64:1604–16PubMedCrossRefGoogle Scholar
  10. Bhattacharyya N, Dey A, Minucci S, Zimmer A, John S, Hager G, Ozato K (1997) Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta2 promoter. Mol Cell Biol 17:6481–90PubMedGoogle Scholar
  11. Chen JD, Evans RM (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors [see comments]. Nature 377:454–7PubMedCrossRefGoogle Scholar
  12. Cote J, Quinn J, Workman JL, Peterson CL (1994) Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex. Science 265: 53–60PubMedCrossRefGoogle Scholar
  13. Desbois C, Rousset R, Bantignies F, Jalinot P (1996) Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein. Science 273: 951–3PubMedCrossRefGoogle Scholar
  14. Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S Google Scholar
  15. Tenbaum SP, Renkawitz R, Baniahmad A (1999) Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol Cell Biol 19:3383–94PubMedGoogle Scholar
  16. Edmondson DG, Zhang W, Watson A, Xu W, Bone JR, Yu Y, Stillman D, Roth SY (1998) In vivo functions of histone acetylation/deacetylation in Tuplp repression and Gcn5p activation. Cold Spring Harb Symp Quant Biol 63:459–68PubMedCrossRefGoogle Scholar
  17. Eliceiri BP, Brown DD (1994) Quantitation of endogenous thyroid hormone receptors alpha and beta during embryogenesis and metamorphosis in Xenopus laevis. J Biol Chem 269:24459–65PubMedGoogle Scholar
  18. Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (2002) Enzymatic Activity Associated with Class II HDACsIs Dependent on a Multiprotein Complex Containing HDAC3and SMRT/N-CoR. Mol Cell 9:45–57PubMedCrossRefGoogle Scholar
  19. Fondell JD, Roy AL, Roeder RG (1993) Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression. Genes Dev 7:1400–10PubMedCrossRefGoogle Scholar
  20. Forrest D, Erway LC, Ng L, Altschuler R, Curran T (1996) Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet 13:354–7PubMedCrossRefGoogle Scholar
  21. Friedman JR, Fredericks WI, Jensen DE, Speicher DW, Huang XP, Neilson EG, Rauscher FJ, 3rd (1996) KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev 10:2067–78PubMedCrossRefGoogle Scholar
  22. Glass CK, Lipkin SM, Devary OV, Rosenfeld MG (1989) Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer. Cell 59:697–708PubMedCrossRefGoogle Scholar
  23. Grunstein M (1997) Histone acetylation in chromatin structure and transcription. Nature 389:349–52PubMedCrossRefGoogle Scholar
  24. Guenther MG, Barak O, Lazar MA (2001) The SMRTand N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol 21:6091–101PubMedCrossRefGoogle Scholar
  25. Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (2000) A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev 14:1048–1057PubMedGoogle Scholar
  26. Hager GL, Archer TK, Fragoso G, Bresnick EH, Tsukagoshi Y, John S, Smith CL (1993) Influence of chromatin structure on the binding of transcription factors to DNA. Cold Spring Harb Symp Quant Biol 58:63–71PubMedCrossRefGoogle Scholar
  27. Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE (1997) Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 89:341–7PubMedCrossRefGoogle Scholar
  28. Holstege FC, Jennings EG, Wyrick JJ, Lee TI, Hengartner CJ, Green MR, Golub TR, Lander ES, Young RA (1998) Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95: 717–28PubMedCrossRefGoogle Scholar
  29. Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamel Y, Soderstrom M, Glass CK, Rosenfeld MG (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor [see comments]. Nature 377:397–404PubMedCrossRefGoogle Scholar
  30. Hu X, Lazar MA (1999) The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature 402:93–6PubMedCrossRefGoogle Scholar
  31. Hu X, Li Y, Lazar MA (2001) Determinants of CoRNR-dependent repression complex assembly on nuclear hormone receptors. Mol Cell Biol 21:1747–58PubMedCrossRefGoogle Scholar
  32. Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (2000) Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3independent repression pathway. Genes Dev 14:45–54PubMedGoogle Scholar
  33. Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001) Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-Ll. JBiol Chem 276:6817–24CrossRefGoogle Scholar
  34. Ito M, Roeder RG (2001) The TRAP/SMCC/Mediator complex and thyroid hormone receptor function. Trends Endocrinol Metab 12:127–34PubMedCrossRefGoogle Scholar
  35. James TC, Eissenberg JC, Craig C, Dietrich V, Hobson A, Elgin SC (1989) Distribution patterns of HP1,a heterochromatin-associated nonhistone chromosomal protein of Drosophila. Eur J Cell Biol 50:170–80PubMedGoogle Scholar
  36. James TC, Elgin SC (1986) Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene. Mol Cell Biol 6:3862–72PubMedGoogle Scholar
  37. Johnson CA, White DA, Lavender JS, O’neill LP, Turner BM (2002) Human class I HDACcomplexes show enhanced catalytic activity in the presence of ATPand coimmunoprecipitate with the ATP-dependent chaperone protein Hsp70. J BiolChemGoogle Scholar
  38. Jones PL, Sachs LM, Rouse N, Wade PA, Shi YB (2001) Multiple N-CoR complexes contain distinct histone deacetylases. J Biol Chem 276:8807–11PubMedCrossRefGoogle Scholar
  39. Kadosh D, Struhl K (1998) Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol Cell Biol 18:5121–7PubMedGoogle Scholar
  40. Kao HY, Downes M, Ordentlich P, Evans RM (2000) Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev 14:55–66PubMedGoogle Scholar
  41. Knezetic JA, Luse DS (1986) The presence of nucleosomes on a DNA template prevents initiation by RNApolymerase II in vitro. Cell 45:95–104PubMedCrossRefGoogle Scholar
  42. Kwon H, Imbalzano AN, Khavari PA, Kingston RE, Green MR (1994) Nucleosome disruption and enhancement of activator binding by a human SWI/SNF complex. Nature 370:477–81PubMedCrossRefGoogle Scholar
  43. Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN (1998) SAP30, a component of the mSin3 corepressor complex involved in N-CoR-medi ated repression by specific transcription factors. Mol Cell 2:33–42PubMedCrossRefGoogle Scholar
  44. Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (1997) Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell 89:349–56PubMedCrossRefGoogle Scholar
  45. Le Douarin B, Nielsen AL, Garnier JM, Ichinose H, Jeanmougin F, Losson R, Chambon P (1996) A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J 15:6701–15PubMedGoogle Scholar
  46. Li J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (2000) Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. Embo J 19:4342–50PubMedCrossRefGoogle Scholar
  47. Marchetti A, Buttitta F, Miyazaki S, Gallahan D, Smith GH, Callahan R (1995) Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia. J Virol 69:1932–8PubMedGoogle Scholar
  48. McKenna NJ, Lanz RB, O’malley BW (1999) Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev 20:321–44PubMedCrossRefGoogle Scholar
  49. Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W (1996) Transcriptional repression by RING finger protein TIFI beta that interacts with the KRABrepressor domain of KOXI. Nucleic Acids Res 24:4859–67PubMedCrossRefGoogle Scholar
  50. Morris-Desbois C, Bochard V, Reynaud C, Jalinot P (1999) Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. J Cell Sci 112 (Pt 19):3331–42PubMedGoogle Scholar
  51. Muscat GE, Burke LJ, Downes M (1998) The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32and TAFII70. Nucleic Acids Res 26:2899–907PubMedCrossRefGoogle Scholar
  52. Nagy L, Kao HY, Love JD, Li C, Banayo E, Gooch JT, Krishna V, Chatterjee K, Evans RM, Schwabe JW (1999) Mechanism of corepressor binding and release from nuclear hormone receptors. Genes Dev 13:3209–16PubMedCrossRefGoogle Scholar
  53. Nielsen AL, Ortiz JA, You J, Oulad-Abdelghani M, Khechumian R, Gansmuller A, Chambon P, Losson R (1999) Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIFI family. EMBOJ 18:6385–95CrossRefGoogle Scholar
  54. Park EJ, Schroen DJ, Yang M, Li H, Li L, Chen JD (1999) SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. Proc Natl Acad Sci USA 96:3519–24PubMedCrossRefGoogle Scholar
  55. Perissi V, Staszewski LM, McInerney EM, Kurokawa R, Krones A, Rose DW, Lambert MH, Milburn MV, Glass CK, Rosenfeld MG (1999) Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev 13:3198–208PubMedCrossRefGoogle Scholar
  56. Peterson CL, Herskowitz I (1992) Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription. Cell 68:573–83PubMedCrossRefGoogle Scholar
  57. Puzianowska-Kuznicka M, Damjanovski S, Shi YB (1997) Both thyroid hormone and 9-cis retinoic acid receptors are required to efficiently mediate the effects of thyroid hormone on embryonic development and specific gene regulation in Xenopus laevis. Mol Cell Biol 17:4738–49PubMedGoogle Scholar
  58. Qian YW, Wang YC, Hollingsworth RE, Jr., Jones D, Ling N, Lee EY (1993) A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 364:648–52PubMedCrossRefGoogle Scholar
  59. Rachez C, Freedman LP (2000) Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions. Gene 246:9–21PubMedCrossRefGoogle Scholar
  60. Ranjan M, Wong J, Shi YB (1994) Transcriptional repression of Xenopus TRbeta gene is mediated by a thyroid hormone response element located near the start site. J Biol Chem 269:24699–705PubMedGoogle Scholar
  61. Sachs LM, Amano T, Shi YB (2001) An essential role of histone deacetylases in postembryonic organ transformations in Xenopus laevis. Int J Mol Med 8:595–601PubMedGoogle Scholar
  62. Sachs LM, Shi YB (2000) Targeted chromatin binding and histone acetylation in vivo by thyroid hormone receptor during amphibian development. Proc Natl Acad Sci USA 97:13138–43PubMedCrossRefGoogle Scholar
  63. Sap J, Munoz A, Schmitt J, Stunnenberg H, Vennstrom B (1989) Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Nature 340:242–4PubMedCrossRefGoogle Scholar
  64. Schreiber-Agus N, Chin L, Chen K, Torres R, Rao G, Guida P, Skoultchi AI, Depinho RA (1995) An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80:777–86PubMedCrossRefGoogle Scholar
  65. Seol W, Mahon MJ, Lee YK, Moore DD (1996) Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR. Mol Endocrinol 10: 1646–55PubMedCrossRefGoogle Scholar
  66. Shi YB (1999) Amphibian metamorphosis: From morphology to molecular biology. Wiley, NewYorkGoogle Scholar
  67. Shi YB, Yaoita Y, Brown DD (1992) Genomic organization and alternative promoter usage of the two thyroid hormone receptor beta genes in Xenopus laevis, J Biol Chem 267:733–8PubMedGoogle Scholar
  68. Sternberg PW, Stern MJ, Clark I, Herskowitz I (1987) Activation of the yeast HO gene by release from multiple negative controls. Cell 48:567–77PubMedCrossRefGoogle Scholar
  69. Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403:41–5PubMedCrossRefGoogle Scholar
  70. Struhl K (1998) Histone acetylation and transcriptional regulatory mechanisms. Genes Dev 12:599–606PubMedCrossRefGoogle Scholar
  71. Sudarsanam P, Iyer VR, Brown PO, Winston F (2000) Whole-genome expression analysi s of snf/swi mutants of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 97:3364–9PubMedCrossRefGoogle Scholar
  72. Sudarsanam P, Winston F (2000) The Swi/Snf family nucleosome-remodeling complexes and transcriptional control. Trends Genet 16:345–51PubMedCrossRefGoogle Scholar
  73. Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (1998) Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 395:917–21PubMedCrossRefGoogle Scholar
  74. Tyler JK, Bulger M, Kamakaka RT, Kobayashi R, Kadonaga JT (1996) The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Mol Cell Biol 16:6149–59PubMedGoogle Scholar
  75. Underhill C, Qutob MS, Yee SP, Torchia J (2000) A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWIISNF complex and the corepressor KAP-l. J Biol Chem 275:40463–70PubMedCrossRefGoogle Scholar
  76. Urnov FD, Wolffe AP (2001a) An array of positioned nucleosomes potentiates thyroid hormone receptor action in vivo. J Biol Chem 276:19753–61PubMedCrossRefGoogle Scholar
  77. Urnov FD, Wolffe AP (2001b) A necessary good: nuclear hormone receptors and their chromatin templates. Mol Endocrinol 15:1–16PubMedCrossRefGoogle Scholar
  78. Vermaak D, Wade PA, Jones PL, Shi YB, Wolffe AP (1999) Functional analysis of the SIN3-histone deacetylase RPD3-RbAp48-histone H4 connection in the Xenopus oocyte. Mol Cell Biol 19:5847–60PubMedGoogle Scholar
  79. Verreault A, Kaufman PD, Kobayashi R, Stillman B (1996) Nucleosome assembly by a complex of CAF-l and acetylated histones H3/H4. Cell 87:95–104PubMedCrossRefGoogle Scholar
  80. Vignali M, Hassan AH, Neely KE, Workman JL (2000) ATP-dependent chromatinremodeling complexes. Mol Cell Biol 20:1899–910PubMedCrossRefGoogle Scholar
  81. Wade PA, Jones PL, Vermaak D, Wolffe AP (1998) A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase. Curr Biol 8:843–6PubMedCrossRefGoogle Scholar
  82. Wade PA, Jones PL, Vermaak D, Wolffe AP (1999) Purification of a histone deacetylase complex from Xenopus laevis: preparation of substrates and assay procedures. Methods EnzymoI 304:715–25CrossRefGoogle Scholar
  83. Wahi M, Komachi K, Johnson AD (1998) Gene regulation by the yeast Ssn6-Tupl corepressor. Cold Spring Harb Symp Quant Biol 63:447–57PubMedCrossRefGoogle Scholar
  84. Wang W, Cote J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (1996a) Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J 15:5370–82PubMedGoogle Scholar
  85. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (1996b) Diversity and specialization of mammalian SWIISNF complexes. Genes Dev 10:2117–30PubMedCrossRefGoogle Scholar
  86. Wen YD, Perissi V, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG, Seto E (2000) The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc Nat! Acad Sci USA 97:7202–7207PubMedCrossRefGoogle Scholar
  87. Wolffe AP (1997) Transcriptional control. Sinful repression [news; comment]. Nature 387:16–7PubMedCrossRefGoogle Scholar
  88. Wolffe AP, Hayes JJ (1999) Chromatin disruption and modification. Nucleic Acids Res 27:711–720PubMedCrossRefGoogle Scholar
  89. Wong CW, Privalsky ML (1998) Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB. Mol Cell Biol 18:5500–10PubMedGoogle Scholar
  90. Wong J, Li Q, Levi BZ, Shi YB, Wolffe AP (1997a) Structural and functional features of a specific nucleosome containing a recognition element for the thyroid hormone receptor. EMBO J 16:7130–45PubMedCrossRefGoogle Scholar
  91. Wong J, Patterton D, Imhof A, Guschin D, Shi YB, Wolffe AP (1998) Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase. Embo J 17:520–34PubMedCrossRefGoogle Scholar
  92. Wong J, Shi YB, Wolffe AP (1995) A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor. Genes Dev 9:2696–711PubMedCrossRefGoogle Scholar
  93. Wong J, Shi YB, Wolffe AP (1997b) Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormoneregulated chromatin disruption is not sufficient for transcriptional activation. EMBO J 16:3158–71PubMedCrossRefGoogle Scholar
  94. Workman JL, Kingston RE (1998) Alteration of nucleosome structure as a mechanism of transcriptional regulation. Annu Rev Biochem 67:545–79PubMedCrossRefGoogle Scholar
  95. Workman JL, Roeder RG (1987) Binding of transcription factor TFIID to the major late promoter during in vitro nucleosome assembly potentiates subsequent initiation by RNApolymerase II. Cell 51:613–22PubMedCrossRefGoogle Scholar
  96. Xue Y, Wong J, Moreno GT, Young MK, Cote J, Wang W (1998) NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell 2:851–61PubMedCrossRefGoogle Scholar
  97. Yaoita Y, Brown DD (1990) A correlation of thyroid hormone receptor gene expression with amphibian metamorphosis. Genes Dev 4:1917–24PubMedCrossRefGoogle Scholar
  98. Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Naar AM, Kim SY, Boutin JM, Glass CK, Rosenfeld MG (1991) RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251–66PubMedCrossRefGoogle Scholar
  99. Zamir I, Harding HP, Atkins GB, Horlein A, Glass CK, Rosenfeld MG, Lazar MA (1996) A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains. Mol Cell Biol 16:5458–65PubMedGoogle Scholar
  100. Zhang J, Guenther MG, Carthew RW, Lazar MA (1998) Proteasomal regulation of nuclear receptor corepressor-mediated repression. Genes Dev 12:1775–80PubMedCrossRefGoogle Scholar
  101. Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (1997) Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89:357–64PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  1. 1.Department of Cell and Structural BiologyUniversity of Illinois at Urbana-ChampaignUrbanaUSA
  2. 2.Unit on Molecular MorphogenesisNational Institute of Child Health and Human Development, National Institutes of HealthBethesdaUSA

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