The SWI/SNF Family of ATP-Dependent Chromatin Remodelers: Similar Mechanisms for Diverse Functions

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 274)


The SWI/SNF family of complexes utilizes the energy of ATP hydrolysis to remodel chromatin structures, thereby allowing transcription factors to gain access to DNA. Recent studies suggest that these remodelers also participate in other DNA metabolic reactions such as replication and viral integration, and even in control of cell growth and tumor suppression. The SWI/SNF remodelers can be classified into at least two distinct subfamilies: one includes human BAF (also known as hSWI/SNF-A) and yeast SWI/SNF; the other comprises human PBAF (hSWI/SNF-B) and yeast RSC. Although both types of complexes have similar subunit composition and chromatin remodeling activity in vitro, they cannot replace each other during transcription mediated by specific activators. Thus, each remodeler probably works with a specific set of activators during gene activation. The availability of distinct types of remodelers can allow cells to regulate expression of a specific group of genes by modulating the activity of corresponding remodelers.


Chromatin Structure Chromatin Remodeler Centromeric Chromatin Trithorax Group Yeast Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  1. 1.Laboratory of GeneticsNational Institute on Aging, National Institute of HealthBaltimoreUSA

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