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Selective Gene Regulation by SWI/SNF-Related Chromatin Remodeling Factors

  • Chapter
Protein Complexes that Modify Chromatin

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 274))

Abstract

Chromatin is a highly dynamic structure that plays a key role in the orchestration of gene expression patterns during cellular differentiation and development. The packaging of DNA into chromatin generates a barrier to the transcription machinery. The two main strategies by which cells alleviate chromatin-mediated repression are through the action of ATP-dependent chromatin remodeling complexes and enzymes that covalently modify the histones. Various signaling pathways impinge upon the targeting and activity of these enzymes, thereby controlling gene expression in response to physiological and developmental cues. Chromatin structure also underlies many so-called epigenetic phenomena, leading to the mitotically stable propagation of differential expression of genetic information. Here, we will focus on the role of SWI/SN-Frelated ATP-dependent chromatin remodeling complexes in developmental gene regulation. First, we compare different models for how remodelers can act in a gene-selective manner, and either cooperate or antagonize other chromatin-modulating systems in the cell. Next, we discuss their functioning during the control of developmental gene expression programs.

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Authors and Affiliations

  1. Department of Molecular and Cell Biology, Center for Biomedical Genetics, Leiden University Medical Center, P.O. Box 9503, 2300 RA, Leiden, The Netherlands

    K. R. Katsani, T. Mahmoudi & C. P. Verrijzer

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  1. K. R. Katsani
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  2. T. Mahmoudi
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  3. C. P. Verrijzer
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Editors and Affiliations

  1. Howard Hughes Medical Institute Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 306 Althouse Lab, University Park, PA, 16802, USA

    J. L. Workman Ph. D

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© 2003 Springer-Verlag Berlin Heidelberg

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Katsani, K.R., Mahmoudi, T., Verrijzer, C.P. (2003). Selective Gene Regulation by SWI/SNF-Related Chromatin Remodeling Factors. In: Workman, J.L. (eds) Protein Complexes that Modify Chromatin. Current Topics in Microbiology and Immunology, vol 274. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55747-7_5

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  • DOI: https://doi.org/10.1007/978-3-642-55747-7_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62909-9

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