The NuRD Complex: Linking Histone Modification to Nucleosome Remodeling
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ATP-dependent nucleosome remodeling and core histone tail modifications play important roles in chromatin function. Purification and characterization of the NuRD/Mi-2 complex, which possesses both nucleosome remodeling and histone deacetylase activities, suggests that ATP-dependent nucleosome remodeling and histone tail modification can be coupled. Recent studies indicate that NuRD is an integral part of the MeCPl complex, suggesting that nucleosome remodeling and histone deacetylation play important roles in methylated DNA silencing. Studies in Caenorhabditis elegans have revealed important functions of the NuRD complex in embryonic patterning and Ras signaling. Accumulating evidence indicates that NuRD may regulate transcription of specific genes by interacting with specific transcriptional factors. In addition, it may also participate in genome-wide transcriptional regulation through an association with histone tails.
KeywordsHistone Deacetylase Histone Deacetylation Histone Tail Nucleosome Remodel Embryonic Patterning
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- Ch’ng Q, Kenyon C (1999) egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function. Development 126:3303–12Google Scholar
- Hebbes TR, Thorne AW, Crane-Robinson C (1988) A direct link between core histone acetylation and transcriptionally active chromatin. EMBOJ 7:1395–402Google Scholar
- Van Holde KE (1988) Histone modifications. In Chromatin,Springerseries in molecular biology (ed. A. Rich), pp.111–148. Springer, NewYorkGoogle Scholar
- Von Zelewsky T, Palladino F, Brunschwig K, Tobler H, Hajnal A, Muller F (2000) The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination. Development 127:5277–84Google Scholar
- Zegerman P, Canas B, Pappin D, Kouzarides T (2002) Histone H3lysine 4 methylation disrupts the binding of the nucleosome remodelling and deacetylase (NuRD) repressor complex. J Biol Chem 15:15Google Scholar