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The NuRD Complex: Linking Histone Modification to Nucleosome Remodeling

  • Chapter
Protein Complexes that Modify Chromatin

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 274))

Abstract

ATP-dependent nucleosome remodeling and core histone tail modifications play important roles in chromatin function. Purification and characterization of the NuRD/Mi-2 complex, which possesses both nucleosome remodeling and histone deacetylase activities, suggests that ATP-dependent nucleosome remodeling and histone tail modification can be coupled. Recent studies indicate that NuRD is an integral part of the MeCPl complex, suggesting that nucleosome remodeling and histone deacetylation play important roles in methylated DNA silencing. Studies in Caenorhabditis elegans have revealed important functions of the NuRD complex in embryonic patterning and Ras signaling. Accumulating evidence indicates that NuRD may regulate transcription of specific genes by interacting with specific transcriptional factors. In addition, it may also participate in genome-wide transcriptional regulation through an association with histone tails.

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  1. Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, 27599-7295, USA

    Q. Feng & Y. Zhang

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  1. Q. Feng
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  1. Howard Hughes Medical Institute Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 306 Althouse Lab, University Park, PA, 16802, USA

    J. L. Workman Ph. D

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Feng, Q., Zhang, Y. (2003). The NuRD Complex: Linking Histone Modification to Nucleosome Remodeling. In: Workman, J.L. (eds) Protein Complexes that Modify Chromatin. Current Topics in Microbiology and Immunology, vol 274. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55747-7_10

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