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Exploitation of Macrophage Clearance Functions In Vivo

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Book cover The Macrophage as Therapeutic Target

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 158))

Abstract

The propensity of macrophages for the phagocytic clearance of colloidal particles provides a rational approach to macrophage-specific targeting and drug delivery. Furthermore, by precision engineering, colloidal drug carriers can be targeted to selective population of macrophages in the body as well as intracellular locations. These approaches have led to the development of a number of regulatory-approved particulate formulations for delivery of therapeutic and diagnostic agents to macrophages. This article will briefly discuss selected approaches and highlight barriers in in vivo macrophage-specific targeting with colloidal carriers via intravenous, subcutaneous and oral routes of administration, and it explores avenues for selective modification of macrophage cellular activity.

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Abbreviations

APC:

antigen-presenting cell

EO:

ethylene oxide

IES:

interendothelial cell slits

MHC:

major histocompatibility complex

PO:

propylene oxide

TAT:

trans-activating transcriptional activator

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Authors and Affiliations

  1. Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, BN2 4GJ, Brighton, UK

    S. M. Moghimi

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  1. S. M. Moghimi
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Editors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK

    Siamon Gordon

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© 2003 Springer-Verlag Berlin Heidelberg

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Moghimi, S.M. (2003). Exploitation of Macrophage Clearance Functions In Vivo. In: Gordon, S. (eds) The Macrophage as Therapeutic Target. Handbook of Experimental Pharmacology, vol 158. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55742-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-55742-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62919-8

  • Online ISBN: 978-3-642-55742-2

  • eBook Packages: Springer Book Archive

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