Skip to main content

Self-Organizing Maps and its Applications in Sleep Apnea Research and Molecular Genetics

  • Conference paper
Exploratory Data Analysis in Empirical Research
  • 1041 Accesses

Abstract

This paper presents the application of special unsupervised neural networks (Self-Organizing Maps) to different domains, such as sleep apnea discovery, protein sequence analysis and tumor classification. An enhancement of the original algorithm, as well as the introduction of several hierachical levels enables the discovery of complex stru ctures as present in this type of applications. Finally we recommend the use of regression-type models for Kohonen’s Self-Organizing Networkin gene expression data analysis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • ANDRADE, M.A., CASARI, G., SANDER, C., VALENCIA, A. (1997): Classification of protein families and detection of the determinant residues with an improved self-organizing map, Biological Cybernetics, 76, 441–450.

    Article  MATH  Google Scholar 

  • BEHME, H., BRANDT, W.D., STRUBE, H.W. (1993): Speech Recognition by Hierarchical Segment Classification, in: S. Gielen, B. Kappen (Eds.): Proc. IntI. Conf. on Aritificial Neural Networks (ICANN 93), Amsterdam, Springer Verlag, London, 416–419.

    Google Scholar 

  • BISHOP, C.M. (1995): Neural Networks for Pattern Recognition, Oxford, Clarendon Press.

    Google Scholar 

  • BOCK, H.H. (2000): Regression-Type Models for Kohonen’s Self-Organizing Networks, in: R. Decker, W. Gaul (Eds.): Classification and Information Processing at the Turn of the Millenium, Procs. of the 23rd Annual Conference of the Gesellschaft für Klassifikation, Bielefeld, 10–12 March, 1999, Springer, 18–31.

    Google Scholar 

  • BRAZMA, A., VILO, J. (2000): Gene expression data analysis, FEBS Letters, 480, 17–24.

    Article  Google Scholar 

  • BRUNNERT, M., MÜLLER, O. and URFER, W. (2000): Genetical and statistical aspects of polymerase chain reactions, Technical Report 6/2000, University of Dortmund.

    Google Scholar 

  • GILBERG, F., EDLER, L. URFER, W. (1999): Heteroscedastic Nonlinear Regression Models with Random Effects and Their Application to Enzyme Kinetic Data, Biometrical Journal, 41, 543–557.

    Article  MATH  Google Scholar 

  • GOLUB, T.R., SLONIM, D.K., TAMAYO, P., HUARD, C., GAASENBEEK, M., MESIROV, J.P., COLLER, H., LOH, M.L., DOWNING, J.R., CALIGIURI, M.A., BLOOMFIELD, C.D., LANDER, E.S. (1999): Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring, Science, Vol. 286, October, 531–537.

    Article  Google Scholar 

  • GUIMARÃES, G. (2000): Temporal Knowledge Discovery for Multivariate Time Series with Enhanced Self-Organizing Maps, To appear in: IEEE-INNS-ENNS Intl. Joint Conf. on Neural Networks (IJCNN’2000), Como, 24–27 July, Italy.

    Google Scholar 

  • GUIMARÃES, G. (1998): Eine Methode zur Entdeckung von komplexen Mustern in Zeitreihen mit Neuronalen Netzen and deren Überführung in eine symbolische Wissenrepräsentation, PhD Dissertation, University of Marburg, Germany.

    Google Scholar 

  • GUIMARAES, G., MOURA-PIRES, F. (2001): An Essay in Classifying Self-Organizing Maps for Temporal Sequence Processing. In Allison, N., Yin, H., Allison L., Slack J. (eds), Advances in self-Organizing Maps, (pp. 259–266), Springer.

    Google Scholar 

  • GUIMARÃES, G., ULTSCH, A. (1999): A Method for Temporal Knowledge Conversion, Procs. of IDA99, The Third Symposium on Intelligent Data Analysis, August 9–11, Amsterdam, Netherlands, Lecture Notes in Computer Science, Springer Verlag, 369–380.

    Google Scholar 

  • HIMBERG, J. (2000): A SOM based cluster visualization and its application for false coloring. In: Proceedings of the IEEE-INNS-ENNS IntI. Joint Conf. on Neural Networks (IJCNN’2000), (pp. 587–592), Vol. 3, 24–27 July, Como, Italy.

    Google Scholar 

  • JOUTSINIEMI, S.L., KASKI, S., LARSEN, T.A., (1995): Self-Organizing Map in Recognition of Topographic Patterns of EEG Spectra, IEEE Transactions on Biomedical Engineering, Vol. 42, No. 11, 1062–1068.

    Article  Google Scholar 

  • KASKI, S., KOHONEN, T., (1996): Exploratory Data Analysis by Self-Organizing Map: Structures of Welfare and Poverty in the World, in: A.P.N Refenes, Y. Abu-Mostafa, J. Moody, A. Weigend (Eds.): Neural Networks in Financial Engineering. Proc. of the Intl. Conf. on Neural Networks in the Capital Markets, London, England, 11–13 October, 1995, Singapore, 498–507.

    Google Scholar 

  • KEMKE, C., WICHERT, A., (1993): Hierarchical Self-Organizing Feature Maps for Speech Recognition, Proc. of the World Congress on Neural Networks (WCNN 93), Hillsdale, Vol. III, 45–47.

    Google Scholar 

  • KOH, J., SUK, M., BHANDARKAR, S.M., (1995): A Multilayer Self-Organizing Feature Map for Range Image Segmentation, Neural Networks, Vol.8, No.1, Elsevier Science Publisher, 67–86.

    Article  Google Scholar 

  • KOHONEN, T. (2001): Self-Organizing Maps, Springer, New York.

    Book  MATH  Google Scholar 

  • KOHONEN, T. (1982): Self-organized formation of topologically correct feature maps, Biological Cybernetics 43, 141–152.

    Article  MathSciNet  Google Scholar 

  • MUJUNEN, R., LEINONEN, L, KANGAS, J., TORKKOLA, K., (1993): Acoustic Pattern Recognition of /s/ Misarticulation by the Self-Organizing Map, Folia Phoniatr., 45, 135–144.

    Article  Google Scholar 

  • PENZEL, T., Peter, J.H.: Design of an Ambulatory Sleep Apnea Recorder, in: H.T. Nagle, W.J. Tompkins (Eds.): Case Studies in Medical Instrument Design, IEEE, New York, 1992, 171–179.

    Google Scholar 

  • PETER, J.H., BECKER, H., BRANDENBURG, U., CASSEL, W., CONRADT, R., HOCHBAN, W., KNAACK, L., MAYER, G., PENZEL, T. (1998): Investigation and diagnosis of sleep apnoea syndrome, in: McNicholas, W.T. (ed.): Respiratory Disorders during Sleep. European Respiratory Society Journals, Sheffield, 106–143.

    Google Scholar 

  • SELINSKI, S., GOLKA, K., BOLT, H.M. and URFER, W. (2000): Estimation of toxicokinetic parameters in population models for inhalation studies with ethylene, Environmetrics, 11, 479–495.

    Article  Google Scholar 

  • ULTSCH, A., SIEMON, H.P. (1990): Kohonen’s Self-Organizing Neural Networks for Exploratory Data Analysis, Proc. Intl, Neural Network Conf. INNC90, Paris, Kluwer Academic, 305–308.

    Google Scholar 

  • URFER, W. (2002): Hazardous Agents. In: Encyclopedia of Environmetrics. A.H. El-Shaarawi, W.W. Piegorsch (Eds.), Wiley, Chichester, Vol. 2, 983–987.

    Google Scholar 

  • VESANTO, J., ALHONIEMI, E. (2000): Clustering of the Self-Organizing Map. IEEE Transactions on Neural Networks, Special Issue on Data Mining, 11 (3), 586–600.

    Article  Google Scholar 

  • WALTER, J.A., SCHULTEN, K.J. (1993): Implementation of Self-Organizing Neural Networks for Visual-Motor Control of an Industrial Robot, IEEE Transactions on Neural Networks, Vol. 4, No.1, January 86–95.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Guimarães, G., Urfer, W. (2003). Self-Organizing Maps and its Applications in Sleep Apnea Research and Molecular Genetics. In: Schwaiger, M., Opitz, O. (eds) Exploratory Data Analysis in Empirical Research. Studies in Classification, Data Analysis, and Knowledge Organization. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55721-7_34

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-55721-7_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-44183-0

  • Online ISBN: 978-3-642-55721-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics