Abstract
This paper presents the application of special unsupervised neural networks (Self-Organizing Maps) to different domains, such as sleep apnea discovery, protein sequence analysis and tumor classification. An enhancement of the original algorithm, as well as the introduction of several hierachical levels enables the discovery of complex stru ctures as present in this type of applications. Finally we recommend the use of regression-type models for Kohonen’s Self-Organizing Networkin gene expression data analysis.
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ANDRADE, M.A., CASARI, G., SANDER, C., VALENCIA, A. (1997): Classification of protein families and detection of the determinant residues with an improved self-organizing map, Biological Cybernetics, 76, 441–450.
BEHME, H., BRANDT, W.D., STRUBE, H.W. (1993): Speech Recognition by Hierarchical Segment Classification, in: S. Gielen, B. Kappen (Eds.): Proc. IntI. Conf. on Aritificial Neural Networks (ICANN 93), Amsterdam, Springer Verlag, London, 416–419.
BISHOP, C.M. (1995): Neural Networks for Pattern Recognition, Oxford, Clarendon Press.
BOCK, H.H. (2000): Regression-Type Models for Kohonen’s Self-Organizing Networks, in: R. Decker, W. Gaul (Eds.): Classification and Information Processing at the Turn of the Millenium, Procs. of the 23rd Annual Conference of the Gesellschaft für Klassifikation, Bielefeld, 10–12 March, 1999, Springer, 18–31.
BRAZMA, A., VILO, J. (2000): Gene expression data analysis, FEBS Letters, 480, 17–24.
BRUNNERT, M., MÜLLER, O. and URFER, W. (2000): Genetical and statistical aspects of polymerase chain reactions, Technical Report 6/2000, University of Dortmund.
GILBERG, F., EDLER, L. URFER, W. (1999): Heteroscedastic Nonlinear Regression Models with Random Effects and Their Application to Enzyme Kinetic Data, Biometrical Journal, 41, 543–557.
GOLUB, T.R., SLONIM, D.K., TAMAYO, P., HUARD, C., GAASENBEEK, M., MESIROV, J.P., COLLER, H., LOH, M.L., DOWNING, J.R., CALIGIURI, M.A., BLOOMFIELD, C.D., LANDER, E.S. (1999): Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring, Science, Vol. 286, October, 531–537.
GUIMARÃES, G. (2000): Temporal Knowledge Discovery for Multivariate Time Series with Enhanced Self-Organizing Maps, To appear in: IEEE-INNS-ENNS Intl. Joint Conf. on Neural Networks (IJCNN’2000), Como, 24–27 July, Italy.
GUIMARÃES, G. (1998): Eine Methode zur Entdeckung von komplexen Mustern in Zeitreihen mit Neuronalen Netzen and deren Überführung in eine symbolische Wissenrepräsentation, PhD Dissertation, University of Marburg, Germany.
GUIMARAES, G., MOURA-PIRES, F. (2001): An Essay in Classifying Self-Organizing Maps for Temporal Sequence Processing. In Allison, N., Yin, H., Allison L., Slack J. (eds), Advances in self-Organizing Maps, (pp. 259–266), Springer.
GUIMARÃES, G., ULTSCH, A. (1999): A Method for Temporal Knowledge Conversion, Procs. of IDA99, The Third Symposium on Intelligent Data Analysis, August 9–11, Amsterdam, Netherlands, Lecture Notes in Computer Science, Springer Verlag, 369–380.
HIMBERG, J. (2000): A SOM based cluster visualization and its application for false coloring. In: Proceedings of the IEEE-INNS-ENNS IntI. Joint Conf. on Neural Networks (IJCNN’2000), (pp. 587–592), Vol. 3, 24–27 July, Como, Italy.
JOUTSINIEMI, S.L., KASKI, S., LARSEN, T.A., (1995): Self-Organizing Map in Recognition of Topographic Patterns of EEG Spectra, IEEE Transactions on Biomedical Engineering, Vol. 42, No. 11, 1062–1068.
KASKI, S., KOHONEN, T., (1996): Exploratory Data Analysis by Self-Organizing Map: Structures of Welfare and Poverty in the World, in: A.P.N Refenes, Y. Abu-Mostafa, J. Moody, A. Weigend (Eds.): Neural Networks in Financial Engineering. Proc. of the Intl. Conf. on Neural Networks in the Capital Markets, London, England, 11–13 October, 1995, Singapore, 498–507.
KEMKE, C., WICHERT, A., (1993): Hierarchical Self-Organizing Feature Maps for Speech Recognition, Proc. of the World Congress on Neural Networks (WCNN 93), Hillsdale, Vol. III, 45–47.
KOH, J., SUK, M., BHANDARKAR, S.M., (1995): A Multilayer Self-Organizing Feature Map for Range Image Segmentation, Neural Networks, Vol.8, No.1, Elsevier Science Publisher, 67–86.
KOHONEN, T. (2001): Self-Organizing Maps, Springer, New York.
KOHONEN, T. (1982): Self-organized formation of topologically correct feature maps, Biological Cybernetics 43, 141–152.
MUJUNEN, R., LEINONEN, L, KANGAS, J., TORKKOLA, K., (1993): Acoustic Pattern Recognition of /s/ Misarticulation by the Self-Organizing Map, Folia Phoniatr., 45, 135–144.
PENZEL, T., Peter, J.H.: Design of an Ambulatory Sleep Apnea Recorder, in: H.T. Nagle, W.J. Tompkins (Eds.): Case Studies in Medical Instrument Design, IEEE, New York, 1992, 171–179.
PETER, J.H., BECKER, H., BRANDENBURG, U., CASSEL, W., CONRADT, R., HOCHBAN, W., KNAACK, L., MAYER, G., PENZEL, T. (1998): Investigation and diagnosis of sleep apnoea syndrome, in: McNicholas, W.T. (ed.): Respiratory Disorders during Sleep. European Respiratory Society Journals, Sheffield, 106–143.
SELINSKI, S., GOLKA, K., BOLT, H.M. and URFER, W. (2000): Estimation of toxicokinetic parameters in population models for inhalation studies with ethylene, Environmetrics, 11, 479–495.
ULTSCH, A., SIEMON, H.P. (1990): Kohonen’s Self-Organizing Neural Networks for Exploratory Data Analysis, Proc. Intl, Neural Network Conf. INNC90, Paris, Kluwer Academic, 305–308.
URFER, W. (2002): Hazardous Agents. In: Encyclopedia of Environmetrics. A.H. El-Shaarawi, W.W. Piegorsch (Eds.), Wiley, Chichester, Vol. 2, 983–987.
VESANTO, J., ALHONIEMI, E. (2000): Clustering of the Self-Organizing Map. IEEE Transactions on Neural Networks, Special Issue on Data Mining, 11 (3), 586–600.
WALTER, J.A., SCHULTEN, K.J. (1993): Implementation of Self-Organizing Neural Networks for Visual-Motor Control of an Industrial Robot, IEEE Transactions on Neural Networks, Vol. 4, No.1, January 86–95.
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Guimarães, G., Urfer, W. (2003). Self-Organizing Maps and its Applications in Sleep Apnea Research and Molecular Genetics. In: Schwaiger, M., Opitz, O. (eds) Exploratory Data Analysis in Empirical Research. Studies in Classification, Data Analysis, and Knowledge Organization. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55721-7_34
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DOI: https://doi.org/10.1007/978-3-642-55721-7_34
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