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The Foamy Virus Envelope Glycoproteins

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Foamy Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 277))

Abstract

The main functions of retroviral glycoproteins are recognition and binding to the cellular virus receptor as well as fusion of viral and cellular lipid membranes to release the viral particle into the cytoplasm of the host cell. Foamy viruses (FVs) are a special group of retroviruses with a very broad host range that use a currently unknown cellular receptor for entry. Nevertheless, many functions of the FV envelope glycoproteins in the viral replication cycle have been characterized in detail over the last years. Several unique features not found for any other retro-virus were identified.

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References

  • Baldwin DN, Linial ML (1998) The roles of Pol and Env in the assembly pathway of human foamy virus. J Virol 72:3658–3665

    PubMed  CAS  Google Scholar 

  • Bansal A, Shaw KL, Edwards BH, Goepfert PA, Mulligan MJ (2000) Characterization of the R572T point mutant of a putative cleavage site in human foamy virus Env. J Virol 74:2949–2954

    Article  PubMed  CAS  Google Scholar 

  • Bodem J, Löchelt M, Delius H, Fl¨¹gel RM (1998) Detection of subgenomic cDNAs and mapping of feline foamy virus mRNAs reveals complex patterns of transcription. Virology 244:417–426

    Article  PubMed  CAS  Google Scholar 

  • Bullough PA, Hughson FM, Skehel JJ, Wiley DC (1994) Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 371:37–43

    Article  PubMed  CAS  Google Scholar 

  • Carr CM, Chaudhry C, Kim PS (1997) Influenza hemagglutinin is spring-loaded by a metastable native conformation. Proc Natl Acad Sci USA 94:14306–14313

    Article  PubMed  CAS  Google Scholar 

  • Carr CM, Kim PS (1993) A spring-loaded mechanism for the conformational change of influenza hemagglutinin. Cell 73:823–832

    Article  PubMed  CAS  Google Scholar 

  • Chan DC, Fass D, Berger JM, Kim PS (1997) Core structure of gp41 from the HIV envelope glycoprotein. Cell 89:263–273

    Article  PubMed  CAS  Google Scholar 

  • Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661–666

    Article  PubMed  CAS  Google Scholar 

  • Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA (1996) HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667–673

    Article  PubMed  CAS  Google Scholar 

  • Epand RM, Epand RF (2001) Factors contributing to the fusogenic potency of foamy virus. Biochem Biophys Res Commun 284:870–874

    Article  PubMed  CAS  Google Scholar 

  • Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM (1997) Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution. Science 277:1662–1666

    Article  PubMed  CAS  Google Scholar 

  • Fass D, Harrison SC, Kim PS (1996) Retrovirus envelope domain at 1.7 angstrom resolution. Nat Struct Biol 3:465–469

    Article  PubMed  CAS  Google Scholar 

  • Feng Y, Broder CC, Kennedy PE, Berger EA (1996) HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872–877

    Article  PubMed  CAS  Google Scholar 

  • Fischer N, Heinkelein M, Lindemann D, Enssle J, Baum C, Werder E, Zentgraf H, Muller JG, Rethwilm A (1998) Foamy virus particle formation. J Virol 72:1610–1615

    PubMed  CAS  Google Scholar 

  • Flint S, Enquist L, Krug R, Racaniello V, Skalka A (2000) Principles of virology: molecular biology, pathogenesis, and control. American Society for Microbiology, Washington DC.

    Google Scholar 

  • Fl¨¹gel RM, Rethwilm A, Maurer B, Darai G (1987) Nucleotide sequence analysis of the env gene and its flanking regions of the human spumaretrovirus reveals two novel genes. EMBO J 6:2077–2084

    Google Scholar 

  • Giron ML, de The H, Saïb A (1998) An evolutionarily conserved splice generates a secreted env-Bet fusion protein during human foamy virus infection. J Virol 72:4906–4910

    PubMed  CAS  Google Scholar 

  • Giron ML, Rozain F, Debons Guillemin MC, Canivet M, Perks J, Emanoil Ravier R (1993) Human foamy virus polypeptides: identification of env and bel gene products. J Virol 67:3596–3600

    PubMed  CAS  Google Scholar 

  • Goepfert PA, Shaw K, Wang G, Bansal A, Edwards BH, Mulligan MJ (1999) An endoplasmic reticulum retrieval signal partitions human foamy virus maturation to intracytoplasmic membranes. J Virol 73:7210–7217

    PubMed  CAS  Google Scholar 

  • Goepfert PA, Shaw KL, Ritter GD Jr., Mulligan MJ (1997) A sorting motif localizes the foamy virus glycoprotein to the endoplasmic reticulum. J Virol 71:778–784

    Google Scholar 

  • Goepfert PA, Wang G, Mulligan MJ (1995) Identification of an ER retrieval signal in a retroviral glycoprotein. Cell 82:543–544

    Article  PubMed  CAS  Google Scholar 

  • Hunter E (1997) Viral entry and receptors. In: Coffin JM, Hughes SH, Varmus HE (eds) Retroviruses. Cold Spring Harbor Laboratory Press, New York

    Google Scholar 

  • Lindemann D, Bock M, Schweizer M, Rethwilm A (1997) Efficient pseudotyping of murine leukemia virus particles with chimeric human foamy virus envelope proteins. J Virol 71:4815–4820

    PubMed  CAS  Google Scholar 

  • Lindemann D, Pietschmann T, Picard-Maureau M, Berg A, Heinkelein M, Thurow J, Knaus P, Zentgraf H, Rethwilm A (2001) A particle-associated glycoprotein signal peptide essential for virus maturation and infectivity. J Virol 75:5762–5771

    Article  PubMed  CAS  Google Scholar 

  • Lindemann D, Rethwilm A (1998) Characterization of a human foamy virus 170-kilodalton Env-Bet fusion protein generated by alternative splicing. J Virol 72:4088–4094

    Google Scholar 

  • Löchelt M, Fl¨¹gel RM, Aboud M (1994) The human foamy virus internal promoter directs the expression of the functional Bel 1 transactivator and Bet protein early after infection. J Virol 68:638–645

    PubMed  Google Scholar 

  • Mergia A (1994) Simian foamy virus type 1 contains a second promoter located at the 3’ end of the env gene. Virology 199:219–222

    Article  PubMed  CAS  Google Scholar 

  • Netzer KO, Rethwilm A, Maurer B, ter Meulen V (1990) Identification of the major immunogenic structural proteins of human foamy virus. J Gen Virol 71:12371241

    Google Scholar 

  • Peisajovich SG, Shai Y (2002) High similarity between reverse-oriented sequences from HIV and foamy virus envelope glycoproteins. AIDS Res Hum Retroviruses 18:309–312

    Article  PubMed  Google Scholar 

  • Pietschmann T, Heinkelein M, Heldmann M, Zentgraf H, Rethwilm A, Lindemann D (1999) Foamy virus capsids require the cognate envelope protein for particle export. J Virol 73:2613–2621

    PubMed  CAS  Google Scholar 

  • Pietschmann T, Zentgraf H, Rethwilm A, Lindemann D (2000) An evolutionarily conserved positively charged amino acid in the putative membrane-spanning domain of the foamy virus envelope protein controls fusion activity. J Virol 74:4474–4482

    Article  PubMed  CAS  Google Scholar 

  • Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C, Burtonboy G, Georges M, Imai T, Rana S, Yi Y, Smyth RJ, Coltman RG, Doms RW, Vassart G, Parmentier M (1996) Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722–725

    Article  PubMed  CAS  Google Scholar 

  • Shaw KL, Lindemann D, Mulligan MJ, Goepfert PA (2003) Foamy virus envelope gly-coprotein is sufficient for particle budding and release. J Virol 77: (in press)

    Google Scholar 

  • Skehel JJ, Wiley DC (2000) Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu Rev Biochem 69.531–569

    Article  PubMed  CAS  Google Scholar 

  • Swanstrom R, Wills J (1997) Synthesis, assembly, and processing of viral proteins. In: Coffin JM, Hughes SH and Varmus HE (eds) Retroviruses. Cold Spring Harbor Laboratory Press, New York

    Google Scholar 

  • Tobaly-Tapiero J, Bittoun P, Neves M, Guillemin MC, Lecellier CH, Puvion-Dutilleul F, Gicquel B, Zientara S, Giron ML, de The H, Saib A (2000) Isolation and characterization of an equine foamy virus. J Virol 74:4064–4073

    Article  PubMed  CAS  Google Scholar 

  • Wang G, Mulligan MJ (1999) Comparative sequence analysis and predictions for the envelope glycoproteins of foamy viruses. J Gen Virol 80:245–254

    PubMed  CAS  Google Scholar 

  • Weissenhorn W, Dessen A, Harrison SC, Skehel JJ, Wiley DC (1997) Atomic structure of the ectodomain from HIV-1 gp41. Nature 387:426–430

    Article  PubMed  CAS  Google Scholar 

  • Wilk T, de Haas F, Wagner A, Rutten T, Fuller S, Fl¨¹gel RM, Löchelt M (2000) The intact retroviral Env glycoprotein of human foamy virus is a trimer. J Virol 74:2885–2887

    Article  PubMed  CAS  Google Scholar 

  • Wilk T, Geiselhart V, Frech M, Fuller SD, Fl¨¹gel RM, Löchelt M (2001) Specific interaction of a novel foamy virus env leader protein with the n-terminal gag domain. J Virol 75:7995–8007

    Article  PubMed  CAS  Google Scholar 

  • Zemba M, Wilk T, Rutten T, Wagner A, Flugel RM, Lochelt M (1998) The carboxyterminal p3 gag domain of the human foamy virus gag precursor is required for efficient virus infectivity. Virology 247:7–13

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institut für Virologie, Medizinische Fakultät Carl-Gustav-Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany

    D. Lindemann

  2. Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, 220 Bevill Biomedical Research Building, 845 19th St. South, Birmingham, AL, 35294, USA

    P. A. Goepfert

Authors
  1. D. Lindemann
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  2. P. A. Goepfert
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Editors and Affiliations

  1. Medizinische Fakultät der TU Dresden, Institut für Virologie im MTZ, Fiedlerstr. 42, 01307, Dresden, Germany

    Axel Rethwilm

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© 2003 Springer-Verlag Berlin Heidelberg

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Lindemann, D., Goepfert, P.A. (2003). The Foamy Virus Envelope Glycoproteins. In: Rethwilm, A. (eds) Foamy Viruses. Current Topics in Microbiology and Immunology, vol 277. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55701-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-55701-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62934-1

  • Online ISBN: 978-3-642-55701-9

  • eBook Packages: Springer Book Archive

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