Particle Assembly and Genome Packaging

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 277)


Foamy virus (FV) replication is distinct from that of all other retroviruses in many respects, including viral assembly. In fact, the viral assembly pathway is rather similar to that of hepadnaviruses such as hepatitis B virus. Foamy virus Gag does not contain landmark retroviral assembly domains such as the major homology region, Cys-His boxes, or a defined M domain Like hepadnaviruses, the FV Gag protein is not cleaved and contains arginine-rich regions at the carboxyl terminus. In addition, egress of FV particles requires presence of the envelope glycoproteins Finally, the cis-acting sequences in the FV genome required for genome incorporation, although poorly defined, differ in location from other retroviruses.


Human Immunodeficiency Virus Type Rous Sarcoma Virus Foamy Virus Prototypic Foamy Virus Bovine Foamy Virus 
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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  1. 1.Division of Basic Sciences A3–015Fred Hutchinson Cancer Research CenterSeattleUSA

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