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Komplikationen bei Zeckenstichen: Ehrlichiose und Borreliose

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Fortschritte der praktischen Dermatologie und Venerologie

Part of the book series: Fortschritte der praktischen Dermatologie und Venerologie ((DERMATOLOGIE,volume 18))

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Zusammenfassung

Zecken können weltweit zahlreiche Krankheitserreger auf den Menschen übertragen (Tabelle 1.) In Mitteleuropa kommt insbesondere dem Holzbock (Ixodes ricinus) Bedeutung als Vektor zu. Er überträgt vor allem die Spirochäte Borrelia burgdorferi sensu lato (Bb), den Auslöser der Lyme-Borreliose (LB), verschiedene Anaplasma- und Ehrlichien-Spezies (Auslöser der Ehrlichiose) sowie bestimmte Flaviviren als Auslöser der Frühsommermeningoenzephalitis (FSME). Diese drei Infektionskrankheiten unterscheiden sich deutlich hinsichtlich klinischem Bild, Häufigkeit, Schweregrad, Verlauf sowie Möglichkeiten der Behandlung und Prophylaxe. Die LB ist die häufigste zeckenübertragene Krankheit. In den USA werden jährlich mehr als 17.000 Fälle gemeldet, die Erkrankungszahlen haben über die Jahre laufend zugenommen. Die höchste Inzidenz wird von Connecticut berichtet (110/100.000 Einwohner und Jahr). In Europa kann von einer durchschnittlichen Inzidenz von 300/100.000 Einwohnern und Jahr ausgegangen werden [23].

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Literatur

  1. Aguero-Rosenfeld ME, Horowitz HW, Wormser GP, McKenna DF, Nowakowski J, Munoz J, Dumler JS (1996) Human granulocytic ehrlichiosis (HGE). A case series from a single medical center in New York State. Ann Intern Med 125: 904–908

    Article  CAS  PubMed  Google Scholar 

  2. Aguero-Rosenfeld ME, Kalantarpour F, Baluch M, Horowitz HW, McKenna DF, Raffalli JT, Hsieh TC, Wu J, Dumler JS, Wormser GP (2000) Serology of culture-confirmed cases of human granulocytic ehrlichiosis. J Clin Microbiol 38: 635–638

    CAS  PubMed Central  PubMed  Google Scholar 

  3. Anonymous (1995) Lyme disease—United States, 1994. Morb Mortal Wkly Rep 44: 459–462

    Google Scholar 

  4. Åsbrink E, Hovmark A (1985) Successful cultivation of spi-rochetes from skin lesions of patients with erythema chro- nicum migrans Afzelius and acrodermatitis chronica atro-phicans. Acta Pathol Microbiol Immunol Scand B 93: 161–163

    PubMed  Google Scholar 

  5. Åsbrink E, Olsson I (1985) Clinical manifestations of erythema chronicum migrans Afzelius in 161 patients. Acta Dermato Venereol (Stockh) 65:43–52

    Google Scholar 

  6. Åsbrink E, Hovmark A, Hederstedt B (1985) Serologic studies of erythema chronicum migrans Afzelius and acrodermatitis chronica atrophicans with indirect immunofluores-cence and enzyme-linked immunosorbent assays. Acta Dermato Venereol (Stockh) 65: 509–514

    Google Scholar 

  7. Bakken JS, Dumler JS, Chen SM, Eckman MR, Van Etta LL, Walker DH (1994) Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging? J Am Med Ass 272: 212–218

    Article  CAS  Google Scholar 

  8. Bakken JS, Krueth J, Wilson-Nordskog C, Tilden RL, Asanovich K, Dumler JS (1996) Clinical and laboratory char-acteristics of human granulocytic ehrlichiosis. J Am Med Ass 275:199–205

    Article  CAS  Google Scholar 

  9. Dumler JS (2001) Molecular diagnosis of Lyme disease. Re-view and metaanalysis. Mol Diagn 6:1 -11

    Article  CAS  PubMed  Google Scholar 

  10. Dumler JS, Barbet AF, Bekker CPJ, Dasch GA, Palmer GH, Ray SC, Rikihisa Y, Rurangirwa FR (2001) Reorganization of genera in the families Rickettsiaceae and Anaplasmata-ceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia, and Ehrlichia with Neorickettsia, description of six new species combinations and designation of Ehrlichia equi and ’HGE agent’ as subjective synonyms of Ehrlichia phagocytophila. Int J Syst Evol Bacteriol 51: 2145–2165

    Article  CAS  Google Scholar 

  11. Edelman DC, Dumler JS (1996) Evaluation of an improved PCR diagnostic assay for human granulocytic ehrlichiosis. Mol Diagnosis 1:41–49

    Article  Google Scholar 

  12. Goodman JL, Nelson C, Vitale B, Madigan JE, Dumler JS, Kurtti TJ, Munderloh UG (1996) Direct cultivation of the causative agent of human granulocytic ehrlichiosis. N Engl J Med 334: 209–215

    Article  CAS  PubMed  Google Scholar 

  13. Hansen K (1993) Laboratory diagnostic methods in Lyme borreliosis. Clin Dermatol 11:407 - 414

    Article  CAS  PubMed  Google Scholar 

  14. Krause P, McKay K, Thompson CA, Sikand VK, Lentz R, Lepore T, Closter L, Christianson D, Telford SR, Persing D, Radolf JD, Spielman A (2002) Disease-specific diagnosis of coinfecting tick-borne zoonoses; Babesiosis, human granulocytic ehrlichiosis, and Lyme disease. Clin Infect Dis 34: 1184–1191

    Article  PubMed  Google Scholar 

  15. Lebech AM (2002) Polymerase chain reaction in diagnosis of Borrelia burgdorferi infections and studies on taxo-nomic classification. APMIS 105 [suppl]: S1 -40

    Google Scholar 

  16. Maraspin V, Cimperman J, Lotric-Furlan S, Pleterski-Rig-ler D, Strle F (1996) Treatment of erythema migrans in pregnancy. Clin Infect Dis 22: 788 - 793

    Article  CAS  PubMed  Google Scholar 

  17. Müllegger RR, McHugh G, Ruthazer R, Binder B, Kerl H, Steere AC (2000) Differential expression of cytokine mRNA in skin specimens from patients with erythema migrans or acrodermatitis chronica atrophicans. J Invest Dermatol 115:1115–1123

    Article  PubMed  Google Scholar 

  18. Müllegger RR, Glatz M, Kerl H (2002) Serologic follow-up of patients with erythema migrans after antibiotic therapy. J Invest Dermatol 119: 316

    Google Scholar 

  19. Nadelman RB, Nowakowski J, Fish D, Falco RC, Freeman K, McKenna D, Welch P, Marcus R, Aguero-Rosenfeld ME, Dennis DT, Wormser GP (2001) Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med 345: 79–84

    Article  CAS  PubMed  Google Scholar 

  20. Nowakowski J, Nadelman RB, Forseter G, McKenna D, Wormser GP (1995) Doxycycline versus tetracycline therapy for Lyme disease associated with erythema migrans. J Am Acad Dermatol 32: 223 - 227

    Article  CAS  PubMed  Google Scholar 

  21. Seinost G, Dykhuizen DE, Dattwyler RJ, Golde WT, Dunn JJ, Wang IN, Wormser GP, Schriefer ME, Luft BJ (1999) Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans. Infect Immun 67: 3518 - 3524

    CAS  PubMed Central  PubMed  Google Scholar 

  22. Stanek G (1991) Laboratory diagnosis and seroprevalence of Lyme borreliosis. Infection 19: 263 - 267

    Article  CAS  PubMed  Google Scholar 

  23. Stanek G (1995) Lyme borreliosis. Wien Med Wochenschr 145 (7-8): 155–161

    CAS  PubMed  Google Scholar 

  24. Stanek G, Kahl 0 (1999) Chemoprophylaxis for Lyme borreliosis? Zentralbl Bakteriol 289: 655–665

    Article  CAS  PubMed  Google Scholar 

  25. Stanek G, O’Connell S, Cimmino M, Aberer E, Kristoferitsch W, Granström M, Guy E, Gray J (1996) European Union concerted action on risk assessment in Lyme borreliosis. Clinical case definitions for Lyme borreliosis. Wien Klin Wochenschr 108: 741–747

    CAS  PubMed  Google Scholar 

  26. Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Rahn DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE (1983) The early clinical manifestations of Lyme disease. Ann Intern Med 99: 76–82

    Article  CAS  PubMed  Google Scholar 

  27. Weber K, Neubert U, Büchner SA (1993) Erythema mi-grans and early signs and symptoms. In: Weber K, Burgdorfer W (eds) Aspects of Lyme borreliosis. Springer, Berlin Heidelberg New York, pp 105 -121

    Chapter  Google Scholar 

  28. Weger W, Müllegger RR (2002) Histopathology and immu-nohistochemistry of dermatoborrelioses. Acta Dermato-ven APA 10: 135–142

    Google Scholar 

  29. Wormser GP, Nadelman RB, Dattwyler RJ, Dennis DT, Shapiro ED, Steere AC, Rush TJ, Rahn DW, Coyle PK, Persing DH, Fish D, Luft BJ (2000) Practice guidelines for the treatment of Lyme disease. Clin Infect Dis 31 [suppl 1]: S1 -14

    Article  CAS  Google Scholar 

  30. Zöchling N, Müllegger RR, Schlüpen EM, Stumpenhausen G, Soyer HP, Wienecke R, Hödl S, Volkenandt M, Kerl H (1995) Molecular subtyping of Borrelia burgdorferi (Bb) in lesional skin from Styrian (Austrian) patients with various manifestations of dermatoborreliosis (DB). J Invest Der-matol 104: 687

    Google Scholar 

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Müllegger, R.R., Rieger, A., Weger, W. (2003). Komplikationen bei Zeckenstichen: Ehrlichiose und Borreliose. In: Plewig, G., Prinz, J. (eds) Fortschritte der praktischen Dermatologie und Venerologie. Fortschritte der praktischen Dermatologie und Venerologie, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55661-6_15

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  • DOI: https://doi.org/10.1007/978-3-642-55661-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

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