Abstract
Substantial reduction in breast cancer mortality has been proven in randomized trials of screening mammography. These trials have found a statistically significant benefit both for women ages 40–49 years and for women age 50 years and older at onset of screening. In fact, it is likely that the trials actually underestimate the benefit for an individual woman who is screened. Service screening programs have shown a 63% reduction in deaths from breast cancer among women who are screened. Virtually all major medical organizations now advise screening mammography for women ages 40 and older. Two recent studies that questioned the validity of results from screening mammography trials are themselves fatally flawed.
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Alexander FE, Anderson TJ, Brown HK, et al. (1999) 14 years of follow-up from Edinburgh randomized trial of breast cancer screening. Lancet 3353:1903–1909
Andersson I, Aspegren K, Janzon L, et al. (1988) Mammographic screening and mortality from breast cancer: the Malmo Mammographic Screening Trial. BMJ, Brit Med J 297:943–948
Andersson I, Janzon L (1997) Reduced breast cancer mortality in women under 50: updated results from the Malmo Mammographic Screening Program. NCI Monogr 22:63–68
Andersson I, Nystrom L (1995) Mammography screening. J Natl Cancer Inst 87:1263
Bailar JC III, MacMahon B (1997) Randomization in the Canadian National Breast Screening Study: a review of evidence for subversion. Can Med Assoc J 156:193–199
Baines CJ, Miller AB, Kopans DB, et al (1990) Canadian National Breast Screening Study: assessment of technical quality by external review. AJR Am J Roentgenol 155:743–747
Bjurstam N, Bjorneld L, Duffy SW (1997) The Gothenburg Breast Screening Trial: first results on mortality, incidence, and mode of detection for women ages 39–49 years of randomization. Cancer 80:2091–2099
Bjurstam N, Bjorneld L, Duffy SW, Prevost TC (1998) The Gothenburg Breast Screening Trial (authors’ reply). Cancer 83:188–190
Boyd NF (1997) The review of randomization in the Canadian National Breast Screening Study: Is the debate over? Can Med Assoc J 156:207–209
Boyd NF, Jong RA, Yaffe MJ, et al (1993) A critical appraisal of the Canadian National Breast Screening Study. Radiology 189:681–663
Chu KC, Smart CR, Tarone RE (1988) Analysis of breast cancer mortality and stage distribution by age for the Health Insurance Plan Trial. J Natl Cancer Inst 80:1125–1132
Conway BJ, Suleiman OH, Reuter FG, Antonsen RG, Slayton RJ (1994) National survey of mammographic facilities in 1985, 1988, and 1992. Radiology 191:323–330
de Koning HJ (2000) Assessment of nationwide cancer-screening programmes. Lancet 355:80–81
Duffy SW (2001) Interpretation of the breast screening trials: a commentary on the recent paper by Gotzsche and Olsen. The Breast 10:209–212
Duffy SW, Tabar L (2000) Screening mammography re-evaluated (letter to the editor) Lancet 355:747–748
Duffy SW, Tabar L, Chen H-H, et al. (2002) The impact of organized mammography service screening on breast cancer mortality in seven Swedish counties: a collaborative evaluation. Cancer 95:458–469
Falun Meeting Committee and Collaborators (1996) Falun meeting on breast cancer screening with mammography in women aged 40–49 years: report of the organizing committee and collaborators. Int J Cancer 68:693–699
Feig SA (1994) Determination of mammographic screening intervals with surrogate measures for women aged 40–49 years. Radiology 193:311–314
Feig SA (1995) Estimation of currently attainable benefit from mammographic screening of women aged 40–49 years. Cancer 75:2412–2419
Feig SA (1997) Increased benefit from shorter screening mammography intervals for women ages 40–49 years. Cancer 80:2035–2039
Feig SA, D’Orsi CJ, Hendrick RE, et al (1997b) American College of Radiology Guidelines for Breast Cancer Screening. AJR Am J Roentgenol 171:29–33
Feig SA (2002a) Screening mammography: effect of image quality on clinical outcome. AJR, Am J Roentgenol 178:805–807
Feig SA (2000b) Effect of service screening mammography on population mortality from breast carcinoma. Cancer 95:451–457
Garne JP, Aspegren K, Balldin G, Ranstam J (1997) Increasing incidence of and declining mortality from breast carcinoma: trends in Malmo, Sweden, 1961–1992. Cancer 79:69–74
Gotzsche PC, Olsen O (2000) Is screening for breast cancer with mammography justifiable? Lancet 355:129–1134
Hakama M, Pukkala E, Heikkila M, Kallio M (1997) Effectiveness of the public health policy for breast cancer screening in Finland: a population based cohort study. Brit Med J 314:864–867
Haus AG (1999) Dedicated mammographic x-ray equipment, screen-film processing systems, and viewing conditions for mammography. Seminars in Breast Disease 2:30–54
Hendrick RE, Smith RA, Rutledge JH III, et al. (1997) Benefit of screening mammography in women aged 40–49: a new meta-analysis of randomized controlled trials. NCI Monogr 33:87–92
Humphrey LL, Helfant M, Chan BKS, Woolf SH (2002) Breast cancer screen ing: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 137:347–360
Hurley SF, Kaldor JM (1992) The benefits and risks of mammographic screening for breast cancer. Epidemiol Rev 14:101–130
Jonsson H, Nystrom L, Tornberg S, Lenner P (2001) Service screening with mammography of women aged 50–69 years in Sweden: effects on mortality from breast cancer. J Med Screen 8:152–160
Kerlikowske K, Grady D, Rubin SM, et al (1995) Efficacy of screening mammography: a meta-analysis. JAMA 273:149–154
Kopans DB (1990) The Canadian Screening Program: a different perspective. AJR Am J Roentgenol 155:748–749
Kopans DB, Feig SA (1993) The Canadian National Breast Screening Study: a critical review. AJR Am J Roentgenol 161:755–760
Leitch AM, Dodd GD, Costanza M, et al (1997) American Cancer Society Guidelines for the Early Detection of Breast Cancer. CA Cancer J Clin 47:150–153
Lerner P, Jonsson H (1997) Excess mortality from breast cancer in relation to mammography screening in northern Sweden. J Med Screen 4:6–9
Mettlin CJ, Smart CR (1993) The Canadian National Breast Screening Study: an appraisal and implications for early detection policy. Cancer 72:1461–1465
Michaelson JS, Halpern E, Kopans DB (1999) Breast cancer computer simulation method for estimation of optimal intervals for screening. Radiology 212:551–560
Miettinen OS, Henschke CI, Pasmantier MW, et al. (2002) Mammographic screening: no reliable supporting evidence? Lancet 359:404–406
Miller AB, Baines CJ, To T, Wall C (1992) Canadian National Breast Screening Study: 1. Breast cancer detection and death rates among women aged 40 to 49 years. Can Med Assoc J 147:1459–1476
Miller A, To T, Baines CJ, Wall C (2002a) Canadian National Breast Screening Study: 2. 13year results of a randomized trial in women aged 50–59 years. J Natl Cancer Inst 92:1490–1499
Miller AB, To T, Baines CJ, Wall C (2002b) The Canadian National Breast Screening Study-1: breast cancer mortality after 11 to 16 years of follow-up. A randomized trial of mammography in women age 40 to 49 years. Ann Intern Med 137:305–312
Nystrom L (2000) Screening mammography re-evaluated (letter to the editor). Lancet 355:748–749
Nystrom L, Andersson I, Bjurstam N, Frisell J, Nordenskjold B, Rutqvist LE (2002) Long-term effects of mammography screening: updated overview of the Swedish randomized trials. Lancet 359:909–919
Nystrom L, Rutqvist L-E, Wall S, et al (1993) Breast cancer screening with mammography: overview of Swedish randomized trials [published erratum appears in Lancet 1993; 342:1372]. Lancet 341:973–978
Nystrom L, Larsson L-G, Rutqvist L-E, et al (1995) Determination of cause of death among breast cancer cases in the Swedish randomized mammography screening trials. A comparison between official statistics and validation by an end point committee. Acta Oncol 34:145–152
Olsen O, Gotzsche PC (2001) Cochrane review on screening for breast cancer with mammography. Lancet 358:1340–1342
Rosen M, Rehnqvist N (1999) No need to reconsider breast screening programme on basis of results from defective study (letter to the editor). Br Med J 318:809–810
Shapiro S, Venet W, Strax P, Venet L (1988) Periodic screening for breast cancer. The Health Insurance Plan Project and its sequelae, 1963–1986. Johns Hopkins University Press, Baltimore
Sjonell G, Stahle L (1999) Mammography screening does not reduce breast cancer mortality [Swedish]. Lakartidningen 96:904–913
Smart CR, Hendrick RE, Rutledge JH III, et al (1995) Benefit of mammography screening in women ages 40–49 years: current evidence from randomized trials. Cancer 75:1619–1626 [errratum appears in Cancer 75: 2788, 1995]
Smith RA (2000) Breast cancer screening among women younger than 50: a current assessment of the issues. CA Cancer J Clin 50:312–336
Tabar L, Fagerberg G, Chen H-H, et al (1995) Efficacy of breast cancer screening by age: new results from the Swedish Two-County Trial. Cancer 75:2507–2517
Tabar L, Fagerberg G, Duffy SW, Day NE (1989) The Swedish Two-County Trial of mammographic screening for breast cancer: recent results and calculation of benefit. J Epidemiol Comm Hlth 43:107–114
Tabar L, Vitak B, Chen H-H, et al (2000) The Swedish Two-County Trial twenty years later. Updated mortality results and new insights from long-term follow-up. Radiol Clin North Am 38:625–651
Tabar L, Vitak B, Chen H-H, Yen M-F, Duffy SW, Smith RA (2001) Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality. Cancer 91:1724–1731
Taplin SH, Rutter CM, Finder C, Mandelson MT, Houn F, White E (2002) Screening mammography: clinical image quality and the risk of interval breast cancer. AJR Am J Roentgenol 178:797–804
Tarone RE (1995) The excess of patients with advanced breast cancer in young women screened with mammography in the Canadian National Breast Screening Study. Cancer 75:997–1003
Tornberg S, Carstensen J, Hakulinen T, Lenner P, Hatschek T, Lundgren B (1994) Evaluation of the effect on breast cancer mortality of population based mammography screening programmes. J Med Screen 1:184–187
Warren-Burhenne LT, Burhenne HJ (1993) The Canadian National Breast Screening Study: a Canadian critique. AJR Am J Roentgenol 161:761–763
Young KC, Wallis MG, Ramsdale ML (1994) Mammographic film density and detection of small breast cancers. Clin Radiol 49:461–465
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Feig, S.A. (2003). How Reliable Is the Evidence for Screening Mammography?. In: Senn, HJ., Morant, R. (eds) Tumor Prevention and Genetics. Recent Results in Cancer Research, vol 163. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55647-0_12
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DOI: https://doi.org/10.1007/978-3-642-55647-0_12
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