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Role of Signaling Pathway Modification

  • Chapter
Modification of Radiation Response

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

A unique aspect of ionizing radiation as a therapeutic tool is the locoregional application of the cytotoxic therapy without systemic toxicity. However, there are several limitations to the efficacy of radiation treatment: ionizing radiation is mainly effective for the treatment of cancers that have not spread. Furthermore, in patients presenting with locoregional disease, some are cured whereas in others disease recurs and progresses either locally and/or systemically. Some tumors are controlled with high probability by low doses of radiation (e.g., seminomas, lymphomas), others are controlled by moderate to high radiation doses (e.g., breast and prostate adenocarcinomas) and still others will progress even after treatment with high radiation doses, exceeding normal tissue tolerance (e.g., glioblastoma, melanoma). The reason for failure to cure may include treatment-related factors (e.g., metastases out of treatment volume, large volume, unfavorable location) or tumor-related factors (e.g., radiation-resistant tumor cells, limited tolerance of the surrounding normal tissue, hypoxic tumor cells) (Jung and Dritschilo 1996). Research for improvement of radiotherapy focuses on physical and biological aspects: with the improvement of radiation technology (e.g., intensity-modulated radiation therapy [IMRT]) and the introduction of novel imaging techniques (e.g., PET), the control of treatment-related factors has increased. Modern radiobiology focuses on the modulation of molecular processes, thereby overcoming inherent radiation resistance of the tumor cell.

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Authors and Affiliations

  1. Laboratory for Molecular Radiobiology, Department Radiation Oncology, University Hospital Zurich, 8091, Zurich, Switzerland

    O. Riesterer MD, M. Pruschy PhD & S. Bodis MD

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  1. O. Riesterer MD
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  2. M. Pruschy PhD
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  3. S. Bodis MD
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Editors and Affiliations

  1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Carsten Nieder MD

  2. Department of Experimental Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    Luka Milas MD, PhD

  3. Department of Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    K. Kian Ang MD, PhD

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© 2003 Springer-Verlag Berlin Heidelberg

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Riesterer, O., Pruschy, M., Bodis, S. (2003). Role of Signaling Pathway Modification. In: Nieder, C., Milas, L., Ang, K.K. (eds) Modification of Radiation Response. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55613-5_13

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  • DOI: https://doi.org/10.1007/978-3-642-55613-5_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62670-8

  • Online ISBN: 978-3-642-55613-5

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