Zusammenfassung
Das kleinzellige Lungenkarzinom ist durch
-
• eine sehr rasche Tumorverdoppelungszeit,
-
• eine sehr hohe Zellproliferationsrate und
-
• eine frühzeitige Metastasierungstendenz gekennzeichnet.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Arriagada R, Le Chevalier T, Borie F et al. (1995) Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. J Natl Cancer Inst 87: 161–162
Auperin A, Arriagada R, Pignon J-P et al. (1999) Prophylactic cranial irradiation for patients with small cell lung cancer in complete remission. N Engl Med 341: 476
Bonner JA, Shanahan TG, Brooks BJ et al. (1998) Phase III comparison of once-daily thoracic radiation versus twice-daily thoracic irradiation in patients with limited stage small cell lung cancer. Proc Am Soc Clin Oncol 17: 456
Bunn A (1986) Recent advances in the biology and treatment of small cell lung cancer. Adv Oncollgy 2: 9–15
Bunn PA, Lichter AS, Makuch RW et al. (1987) Chemotherapy alone or chemotherapy with chest radiation therapy in limited stage small cell lung cancer: a prospective randomized trial. Ann Intern Med 106:655
Calderoni A, Cerny T (1996) Small cell lung cancer 1996: News? Schweiz Krebsbull 16: 5–12
Carney DN (1999) Prophylactic cranial irradiation and small-cell lung cancer. N Engl J Med 341: 524–526
Cox JD, Stanley K, Petrovich Z, Paig C, Yesner R (1981) Cranial irradiation in cancer of the lung of all cell types. JAMA 245: 469–472
Cull A, Gregor A, Hopwood P et al. (1994) Neurological and cognitive impairment in long-term survivor of small cell lung cancer. Eur J Cancer 30A: 1067–1074
De Vore III RF, Johnson DH (1996) Chemotherapy of small cell lung cancer. In: Pass HJ, Mitchel JB, Johnson DH, Turrisi AT (eds) Lung cancer: principles and practice. Lippincott Raven, Philiadelphia, pp 825–835
Eberhardt W, Wolf M (2001) Chemotherapy in stage IV lung cancer (take home massages). Lung Cancer 33(Suppl 1): 121–123
Feld R, Ginsberg RJ (1999) Small lung cell cancer. In: Shields TW, LoCicero J (eds) General thoracic surgery, 5th edn. Lippincott, Williams&Wilkins, New York, p 1443
Flentje M, Zierhut D, Schraube P, Wannenmacher M (1993) Integration of coronal magnetic resonance imaging (MRI) into radiation treatment planning of mediastinal tumors. Strahlenther Onkol 169: 351–357
Fox W, Scadding JG (1973) Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small celled or oat celled carcinoma of the bronchus. Ten year follow-up. Lancet 2:63
Fu KK, Lam KN, Rayner PA (1985) The influence of time sequence of cisplatin administration and continuous low dose rate irradiation (CLDRI) on their combined effects on a murine squamous cell carcinoma. Int J Radiat Oncol Biol Phys 11: 2119–2124
Giaccone G (2001) State of the art in systemic treatment of lung cancer. Europ J Cancer (Suppl 7): 99–114
Glanzmann C (1990) Palliative Radiotherapie von Hirnmetastasen solider Tumoren: Erfahrungen mit hohen Dosen. Strahlenther Onkol 166: 119–124
Glasziou PP, Simes RJ, Gelber RD (1990) Quality adjusted survival analysis. Stat Med 9:1259
Gregor A, Cull A, Stephens RJ et al. (1997) Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: results of a multicentre randomised trial. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) and the Europe-an Organisation for Research and Treatment of Cancer (EORTC). Eur J Cancer 33: 1717–1719
Gregor A, Drings P, Burghouts J et al. (1997) Randomized trial of alternating versus sequential radiotherapy/chemotherapy in limited-disease patients with small-cell lung cancer: a European organization for research and treatment of cancer. lung cancer cooperative group study. J Clin Oncol 15: 2840
Ihde CD (1992) Chemotherapy of lung cancer. N Engl J Med 327: 1434–1441
Jeremic B, Shibamato Y, Acimovic L et al. (1997) Initial versus delayed accelerated hyperfractionated radiation therapy and concurrent chemotherapy in limited small-cell lung cancer: a randomized study. J Clin Oncol 15:893
Kelland LR, Steel GG (1988) Inhibition of recovery from damage induced by ionizing radiation in mammalian cells. Radiother Oncol 13: 285–299
Kies MS, Mira JG, Crowley JJ, Chen TT, Pazdur R, Grozea PN, Rivkin SE, Coltman CA Jr, Ward JH, Livingston RB (1987) Multimodal therapy for limited small-cell lung cancer: a randomized study of induction combination chemotherapy with or without thoracic radiation in complete responders; and with wide-field versus reduced-field radiation in partial responders: a Southwest Oncology Group Study. J Clin Oncol 5: 592–600
Kohman LJ (1997) Is there a place for surgery in central small lung cell cancer? In: Chest Surgery Clinics of North America (eds) Small cell lung carcinoma. WB Saunders, Philadelphia, P 105
Korbelik M, Skov KA (1989) Inactivation of hypoxic cells by cisplatin and radiation at clinically relevant doses. Radiat Res 119: 145–156
Krempien R, Schubert K, Latz D, Wenz F, Wannenmacher M (1999) MRT-Simulation von Lungencarcinomen mittels eines offenen Niederfeld-MRT. Strahlenther Onkol 175: 279–283
Krempien R, Schubert K, Zierhut D, Steckner MC, Treiber M, Harms W, Mende U, Latz D, Wannenmacher M, Wenz F (in press) Open low field magnetic resonance imaging (MRI) in radiation therapy treatment planning. Int J Radiat Oncol Biol Phys
LeChevalier T, Arriagada R, Pignon JP et al. (1993) Initial chemotherapy dosis have a significant impact on survival in limited small cell lung cancer — Results of a multicentric retrospective randomized study in 105 patients. N Engl J Med 329: 1848
Livingston RB, Moore TN, Heilbrun I et al. (1978) Small-cell carcinoma of the lung: combined chemotherapy and radiation. A Southwest Oncology Group study. Ann Intern Med 88:194
Mehta C, Vogl SE (1982) High-dose cyclophosphamide in the induction therapy of small cell lung cancer: minor improvements in rate of remission and survival. Proc Am Assoc Cancer Res 23:155
Murray N, Shah A, Brown E et al. (1986) Alternating chemotherapy and thoracic radiotherapy with concurrent cisplatin-etoposide for limited-stage small-cell carcinoma of the lung. Semin Oncol [Suppl 3] 13:24
Murray N, Coy P, Pater J et al. (1993) Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer. J Clin Oncol 11:336
Murray N, Grafton C, Shah A et al. (1998) Abbreviated treatment for elderly, infirm, or non-compliant patients with limited-stage small-cell lung cancer. J Clin Oncol 16:3323
Niederle N, Weidman B, Budach V, Schirren J (1999) Kleinzelliges Lungenkarzinom. In: Schmoll HJ, Höffken K, Possinger H (Hrsg) Kompendium internistische Onkologie, Teil 2: Therapie von Leukämien, Lymphomen, soliden Tumoren — Spezielle Therapiemodalitäten — Regionale Chemotherapie — Notfälle. Springer, Berlin Heidelberg New York Tokyo, pp 711–751
Nugent JL, Bunn PA jr, Matthews MJ, Ihde DC, Cohen MH, Gazdar A, Minna JD (1979) CNS metastasis in small cell bronchogenic carcinoma: increasing frequency and changing pattern with lengthening survival. Cancer 44: 1885–1893
Osoba D, Aaronson N, Zee B, Sprangers M, te Velde A (1996) Modification of the EORTC QLQ-C30 (version 2.0) based on content validity and reliability testing in large samples of patients with cancer. The Study Group on Quality of Life of the EORTC and the Symptom Control and Quality of Life Committees of the NCI of Canada Clinical Trials Group. Qual Life Res 6: 103–108
Osterlind K (2001) Chemotherapy in small cell lung cancer. In: Spiro SG (ed) Lung Cancer. European Respiratory Monograph 17, Vol 6
Pedersen AG, Kristjansen PEG, Hansen HH (1988) Prophylactic cranial irradiation and small cell lung cancer. Cancer Treat Rev 15: 85–103
Perez CA, Einhorn L, Oldham RK et al. (1984) Randomized trial or radiotherapy to the thorax in limited small-cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation: a preliminary report. J Clin Oncol 2:1200
Perry MC, Herndon JE, Eaton WL et al. (1998) Thoracic radiation therapy added to chemotherapy modality treatment of limited-stage small-cell lung cancer: an update of cancer and leukemia group B study 8083. J Clin Oncol 16:2466
Pignon JP, Arriagada R, Ihde DC et al. (1992) A meta-analysis of thoracic radiotherapy for small-cell lung cancer. N Engl J Med 327: 11618–1624
Richter MP, Lawrence RC (1985) Palliative radiation therapy. Semin Oncol 12: 375–383
Rieden K, Adolph J, Lellig U, Winkel K zum (1989) Strahlentherapeutischer Effekt bei Knochenmetastasen in Abhängigkeit von der Metastasierungshäufigkeit, Metastasenlokalisation und Histologie des Primärtumors. Strahlenther Onkol 165: 380–385
Rowinsky EK, Ettinger DS (1996) Drug development and new drugs for lung cancer: In: Pass HJ, Mitchel JB, Johnson DH, Ruttisi AG (eds) Lung cancer: principles and practice. Lippincott Raven, Philadelphia, pp 793–810
Schubert K, Wenz F, Krempien R, Schramm O, Sroka-Perez G, Schraube P, Wannenmacher M (1999) Einsatzmöglichkeiten eines offenen Magnetresonanztomographen in der Therapiesimulation und dreidimensionalen Bestrahlungsplanung. Strahlenther Onkol 175: 225–231
Schütte W (2001) Chemotherapy as treatment of primary and recurrent small cell lung cancer. Lung Cancer 33(Suppl 1): 99–107
Shepherd F, Ginsberg RJ, Haddad R et al. (1993) Importance of clinical staging in limited small-cell lung cancer: a valuable system to separate prognostic subgroups. J Clin Oncol 11:1592
Shepherd FA (1998) Surgical management of small lung cell cancer. In: Pass HI, Mitchell JB, Johnson DH, Turrisi AT (eds) Lung cancer: principles and practice. Lippincott-Raven, Philadelphia, p 967
Sierocki JS, Hilaris BS, Hopfan S et al. (1979) Cis-dichlorodiammineplatinum (II) and VP-16-213: an active induction regimen for small cell carcinoma of the lung. Cancer Treat Rep 63:1593
Sloan JA, Bonner JA, Hillman SL et al. (2002) A quality-adjusted reanalysis of a phase III trial comparing once-daily thoracic radiation vs. twice-daily thoracic radiation in patients with limited-stage small-cell lung cancer. Int J Radiation Oncoloy Biol Phys 52: 371–381
Takada M, Fukuoka M, Furuse K et al. (1996) Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small cell lung cancer: preliminary results of the apan Clinical Oncology Group (JCOG). Proc Am Soc Clin Oncol 15:372
Turrisi AT, Kim K, Blum R et al. (1999) Twice daily thoracic radiotherapy versus once daily radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin-etoposide chemotherapy. N Engl J Med 340:265
Turrisi AT III, Kyungmann K, Blum R, Sause WT, Livingston RB, Komaki R, Wagner H, Aisner S, Johnson DH (1999) Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med 340: 265–271
Urschel JD (1997) Surgical treatment of peripheral small lung cell cancer. In: Chest Surgery Clinics of North America (eds) Small cell lung carcinoma. WB Saunders, Philadelphia, p 95
Warde P, Payne D (1992) Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-analysis. J Clin Oncol 10:890
Wolf M (2001) Dose intensive chemotherapy in small cell lung cancer. Lung cancer 33(Suppl 1): 125–135
Wolf M, Havemann M (1998) Kleinzellige Lungenkarzinome. In Seebers, Schütte J (Hrsg) Therapiekonzepte Onkologie, 3. Aufl. Springer, Berlin Heidelberg New York Tokyo, S 496–525
Work E, Nielsen O, Bentzen S et al. (1997) Randomized study of initial versus late chest irradiation combined with chemotherapy in limited-stage small cell lung cancer. J Clin Oncol 15:3030
Zimm S, Wampler GL, Stablein D, Hazra T, Young HF (1981) Intracerebral metastases in solid-tumor patients: natural history and results of treatment. Strahlenther Onkol 48: 384–394
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Drings, P., Manegold, C. (2003). Kleinzellige Lungenkarzinome. In: Drings, P., Dienemann, H., Wannenmacher, M. (eds) Management des Lungenkarzinoms. Onkologie Aktuell . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55602-9_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-55602-9_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-62774-3
Online ISBN: 978-3-642-55602-9
eBook Packages: Springer Book Archive