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Sexuell übertragbare Viren

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Infektionskrankheiten in Gynäkologie und Geburtshilfe

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Zusammenfassung

Die α-Herpesviren besitzen innerhalb eines ca. 100 nm ikosaedrischen Kapsids ein lineares doppel-strängiges DNA-Genom mit 125 000–250 000 Basenpaaren. Die DNA-Struktur der HSV 1 und 2 weisen eine ähnliche, wenn auch nicht identische, Basensequenz auf. Das Virus bindet über Glykoproteine auf der äußeren Umhüllung an unbekannte Komponenten der mukosalen Zielzelle. Nach Fusion seiner Umhüllung mit der Zellmembran des Wirtes schleust es sein Nukleokapsid in die Zielzelle ein. Dadurch wird das virale Genom in den Zellkern transportiert. Gesteuert von viralen Regulatorproteinen wird es dann durch die zelleigene DNA-Polymerase II transkribiert.

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Literatur

  • Andrews EB, Yankaskas BC, Cordero JF et al. (1992) Acyclovir in pregnancy registry: six years’ experience. Obstet Gynecol 797–13

    Google Scholar 

  • Barton IG, Kinghorn GR, Najem S et al. (1982) Incidence of herpes simplex virus types 1 and 2 isolated from patients with herpes genitalis in Sheffield. Br J Ven Dis 58:44–47

    CAS  Google Scholar 

  • Brown ZA, Annholm A, Ashley R et al. (1993) HSV serological discordancy among sexual partners and rates of sero-conversion during pregnancy. Infectious Disease Society for Obstetrics and Gynecology, Stowe

    Google Scholar 

  • Koutsky LA, Stevens CE, Holmes KK et al. (1992) Under diagnosis of genital herpes by current clinical and viral-isolation procedures. N Engl J Med 326:1533–1539

    Article  PubMed  CAS  Google Scholar 

  • Kulhanjian JA, Soroush V, Au DS et al. (1992) Identification of women at unsuspected risk of primary infection with herpes simplex virus type 2 during pregnancy. N Engl J Med 326:916–920

    Article  PubMed  CAS  Google Scholar 

  • Martius J (1996) Genitale Infektionen mit Herpes-simplex-Viren und humanen Papillomviren. Gynäkologe 29:96–104

    Google Scholar 

  • Randolph AG, Washington AE, Prober CG (1993) Cesarean delivery for women presenting with genital herpes lesions. Efficacy, risks and costs. JAMA 270:77–82

    Article  PubMed  CAS  Google Scholar 

  • Stray-Pedersen B (1990) Acyclovir in late pregnancy to prevent neonatal herpes simplex (letter). Lancet 336:756

    Article  PubMed  CAS  Google Scholar 

  • Stray-Pedersen B (1993) New aspects of perinatal infections. Ann Med 25:295–300

    Article  PubMed  CAS  Google Scholar 

  • Whitley RJ (1990) Herpes simplex viruses. In: Fields BN, Knipe DM (eds) Fields virology, 2nd edn. Raven, New York, pp 1843–1887

    Google Scholar 

  • Whitley RJ, Corey L, Arvin A et al. (1988) Changing presentation of herpes simplex virus infection in neonates. J Infect Dis 158:109–116

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Adler SP (1992) Cytomegalovirus and pregnancy. Curr Opin Obstet Gynecol 4:670–675

    Article  PubMed  CAS  Google Scholar 

  • Demmler G (1996) Congenital cytomegalovirus infection and disease. Adv Pediatr Infect Dis 11:135–162

    PubMed  CAS  Google Scholar 

  • Donner C, Liesnard C, Brancart F, Rodesch F (1994) Accuracy of amniotic fluid testing before 21 weeks gestation in prenatal diagnosis of congenital cytomegalovirus infection. Prenat Diagn 14:1055–1059

    Article  PubMed  CAS  Google Scholar 

  • Enders G (1997) Zytomegalie. In: Friese K, Kachel W (Hrsg) Infektionserkrankungen der Schwangeren und des Neugeborenen, 2. Aufl. Springer, Berlin Heidelberg New York, S 90–102

    Google Scholar 

  • Fowler KB, Stagno S, Pass RF, Britt WJ, Boll TJ, Alford CA (1992) The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med 326:663–667

    Article  PubMed  CAS  Google Scholar 

  • Fowler KB, Stagno S, Pass RF (1993) Maternal age and congenital cytomegalovirus infection: screening of two diverse newborn population, 1980–1990. J Infect Dis 168:552–556

    Article  PubMed  CAS  Google Scholar 

  • Istas AS, Demmler GJ, Dobbins JG, Stewart JA (1995) National Cytomegalovirus Disease Registry Collaborating Group Surveillance for congenital cytomegalovirus disease: a report from the National Congenital Cytomegalovirus Disease Registry. Clin Infect Dis 20:665–670

    Article  PubMed  CAS  Google Scholar 

  • Pass RF, Fowler KB, Boppana SB (1991) Progress in cytomegalovirus research. In: Landini MP (ed) Proceedings of the third internatioal cytomegalovirus workshop. Bologna, Italy, June 1991. Excerpta Medica, London, pp 3–10

    Google Scholar 

  • Pass RF, Duliegè AM, Boppana S, Sekulovich R, Percell S, Britt W, Burke RL (1999) A subunit cytomegalovirus vaccine based on recombinant envelope glycoprotein B and a new adjuvant. J Infect Dis 180:970–975

    Article  PubMed  CAS  Google Scholar 

  • Plotkin SA (1999) Vaccination against cytomegalovirus, the changeling demon. Pediatric Infect Dis J 18:313–326

    Article  CAS  Google Scholar 

  • Porath A, McNutt RA, Smiley LM et al. (1990) Effectiveness and cost benefit of a proposed live cytomegalovirus vaccine in the prevention of congenital disease. Rev Infect Dis 12:31–40

    Article  PubMed  CAS  Google Scholar 

  • Shen CY, Chang SF, Yang SL et al. (1994) Cytomegalovirus is present in semen from a population of men seeking fertility evaluation. J Infect Dis 169:222–223

    Article  PubMed  CAS  Google Scholar 

  • Sinzger C, Plachter B, Grefte A, Jahn G (1996) Tissue macrophages are infected by human cytomegalovirus in vivo. J Infect Dis 173:240–245

    Article  PubMed  CAS  Google Scholar 

  • Stagno S (1995) Cytomegalovirus. In: Remington JS, Klein JO (eds) Infectious diseases of the fetus & newborn infants. Saunders, Philadelphia, pp 312–353

    Google Scholar 

  • Vochem M, Hamprecht K, Speer CP (1997) Zytomegalievirus-infektionen von Frühgeborenen über die Muttermilch. Monatsschr Kinderheilk 145:619–625

    Article  Google Scholar 

Literatur

  • Fleischer G, Bologonese R (1984) Epstein-Barr virus infection in pregnancy: a prospective study. J Pediatr 104:374–379

    Article  Google Scholar 

  • Icart J, Didier J, Dalens M, Chabanon G, Boucays A (1981) Prospective study of Epstein Barr virus (EBV) infection during pregnancy. Biomedicine 34:160–163

    PubMed  CAS  Google Scholar 

  • Kusahara K, Takabayashi A, Ueda K et al. (1997) Breast milk is not a significant source for early Epstein-Barr virus or human herpesvirus 6 infection in infants: a seroepidemiologic study in 2 endemic areas of human T-cell lymphotropic virus type 1 in Japan. Microbiol Immunol 41:309–312

    Google Scholar 

  • Meyohas MC, Marechal V, Desire N et al. (1996): Study of mother-to-child Epstein Barr virus transmission by means of nested PCRs. J Virol 70:6816–6819

    PubMed  CAS  Google Scholar 

Literatur

  • Boysiewicz LK Fiander A, Mimako M et al. (1996) A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer. Lancet 347:1523–1527

    Article  Google Scholar 

  • Gaarenstroom KN, Melkert P, Walboomers JM et al. (1994) Human papillomavirus DNA and genotypes: prognostic factors for progession of cervical intraepithelial neoplasia. Int J Gynecol Cancer 4:73–78

    Article  PubMed  Google Scholar 

  • Koch A, Hansen SV, Nielson NM, Palefsky J, Melbye M (1997) HPV detection in children prior to sexual debut. Int J Cancer 73:621–624

    Article  PubMed  CAS  Google Scholar 

  • Moscicki AB, Shiroboski S, Broering J et al. (1998) The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women. J Pediatr 132:277–284

    Article  PubMed  CAS  Google Scholar 

  • Pearlstone AC, Grigsby PY, Mutch (1992) High rates of atypical cervical cytology: occurrence and clinical significance. Obstet Gynecol 80:191–195

    PubMed  CAS  Google Scholar 

  • Raffle AE, Alden B, Mackenzie EF (1995) Detection rates for abnormal cervical smears: what are we screening for? Lancet 345:1469–1473

    Article  PubMed  CAS  Google Scholar 

  • Tseng CJ, Liang CC, Soong YK, Pao CC (1998) Perinatal transmission of HPV in infants: relationship between infection rate and mode of delivery. Obstet Gynecol 91:92–96

    Article  PubMed  CAS  Google Scholar 

  • Wallin, KL, Wiklund F, Angstrom T et al. (1998) Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer. N Engl J Med 341:1633–1638

    Article  Google Scholar 

Literatur

  • Konya J, Thompson CH (1999) Molluscum contagiosum virus: antibody responces in persons with clinical lesions and seroepidemiology in a representative Australian population. J Infect Dis 179:701–704

    Article  PubMed  CAS  Google Scholar 

  • Silverberg NB, Sibury R, Mancini A (2000) Childhood molluscum contagiosum experience with cantharidin therapy in 300 patients. J Am Acad Dermatol 43:503–507

    Article  PubMed  CAS  Google Scholar 

  • Watanabe T, Nakamura K, Wakugawa M et al. (2000) Antibodies to molluscum contagiosum virus in the general population and susceptible patients. Arch Dermatol 136:1518–1522

    Article  PubMed  CAS  Google Scholar 

  • Wilkin JK (1977) Molluscum contagiosum venereum in a women’s outpatient clinic: a venereally transmitted disease. Am J Obstet Gynecol 128:531–535

    PubMed  CAS  Google Scholar 

Literatur

  • Brettle RP, Raab GM, Ross A et al. (1995) HIV infection in women: immunological markers and the influence of pregnancy. AIDS 9:1177–1184

    Article  PubMed  CAS  Google Scholar 

  • Brocklehurst P, French R (1998) The association between maternal HIV infection and perinatal outcome: a systematic review of literature and meta-analysis. Br J Obstet Gynecol 105:836–848

    Article  CAS  Google Scholar 

  • Duerr A, Sierra MF, Feldman J et al. (1997) Immune compromise and prevalence of Candida vulvovaginitis in human immunodeficiency virus-infected women. Obstet Gynecol 90:252–256

    Article  PubMed  CAS  Google Scholar 

  • D’Souza M, Harden VA (1996) Chemokines and HIV-1 second receptors. Confluence of two fields generates optimism in AIDS research. Nat Med 2:1293–1300

    Article  PubMed  Google Scholar 

  • Ellerbrock TV, Wright TC, Bush TJ et al. (1996) Characteristics of menstruation in women infected with human immunodeficiency virus. Obstet Gynecol 87:1030–1034

    Article  PubMed  CAS  Google Scholar 

  • Frankel RE, Selwyn PA, Nezger J, Andrews S (1997) High prevalence of gynecologic disease among hospitalized women with immunodeficiency virus infection. Clin Infect Dis 25:706–712

    Article  PubMed  CAS  Google Scholar 

  • Ho RJ, Larsen K, Bui T et al. (2000) Suppression of maternal virus load with zidovudine, didanosine, and indinavir combination therapy prevents mother-to-fetus HIV transmission in macaques. J Acquir Immune Defic Syndr 25:140–149

    Article  PubMed  CAS  Google Scholar 

  • Kestens L, Vingerhoets J, Peeters M al. (1995) Phenotypic and functional parameters of cellular immunity in a chimpanzee with a naturally acquired simian immunodeficiency virus infection. J Infect Dis 172:957–963

    Article  PubMed  CAS  Google Scholar 

  • Nduati R, Mbori-Nagacha D, Richardson B et al. (2000) Effects of breastfeeding and formula feeding on transmission of HIV-1. JAMA 283:1167–1174

    Article  PubMed  CAS  Google Scholar 

  • Schäfer A (1996) HIV in Gynäkologie und Geburtshilfe. Gynäkologe 29:129–137

    Google Scholar 

  • Schäfer A, Friedmann W, Mielke M, Schwartländer B, Koch MA (1991) The increased frequency of cervical dysplasia-neoplasia in women infected with the human immunodeficiency virus is related to the degree of immunosuppression. Am J Obst Gyn 164:593–599

    Article  Google Scholar 

  • Towers CV, Deveikis A, Asrat T, Major C, Nagarotte MP (1998) A „bloodless cesarean section“ and perinatal transmission of the human immunodeficency virus. Am J Obstet Gynecol 179:708–714

    Article  PubMed  CAS  Google Scholar 

  • Wade NA, Birkhead GS, Warren BL et al. (1998) Abbreviated regimens of zidovudine prophylaxis and perinatal transmission of the human immunodeficiency virus. N Engl J Med 339:1409–1414

    Article  PubMed  CAS  Google Scholar 

  • Wright TC, Koulos JP, Liu P, Sun XW (1996) Invasive vulvar carcinoma in two women infected with human immunodeficiency virus. Gynecol Oncol 60:500–503

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Bazarbachi A, Hermine O (2001) Treatment of adult T-cell leukemia/lymphoma: current strategy and future perspectives. Virus Res 78:79–92

    Article  PubMed  CAS  Google Scholar 

  • Caterino de Araujo A, Santos-Fortuna E de los (1999) No evidence of vertical transmission of HTLV-I and HTLV II in children at high risk for HIV-1 infection from Sao Paulo, Brazil. J Trop Pediatr 45:42–47

    Article  Google Scholar 

  • Tynell E, Anderson S, Lithander E et al. (1998) Screening for human T cell leukemia/lymphoma virus among blood donors in Sweden: cost effectiveness analysis. BMJ 316:1471–1422

    Article  Google Scholar 

  • Uchiyama T, Yodoi T, Sagawa K, Takatsuki K, Uchino H (1977) Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blodd 50:481–492

    CAS  Google Scholar 

  • Ureta-Vidal A, Angelin-Duclos C, Tortevoye P et al. (1999) Mother-to-child transmission of human T-cell-leukemia/lymphoma virus type 1: Implication of high antiviral antibody titer and high proviral load in carrier mothers. Int J Cancer 82:832–836

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Frösner G (1996) Moderne Hepatitisdiagnostik. Kilian, Marburg

    Google Scholar 

  • Böker KHW, Manns MP (1995) Diagnostik und Therapie chronischer Hepatitiden. Med Klin 90:411–422

    Google Scholar 

  • STIKO (2001) Impfempfehlungen der ständigen Impfkommission (STIKO) am Robert Koch-Institut/ Stand Juli 2001, Epidemiol Bull RKI 28:203–218

    Google Scholar 

Literatur

  • Frösner G (1996) Moderne Hepatitisdiagnostik. Kilian, Marburg

    Google Scholar 

  • Böker KHW, Manns MP (1995) Diagnostik und Therapie chronischer Hepatitiden. Med Klin 90:411–422

    Google Scholar 

  • Polywka S, Feucht H, Zöllner B, Laufs R (1997) Hepatitis C Virus infection in pregnancy and the risk of mother-to-child transmission. Europ J Clin Microbiol Infect Dis 16:121–124

    Article  PubMed  CAS  Google Scholar 

  • Zeuzem S, Roth WK, Herrmann G (1995) Virushepatitis C. Z Gastroenterol 33:117–132

    PubMed  CAS  Google Scholar 

Literatur

  • Zuckerman AJ (1990) Hepatitis E. The main cause of enterically transmitted non-A, non-B hepatitis. Brit Med J 300:1475

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. I. Frauenklinik und Hebammenschule, LMU München, Maistraße 11, D-80337, München, Deutschland

    Prof. Dr. med. Klaus Friese (Direktor)

  2. Klinik für Gynäkologie und Geburtshilfe Charité, Augustenburger Platz 1, D-13353, Berlin, Deutschland

    Priv.-Doz. Dr. med. Dr. rer. nat. Axel Schäfer

  3. Institut für Medizinische Mikrobiologie und Hygiene, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer, D-68167, Mannheim, Deutschland

    Ordinarius Prof. Dr. med. Herbert Hof

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  1. Prof. Dr. med. Klaus Friese
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  2. Priv.-Doz. Dr. med. Dr. rer. nat. Axel Schäfer
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  3. Ordinarius Prof. Dr. med. Herbert Hof
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Friese, K., Schäfer, A., Hof, H. (2003). Sexuell übertragbare Viren. In: Infektionskrankheiten in Gynäkologie und Geburtshilfe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55586-2_4

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  • DOI: https://doi.org/10.1007/978-3-642-55586-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62945-7

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